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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25877

FusionGeneSummary for PAN3_KATNAL1

check button Fusion gene summary
Fusion gene informationFusion gene name: PAN3_KATNAL1
Fusion gene ID: 25877
HgeneTgene
Gene symbol

PAN3

KATNAL1

Gene ID

255967

84056

Gene namepoly(A) specific ribonuclease subunit PAN3katanin catalytic subunit A1 like 1
Synonyms--
Cytomap

13q12.2

13q12.3

Type of geneprotein-codingprotein-coding
DescriptionPAN2-PAN3 deadenylation complex subunit PAN3PAB-dependent poly(A)-specific ribonuclease subunit 3PAB-dependent poly(A)-specific ribonuclease subunit PAN3PAB1P-dependent poly(A)-nucleasePAB1P-dependent poly(A)-specific ribonucleasePABP-dependent poly(katanin p60 ATPase-containing subunit A-like 1katanin catalytic subunit A like 1katanin p60 subunit A like 1p60 katanin-like 1
Modification date2018052320180523
UniProtAcc

Q58A45

Q9BW62

Ensembl transtripts involved in fusion geneENST00000380958, ENST00000399613, 
ENST00000282391, ENST00000483842, 
ENST00000380615, ENST00000380617, 
Fusion gene scores* DoF score10 X 7 X 7=4901 X 1 X 1=1
# samples 111
** MAII scorelog2(11/490*10)=-2.15527822547791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: PAN3 [Title/Abstract] AND KATNAL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKATNAL1

GO:0051013

microtubule severing

26929214


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVREADTCGA-DC-6154-01APAN3chr13

28752072

+KATNAL1chr13

30857928

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000380958ENST00000380615PAN3chr13

28752072

+KATNAL1chr13

30857928

-
5CDS-5UTRENST00000380958ENST00000380617PAN3chr13

28752072

+KATNAL1chr13

30857928

-
5CDS-5UTRENST00000399613ENST00000380615PAN3chr13

28752072

+KATNAL1chr13

30857928

-
5CDS-5UTRENST00000399613ENST00000380617PAN3chr13

28752072

+KATNAL1chr13

30857928

-
intron-5UTRENST00000282391ENST00000380615PAN3chr13

28752072

+KATNAL1chr13

30857928

-
intron-5UTRENST00000282391ENST00000380617PAN3chr13

28752072

+KATNAL1chr13

30857928

-
intron-5UTRENST00000483842ENST00000380615PAN3chr13

28752072

+KATNAL1chr13

30857928

-
intron-5UTRENST00000483842ENST00000380617PAN3chr13

28752072

+KATNAL1chr13

30857928

-

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FusionProtFeatures for PAN3_KATNAL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PAN3

Q58A45

KATNAL1

Q9BW62

Regulates microtubule dynamics in Sertoli cells, aprocess that is essential for spermiogenesis and male fertility.Severs microtubules in an ATP-dependent manner, promoting rapidreorganization of cellular microtubule arrays (By similarity). Hasmicrotubule-severing activity in vitro (PubMed:26929214).{ECO:0000250|UniProtKB:Q8K0T4, ECO:0000269|PubMed:26929214}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PAN3_KATNAL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PAN3_KATNAL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PAN3PAN2, PABPC1, SVIL, ELAVL1, TNRC6C, TNRC6A, TNRC6B, PABPC3, XPO1, ASF1A, ASF1B, KIAA0430, HELZKATNAL1COX17, ELAVL1, SIAH1, ZNF69, C1orf109, KATNBL1, KATNAL1, KLC4, CEP57L1, FBXW7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PAN3_KATNAL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PAN3_KATNAL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource