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Fusion gene ID: 25877 |
FusionGeneSummary for PAN3_KATNAL1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: PAN3_KATNAL1 | Fusion gene ID: 25877 | Hgene | Tgene | Gene symbol | PAN3 | KATNAL1 | Gene ID | 255967 | 84056 |
Gene name | poly(A) specific ribonuclease subunit PAN3 | katanin catalytic subunit A1 like 1 | |
Synonyms | - | - | |
Cytomap | 13q12.2 | 13q12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | PAN2-PAN3 deadenylation complex subunit PAN3PAB-dependent poly(A)-specific ribonuclease subunit 3PAB-dependent poly(A)-specific ribonuclease subunit PAN3PAB1P-dependent poly(A)-nucleasePAB1P-dependent poly(A)-specific ribonucleasePABP-dependent poly( | katanin p60 ATPase-containing subunit A-like 1katanin catalytic subunit A like 1katanin p60 subunit A like 1p60 katanin-like 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q58A45 | Q9BW62 | |
Ensembl transtripts involved in fusion gene | ENST00000380958, ENST00000399613, ENST00000282391, ENST00000483842, | ENST00000380615, ENST00000380617, | |
Fusion gene scores | * DoF score | 10 X 7 X 7=490 | 1 X 1 X 1=1 |
# samples | 11 | 1 | |
** MAII score | log2(11/490*10)=-2.15527822547791 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: PAN3 [Title/Abstract] AND KATNAL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | KATNAL1 | GO:0051013 | microtubule severing | 26929214 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | READ | TCGA-DC-6154-01A | PAN3 | chr13 | 28752072 | + | KATNAL1 | chr13 | 30857928 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000380958 | ENST00000380615 | PAN3 | chr13 | 28752072 | + | KATNAL1 | chr13 | 30857928 | - |
5CDS-5UTR | ENST00000380958 | ENST00000380617 | PAN3 | chr13 | 28752072 | + | KATNAL1 | chr13 | 30857928 | - |
5CDS-5UTR | ENST00000399613 | ENST00000380615 | PAN3 | chr13 | 28752072 | + | KATNAL1 | chr13 | 30857928 | - |
5CDS-5UTR | ENST00000399613 | ENST00000380617 | PAN3 | chr13 | 28752072 | + | KATNAL1 | chr13 | 30857928 | - |
intron-5UTR | ENST00000282391 | ENST00000380615 | PAN3 | chr13 | 28752072 | + | KATNAL1 | chr13 | 30857928 | - |
intron-5UTR | ENST00000282391 | ENST00000380617 | PAN3 | chr13 | 28752072 | + | KATNAL1 | chr13 | 30857928 | - |
intron-5UTR | ENST00000483842 | ENST00000380615 | PAN3 | chr13 | 28752072 | + | KATNAL1 | chr13 | 30857928 | - |
intron-5UTR | ENST00000483842 | ENST00000380617 | PAN3 | chr13 | 28752072 | + | KATNAL1 | chr13 | 30857928 | - |
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FusionProtFeatures for PAN3_KATNAL1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
PAN3 | KATNAL1 |
Regulates microtubule dynamics in Sertoli cells, aprocess that is essential for spermiogenesis and male fertility.Severs microtubules in an ATP-dependent manner, promoting rapidreorganization of cellular microtubule arrays (By similarity). Hasmicrotubule-severing activity in vitro (PubMed:26929214).{ECO:0000250|UniProtKB:Q8K0T4, ECO:0000269|PubMed:26929214}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PAN3_KATNAL1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PAN3_KATNAL1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PAN3 | PAN2, PABPC1, SVIL, ELAVL1, TNRC6C, TNRC6A, TNRC6B, PABPC3, XPO1, ASF1A, ASF1B, KIAA0430, HELZ | KATNAL1 | COX17, ELAVL1, SIAH1, ZNF69, C1orf109, KATNBL1, KATNAL1, KLC4, CEP57L1, FBXW7 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PAN3_KATNAL1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PAN3_KATNAL1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |