FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 26016

FusionGeneSummary for PARN_WT1-AS

check button Fusion gene summary
Fusion gene informationFusion gene name: PARN_WT1-AS
Fusion gene ID: 26016
HgeneTgene
Gene symbol

PARN

WT1-AS

Gene ID

5073

51352

Gene namepoly(A)-specific ribonucleaseWT1 antisense RNA
SynonymsDAN|DKCB6|PFBMFT4WIT-1|WIT1|WT1-AS1|WT1AS
Cytomap

16p13.12

11p13

Type of geneprotein-codingncRNA
Descriptionpoly(A)-specific ribonuclease PARNdeadenylating nucleasedeadenylation nucleasepolyadenylate-specific ribonucleaseWT1 antisense RNA (non-protein coding)Wilms tumor associated proteinWilms tumor upstream neighbor 1
Modification date2018052320180519
UniProtAcc

O95453

Ensembl transtripts involved in fusion geneENST00000437198, ENST00000420015, 
ENST00000341484, ENST00000539279, 
ENST00000566021, 
ENST00000494911, 
ENST00000395900, ENST00000459866, 
ENST00000525436, ENST00000478367, 
ENST00000426618, ENST00000442957, 
Fusion gene scores* DoF score9 X 8 X 5=3602 X 1 X 2=4
# samples 102
** MAII scorelog2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: PARN [Title/Abstract] AND WT1-AS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-UB-A7ME-01APARNchr16

14693761

-WT1-ASchr11

32473567

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000437198ENST00000494911PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-intronENST00000437198ENST00000395900PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-intronENST00000437198ENST00000459866PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-3UTRENST00000437198ENST00000525436PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-intronENST00000437198ENST00000478367PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-intronENST00000437198ENST00000426618PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-intronENST00000437198ENST00000442957PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-intronENST00000420015ENST00000494911PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-intronENST00000420015ENST00000395900PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-intronENST00000420015ENST00000459866PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-3UTRENST00000420015ENST00000525436PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-intronENST00000420015ENST00000478367PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-intronENST00000420015ENST00000426618PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-intronENST00000420015ENST00000442957PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-intronENST00000341484ENST00000494911PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-intronENST00000341484ENST00000395900PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-intronENST00000341484ENST00000459866PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-3UTRENST00000341484ENST00000525436PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-intronENST00000341484ENST00000478367PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-intronENST00000341484ENST00000426618PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-intronENST00000341484ENST00000442957PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-intronENST00000539279ENST00000494911PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-intronENST00000539279ENST00000395900PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-intronENST00000539279ENST00000459866PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-3UTRENST00000539279ENST00000525436PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-intronENST00000539279ENST00000478367PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-intronENST00000539279ENST00000426618PARNchr16

14693761

-WT1-ASchr11

32473567

+
5CDS-intronENST00000539279ENST00000442957PARNchr16

14693761

-WT1-ASchr11

32473567

+
intron-intronENST00000566021ENST00000494911PARNchr16

14693761

-WT1-ASchr11

32473567

+
intron-intronENST00000566021ENST00000395900PARNchr16

14693761

-WT1-ASchr11

32473567

+
intron-intronENST00000566021ENST00000459866PARNchr16

14693761

-WT1-ASchr11

32473567

+
intron-3UTRENST00000566021ENST00000525436PARNchr16

14693761

-WT1-ASchr11

32473567

+
intron-intronENST00000566021ENST00000478367PARNchr16

14693761

-WT1-ASchr11

32473567

+
intron-intronENST00000566021ENST00000426618PARNchr16

14693761

-WT1-ASchr11

32473567

+
intron-intronENST00000566021ENST00000442957PARNchr16

14693761

-WT1-ASchr11

32473567

+

Top

FusionProtFeatures for PARN_WT1-AS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PARN

O95453

WT1-AS

3'-exoribonuclease that has a preference for poly(A)tails of mRNAs, thereby efficiently degrading poly(A) tails.Exonucleolytic degradation of the poly(A) tail is often the firststep in the decay of eukaryotic mRNAs and is also used to silencecertain maternal mRNAs translationally during oocyte maturationand early embryonic development. Interacts with both the 3'-endpoly(A) tail and the 5'-end cap structure during degradation, theinteraction with the cap structure being required for an efficientdegradation of poly(A) tails. Involved in nonsense-mediated mRNAdecay, a critical process of selective degradation of mRNAs thatcontain premature stop codons. Also involved in degradation ofinherently unstable mRNAs that contain AU-rich elements (AREs) intheir 3'-UTR, possibly via its interaction with KHSRP. Probablymediates the removal of poly(A) tails of AREs mRNAs, whichconstitutes the first step of destabilization (PubMed:10882133,PubMed:11359775, PubMed:12748283, PubMed:15175153,PubMed:9736620). Also able to recognize and trim poly(A) tails ofmicroRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolarRNAs) leading to microRNAs degradation or snoRNA increasedstability (PubMed:25049417, PubMed:22442037).{ECO:0000269|PubMed:10882133, ECO:0000269|PubMed:11359775,ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15175153,ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417,ECO:0000269|PubMed:9736620}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PARN_WT1-AS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PARN_WT1-AS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PARNSPATC1L, KHSRP, UPF1, UPF2, UPF3A, SIRT7, CSTF1, CSTF2, PARN, BARD1, MAPKAPK2, MPP6, SUMO2, HIST1H1A, BYSL, TEAD4, C9orf41, PSG1, TSR1, TULP3, FOXA1WT1-ASTRIM27, TRIP6, PNMA1, TMCC2, MID2, LZTS2, KRT40, KRTAP10-9, KRTAP10-5, KRTAP10-8, NOTCH2NL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PARN_WT1-AS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PARN_WT1-AS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePARNC1800706Idiopathic Pulmonary Fibrosis1CTD_human;ORPHANET
HgenePARNC4225347PULMONARY FIBROSIS AND/OR BONE MARROW FAILURE, TELOMERE-RELATED, 41UNIPROT
HgenePARNC4225356DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 61UNIPROT