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Fusion gene ID: 26010 |
FusionGeneSummary for PARN_GOLPH3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PARN_GOLPH3 | Fusion gene ID: 26010 | Hgene | Tgene | Gene symbol | PARN | GOLPH3 | Gene ID | 5073 | 64083 |
| Gene name | poly(A)-specific ribonuclease | golgi phosphoprotein 3 | |
| Synonyms | DAN|DKCB6|PFBMFT4 | GOPP1|GPP34|MIDAS|Vps74 | |
| Cytomap | 16p13.12 | 5p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | poly(A)-specific ribonuclease PARNdeadenylating nucleasedeadenylation nucleasepolyadenylate-specific ribonuclease | Golgi phosphoprotein 3coat protein GPP34coat-proteingolgi peripheral membrane protein 1, 34 kDagolgi proteingolgi-associated proteinmitochondrial DNA absence factor | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O95453 | Q9H4A6 | |
| Ensembl transtripts involved in fusion gene | ENST00000437198, ENST00000420015, ENST00000341484, ENST00000539279, ENST00000566021, | ENST00000265070, ENST00000512668, | |
| Fusion gene scores | * DoF score | 9 X 8 X 5=360 | 3 X 3 X 2=18 |
| # samples | 10 | 3 | |
| ** MAII score | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PARN [Title/Abstract] AND GOLPH3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GOLPH3 | GO:0010821 | regulation of mitochondrion organization | 16263763 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW857210 | PARN | chr16 | 14705270 | - | GOLPH3 | chr5 | 32126215 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000437198 | ENST00000265070 | PARN | chr16 | 14705270 | - | GOLPH3 | chr5 | 32126215 | + |
| intron-intron | ENST00000437198 | ENST00000512668 | PARN | chr16 | 14705270 | - | GOLPH3 | chr5 | 32126215 | + |
| intron-3UTR | ENST00000420015 | ENST00000265070 | PARN | chr16 | 14705270 | - | GOLPH3 | chr5 | 32126215 | + |
| intron-intron | ENST00000420015 | ENST00000512668 | PARN | chr16 | 14705270 | - | GOLPH3 | chr5 | 32126215 | + |
| intron-3UTR | ENST00000341484 | ENST00000265070 | PARN | chr16 | 14705270 | - | GOLPH3 | chr5 | 32126215 | + |
| intron-intron | ENST00000341484 | ENST00000512668 | PARN | chr16 | 14705270 | - | GOLPH3 | chr5 | 32126215 | + |
| intron-3UTR | ENST00000539279 | ENST00000265070 | PARN | chr16 | 14705270 | - | GOLPH3 | chr5 | 32126215 | + |
| intron-intron | ENST00000539279 | ENST00000512668 | PARN | chr16 | 14705270 | - | GOLPH3 | chr5 | 32126215 | + |
| intron-3UTR | ENST00000566021 | ENST00000265070 | PARN | chr16 | 14705270 | - | GOLPH3 | chr5 | 32126215 | + |
| intron-intron | ENST00000566021 | ENST00000512668 | PARN | chr16 | 14705270 | - | GOLPH3 | chr5 | 32126215 | + |
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FusionProtFeatures for PARN_GOLPH3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PARN | GOLPH3 |
| 3'-exoribonuclease that has a preference for poly(A)tails of mRNAs, thereby efficiently degrading poly(A) tails.Exonucleolytic degradation of the poly(A) tail is often the firststep in the decay of eukaryotic mRNAs and is also used to silencecertain maternal mRNAs translationally during oocyte maturationand early embryonic development. Interacts with both the 3'-endpoly(A) tail and the 5'-end cap structure during degradation, theinteraction with the cap structure being required for an efficientdegradation of poly(A) tails. Involved in nonsense-mediated mRNAdecay, a critical process of selective degradation of mRNAs thatcontain premature stop codons. Also involved in degradation ofinherently unstable mRNAs that contain AU-rich elements (AREs) intheir 3'-UTR, possibly via its interaction with KHSRP. Probablymediates the removal of poly(A) tails of AREs mRNAs, whichconstitutes the first step of destabilization (PubMed:10882133,PubMed:11359775, PubMed:12748283, PubMed:15175153,PubMed:9736620). Also able to recognize and trim poly(A) tails ofmicroRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolarRNAs) leading to microRNAs degradation or snoRNA increasedstability (PubMed:25049417, PubMed:22442037).{ECO:0000269|PubMed:10882133, ECO:0000269|PubMed:11359775,ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15175153,ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417,ECO:0000269|PubMed:9736620}. | Phosphatidylinositol-4-phosphate-binding protein thatlinks Golgi membranes to the cytoskeleton and may participate inthe tensile force required for vesicle budding from the Golgi.Thereby, may play a role in Golgi membrane trafficking and couldindirectly give its flattened shape to the Golgi apparatus. Mayalso bind to the coatomer to regulate Golgi membrane trafficking.May play a role in anterograde transport from the Golgi to theplasma membrane and regulate secretion. Has also been involved inthe control of the localization of Golgi enzymes throughinteraction with their cytoplasmic part. May play an indirect rolein cell migration. Has also been involved in the modulation ofmTOR signaling. May also be involved in the regulation ofmitochondrial lipids biosynthesis. {ECO:0000269|PubMed:16263763,ECO:0000269|PubMed:19553991, ECO:0000269|PubMed:19837035,ECO:0000269|PubMed:22745132, ECO:0000269|PubMed:23027862,ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:23500462}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PARN_GOLPH3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PARN_GOLPH3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PARN_GOLPH3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PARN_GOLPH3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PARN | C1800706 | Idiopathic Pulmonary Fibrosis | 1 | CTD_human;ORPHANET |
| Hgene | PARN | C4225347 | PULMONARY FIBROSIS AND/OR BONE MARROW FAILURE, TELOMERE-RELATED, 4 | 1 | UNIPROT |
| Hgene | PARN | C4225356 | DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 6 | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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