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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25880

FusionGeneSummary for PAN3_MTMR6

check button Fusion gene summary
Fusion gene informationFusion gene name: PAN3_MTMR6
Fusion gene ID: 25880
HgeneTgene
Gene symbol

PAN3

MTMR6

Gene ID

255967

9107

Gene namepoly(A) specific ribonuclease subunit PAN3myotubularin related protein 6
Synonyms--
Cytomap

13q12.2

13q12.13

Type of geneprotein-codingprotein-coding
DescriptionPAN2-PAN3 deadenylation complex subunit PAN3PAB-dependent poly(A)-specific ribonuclease subunit 3PAB-dependent poly(A)-specific ribonuclease subunit PAN3PAB1P-dependent poly(A)-nucleasePAB1P-dependent poly(A)-specific ribonucleasePABP-dependent poly(myotubularin-related protein 6
Modification date2018052320180519
UniProtAcc

Q58A45

Q9Y217

Ensembl transtripts involved in fusion geneENST00000380958, ENST00000399613, 
ENST00000282391, ENST00000483842, 
ENST00000540661, ENST00000381801, 
ENST00000482345, 
Fusion gene scores* DoF score10 X 7 X 7=4903 X 3 X 3=27
# samples 113
** MAII scorelog2(11/490*10)=-2.15527822547791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PAN3 [Title/Abstract] AND MTMR6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMTMR6

GO:0046856

phosphatidylinositol dephosphorylation

22647598


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVREADTCGA-F5-6571-01APAN3chr13

28771483

+MTMR6chr13

25802719

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000380958ENST00000540661PAN3chr13

28771483

+MTMR6chr13

25802719

-
5CDS-intronENST00000380958ENST00000381801PAN3chr13

28771483

+MTMR6chr13

25802719

-
5CDS-intronENST00000380958ENST00000482345PAN3chr13

28771483

+MTMR6chr13

25802719

-
intron-3CDSENST00000399613ENST00000540661PAN3chr13

28771483

+MTMR6chr13

25802719

-
intron-intronENST00000399613ENST00000381801PAN3chr13

28771483

+MTMR6chr13

25802719

-
intron-intronENST00000399613ENST00000482345PAN3chr13

28771483

+MTMR6chr13

25802719

-
intron-3CDSENST00000282391ENST00000540661PAN3chr13

28771483

+MTMR6chr13

25802719

-
intron-intronENST00000282391ENST00000381801PAN3chr13

28771483

+MTMR6chr13

25802719

-
intron-intronENST00000282391ENST00000482345PAN3chr13

28771483

+MTMR6chr13

25802719

-
intron-3CDSENST00000483842ENST00000540661PAN3chr13

28771483

+MTMR6chr13

25802719

-
intron-intronENST00000483842ENST00000381801PAN3chr13

28771483

+MTMR6chr13

25802719

-
intron-intronENST00000483842ENST00000482345PAN3chr13

28771483

+MTMR6chr13

25802719

-

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FusionProtFeatures for PAN3_MTMR6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PAN3

Q58A45

MTMR6

Q9Y217

Phosphatase that acts on lipids with a phosphoinositolheadgroup. Acts as a negative regulator of KCNN4/KCa3.1 channelactivity in CD4+ T-cells possibly by decreasing intracellularlevels of phosphatidylinositol 3 phosphatase. Negatively regulatesproliferation of reactivated CD4+ T-cells.{ECO:0000269|PubMed:15831468, ECO:0000269|PubMed:16847315}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PAN3_MTMR6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PAN3_MTMR6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PAN3PAN2, PABPC1, SVIL, ELAVL1, TNRC6C, TNRC6A, TNRC6B, PABPC3, XPO1, ASF1A, ASF1B, KIAA0430, HELZMTMR6MTMR9, ELAVL1, RARG, TRIM27, NMI, MTUS2, AMOTL2, ZWINT, KCTD17, STK25, HIP1R, CEP170, CEP19, STIL, TMEM17, MTMR6, IFI30, CARM1, SOAT1, BBS7, RPL34, MTMR7, CDA, FHIT, KCNJ5, BHMT, CTSE, LMTK2, AATK, ERBB4, ERBB3, ROR2, PTK7, MTNR1B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PAN3_MTMR6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PAN3_MTMR6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource