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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26051

FusionGeneSummary for PARVA_SPON1

check button Fusion gene summary
Fusion gene informationFusion gene name: PARVA_SPON1
Fusion gene ID: 26051
HgeneTgene
Gene symbol

PARVA

SPON1

Gene ID

55742

10418

Gene nameparvin alphaspondin 1
SynonymsCH-ILKBP|MXRA2VSGP/F-spondin|f-spondin
Cytomap

11p15.3

11p15.2

Type of geneprotein-codingprotein-coding
Descriptionalpha-parvinactopaxincalponin-like integrin-linked kinase-binding proteinmatrix-remodeling-associated protein 2spondin-1spondin 1, (f-spondin) extracellular matrix proteinspondin 1, extracellular matrix proteinvascular smooth muscle cell growth-promoting factor
Modification date2018052320180522
UniProtAcc

Q9NVD7

Q9HCB6

Ensembl transtripts involved in fusion geneENST00000334956, ENST00000539723, 
ENST00000550549, ENST00000538608, 
ENST00000526746, 
ENST00000310358, 
Fusion gene scores* DoF score9 X 6 X 5=2705 X 4 X 5=100
# samples 95
** MAII scorelog2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PARVA [Title/Abstract] AND SPON1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-EO-A3KU-01APARVAchr11

12499496

+SPON1chr11

14156966

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000334956ENST00000310358PARVAchr11

12499496

+SPON1chr11

14156966

+
5CDS-3UTRENST00000539723ENST00000310358PARVAchr11

12499496

+SPON1chr11

14156966

+
5CDS-3UTRENST00000550549ENST00000310358PARVAchr11

12499496

+SPON1chr11

14156966

+
5CDS-3UTRENST00000538608ENST00000310358PARVAchr11

12499496

+SPON1chr11

14156966

+
intron-3UTRENST00000526746ENST00000310358PARVAchr11

12499496

+SPON1chr11

14156966

+

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FusionProtFeatures for PARVA_SPON1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PARVA

Q9NVD7

SPON1

Q9HCB6

Plays a role in sarcomere organization and in smoothmuscle cell contraction. Required for normal development of theembryonic cardiovascular system, and for normal septation of theheart outflow tract. Plays a role in sprouting angiogenesis and isrequired for normal adhesion of vascular smooth muscle cells toendothelial cells during blood vessel development (By similarity).Plays a role in the reorganization of the actin cytoskeleton,formation of lamellipodia and ciliogenesis. Plays a role in theestablishement of cell polarity, cell adhesion, cell spreading,and directed cell migration. {ECO:0000250,ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308,ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:20393563}. Cell adhesion protein that promotes the attachment ofspinal cord and sensory neuron cells and the outgrowth of neuritesin vitro. May contribute to the growth and guidance of axons inboth the spinal cord and the PNS (By similarity). Major factor forvascular smooth muscle cell. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PARVA_SPON1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PARVA_SPON1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PARVAILK, DHX36, UBE3A, ELAVL1, APP, MLH1, SOX2, HSPH1, CARM1, CORO1B, CRMP1, OSBP, OTUD6B, PPAT, TBC1D17, UGP2, ZRANB2, RSU1, SEC24C, MOCOS, LIMS1, PARVB, IQGAP1, VPS11, GCA, DDX47, CHMP2A, CMTR2, DDX17, DPH5, HSPB2, UBQLN1, SNW1, CDC5L, CDH1, LPXN, CCNB1SPON1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PARVA_SPON1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PARVA_SPON1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePARVAC0236969Substance-Related Disorders1CTD_human