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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25993

FusionGeneSummary for PARD6G_SLC14A2

check button Fusion gene summary
Fusion gene informationFusion gene name: PARD6G_SLC14A2
Fusion gene ID: 25993
HgeneTgene
Gene symbol

PARD6G

SLC14A2

Gene ID

84552

8170

Gene namepar-6 family cell polarity regulator gammasolute carrier family 14 member 2
SynonymsPAR-6G|PAR6gammaHUT2|UT-A2|UT2|UTA|UTR|hUT-A6
Cytomap

18q23

18q12.3

Type of geneprotein-codingprotein-coding
Descriptionpartitioning defective 6 homolog gammaPAR-6 gamma proteinPAR6Dpar-6 partitioning defective 6 homolog gammaurea transporter 2solute carrier family 14 (urea transporter), member 2urea transporter, kidney
Modification date2018052320180519
UniProtAcc

Q9BYG4

Q15849

Ensembl transtripts involved in fusion geneENST00000353265, ENST00000470488, 
ENST00000586448, ENST00000255226, 
ENST00000589658, 
Fusion gene scores* DoF score3 X 2 X 2=123 X 3 X 3=27
# samples 33
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PARD6G [Title/Abstract] AND SLC14A2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A24L-01APARD6Gchr18

77960593

-SLC14A2chr18

43063198

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000353265ENST00000586448PARD6Gchr18

77960593

-SLC14A2chr18

43063198

+
5CDS-intronENST00000353265ENST00000255226PARD6Gchr18

77960593

-SLC14A2chr18

43063198

+
5CDS-intronENST00000353265ENST00000589658PARD6Gchr18

77960593

-SLC14A2chr18

43063198

+
5CDS-5UTRENST00000470488ENST00000586448PARD6Gchr18

77960593

-SLC14A2chr18

43063198

+
5CDS-intronENST00000470488ENST00000255226PARD6Gchr18

77960593

-SLC14A2chr18

43063198

+
5CDS-intronENST00000470488ENST00000589658PARD6Gchr18

77960593

-SLC14A2chr18

43063198

+

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FusionProtFeatures for PARD6G_SLC14A2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PARD6G

Q9BYG4

SLC14A2

Q15849

Adapter protein involved in asymmetrical cell divisionand cell polarization processes. May play a role in the formationof epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (Bysimilarity). {ECO:0000250}. Specialized low-affinity vasopressin-regulated ureatransporter. Mediates rapid transepithelial urea transport acrossthe inner medullary collecting duct and plays a major role in theurinary concentrating mechanism. {ECO:0000269|PubMed:11502588,ECO:0000269|PubMed:8647271}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PARD6G_SLC14A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PARD6G_SLC14A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PARD6GPARD3, PRKCZ, RAC1, CDC42, YWHAH, PRKCI, LLGL1, YWHAE, PARD6B, MARK2, LLGL2, BRINP1, HSPA4, PNMA3, PNMA2, PNMAL1, WDR83, RHOJSLC14A2PKP2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PARD6G_SLC14A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PARD6G_SLC14A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource