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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 25926

FusionGeneSummary for PAPOLG_ABCA12

check button Fusion gene summary
Fusion gene informationFusion gene name: PAPOLG_ABCA12
Fusion gene ID: 25926
HgeneTgene
Gene symbol

PAPOLG

ABCA12

Gene ID

64895

26154

Gene namepoly(A) polymerase gammaATP binding cassette subfamily A member 12
Synonyms-ARCI4A|ARCI4B|ICR2B|LI2
Cytomap

2p16.1

2q35

Type of geneprotein-codingprotein-coding
Descriptionpoly(A) polymerase gammaPAP-gammaSRP RNA 3' adenylating enzyme/pap2SRP RNA 3'-adenylating enzymeSRP RNA-adenylating enzymeneo-PAPneo-poly(A) polymerasenuclear poly(A) polymerase gammapolynucleotide adenylyltransferase gammasignal recognition partATP-binding cassette sub-family A member 12ATP-binding cassette transporter 12ATP-binding cassette, sub-family A (ABC1), member 12
Modification date2018052320180523
UniProtAcc

Q9BWT3

Q86UK0

Ensembl transtripts involved in fusion geneENST00000238714, ENST00000483370, 
ENST00000272895, ENST00000389661, 
ENST00000412081, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: PAPOLG [Title/Abstract] AND ABCA12 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePAPOLG

GO:0043631

RNA polyadenylation

11287430|11463842

TgeneABCA12

GO:0006869

lipid transport

16007253

TgeneABCA12

GO:0010875

positive regulation of cholesterol efflux

23931754

TgeneABCA12

GO:0072659

protein localization to plasma membrane

23931754


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-7784-01APAPOLGchr2

60997646

+ABCA12chr2

215821502

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000238714ENST00000272895PAPOLGchr2

60997646

+ABCA12chr2

215821502

-
In-frameENST00000238714ENST00000389661PAPOLGchr2

60997646

+ABCA12chr2

215821502

-
5CDS-intronENST00000238714ENST00000412081PAPOLGchr2

60997646

+ABCA12chr2

215821502

-
intron-3CDSENST00000483370ENST00000272895PAPOLGchr2

60997646

+ABCA12chr2

215821502

-
intron-3CDSENST00000483370ENST00000389661PAPOLGchr2

60997646

+ABCA12chr2

215821502

-
intron-intronENST00000483370ENST00000412081PAPOLGchr2

60997646

+ABCA12chr2

215821502

-

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FusionProtFeatures for PAPOLG_ABCA12


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PAPOLG

Q9BWT3

ABCA12

Q86UK0

Responsible for the post-transcriptional adenylation ofthe 3'-terminal of mRNA precursors and several small RNAsincluding signal recognition particle (SRP) RNA, nuclear 7SK RNA,U2 small nuclear RNA, and ribosomal 5S RNA.{ECO:0000269|PubMed:11287430, ECO:0000269|PubMed:11463842}. Probable transporter involved in lipid homeostasis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAPOLGchr2:60997646chr2:215821502ENST00000238714+622112_114164737Nucleotide bindingATP
HgenePAPOLGchr2:60997646chr2:215821502ENST00000238714+62299_101164737Nucleotide bindingATP
TgeneABCA12chr2:60997646chr2:215821502ENST00000272895-40532254_248920392596DomainABC transporter 2
TgeneABCA12chr2:60997646chr2:215821502ENST00000389661-32452254_248917212278DomainABC transporter 2
TgeneABCA12chr2:60997646chr2:215821502ENST00000272895-40532290_229720392596Nucleotide bindingATP 2
TgeneABCA12chr2:60997646chr2:215821502ENST00000389661-32452290_229717212278Nucleotide bindingATP 2
TgeneABCA12chr2:60997646chr2:215821502ENST00000272895-40532072_209220392596TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000272895-40532103_212320392596TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000272895-40532187_220720392596TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000272895-40532270_229020392596TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000389661-32451747_176717212278TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000389661-32451979_199917212278TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000389661-32452035_205517212278TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000389661-32452072_209217212278TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000389661-32452103_212317212278TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000389661-32452187_220717212278TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000389661-32452270_229017212278TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAPOLGchr2:60997646chr2:215821502ENST00000238714+622245_246164737Nucleotide bindingATP
TgeneABCA12chr2:60997646chr2:215821502ENST00000272895-40531346_157720392596DomainABC transporter 1
TgeneABCA12chr2:60997646chr2:215821502ENST00000389661-32451346_157717212278DomainABC transporter 1
TgeneABCA12chr2:60997646chr2:215821502ENST00000272895-40531378_138520392596Nucleotide bindingATP 1
TgeneABCA12chr2:60997646chr2:215821502ENST00000389661-32451378_138517212278Nucleotide bindingATP 1
TgeneABCA12chr2:60997646chr2:215821502ENST00000272895-40531065_108520392596TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000272895-40531112_113220392596TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000272895-40531145_116520392596TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000272895-40531174_119420392596TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000272895-40531200_122020392596TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000272895-40531250_127020392596TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000272895-40531747_176720392596TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000272895-40531979_199920392596TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000272895-40532035_205520392596TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000272895-405323_4320392596TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000389661-32451065_108517212278TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000389661-32451112_113217212278TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000389661-32451145_116517212278TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000389661-32451174_119417212278TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000389661-32451200_122017212278TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000389661-32451250_127017212278TransmembraneHelical
TgeneABCA12chr2:60997646chr2:215821502ENST00000389661-324523_4317212278TransmembraneHelical


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FusionGeneSequence for PAPOLG_ABCA12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PAPOLG_ENST00000238714_chr2_60997646_+_ABCA12_ENST00000272895_chr2_215821502_-_721aa
MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHRLVVLGKLNNLVKEWISDVSESKNLPPSVVA
TVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEVFYLVPVAFSIGIIAI
FKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFL
IFPQFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRLFFRKFNSSHVRETIDEDE
DVRAERLRVESGAAEFDLVQLYCLTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGH
VDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDE
PSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQ
LHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQKSYETADTSSQGSTISVDSQDDQMES

>In-frame_PAPOLG_ENST00000238714_chr2_60997646_+_ABCA12_ENST00000389661_chr2_215821502_-_721aa
MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHRLVVLGKLNNLVKEWISDVSESKNLPPSVVA
TVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEVFYLVPVAFSIGIIAI
FKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFL
IFPQFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRLFFRKFNSSHVRETIDEDE
DVRAERLRVESGAAEFDLVQLYCLTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGH
VDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDE
PSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQ
LHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQKSYETADTSSQGSTISVDSQDDQMES


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PAPOLG_ENST00000238714_chr2_60997646_+_ABCA12_ENST00000272895_chr2_215821502_-_2163nt
ATGAAAGAGATGTCTGCAAACACCGTGCTGGACAGCCAGCGTCAACAAAAGCATTATGGAATTACCTCCCCAATTAGTTTGGCATCTCCT
AAAGAAATTGATCATATTTACACACAGAAATTAATTGACGCCATGAAACCATTTGGAGTGTTTGAAGATGAGGAAGAATTGAACCACAGG
CTGGTGGTTCTTGGTAAATTGAACAATTTAGTAAAAGAATGGATTTCTGATGTCAGCGAGAGTAAGAACCTCCCACCTTCTGTTGTGGCT
ACTGTTGGTGGTAAAATTTTCACATTTGGATCCTATAGGCTTGGAGTACACACCAAAGGAGCTGACATTGATGCACTTTGTGTAGCTCCA
AGACATGTGGAAAGATCTGATTTTTTTCAGTCTTTTTTTGAAAAATTGAAACATCAAGATGGCATTAGAAACTTAAGAGCTGTAGAAGAT
GCCTTTGTACCTGTTATAAAATTTGAATTTGATGGTATTGAAGTTTTCTACTTGGTGCCTGTAGCGTTTTCAATTGGTATCATTGCGATT
TTCAAATTACCTGCATTCTACAGTGAAAACAACCTAGGCGCTGTATCTCTCCTACTTCTCCTGTTTGGGTATGCAACATTTTCCTGGATG
TACTTGCTGGCTGGGCTCTTCCATGAAACAGGAATGGCCTTCATCACTTACGTCTGTGTCAACTTGTTTTTTGGCATTAATTCCATTGTT
TCCCTGTCAGTGGTATACTTTCTTTCCAAGGAAAAGCCTAATGATCCGACTTTAGAACTTATTTCTGAAACCCTCAAGCGCATTTTCCTG
ATTTTCCCACAATTCTGTTTTGGCTACGGTTTGATTGAACTTTCTCAACAACAGTCGGTCCTAGACTTCTTAAAAGCATATGGAGTGGAA
TACCCAAATGAAACCTTTGAGATGAATAAACTAGGTGCAATGTTTGTGGCTTTGGTTTCTCAGGGCACCATGTTTTTTTCCTTGCGACTC
TTAATCAACGAATCCCTGATAAAGAAACTCAGGCTTTTCTTCAGAAAATTTAATTCTTCACATGTAAGGGAGACAATAGATGAGGATGAA
GATGTGCGGGCTGAGAGATTAAGAGTTGAGAGTGGTGCAGCTGAATTTGACTTGGTCCAACTTTATTGTCTCACAAAGACCTACCAACTT
ATCCACAAAAAGATTATAGCTGTAAACAACATCAGCATTGGGATACCTGCTGGAGAGTGTTTTGGGCTTCTTGGAGTGAATGGAGCAGGA
AAGACCACTATATTCAAGATGCTGACAGGAGACATCATTCCTTCAAGTGGAAACATTCTGATCAGAAATAAGACCGGATCTCTGGGTCAC
GTTGATTCTCACAGCTCATTAGTTGGCTACTGTCCTCAGGAAGATGCCTTAGATGACCTGGTAACTGTGGAAGAACATTTGTATTTCTAT
GCCAGGGTACATGGAATTCCAGAAAAGGATATTAAAGAAACTGTTCATAAACTCCTTAGGAGACTTCACCTGATGCCCTTCAAGGACAGA
GCTACCTCTATGTGCAGTTATGGCACAAAAAGAAAATTATCCACTGCACTGGCCTTGATAGGGAAACCTTCCATTCTACTGCTGGATGAG
CCGAGCTCTGGCATGGATCCGAAGTCGAAACGGCACCTCTGGAAGATCATTTCAGAAGAAGTACAGAACAAATGTTCCGTCATCCTCACA
TCTCACAGCATGGAAGAATGTGAAGCTCTCTGTACCAGGTTGGCCATTATGGTGAATGGAAAGTTTCAATGTATTGGATCTTTGCAGCAC
ATAAAGAGCAGGTTTGGACGAGGATTTACTGTCAAAGTTCACTTGAAGAATAACAAAGTGACCATGGAGACCCTCACAAAGTTCATGCAG
CTGCACTTTCCAAAAACATACTTAAAAGATCAGCACCTCAGCATGCTAGAGTATCATGTACCAGTCACAGCAGGAGGAGTCGCAAACATT
TTTGATCTGCTGGAAACCAACAAGACTGCTTTAAATATTACAAATTTCTTAGTGAGTCAGACCACTCTGGAAGAGGTTTTCATCAACTTT
GCCAAAGACCAGAAGTCCTATGAAACTGCTGATACCAGCAGCCAAGGTTCCACTATAAGTGTTGACTCACAAGATGACCAGATGGAGTCT

>In-frame_PAPOLG_ENST00000238714_chr2_60997646_+_ABCA12_ENST00000389661_chr2_215821502_-_2163nt
ATGAAAGAGATGTCTGCAAACACCGTGCTGGACAGCCAGCGTCAACAAAAGCATTATGGAATTACCTCCCCAATTAGTTTGGCATCTCCT
AAAGAAATTGATCATATTTACACACAGAAATTAATTGACGCCATGAAACCATTTGGAGTGTTTGAAGATGAGGAAGAATTGAACCACAGG
CTGGTGGTTCTTGGTAAATTGAACAATTTAGTAAAAGAATGGATTTCTGATGTCAGCGAGAGTAAGAACCTCCCACCTTCTGTTGTGGCT
ACTGTTGGTGGTAAAATTTTCACATTTGGATCCTATAGGCTTGGAGTACACACCAAAGGAGCTGACATTGATGCACTTTGTGTAGCTCCA
AGACATGTGGAAAGATCTGATTTTTTTCAGTCTTTTTTTGAAAAATTGAAACATCAAGATGGCATTAGAAACTTAAGAGCTGTAGAAGAT
GCCTTTGTACCTGTTATAAAATTTGAATTTGATGGTATTGAAGTTTTCTACTTGGTGCCTGTAGCGTTTTCAATTGGTATCATTGCGATT
TTCAAATTACCTGCATTCTACAGTGAAAACAACCTAGGCGCTGTATCTCTCCTACTTCTCCTGTTTGGGTATGCAACATTTTCCTGGATG
TACTTGCTGGCTGGGCTCTTCCATGAAACAGGAATGGCCTTCATCACTTACGTCTGTGTCAACTTGTTTTTTGGCATTAATTCCATTGTT
TCCCTGTCAGTGGTATACTTTCTTTCCAAGGAAAAGCCTAATGATCCGACTTTAGAACTTATTTCTGAAACCCTCAAGCGCATTTTCCTG
ATTTTCCCACAATTCTGTTTTGGCTACGGTTTGATTGAACTTTCTCAACAACAGTCGGTCCTAGACTTCTTAAAAGCATATGGAGTGGAA
TACCCAAATGAAACCTTTGAGATGAATAAACTAGGTGCAATGTTTGTGGCTTTGGTTTCTCAGGGCACCATGTTTTTTTCCTTGCGACTC
TTAATCAACGAATCCCTGATAAAGAAACTCAGGCTTTTCTTCAGAAAATTTAATTCTTCACATGTAAGGGAGACAATAGATGAGGATGAA
GATGTGCGGGCTGAGAGATTAAGAGTTGAGAGTGGTGCAGCTGAATTTGACTTGGTCCAACTTTATTGTCTCACAAAGACCTACCAACTT
ATCCACAAAAAGATTATAGCTGTAAACAACATCAGCATTGGGATACCTGCTGGAGAGTGTTTTGGGCTTCTTGGAGTGAATGGAGCAGGA
AAGACCACTATATTCAAGATGCTGACAGGAGACATCATTCCTTCAAGTGGAAACATTCTGATCAGAAATAAGACCGGATCTCTGGGTCAC
GTTGATTCTCACAGCTCATTAGTTGGCTACTGTCCTCAGGAAGATGCCTTAGATGACCTGGTAACTGTGGAAGAACATTTGTATTTCTAT
GCCAGGGTACATGGAATTCCAGAAAAGGATATTAAAGAAACTGTTCATAAACTCCTTAGGAGACTTCACCTGATGCCCTTCAAGGACAGA
GCTACCTCTATGTGCAGTTATGGCACAAAAAGAAAATTATCCACTGCACTGGCCTTGATAGGGAAACCTTCCATTCTACTGCTGGATGAG
CCGAGCTCTGGCATGGATCCGAAGTCGAAACGGCACCTCTGGAAGATCATTTCAGAAGAAGTACAGAACAAATGTTCCGTCATCCTCACA
TCTCACAGCATGGAAGAATGTGAAGCTCTCTGTACCAGGTTGGCCATTATGGTGAATGGAAAGTTTCAATGTATTGGATCTTTGCAGCAC
ATAAAGAGCAGGTTTGGACGAGGATTTACTGTCAAAGTTCACTTGAAGAATAACAAAGTGACCATGGAGACCCTCACAAAGTTCATGCAG
CTGCACTTTCCAAAAACATACTTAAAAGATCAGCACCTCAGCATGCTAGAGTATCATGTACCAGTCACAGCAGGAGGAGTCGCAAACATT
TTTGATCTGCTGGAAACCAACAAGACTGCTTTAAATATTACAAATTTCTTAGTGAGTCAGACCACTCTGGAAGAGGTTTTCATCAACTTT
GCCAAAGACCAGAAGTCCTATGAAACTGCTGATACCAGCAGCCAAGGTTCCACTATAAGTGTTGACTCACAAGATGACCAGATGGAGTCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_PAPOLG_ENST00000238714_chr2_60997646_+_ABCA12_ENST00000272895_chr2_215821502_-_3504nt
CTGAGACCTGCGAGAGGCAGGCTGGGAAGCGGCGCCATATTGGCGTCGGCCGCGCTGTATTGTCATAAATAGAGCCGGTTTTGTGGTGTT
TTCACTACTCGGTTGGATGCCTCAGCCATAGTAAGTGGGAAAGTGAGCGAGCAAGCGAGCTACTAGCGACCGGAGGAAAGTGAACAGGGG
GAGAAGGGAACAGCAAGAACAGGACTCCAGAGCGATAAACACTCGCTGGAGAGGGAGACGCAGGAAGCGATGAAAGAGATGTCTGCAAAC
ACCGTGCTGGACAGCCAGCGTCAACAAAAGCATTATGGAATTACCTCCCCAATTAGTTTGGCATCTCCTAAAGAAATTGATCATATTTAC
ACACAGAAATTAATTGACGCCATGAAACCATTTGGAGTGTTTGAAGATGAGGAAGAATTGAACCACAGGCTGGTGGTTCTTGGTAAATTG
AACAATTTAGTAAAAGAATGGATTTCTGATGTCAGCGAGAGTAAGAACCTCCCACCTTCTGTTGTGGCTACTGTTGGTGGTAAAATTTTC
ACATTTGGATCCTATAGGCTTGGAGTACACACCAAAGGAGCTGACATTGATGCACTTTGTGTAGCTCCAAGACATGTGGAAAGATCTGAT
TTTTTTCAGTCTTTTTTTGAAAAATTGAAACATCAAGATGGCATTAGAAACTTAAGAGCTGTAGAAGATGCCTTTGTACCTGTTATAAAA
TTTGAATTTGATGGTATTGAAGTTTTCTACTTGGTGCCTGTAGCGTTTTCAATTGGTATCATTGCGATTTTCAAATTACCTGCATTCTAC
AGTGAAAACAACCTAGGCGCTGTATCTCTCCTACTTCTCCTGTTTGGGTATGCAACATTTTCCTGGATGTACTTGCTGGCTGGGCTCTTC
CATGAAACAGGAATGGCCTTCATCACTTACGTCTGTGTCAACTTGTTTTTTGGCATTAATTCCATTGTTTCCCTGTCAGTGGTATACTTT
CTTTCCAAGGAAAAGCCTAATGATCCGACTTTAGAACTTATTTCTGAAACCCTCAAGCGCATTTTCCTGATTTTCCCACAATTCTGTTTT
GGCTACGGTTTGATTGAACTTTCTCAACAACAGTCGGTCCTAGACTTCTTAAAAGCATATGGAGTGGAATACCCAAATGAAACCTTTGAG
ATGAATAAACTAGGTGCAATGTTTGTGGCTTTGGTTTCTCAGGGCACCATGTTTTTTTCCTTGCGACTCTTAATCAACGAATCCCTGATA
AAGAAACTCAGGCTTTTCTTCAGAAAATTTAATTCTTCACATGTAAGGGAGACAATAGATGAGGATGAAGATGTGCGGGCTGAGAGATTA
AGAGTTGAGAGTGGTGCAGCTGAATTTGACTTGGTCCAACTTTATTGTCTCACAAAGACCTACCAACTTATCCACAAAAAGATTATAGCT
GTAAACAACATCAGCATTGGGATACCTGCTGGAGAGTGTTTTGGGCTTCTTGGAGTGAATGGAGCAGGAAAGACCACTATATTCAAGATG
CTGACAGGAGACATCATTCCTTCAAGTGGAAACATTCTGATCAGAAATAAGACCGGATCTCTGGGTCACGTTGATTCTCACAGCTCATTA
GTTGGCTACTGTCCTCAGGAAGATGCCTTAGATGACCTGGTAACTGTGGAAGAACATTTGTATTTCTATGCCAGGGTACATGGAATTCCA
GAAAAGGATATTAAAGAAACTGTTCATAAACTCCTTAGGAGACTTCACCTGATGCCCTTCAAGGACAGAGCTACCTCTATGTGCAGTTAT
GGCACAAAAAGAAAATTATCCACTGCACTGGCCTTGATAGGGAAACCTTCCATTCTACTGCTGGATGAGCCGAGCTCTGGCATGGATCCG
AAGTCGAAACGGCACCTCTGGAAGATCATTTCAGAAGAAGTACAGAACAAATGTTCCGTCATCCTCACATCTCACAGCATGGAAGAATGT
GAAGCTCTCTGTACCAGGTTGGCCATTATGGTGAATGGAAAGTTTCAATGTATTGGATCTTTGCAGCACATAAAGAGCAGGTTTGGACGA
GGATTTACTGTCAAAGTTCACTTGAAGAATAACAAAGTGACCATGGAGACCCTCACAAAGTTCATGCAGCTGCACTTTCCAAAAACATAC
TTAAAAGATCAGCACCTCAGCATGCTAGAGTATCATGTACCAGTCACAGCAGGAGGAGTCGCAAACATTTTTGATCTGCTGGAAACCAAC
AAGACTGCTTTAAATATTACAAATTTCTTAGTGAGTCAGACCACTCTGGAAGAGGTTTTCATCAACTTTGCCAAAGACCAGAAGTCCTAT
GAAACTGCTGATACCAGCAGCCAAGGTTCCACTATAAGTGTTGACTCACAAGATGACCAGATGGAGTCTTAACACTTCCAGCAAACTCAA
TCTCAGCGTGTGACCAATGGCTTCATTTTGAAGAAAAGCCACAGAAGATACACTTCCGCAAGATATCTTCATTTTAAAGTAAAGTAATAT
ACTGTATGGAAAGTTACAACTGTGTTAGACTAACAAGTAATTATAAAAGGAAATTTTTCCTTCTAAGGTCAGTGAGTGTTGTTGCTACTG
AAATGAATTCCTGTATACTCAACACTGTGAGCATGCTAATGTATATGCTGGTGATTCTTATGCAAAGGTGAAGCCACCTCAAGATGAATA
TCTTAATTTATTACTTTCAATAAAAAGACAGTTTAAAAGGCATGGATTTTGGTAGTTGAAATATAAGAGTGGAGAAGAAAAGTCAGATGG
TTTGTGGCAGGTGCCACCGGGCAAGCAGACAACATAATTTATTTCCAGAAAACAACAGAATGAACATCATCATGAATACATGAATCGGCT
GTGATGTGTGAACTGCTAAGGGCCAAATGAACGTTTGCAGAGCAGTGGGCACAATGTTTACAATGTATGTGTATGTCACTTTCGGTACCT
GTGAATGCATGGGGACGTGCTGAACCCGAAAAAAAGTGCCTTTCCATAAGGACTGCAATAGAGAGGGCAATTTACCCTGGTGGTACACGG
AACCTAGATTCACTCCTGCCATGCCTTGCCAATAGTAAGCTGCAGGGTGGAACAAGAAATCACTTGCTCTGGGGGGAAGGGAGGGGGGAA
TGGGTGTGTCAGCTGGGTAGATACAAACCCTGAAAAGAGAATCCATGTGCTACTGGCAGGCAACATTTTTTAAAGCTCTTTCAGAAACCC
TCATATTTGGGGTTTCTTTTCAGGAAACATTCCTGTGGAGGGAAAACGAATATGAAGATAATTTTCAGCTAATTATCTGGGTGACCCAGA
ATCGTGTATATGGCTATAGGATAGACTTCTTAATAATGGCAAGTGACGTGGCCCTGGGGAAAGGTGCTTTATGTACCGTGTGTGCGTGTA

>In-frame_PAPOLG_ENST00000238714_chr2_60997646_+_ABCA12_ENST00000389661_chr2_215821502_-_2424nt
CTGAGACCTGCGAGAGGCAGGCTGGGAAGCGGCGCCATATTGGCGTCGGCCGCGCTGTATTGTCATAAATAGAGCCGGTTTTGTGGTGTT
TTCACTACTCGGTTGGATGCCTCAGCCATAGTAAGTGGGAAAGTGAGCGAGCAAGCGAGCTACTAGCGACCGGAGGAAAGTGAACAGGGG
GAGAAGGGAACAGCAAGAACAGGACTCCAGAGCGATAAACACTCGCTGGAGAGGGAGACGCAGGAAGCGATGAAAGAGATGTCTGCAAAC
ACCGTGCTGGACAGCCAGCGTCAACAAAAGCATTATGGAATTACCTCCCCAATTAGTTTGGCATCTCCTAAAGAAATTGATCATATTTAC
ACACAGAAATTAATTGACGCCATGAAACCATTTGGAGTGTTTGAAGATGAGGAAGAATTGAACCACAGGCTGGTGGTTCTTGGTAAATTG
AACAATTTAGTAAAAGAATGGATTTCTGATGTCAGCGAGAGTAAGAACCTCCCACCTTCTGTTGTGGCTACTGTTGGTGGTAAAATTTTC
ACATTTGGATCCTATAGGCTTGGAGTACACACCAAAGGAGCTGACATTGATGCACTTTGTGTAGCTCCAAGACATGTGGAAAGATCTGAT
TTTTTTCAGTCTTTTTTTGAAAAATTGAAACATCAAGATGGCATTAGAAACTTAAGAGCTGTAGAAGATGCCTTTGTACCTGTTATAAAA
TTTGAATTTGATGGTATTGAAGTTTTCTACTTGGTGCCTGTAGCGTTTTCAATTGGTATCATTGCGATTTTCAAATTACCTGCATTCTAC
AGTGAAAACAACCTAGGCGCTGTATCTCTCCTACTTCTCCTGTTTGGGTATGCAACATTTTCCTGGATGTACTTGCTGGCTGGGCTCTTC
CATGAAACAGGAATGGCCTTCATCACTTACGTCTGTGTCAACTTGTTTTTTGGCATTAATTCCATTGTTTCCCTGTCAGTGGTATACTTT
CTTTCCAAGGAAAAGCCTAATGATCCGACTTTAGAACTTATTTCTGAAACCCTCAAGCGCATTTTCCTGATTTTCCCACAATTCTGTTTT
GGCTACGGTTTGATTGAACTTTCTCAACAACAGTCGGTCCTAGACTTCTTAAAAGCATATGGAGTGGAATACCCAAATGAAACCTTTGAG
ATGAATAAACTAGGTGCAATGTTTGTGGCTTTGGTTTCTCAGGGCACCATGTTTTTTTCCTTGCGACTCTTAATCAACGAATCCCTGATA
AAGAAACTCAGGCTTTTCTTCAGAAAATTTAATTCTTCACATGTAAGGGAGACAATAGATGAGGATGAAGATGTGCGGGCTGAGAGATTA
AGAGTTGAGAGTGGTGCAGCTGAATTTGACTTGGTCCAACTTTATTGTCTCACAAAGACCTACCAACTTATCCACAAAAAGATTATAGCT
