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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26063

FusionGeneSummary for PATZ1_WDR25

check button Fusion gene summary
Fusion gene informationFusion gene name: PATZ1_WDR25
Fusion gene ID: 26063
HgeneTgene
Gene symbol

PATZ1

WDR25

Gene ID

23598

79446

Gene namePOZ/BTB and AT hook containing zinc finger 1WD repeat domain 25
SynonymsMAZR|PATZ|RIAZ|ZBTB19|ZNF278|ZSG|dJ400N23C14orf67
Cytomap

22q12.2

14q32.2

Type of geneprotein-codingprotein-coding
DescriptionPOZ-, AT hook-, and zinc finger-containing protein 1BTB-POZ domain zinc finger transcription factorMAZ-related factorPOZ-AT hook-zinc finger proteinprotein kinase A RI subunit alpha-associated proteinzinc finger and BTB domain-containing protein 19zWD repeat-containing protein 25
Modification date2018051920180519
UniProtAcc

Q9HBE1

Q64LD2

Ensembl transtripts involved in fusion geneENST00000266269, ENST00000405309, 
ENST00000351933, ENST00000215919, 
ENST00000554998, ENST00000402312, 
ENST00000335290, ENST00000542471, 
ENST00000554175, ENST00000557502, 
Fusion gene scores* DoF score3 X 3 X 2=181 X 1 X 1=1
# samples 42
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/1*10)=4.32192809488736
Context

PubMed: PATZ1 [Title/Abstract] AND WDR25 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF939688PATZ1chr22

31736936

+WDR25chr14

100996329

-
ChiTaRS3.1BF594249PATZ1chr22

31736936

+WDR25chr14

100996329

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000266269ENST00000554998PATZ1chr22

31736936

+WDR25chr14

100996329

-
intron-3CDSENST00000266269ENST00000402312PATZ1chr22

31736936

+WDR25chr14

100996329

-
intron-3CDSENST00000266269ENST00000335290PATZ1chr22

31736936

+WDR25chr14

100996329

-
intron-3CDSENST00000266269ENST00000542471PATZ1chr22

31736936

+WDR25chr14

100996329

-
intron-intronENST00000266269ENST00000554175PATZ1chr22

31736936

+WDR25chr14

100996329

-
intron-3UTRENST00000266269ENST00000557502PATZ1chr22

31736936

+WDR25chr14

100996329

-
intron-3CDSENST00000405309ENST00000554998PATZ1chr22

31736936

+WDR25chr14

100996329

-
intron-3CDSENST00000405309ENST00000402312PATZ1chr22

31736936

+WDR25chr14

100996329

-
intron-3CDSENST00000405309ENST00000335290PATZ1chr22

31736936

+WDR25chr14

100996329

-
intron-3CDSENST00000405309ENST00000542471PATZ1chr22

31736936

+WDR25chr14

100996329

-
intron-intronENST00000405309ENST00000554175PATZ1chr22

31736936

+WDR25chr14

100996329

-
intron-3UTRENST00000405309ENST00000557502PATZ1chr22

31736936

+WDR25chr14

100996329

-
intron-3CDSENST00000351933ENST00000554998PATZ1chr22

31736936

+WDR25chr14

100996329

-
intron-3CDSENST00000351933ENST00000402312PATZ1chr22

31736936

+WDR25chr14

100996329

-
intron-3CDSENST00000351933ENST00000335290PATZ1chr22

31736936

+WDR25chr14

100996329

-
intron-3CDSENST00000351933ENST00000542471PATZ1chr22

31736936

+WDR25chr14

100996329

-
intron-intronENST00000351933ENST00000554175PATZ1chr22

31736936

+WDR25chr14

100996329

-
intron-3UTRENST00000351933ENST00000557502PATZ1chr22

31736936

+WDR25chr14

100996329

-
intron-3CDSENST00000215919ENST00000554998PATZ1chr22

31736936

+WDR25chr14

100996329

-
intron-3CDSENST00000215919ENST00000402312PATZ1chr22

31736936

+WDR25chr14

100996329

-
intron-3CDSENST00000215919ENST00000335290PATZ1chr22

31736936

+WDR25chr14

100996329

-
intron-3CDSENST00000215919ENST00000542471PATZ1chr22

31736936

+WDR25chr14

100996329

-
intron-intronENST00000215919ENST00000554175PATZ1chr22

31736936

+WDR25chr14

100996329

-
intron-3UTRENST00000215919ENST00000557502PATZ1chr22

31736936

+WDR25chr14

100996329

-

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FusionProtFeatures for PATZ1_WDR25


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PATZ1

Q9HBE1

WDR25

Q64LD2

Transcriptional repressor.{ECO:0000269|PubMed:10713105}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PATZ1_WDR25


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PATZ1_WDR25


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PATZ1_WDR25


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PATZ1_WDR25


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource