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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26056

FusionGeneSummary for PARVB_PPARA

check button Fusion gene summary
Fusion gene informationFusion gene name: PARVB_PPARA
Fusion gene ID: 26056
HgeneTgene
Gene symbol

PARVB

PPARA

Gene ID

29780

5465

Gene nameparvin betaperoxisome proliferator activated receptor alpha
SynonymsCGI-56NR1C1|PPAR|PPARalpha|hPPAR
Cytomap

22q13.31

22q13.31

Type of geneprotein-codingprotein-coding
Descriptionbeta-parvinaffixinperoxisome proliferator-activated receptor alphaPPAR-alphanuclear receptor subfamily 1 group C member 1peroxisome proliferative activated receptor, alphaperoxisome proliferator-activated nuclear receptor alpha variant 3
Modification date2018052320180527
UniProtAcc

Q9HBI1

Q07869

Ensembl transtripts involved in fusion geneENST00000406477, ENST00000338758, 
ENST00000404989, ENST00000477795, 
ENST00000396000, ENST00000262735, 
ENST00000407236, ENST00000481567, 
ENST00000402126, ENST00000434345, 
Fusion gene scores* DoF score3 X 1 X 3=93 X 4 X 3=36
# samples 34
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PARVB [Title/Abstract] AND PPARA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPARA

GO:0000122

negative regulation of transcription by RNA polymerase II

9748239|12700342

TgenePPARA

GO:0010745

negative regulation of macrophage derived foam cell differentiation

19114110

TgenePPARA

GO:0010871

negative regulation of receptor biosynthetic process

12700342

TgenePPARA

GO:0010887

negative regulation of cholesterol storage

19114110

TgenePPARA

GO:0010891

negative regulation of sequestering of triglyceride

12700342

TgenePPARA

GO:0045893

positive regulation of transcription, DNA-templated

12955147

TgenePPARA

GO:0045944

positive regulation of transcription by RNA polymerase II

9748239|19955185|20837115

TgenePPARA

GO:0050728

negative regulation of inflammatory response

21636785

TgenePPARA

GO:0072363

regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter

19955185

TgenePPARA

GO:0072366

regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter

19955185

TgenePPARA

GO:0072369

regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter

19955185

TgenePPARA

GO:1902894

negative regulation of pri-miRNA transcription by RNA polymerase II

21636785

TgenePPARA

GO:1903038

negative regulation of leukocyte cell-cell adhesion

21636785


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-FS-A4F4-06APARVBchr22

44420331

+PPARAchr22

46547791

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000406477ENST00000396000PARVBchr22

44420331

+PPARAchr22

46547791

+
intron-5UTRENST00000406477ENST00000262735PARVBchr22

44420331

+PPARAchr22

46547791

+
intron-5UTRENST00000406477ENST00000407236PARVBchr22

44420331

+PPARAchr22

46547791

+
intron-intronENST00000406477ENST00000481567PARVBchr22

44420331

+PPARAchr22

46547791

+
intron-intronENST00000406477ENST00000402126PARVBchr22

44420331

+PPARAchr22

46547791

+
intron-intronENST00000406477ENST00000434345PARVBchr22

44420331

+PPARAchr22

46547791

+
5CDS-5UTRENST00000338758ENST00000396000PARVBchr22

44420331

+PPARAchr22

46547791

+
5CDS-5UTRENST00000338758ENST00000262735PARVBchr22

44420331

+PPARAchr22

46547791

+
5CDS-5UTRENST00000338758ENST00000407236PARVBchr22

44420331

+PPARAchr22

46547791

+
5CDS-intronENST00000338758ENST00000481567PARVBchr22

44420331

+PPARAchr22

46547791

+
5CDS-intronENST00000338758ENST00000402126PARVBchr22

44420331

+PPARAchr22

46547791

+
5CDS-intronENST00000338758ENST00000434345PARVBchr22

44420331

+PPARAchr22

46547791

+
intron-5UTRENST00000404989ENST00000396000PARVBchr22

44420331

+PPARAchr22

46547791

+
intron-5UTRENST00000404989ENST00000262735PARVBchr22

44420331

+PPARAchr22

46547791

+
intron-5UTRENST00000404989ENST00000407236PARVBchr22

44420331

+PPARAchr22

46547791

+
intron-intronENST00000404989ENST00000481567PARVBchr22

44420331

+PPARAchr22

46547791

+
intron-intronENST00000404989ENST00000402126PARVBchr22

44420331

+PPARAchr22

46547791

+
intron-intronENST00000404989ENST00000434345PARVBchr22

44420331

+PPARAchr22

46547791

+
intron-5UTRENST00000477795ENST00000396000PARVBchr22

44420331

+PPARAchr22

46547791

+
intron-5UTRENST00000477795ENST00000262735PARVBchr22

44420331

+PPARAchr22

46547791

+
intron-5UTRENST00000477795ENST00000407236PARVBchr22

44420331

+PPARAchr22

46547791

+
intron-intronENST00000477795ENST00000481567PARVBchr22

44420331

+PPARAchr22

46547791

+
intron-intronENST00000477795ENST00000402126PARVBchr22

44420331

+PPARAchr22

46547791

+
intron-intronENST00000477795ENST00000434345PARVBchr22

44420331

+PPARAchr22

46547791

+

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FusionProtFeatures for PARVB_PPARA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PARVB

Q9HBI1

PPARA

Q07869

Ligand-activated transcription factor. Key regulator oflipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activatedby oleylethanolamide, a naturally occurring lipid that regulatessatiety. Receptor for peroxisome proliferators such ashypolipidemic drugs and fatty acids. Regulates the peroxisomalbeta-oxidation pathway of fatty acids. Functions as transcriptionactivator for the ACOX1 and P450 genes. Transactivation activityrequires heterodimerization with RXRA and is antagonized by NR2C2.May be required for the propagation of clock information tometabolic pathways regulated by PER2.{ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:24043310,ECO:0000269|PubMed:7629123, ECO:0000269|PubMed:7684926,ECO:0000269|PubMed:9556573}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PARVB_PPARA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PARVB_PPARA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PARVBILK, PSME1, RSU1, LIMS1, PARVA, FERMT3, PFKFB2, SNW1, CDC5LPPARANRBF2, STAC3, GADD45G, NCOA1, EP300, RXRG, DAP3, FABP1, MECR, RELA, NRIP1, NCOR1, PPARGC1B, AKAP13, POU1F1, HELZ2, RXRA, NCOR2, NR1H3, PPARGC1A, MED24, HSP90AA1, AIP, TRA, LPIN1, UBE2I, TNP1, CHD9, CDK3, FOXA3, PRMT1, PRMT8, SIRT1, RXRB, NCOA2, NCOA3, CEP350, GRB2, PIK3R3, BCL2, CDC34, STAT1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PARVB_PPARA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePPARAQ07869DB00573FenoprofenPeroxisome proliferator-activated receptor alphasmall moleculeapproved
TgenePPARAQ07869DB01039FenofibratePeroxisome proliferator-activated receptor alphasmall moleculeapproved
TgenePPARAQ07869DB01050IbuprofenPeroxisome proliferator-activated receptor alphasmall moleculeapproved
TgenePPARAQ07869DB01241GemfibrozilPeroxisome proliferator-activated receptor alphasmall moleculeapproved
TgenePPARAQ07869DB13873Fenofibric acidPeroxisome proliferator-activated receptor alphasmall moleculeapproved
TgenePPARAQ07869DB00313Valproic AcidPeroxisome proliferator-activated receptor alphasmall moleculeapproved|investigational
TgenePPARAQ07869DB00328IndomethacinPeroxisome proliferator-activated receptor alphasmall moleculeapproved|investigational
TgenePPARAQ07869DB00412RosiglitazonePeroxisome proliferator-activated receptor alphasmall moleculeapproved|investigational
TgenePPARAQ07869DB00636ClofibratePeroxisome proliferator-activated receptor alphasmall moleculeapproved|investigational
TgenePPARAQ07869DB01132PioglitazonePeroxisome proliferator-activated receptor alphasmall moleculeapproved|investigational
TgenePPARAQ07869DB01393BezafibratePeroxisome proliferator-activated receptor alphasmall moleculeapproved|investigational
TgenePPARAQ07869DB09064CiprofibratePeroxisome proliferator-activated receptor alphasmall moleculeapproved|investigational
TgenePPARAQ07869DB01708PrasteronePeroxisome proliferator-activated receptor alphasmall moleculeapproved|investigational|nutraceutical

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RelatedDiseases for PARVB_PPARA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePPARAC0011853Diabetes Mellitus, Experimental3CTD_human
TgenePPARAC0036341Schizophrenia3PSYGENET
TgenePPARAC0020538Hypertensive disease2CTD_human
TgenePPARAC0021655Insulin Resistance2CTD_human
TgenePPARAC0010346Crohn Disease1CTD_human
TgenePPARAC0011615Dermatitis, Atopic1CTD_human
TgenePPARAC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgenePPARAC0014072Experimental Autoimmune Encephalomyelitis1CTD_human
TgenePPARAC0015695Fatty Liver1CTD_human
TgenePPARAC0015696Fatty Liver, Alcoholic1CTD_human
TgenePPARAC0018800Cardiomegaly1CTD_human
TgenePPARAC0019209Hepatomegaly1CTD_human
TgenePPARAC0020473Hyperlipidemia1CTD_human
TgenePPARAC0020476Hyperlipoproteinemias1CTD_human
TgenePPARAC0020557Hypertriglyceridemia1CTD_human
TgenePPARAC0020615Hypoglycemia1CTD_human
TgenePPARAC0021368Inflammation1CTD_human
TgenePPARAC0022658Kidney Diseases1CTD_human
TgenePPARAC0022661Kidney Failure, Chronic1CTD_human
TgenePPARAC0022672Acute Kidney Tubular Necrosis1CTD_human
TgenePPARAC0023903Liver neoplasms1CTD_human
TgenePPARAC0024667Animal Mammary Neoplasms1CTD_human
TgenePPARAC0024668Mammary Neoplasms, Experimental1CTD_human
TgenePPARAC0026848Myopathy1CTD_human
TgenePPARAC0027055Myocardial Reperfusion Injury1CTD_human
TgenePPARAC0028754Obesity1CTD_human
TgenePPARAC0033578Prostatic Neoplasms1CTD_human
TgenePPARAC0033687Proteinuria1CTD_human
TgenePPARAC0035126Reperfusion Injury1CTD_human
TgenePPARAC0041755Adverse reaction to drug1CTD_human
TgenePPARAC0242339Dyslipidemias1CTD_human
TgenePPARAC0400966Non-alcoholic Fatty Liver Disease1CTD_human
TgenePPARAC2930930Abdominal obesity metabolic syndrome1CTD_human
TgenePPARAC4277682Chemical and Drug Induced Liver Injury1CTD_human