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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26068

FusionGeneSummary for PAX1_CDC37

check button Fusion gene summary
Fusion gene informationFusion gene name: PAX1_CDC37
Fusion gene ID: 26068
HgeneTgene
Gene symbol

PAX1

CDC37

Gene ID

5075

11140

Gene namepaired box 1cell division cycle 37
SynonymsHUP48|OFC2P50CDC37
Cytomap

20p11.22

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionpaired box protein Pax-1paired box gene 1paired domain gene HuP48hsp90 co-chaperone Cdc37CDC37 (cell division cycle 37, S. cerevisiae, homolog)CDC37 cell division cycle 37 homologcell division cycle 37 homologhsp90 chaperone protein kinase-targeting subunit
Modification date2018052220180523
UniProtAcc

P15863

Q16543

Ensembl transtripts involved in fusion geneENST00000398485, ENST00000460221, 
ENST00000444366, 
ENST00000222005, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 6 X 4=120
# samples 17
** MAII scorelog2(1/1*10)=3.32192809488736log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PAX1 [Title/Abstract] AND CDC37 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI004584PAX1chr20

21695719

-CDC37chr19

10506788

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000398485ENST00000222005PAX1chr20

21695719

-CDC37chr19

10506788

-
intron-3CDSENST00000460221ENST00000222005PAX1chr20

21695719

-CDC37chr19

10506788

-
3UTR-3CDSENST00000444366ENST00000222005PAX1chr20

21695719

-CDC37chr19

10506788

-

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FusionProtFeatures for PAX1_CDC37


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PAX1

P15863

CDC37

Q16543

This protein is a transcriptional activator. It may playa role in the formation of segmented structures of the embryo. Mayplay an important role in the normal development of the vertebralcolumn (By similarity). {ECO:0000250}. Co-chaperone that binds to numerous kinases and promotestheir interaction with the Hsp90 complex, resulting instabilization and promotion of their activity (PubMed:8666233).Inhibits HSP90AA1 ATPase activity (PubMed:23569206).{ECO:0000269|PubMed:23569206, ECO:0000269|PubMed:8666233}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PAX1_CDC37


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PAX1_CDC37


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PAX1_CDC37


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PAX1_CDC37


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePAX1C3714942OTOFACIOCERVICAL SYNDROME 21UNIPROT