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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26039

FusionGeneSummary for PARP8_EIF5A2

check button Fusion gene summary
Fusion gene informationFusion gene name: PARP8_EIF5A2
Fusion gene ID: 26039
HgeneTgene
Gene symbol

PARP8

EIF5A2

Gene ID

79668

56648

Gene namepoly(ADP-ribose) polymerase family member 8eukaryotic translation initiation factor 5A2
SynonymsARTD16|pART16EIF-5A2|eIF5AII
Cytomap

5q11.1

3q26.2

Type of geneprotein-codingprotein-coding
Descriptionpoly [ADP-ribose] polymerase 8ADP-ribosyltransferase diphtheria toxin-like 16eukaryotic translation initiation factor 5A-2eIF-5A-2eukaryotic initiation factor 5A
Modification date2018052320180522
UniProtAcc

Q8N3A8

Q9GZV4

Ensembl transtripts involved in fusion geneENST00000514342, ENST00000505697, 
ENST00000511363, ENST00000503750, 
ENST00000281631, ENST00000514067, 
ENST00000505554, ENST00000513738, 
ENST00000503665, 
ENST00000295822, 
ENST00000460117, ENST00000487522, 
ENST00000474096, 
Fusion gene scores* DoF score7 X 5 X 6=2102 X 2 X 2=8
# samples 72
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: PARP8 [Title/Abstract] AND EIF5A2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-5501-01APARP8chr5

49963959

+EIF5A2chr3

170624882

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000514342ENST00000295822PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5UTR-intronENST00000514342ENST00000460117PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5UTR-intronENST00000514342ENST00000487522PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5UTR-intronENST00000514342ENST00000474096PARP8chr5

49963959

+EIF5A2chr3

170624882

-
Frame-shiftENST00000505697ENST00000295822PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5CDS-intronENST00000505697ENST00000460117PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5CDS-intronENST00000505697ENST00000487522PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5CDS-intronENST00000505697ENST00000474096PARP8chr5

49963959

+EIF5A2chr3

170624882

-
3UTR-3CDSENST00000511363ENST00000295822PARP8chr5

49963959

+EIF5A2chr3

170624882

-
3UTR-intronENST00000511363ENST00000460117PARP8chr5

49963959

+EIF5A2chr3

170624882

-
3UTR-intronENST00000511363ENST00000487522PARP8chr5

49963959

+EIF5A2chr3

170624882

-
3UTR-intronENST00000511363ENST00000474096PARP8chr5

49963959

+EIF5A2chr3

170624882

-
Frame-shiftENST00000503750ENST00000295822PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5CDS-intronENST00000503750ENST00000460117PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5CDS-intronENST00000503750ENST00000487522PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5CDS-intronENST00000503750ENST00000474096PARP8chr5

49963959

+EIF5A2chr3

170624882

-
Frame-shiftENST00000281631ENST00000295822PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5CDS-intronENST00000281631ENST00000460117PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5CDS-intronENST00000281631ENST00000487522PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5CDS-intronENST00000281631ENST00000474096PARP8chr5

49963959

+EIF5A2chr3

170624882

-
Frame-shiftENST00000514067ENST00000295822PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5CDS-intronENST00000514067ENST00000460117PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5CDS-intronENST00000514067ENST00000487522PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5CDS-intronENST00000514067ENST00000474096PARP8chr5

49963959

+EIF5A2chr3

170624882

-
Frame-shiftENST00000505554ENST00000295822PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5CDS-intronENST00000505554ENST00000460117PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5CDS-intronENST00000505554ENST00000487522PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5CDS-intronENST00000505554ENST00000474096PARP8chr5

49963959

+EIF5A2chr3

170624882

-
Frame-shiftENST00000513738ENST00000295822PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5CDS-intronENST00000513738ENST00000460117PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5CDS-intronENST00000513738ENST00000487522PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5CDS-intronENST00000513738ENST00000474096PARP8chr5

49963959

+EIF5A2chr3

170624882

-
Frame-shiftENST00000503665ENST00000295822PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5CDS-intronENST00000503665ENST00000460117PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5CDS-intronENST00000503665ENST00000487522PARP8chr5

49963959

+EIF5A2chr3

170624882

-
5CDS-intronENST00000503665ENST00000474096PARP8chr5

49963959

+EIF5A2chr3

170624882

-

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FusionProtFeatures for PARP8_EIF5A2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PARP8

Q8N3A8

EIF5A2

Q9GZV4

mRNA-binding protein involved in translation elongation.Has an important function at the level of mRNA turnover, probablyacting downstream of decapping. Involved in actin dynamics andcell cycle progression, mRNA decay and probably in a pathwayinvolved in stress response and maintenance of cell wallintegrity. Functions as a regulator of apoptosis. Mediates effectsof polyamines on neuronal process extension and survival. May playan important role in brain development and function, and inskeletal muscle stem cell differentiation (By similarity).{ECO:0000250, ECO:0000269|PubMed:14622290}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PARP8_EIF5A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PARP8_EIF5A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PARP8YWHABEIF5A2DHPS, DCC, OPTN, VHL, CUL3, CUL4B, CDK2, RAB30, PTBP2, FAM96B, REL, SDCBP, CDC23, NIF3L1, DOHH, EZR, PPIB, MYCBP, TAGLN2, EWSR1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PARP8_EIF5A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PARP8_EIF5A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource