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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25999

FusionGeneSummary for PARG_VARS

check button Fusion gene summary
Fusion gene informationFusion gene name: PARG_VARS
Fusion gene ID: 25999
HgeneTgene
Gene symbol

PARG

VARS

Gene ID

8505

7407

Gene namepoly(ADP-ribose) glycohydrolasevalyl-tRNA synthetase
SynonymsPARG99G7A|NDMSCA|VARS1|VARS2
Cytomap

10q11.23

6p21.33

Type of geneprotein-codingprotein-coding
Descriptionpoly(ADP-ribose) glycohydrolasemitochondrial poly(ADP-ribose) glycohydrolasepoly(ADP-ribose) glycohydrolase 60 kDa isoformvaline--tRNA ligaseprotein G7avalRSvaline tRNA ligase 1, cytoplasmicvalyl-tRNA synthetase 2
Modification date2018052320180523
UniProtAcc

Q86W56

P26640

Ensembl transtripts involved in fusion geneENST00000402038, ENST00000492350, 
ENST00000375663, ENST00000482996, 
ENST00000444930, ENST00000435657, 
ENST00000487524, ENST00000457796, 
ENST00000469542, ENST00000211402, 
ENST00000462946, ENST00000422694, 
ENST00000491232, ENST00000424974, 
ENST00000425144, ENST00000474299, 
Fusion gene scores* DoF score7 X 7 X 1=495 X 4 X 5=100
# samples 95
** MAII scorelog2(9/49*10)=0.877143252214467
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PARG [Title/Abstract] AND VARS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePARG

GO:1990966

ATP generation from poly-ADP-D-ribose

27257257


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1R32780PARGchr10

51590028

-VARSchr6

3079091

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000402038ENST00000375663PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000402038ENST00000482996PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000402038ENST00000444930PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000402038ENST00000435657PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000402038ENST00000487524PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000402038ENST00000457796PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000402038ENST00000469542PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000402038ENST00000211402PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000402038ENST00000462946PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000402038ENST00000422694PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000402038ENST00000491232PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000402038ENST00000424974PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000402038ENST00000425144PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000402038ENST00000474299PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000492350ENST00000375663PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000492350ENST00000482996PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000492350ENST00000444930PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000492350ENST00000435657PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000492350ENST00000487524PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000492350ENST00000457796PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000492350ENST00000469542PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000492350ENST00000211402PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000492350ENST00000462946PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000492350ENST00000422694PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000492350ENST00000491232PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000492350ENST00000424974PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000492350ENST00000425144PARGchr10

51590028

-VARSchr6

3079091

+
intron-intronENST00000492350ENST00000474299PARGchr10

51590028

-VARSchr6

3079091

+

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FusionProtFeatures for PARG_VARS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PARG

Q86W56

VARS

P26640


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PARG_VARS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PARG_VARS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PARG_VARS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PARG_VARS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePARGC0007621Neoplastic Cell Transformation2CTD_human
HgenePARGC0752351Embryo Loss1CTD_human