GTAAACAACATCAGCATTGGGATACCTGCTGGAGAGTGTTTTGGGCTTCTTGGAGTGAATGGAGCAGGAAAGACCACTATATTCAAGATG
CTGACAGGAGACATCATTCCTTCAAGTGGAAACATTCTGATCAGAAATAAGACCGGATCTCTGGGTCACGTTGATTCTCACAGCTCATTA
GTTGGCTACTGTCCTCAGGAAGATGCCTTAGATGACCTGGTAACTGTGGAAGAACATTTGTATTTCTATGCCAGGGTACATGGAATTCCA
GAAAAGGATATTAAAGAAACTGTTCATAAACTCCTTAGGAGACTTCACCTGATGCCCTTCAAGGACAGAGCTACCTCTATGTGCAGTTAT
GGCACAAAAAGAAAATTATCCACTGCACTGGCCTTGATAGGGAAACCTTCCATTCTACTGCTGGATGAGCCGAGCTCTGGCATGGATCCG
AAGTCGAAACGGCACCTCTGGAAGATCATTTCAGAAGAAGTACAGAACAAATGTTCCGTCATCCTCACATCTCACAGCATGGAAGAATGT
GAAGCTCTCTGTACCAGGTTGGCCATTATGGTGAATGGAAAGTTTCAATGTATTGGATCTTTGCAGCACATAAAGAGCAGGTTTGGACGA
GGATTTACTGTCAAAGTTCACTTGAAGAATAACAAAGTGACCATGGAGACCCTCACAAAGTTCATGCAGCTGCACTTTCCAAAAACATAC
TTAAAAGATCAGCACCTCAGCATGCTAGAGTATCATGTACCAGTCACAGCAGGAGGAGTCGCAAACATTTTTGATCTGCTGGAAACCAAC
AAGACTGCTTTAAATATTACAAATTTCTTAGTGAGTCAGACCACTCTGGAAGAGGTTTTCATCAACTTTGCCAAAGACCAGAAGTCCTAT


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FusionGenePPI for PAPOLG_ABCA12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PAPOLGNFYA, PCBD1, LZTR1, DHX29, NPM1, HARS, HNRNPR, DCTN1, ZFC3H1ABCA12


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PAPOLG_ABCA12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PAPOLG_ABCA12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneABCA12C1832550Lamellar ichthyosis, type 25CTD_human;UNIPROT
TgeneABCA12C0598226Harlequin type ichthyosis3CTD_human;ORPHANET;UNIPROT
TgeneABCA12C0009404Colorectal Neoplasms1CTD_human
TgeneABCA12C0079154Congenital Nonbullous Ichthyosiform Erythroderma1CTD_human;ORPHANET