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Fusion gene ID: 26041 |
FusionGeneSummary for PARP8_FAM159B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PARP8_FAM159B | Fusion gene ID: 26041 | Hgene | Tgene | Gene symbol | PARP8 | FAM159B | Gene ID | 79668 |
| Gene name | poly(ADP-ribose) polymerase family member 8 | ||
| Synonyms | ARTD16|pART16 | ||
| Cytomap | 5q11.1 | ||
| Type of gene | protein-coding | ||
| Description | poly [ADP-ribose] polymerase 8ADP-ribosyltransferase diphtheria toxin-like 16 | ||
| Modification date | 20180523 | ||
| UniProtAcc | Q8N3A8 | ||
| Ensembl transtripts involved in fusion gene | ENST00000514342, ENST00000505697, ENST00000511363, ENST00000503750, ENST00000281631, ENST00000514067, ENST00000505554, ENST00000513738, ENST00000503665, | ENST00000389074, ENST00000512767, | |
| Fusion gene scores | * DoF score | 7 X 5 X 6=210 | 1 X 1 X 1=1 |
| # samples | 7 | 1 | |
| ** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: PARP8 [Title/Abstract] AND FAM159B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCS | TCGA-ND-A4W6-01A | PARP8 | chr5 | 50059076 | + | FAM159B | chr5 | 63991334 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000514342 | ENST00000389074 | PARP8 | chr5 | 50059076 | + | FAM159B | chr5 | 63991334 | + |
| 5UTR-3UTR | ENST00000514342 | ENST00000512767 | PARP8 | chr5 | 50059076 | + | FAM159B | chr5 | 63991334 | + |
| In-frame | ENST00000505697 | ENST00000389074 | PARP8 | chr5 | 50059076 | + | FAM159B | chr5 | 63991334 | + |
| 5CDS-3UTR | ENST00000505697 | ENST00000512767 | PARP8 | chr5 | 50059076 | + | FAM159B | chr5 | 63991334 | + |
| 3UTR-3CDS | ENST00000511363 | ENST00000389074 | PARP8 | chr5 | 50059076 | + | FAM159B | chr5 | 63991334 | + |
| 3UTR-3UTR | ENST00000511363 | ENST00000512767 | PARP8 | chr5 | 50059076 | + | FAM159B | chr5 | 63991334 | + |
| In-frame | ENST00000503750 | ENST00000389074 | PARP8 | chr5 | 50059076 | + | FAM159B | chr5 | 63991334 | + |
| 5CDS-3UTR | ENST00000503750 | ENST00000512767 | PARP8 | chr5 | 50059076 | + | FAM159B | chr5 | 63991334 | + |
| In-frame | ENST00000281631 | ENST00000389074 | PARP8 | chr5 | 50059076 | + | FAM159B | chr5 | 63991334 | + |
| 5CDS-3UTR | ENST00000281631 | ENST00000512767 | PARP8 | chr5 | 50059076 | + | FAM159B | chr5 | 63991334 | + |
| In-frame | ENST00000514067 | ENST00000389074 | PARP8 | chr5 | 50059076 | + | FAM159B | chr5 | 63991334 | + |
| 5CDS-3UTR | ENST00000514067 | ENST00000512767 | PARP8 | chr5 | 50059076 | + | FAM159B | chr5 | 63991334 | + |
| In-frame | ENST00000505554 | ENST00000389074 | PARP8 | chr5 | 50059076 | + | FAM159B | chr5 | 63991334 | + |
| 5CDS-3UTR | ENST00000505554 | ENST00000512767 | PARP8 | chr5 | 50059076 | + | FAM159B | chr5 | 63991334 | + |
| intron-3CDS | ENST00000513738 | ENST00000389074 | PARP8 | chr5 | 50059076 | + | FAM159B | chr5 | 63991334 | + |
| intron-3UTR | ENST00000513738 | ENST00000512767 | PARP8 | chr5 | 50059076 | + | FAM159B | chr5 | 63991334 | + |
| intron-3CDS | ENST00000503665 | ENST00000389074 | PARP8 | chr5 | 50059076 | + | FAM159B | chr5 | 63991334 | + |
| intron-3UTR | ENST00000503665 | ENST00000512767 | PARP8 | chr5 | 50059076 | + | FAM159B | chr5 | 63991334 | + |
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FusionProtFeatures for PARP8_FAM159B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PARP8 | FAM159B |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PARP8_FAM159B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PARP8_ENST00000505697_chr5_50059076_+_FAM159B_ENST00000389074_chr5_63991334_+_270aa MGMCSRQERIQKDIDVVIQKSRAEKDCLFADFRYSDSTFTFTYVGGPRSVSYSVHVSEDYPDNTYVSSSENDEDVLVTTEPIPVIFHRIA TELRKTNDINCCLSIKSKLQKENGEESRQNSTVEEDSEGDNDSEEFYYGGQVNYDGELHKHPQLEADLSAVREIYGPHAVSLSIGALIGL GIAALVLLAFVISVCVLCYLFLYTKPQRLDTGLKLQHLEASSTQEGKSNGKTKALNSNAASNATNETYYEADDIIQEKTMDATQIHIAYX >In-frame_PARP8_ENST00000503750_chr5_50059076_+_FAM159B_ENST00000389074_chr5_63991334_+_270aa MGMCSRQERIQKDIDVVIQKSRAEKDCLFADFRYSDSTFTFTYVGGPRSVSYSVHVSEDYPDNTYVSSSENDEDVLVTTEPIPVIFHRIA TELRKTNDINCCLSIKSKLQKENGEESRQNSTVEEDSEGDNDSEEFYYGGQVNYDGELHKHPQLEADLSAVREIYGPHAVSLSIGALIGL GIAALVLLAFVISVCVLCYLFLYTKPQRLDTGLKLQHLEASSTQEGKSNGKTKALNSNAASNATNETYYEADDIIQEKTMDATQIHIAYX >In-frame_PARP8_ENST00000281631_chr5_50059076_+_FAM159B_ENST00000389074_chr5_63991334_+_270aa MGMCSRQERIQKDIDVVIQKSRAEKDCLFADFRYSDSTFTFTYVGGPRSVSYSVHVSEDYPDNTYVSSSENDEDVLVTTEPIPVIFHRIA TELRKTNDINCCLSIKSKLQKENGEESRQNSTVEEDSEGDNDSEEFYYGGQVNYDGELHKHPQLEADLSAVREIYGPHAVSLSIGALIGL GIAALVLLAFVISVCVLCYLFLYTKPQRLDTGLKLQHLEASSTQEGKSNGKTKALNSNAASNATNETYYEADDIIQEKTMDATQIHIAYX >In-frame_PARP8_ENST00000514067_chr5_50059076_+_FAM159B_ENST00000389074_chr5_63991334_+_270aa MGMCSRQERIQKDIDVVIQKSRAEKDCLFADFRYSDSTFTFTYVGGPRSVSYSVHVSEDYPDNTYVSSSENDEDVLVTTEPIPVIFHRIA TELRKTNDINCCLSIKSKLQKENGEESRQNSTVEEDSEGDNDSEEFYYGGQVNYDGELHKHPQLEADLSAVREIYGPHAVSLSIGALIGL GIAALVLLAFVISVCVLCYLFLYTKPQRLDTGLKLQHLEASSTQEGKSNGKTKALNSNAASNATNETYYEADDIIQEKTMDATQIHIAYX >In-frame_PARP8_ENST00000505554_chr5_50059076_+_FAM159B_ENST00000389074_chr5_63991334_+_249aa MEPAALRCAYFRYSDSTFTFTYVGGPRSVSYSVHVSEDYPDNTYVSSSENDEDVLVTTEPIPVIFHRIATELRKTNDINCCLSIKSKLQK ENGEESRQNSTVEEDSEGDNDSEEFYYGGQVNYDGELHKHPQLEADLSAVREIYGPHAVSLSIGALIGLGIAALVLLAFVISVCVLCYLF |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PARP8_ENST00000505697_chr5_50059076_+_FAM159B_ENST00000389074_chr5_63991334_+_810nt ATGGGGATGTGTTCAAGGCAAGAGCGAATTCAGAAGGATATCGACGTCGTGATCCAGAAGTCCAGAGCTGAGAAGGACTGCCTGTTTGCA GATTTCAGATACTCTGACTCCACCTTTACTTTTACCTACGTTGGCGGCCCCAGAAGTGTATCCTACTCAGTACATGTATCTGAAGATTAC CCAGATAATACATATGTGTCAAGTTCAGAGAATGATGAAGATGTGCTAGTTACTACAGAGCCAATACCAGTAATTTTTCATAGAATAGCA ACAGAATTAAGAAAAACAAATGACATTAACTGTTGCTTATCCATAAAATCCAAATTACAAAAGGAAAATGGGGAGGAATCAAGACAGAAT AGTACAGTGGAGGAAGATTCTGAAGGTGACAATGATTCCGAAGAATTTTATTACGGAGGGCAGGTGAACTATGATGGGGAACTGCACAAG CACCCACAACTGGAAGCTGATTTGTCAGCAGTTAGAGAGATATATGGGCCACATGCAGTTTCTCTCAGCATTGGTGCCTTGATTGGACTA GGAATTGCTGCCCTTGTTTTACTCGCCTTTGTCATCAGTGTCTGTGTCCTTTGCTATTTATTTCTGTATACGAAACCTCAAAGATTAGAC ACTGGCCTTAAGCTTCAACACTTAGAGGCTTCTTCCACTCAAGAAGGCAAGTCAAATGGAAAAACCAAAGCCCTCAATTCAAATGCAGCA TCAAATGCAACAAATGAAACATACTATGAAGCTGATGATATAATTCAAGAAAAAACAATGGATGCAACACAAATCCACATTGCTTATTAA >In-frame_PARP8_ENST00000503750_chr5_50059076_+_FAM159B_ENST00000389074_chr5_63991334_+_810nt ATGGGGATGTGTTCAAGGCAAGAGCGAATTCAGAAGGATATCGACGTCGTGATCCAGAAGTCCAGAGCTGAGAAGGACTGCCTGTTTGCA GATTTCAGATACTCTGACTCCACCTTTACTTTTACCTACGTTGGCGGCCCCAGAAGTGTATCCTACTCAGTACATGTATCTGAAGATTAC CCAGATAATACATATGTGTCAAGTTCAGAGAATGATGAAGATGTGCTAGTTACTACAGAGCCAATACCAGTAATTTTTCATAGAATAGCA ACAGAATTAAGAAAAACAAATGACATTAACTGTTGCTTATCCATAAAATCCAAATTACAAAAGGAAAATGGGGAGGAATCAAGACAGAAT AGTACAGTGGAGGAAGATTCTGAAGGTGACAATGATTCCGAAGAATTTTATTACGGAGGGCAGGTGAACTATGATGGGGAACTGCACAAG CACCCACAACTGGAAGCTGATTTGTCAGCAGTTAGAGAGATATATGGGCCACATGCAGTTTCTCTCAGCATTGGTGCCTTGATTGGACTA GGAATTGCTGCCCTTGTTTTACTCGCCTTTGTCATCAGTGTCTGTGTCCTTTGCTATTTATTTCTGTATACGAAACCTCAAAGATTAGAC ACTGGCCTTAAGCTTCAACACTTAGAGGCTTCTTCCACTCAAGAAGGCAAGTCAAATGGAAAAACCAAAGCCCTCAATTCAAATGCAGCA TCAAATGCAACAAATGAAACATACTATGAAGCTGATGATATAATTCAAGAAAAAACAATGGATGCAACACAAATCCACATTGCTTATTAA >In-frame_PARP8_ENST00000281631_chr5_50059076_+_FAM159B_ENST00000389074_chr5_63991334_+_810nt ATGGGGATGTGTTCAAGGCAAGAGCGAATTCAGAAGGATATCGACGTCGTGATCCAGAAGTCCAGAGCTGAGAAGGACTGCCTGTTTGCA GATTTCAGATACTCTGACTCCACCTTTACTTTTACCTACGTTGGCGGCCCCAGAAGTGTATCCTACTCAGTACATGTATCTGAAGATTAC CCAGATAATACATATGTGTCAAGTTCAGAGAATGATGAAGATGTGCTAGTTACTACAGAGCCAATACCAGTAATTTTTCATAGAATAGCA ACAGAATTAAGAAAAACAAATGACATTAACTGTTGCTTATCCATAAAATCCAAATTACAAAAGGAAAATGGGGAGGAATCAAGACAGAAT AGTACAGTGGAGGAAGATTCTGAAGGTGACAATGATTCCGAAGAATTTTATTACGGAGGGCAGGTGAACTATGATGGGGAACTGCACAAG CACCCACAACTGGAAGCTGATTTGTCAGCAGTTAGAGAGATATATGGGCCACATGCAGTTTCTCTCAGCATTGGTGCCTTGATTGGACTA GGAATTGCTGCCCTTGTTTTACTCGCCTTTGTCATCAGTGTCTGTGTCCTTTGCTATTTATTTCTGTATACGAAACCTCAAAGATTAGAC ACTGGCCTTAAGCTTCAACACTTAGAGGCTTCTTCCACTCAAGAAGGCAAGTCAAATGGAAAAACCAAAGCCCTCAATTCAAATGCAGCA TCAAATGCAACAAATGAAACATACTATGAAGCTGATGATATAATTCAAGAAAAAACAATGGATGCAACACAAATCCACATTGCTTATTAA >In-frame_PARP8_ENST00000514067_chr5_50059076_+_FAM159B_ENST00000389074_chr5_63991334_+_810nt ATGGGGATGTGTTCAAGGCAAGAGCGAATTCAGAAGGATATCGACGTCGTGATCCAGAAGTCCAGAGCTGAGAAGGACTGCCTGTTTGCA GATTTCAGATACTCTGACTCCACCTTTACTTTTACCTACGTTGGCGGCCCCAGAAGTGTATCCTACTCAGTACATGTATCTGAAGATTAC CCAGATAATACATATGTGTCAAGTTCAGAGAATGATGAAGATGTGCTAGTTACTACAGAGCCAATACCAGTAATTTTTCATAGAATAGCA ACAGAATTAAGAAAAACAAATGACATTAACTGTTGCTTATCCATAAAATCCAAATTACAAAAGGAAAATGGGGAGGAATCAAGACAGAAT AGTACAGTGGAGGAAGATTCTGAAGGTGACAATGATTCCGAAGAATTTTATTACGGAGGGCAGGTGAACTATGATGGGGAACTGCACAAG CACCCACAACTGGAAGCTGATTTGTCAGCAGTTAGAGAGATATATGGGCCACATGCAGTTTCTCTCAGCATTGGTGCCTTGATTGGACTA GGAATTGCTGCCCTTGTTTTACTCGCCTTTGTCATCAGTGTCTGTGTCCTTTGCTATTTATTTCTGTATACGAAACCTCAAAGATTAGAC ACTGGCCTTAAGCTTCAACACTTAGAGGCTTCTTCCACTCAAGAAGGCAAGTCAAATGGAAAAACCAAAGCCCTCAATTCAAATGCAGCA TCAAATGCAACAAATGAAACATACTATGAAGCTGATGATATAATTCAAGAAAAAACAATGGATGCAACACAAATCCACATTGCTTATTAA >In-frame_PARP8_ENST00000505554_chr5_50059076_+_FAM159B_ENST00000389074_chr5_63991334_+_747nt ATGGAGCCTGCTGCGCTGCGCTGCGCTTATTTCAGATACTCTGACTCCACCTTTACTTTTACCTACGTTGGCGGCCCCAGAAGTGTATCC TACTCAGTACATGTATCTGAAGATTACCCAGATAATACATATGTGTCAAGTTCAGAGAATGATGAAGATGTGCTAGTTACTACAGAGCCA ATACCAGTAATTTTTCATAGAATAGCAACAGAATTAAGAAAAACAAATGACATTAACTGTTGCTTATCCATAAAATCCAAATTACAAAAG GAAAATGGGGAGGAATCAAGACAGAATAGTACAGTGGAGGAAGATTCTGAAGGTGACAATGATTCCGAAGAATTTTATTACGGAGGGCAG GTGAACTATGATGGGGAACTGCACAAGCACCCACAACTGGAAGCTGATTTGTCAGCAGTTAGAGAGATATATGGGCCACATGCAGTTTCT CTCAGCATTGGTGCCTTGATTGGACTAGGAATTGCTGCCCTTGTTTTACTCGCCTTTGTCATCAGTGTCTGTGTCCTTTGCTATTTATTT CTGTATACGAAACCTCAAAGATTAGACACTGGCCTTAAGCTTCAACACTTAGAGGCTTCTTCCACTCAAGAAGGCAAGTCAAATGGAAAA ACCAAAGCCCTCAATTCAAATGCAGCATCAAATGCAACAAATGAAACATACTATGAAGCTGATGATATAATTCAAGAAAAAACAATGGAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PARP8_ENST00000505697_chr5_50059076_+_FAM159B_ENST00000389074_chr5_63991334_+_1040nt AGAGCAGTATCTCATTTCTGAACACCTGGATTGTAGCTTTCCCTTGACTGTCAAAGGAGGTGGTTTTAAAAATCAAGCCAAACAGGTTTC CATCTTTTAGGAAGACCCTGGAACGTGCCAGTTGATTCTGACCATTTCTCATGAACAGAAACACCTAGGAAGGGAGAACTGGGATTTATT TAATGGGGATGTGTTCAAGGCAAGAGCGAATTCAGAAGGATATCGACGTCGTGATCCAGAAGTCCAGAGCTGAGAAGGACTGCCTGTTTG CAGATTTCAGATACTCTGACTCCACCTTTACTTTTACCTACGTTGGCGGCCCCAGAAGTGTATCCTACTCAGTACATGTATCTGAAGATT ACCCAGATAATACATATGTGTCAAGTTCAGAGAATGATGAAGATGTGCTAGTTACTACAGAGCCAATACCAGTAATTTTTCATAGAATAG CAACAGAATTAAGAAAAACAAATGACATTAACTGTTGCTTATCCATAAAATCCAAATTACAAAAGGAAAATGGGGAGGAATCAAGACAGA ATAGTACAGTGGAGGAAGATTCTGAAGGTGACAATGATTCCGAAGAATTTTATTACGGAGGGCAGGTGAACTATGATGGGGAACTGCACA AGCACCCACAACTGGAAGCTGATTTGTCAGCAGTTAGAGAGATATATGGGCCACATGCAGTTTCTCTCAGCATTGGTGCCTTGATTGGAC TAGGAATTGCTGCCCTTGTTTTACTCGCCTTTGTCATCAGTGTCTGTGTCCTTTGCTATTTATTTCTGTATACGAAACCTCAAAGATTAG ACACTGGCCTTAAGCTTCAACACTTAGAGGCTTCTTCCACTCAAGAAGGCAAGTCAAATGGAAAAACCAAAGCCCTCAATTCAAATGCAG CATCAAATGCAACAAATGAAACATACTATGAAGCTGATGATATAATTCAAGAAAAAACAATGGATGCAACACAAATCCACATTGCTTATT >In-frame_PARP8_ENST00000503750_chr5_50059076_+_FAM159B_ENST00000389074_chr5_63991334_+_1040nt AGAGCAGTATCTCATTTCTGAACACCTGGATTGTAGCTTTCCCTTGACTGTCAAAGGAGGTGGTTTTAAAAATCAAGCCAAACAGGTTTC CATCTTTTAGGAAGACCCTGGAACGTGCCAGTTGATTCTGACCATTTCTCATGAACAGAAACACCTAGGAAGGGAGAACTGGGATTTATT TAATGGGGATGTGTTCAAGGCAAGAGCGAATTCAGAAGGATATCGACGTCGTGATCCAGAAGTCCAGAGCTGAGAAGGACTGCCTGTTTG CAGATTTCAGATACTCTGACTCCACCTTTACTTTTACCTACGTTGGCGGCCCCAGAAGTGTATCCTACTCAGTACATGTATCTGAAGATT ACCCAGATAATACATATGTGTCAAGTTCAGAGAATGATGAAGATGTGCTAGTTACTACAGAGCCAATACCAGTAATTTTTCATAGAATAG CAACAGAATTAAGAAAAACAAATGACATTAACTGTTGCTTATCCATAAAATCCAAATTACAAAAGGAAAATGGGGAGGAATCAAGACAGA ATAGTACAGTGGAGGAAGATTCTGAAGGTGACAATGATTCCGAAGAATTTTATTACGGAGGGCAGGTGAACTATGATGGGGAACTGCACA AGCACCCACAACTGGAAGCTGATTTGTCAGCAGTTAGAGAGATATATGGGCCACATGCAGTTTCTCTCAGCATTGGTGCCTTGATTGGAC TAGGAATTGCTGCCCTTGTTTTACTCGCCTTTGTCATCAGTGTCTGTGTCCTTTGCTATTTATTTCTGTATACGAAACCTCAAAGATTAG ACACTGGCCTTAAGCTTCAACACTTAGAGGCTTCTTCCACTCAAGAAGGCAAGTCAAATGGAAAAACCAAAGCCCTCAATTCAAATGCAG CATCAAATGCAACAAATGAAACATACTATGAAGCTGATGATATAATTCAAGAAAAAACAATGGATGCAACACAAATCCACATTGCTTATT >In-frame_PARP8_ENST00000281631_chr5_50059076_+_FAM159B_ENST00000389074_chr5_63991334_+_1016nt TTCTCTCACCCAGGATCACTTCCGAAACCACTTCGCCTTCAGCCCCTGCCTCGGCCAGAGGTTTCATTTTTAACTGAATATTTACGAAAG CTGGAAGCGTGCGAGGGGGGTGGGGTGGGGTGGAAATAGCGGCTGCTTCTTTTCCAGGGATTTATTTAATGGGGATGTGTTCAAGGCAAG AGCGAATTCAGAAGGATATCGACGTCGTGATCCAGAAGTCCAGAGCTGAGAAGGACTGCCTGTTTGCAGATTTCAGATACTCTGACTCCA CCTTTACTTTTACCTACGTTGGCGGCCCCAGAAGTGTATCCTACTCAGTACATGTATCTGAAGATTACCCAGATAATACATATGTGTCAA GTTCAGAGAATGATGAAGATGTGCTAGTTACTACAGAGCCAATACCAGTAATTTTTCATAGAATAGCAACAGAATTAAGAAAAACAAATG ACATTAACTGTTGCTTATCCATAAAATCCAAATTACAAAAGGAAAATGGGGAGGAATCAAGACAGAATAGTACAGTGGAGGAAGATTCTG AAGGTGACAATGATTCCGAAGAATTTTATTACGGAGGGCAGGTGAACTATGATGGGGAACTGCACAAGCACCCACAACTGGAAGCTGATT TGTCAGCAGTTAGAGAGATATATGGGCCACATGCAGTTTCTCTCAGCATTGGTGCCTTGATTGGACTAGGAATTGCTGCCCTTGTTTTAC TCGCCTTTGTCATCAGTGTCTGTGTCCTTTGCTATTTATTTCTGTATACGAAACCTCAAAGATTAGACACTGGCCTTAAGCTTCAACACT TAGAGGCTTCTTCCACTCAAGAAGGCAAGTCAAATGGAAAAACCAAAGCCCTCAATTCAAATGCAGCATCAAATGCAACAAATGAAACAT ACTATGAAGCTGATGATATAATTCAAGAAAAAACAATGGATGCAACACAAATCCACATTGCTTATTAACTAAAAATTCTGTGTTTTAAAT >In-frame_PARP8_ENST00000514067_chr5_50059076_+_FAM159B_ENST00000389074_chr5_63991334_+_975nt GCCCCTGCCTCGGCCAGAGGTTTCATTTTTAACTGAATATTTACGAAAGCTGGAAGCGTGCGAGGGGGGTGGGGTGGGGTGGAAATAGCG GCTGCTTCTTTTCCAGGGATTTATTTAATGGGGATGTGTTCAAGGCAAGAGCGAATTCAGAAGGATATCGACGTCGTGATCCAGAAGTCC AGAGCTGAGAAGGACTGCCTGTTTGCAGATTTCAGATACTCTGACTCCACCTTTACTTTTACCTACGTTGGCGGCCCCAGAAGTGTATCC TACTCAGTACATGTATCTGAAGATTACCCAGATAATACATATGTGTCAAGTTCAGAGAATGATGAAGATGTGCTAGTTACTACAGAGCCA ATACCAGTAATTTTTCATAGAATAGCAACAGAATTAAGAAAAACAAATGACATTAACTGTTGCTTATCCATAAAATCCAAATTACAAAAG GAAAATGGGGAGGAATCAAGACAGAATAGTACAGTGGAGGAAGATTCTGAAGGTGACAATGATTCCGAAGAATTTTATTACGGAGGGCAG GTGAACTATGATGGGGAACTGCACAAGCACCCACAACTGGAAGCTGATTTGTCAGCAGTTAGAGAGATATATGGGCCACATGCAGTTTCT CTCAGCATTGGTGCCTTGATTGGACTAGGAATTGCTGCCCTTGTTTTACTCGCCTTTGTCATCAGTGTCTGTGTCCTTTGCTATTTATTT CTGTATACGAAACCTCAAAGATTAGACACTGGCCTTAAGCTTCAACACTTAGAGGCTTCTTCCACTCAAGAAGGCAAGTCAAATGGAAAA ACCAAAGCCCTCAATTCAAATGCAGCATCAAATGCAACAAATGAAACATACTATGAAGCTGATGATATAATTCAAGAAAAAACAATGGAT >In-frame_PARP8_ENST00000505554_chr5_50059076_+_FAM159B_ENST00000389074_chr5_63991334_+_812nt AGCGGCGGCGGCCGGGAATGGAGCCTGCTGCGCTGCGCTGCGCTTATTTCAGATACTCTGACTCCACCTTTACTTTTACCTACGTTGGCG GCCCCAGAAGTGTATCCTACTCAGTACATGTATCTGAAGATTACCCAGATAATACATATGTGTCAAGTTCAGAGAATGATGAAGATGTGC TAGTTACTACAGAGCCAATACCAGTAATTTTTCATAGAATAGCAACAGAATTAAGAAAAACAAATGACATTAACTGTTGCTTATCCATAA AATCCAAATTACAAAAGGAAAATGGGGAGGAATCAAGACAGAATAGTACAGTGGAGGAAGATTCTGAAGGTGACAATGATTCCGAAGAAT TTTATTACGGAGGGCAGGTGAACTATGATGGGGAACTGCACAAGCACCCACAACTGGAAGCTGATTTGTCAGCAGTTAGAGAGATATATG GGCCACATGCAGTTTCTCTCAGCATTGGTGCCTTGATTGGACTAGGAATTGCTGCCCTTGTTTTACTCGCCTTTGTCATCAGTGTCTGTG TCCTTTGCTATTTATTTCTGTATACGAAACCTCAAAGATTAGACACTGGCCTTAAGCTTCAACACTTAGAGGCTTCTTCCACTCAAGAAG GCAAGTCAAATGGAAAAACCAAAGCCCTCAATTCAAATGCAGCATCAAATGCAACAAATGAAACATACTATGAAGCTGATGATATAATTC AAGAAAAAACAATGGATGCAACACAAATCCACATTGCTTATTAACTAAAAATTCTGTGTTTTAAATGCTTACTGGAGAGATGGGACAATA |
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FusionGenePPI for PARP8_FAM159B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PARP8 | YWHAB | FAM159B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PARP8_FAM159B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PARP8_FAM159B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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