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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25872

FusionGeneSummary for PAM_PAM

check button Fusion gene summary
Fusion gene informationFusion gene name: PAM_PAM
Fusion gene ID: 25872
HgeneTgene
Gene symbol

PAM

PAM

Gene ID

23077

23077

Gene nameMYC binding protein 2, E3 ubiquitin protein ligaseMYC binding protein 2, E3 ubiquitin protein ligase
SynonymsMyc-bp2|PAM|PhrMyc-bp2|PAM|Phr
Cytomap

13q22.3

13q22.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase MYCBP2HighwireRING-type E3 ubiquitin transferase MYCBP2myc-binding protein 2pam/highwire/rpm-1 proteinprotein associated with MycE3 ubiquitin-protein ligase MYCBP2HighwireRING-type E3 ubiquitin transferase MYCBP2myc-binding protein 2pam/highwire/rpm-1 proteinprotein associated with Myc
Modification date2018052320180523
UniProtAcc

P19021

P19021

Ensembl transtripts involved in fusion geneENST00000438793, ENST00000346918, 
ENST00000379787, ENST00000348126, 
ENST00000304400, ENST00000274392, 
ENST00000455264, ENST00000513648, 
ENST00000438793, ENST00000346918, 
ENST00000379787, ENST00000348126, 
ENST00000304400, ENST00000274392, 
ENST00000455264, ENST00000513648, 
Fusion gene scores* DoF score2 X 2 X 1=45 X 6 X 2=60
# samples 24
** MAII scorelog2(2/4*10)=2.32192809488736log2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PAM [Title/Abstract] AND PAM [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM699806PAMchr5

102345529

-PAMchr5

102353088

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000438793ENST00000438793PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000438793ENST00000346918PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000438793ENST00000379787PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000438793ENST00000348126PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000438793ENST00000304400PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000438793ENST00000274392PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000438793ENST00000455264PAMchr5

102345529

-PAMchr5

102353088

+
5CDS-intronENST00000438793ENST00000513648PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000346918ENST00000438793PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000346918ENST00000346918PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000346918ENST00000379787PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000346918ENST00000348126PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000346918ENST00000304400PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000346918ENST00000274392PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000346918ENST00000455264PAMchr5

102345529

-PAMchr5

102353088

+
5CDS-intronENST00000346918ENST00000513648PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000379787ENST00000438793PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000379787ENST00000346918PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000379787ENST00000379787PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000379787ENST00000348126PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000379787ENST00000304400PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000379787ENST00000274392PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000379787ENST00000455264PAMchr5

102345529

-PAMchr5

102353088

+
5CDS-intronENST00000379787ENST00000513648PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000348126ENST00000438793PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000348126ENST00000346918PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000348126ENST00000379787PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000348126ENST00000348126PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000348126ENST00000304400PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000348126ENST00000274392PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000348126ENST00000455264PAMchr5

102345529

-PAMchr5

102353088

+
5CDS-intronENST00000348126ENST00000513648PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000304400ENST00000438793PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000304400ENST00000346918PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000304400ENST00000379787PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000304400ENST00000348126PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000304400ENST00000304400PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000304400ENST00000274392PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000304400ENST00000455264PAMchr5

102345529

-PAMchr5

102353088

+
5CDS-intronENST00000304400ENST00000513648PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000274392ENST00000438793PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000274392ENST00000346918PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000274392ENST00000379787PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000274392ENST00000348126PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000274392ENST00000304400PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000274392ENST00000274392PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000274392ENST00000455264PAMchr5

102345529

-PAMchr5

102353088

+
5CDS-intronENST00000274392ENST00000513648PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000455264ENST00000438793PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000455264ENST00000346918PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000455264ENST00000379787PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000455264ENST00000348126PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000455264ENST00000304400PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000455264ENST00000274392PAMchr5

102345529

-PAMchr5

102353088

+
In-frameENST00000455264ENST00000455264PAMchr5

102345529

-PAMchr5

102353088

+
5CDS-intronENST00000455264ENST00000513648PAMchr5

102345529

-PAMchr5

102353088

+
intron-3CDSENST00000513648ENST00000438793PAMchr5

102345529

-PAMchr5

102353088

+
intron-3CDSENST00000513648ENST00000346918PAMchr5

102345529

-PAMchr5

102353088

+
intron-3CDSENST00000513648ENST00000379787PAMchr5

102345529

-PAMchr5

102353088

+
intron-3CDSENST00000513648ENST00000348126PAMchr5

102345529

-PAMchr5

102353088

+
intron-3CDSENST00000513648ENST00000304400PAMchr5

102345529

-PAMchr5

102353088

+
intron-3CDSENST00000513648ENST00000274392PAMchr5

102345529

-PAMchr5

102353088

+
intron-3CDSENST00000513648ENST00000455264PAMchr5

102345529

-PAMchr5

102353088

+
intron-intronENST00000513648ENST00000513648PAMchr5

102345529

-PAMchr5

102353088

+

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FusionProtFeatures for PAM_PAM


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PAM

P19021

PAM

P19021


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePAMchr5:102345529chr5:102353088ENST00000304400+0251_494-62975RegionPeptidylglycine alpha-hydroxylating monooxygenase
TgenePAMchr5:102345529chr5:102353088ENST00000304400+025495_817-62975RegionPeptidyl-alpha-hydroxyglycine alpha-amidating lyase
TgenePAMchr5:102345529chr5:102353088ENST00000346918+0231_494-153888RegionPeptidylglycine alpha-hydroxylating monooxygenase
TgenePAMchr5:102345529chr5:102353088ENST00000346918+023495_817-153888RegionPeptidyl-alpha-hydroxyglycine alpha-amidating lyase
TgenePAMchr5:102345529chr5:102353088ENST00000348126+0241_494-125867RegionPeptidylglycine alpha-hydroxylating monooxygenase
TgenePAMchr5:102345529chr5:102353088ENST00000348126+024495_817-125867RegionPeptidyl-alpha-hydroxyglycine alpha-amidating lyase
TgenePAMchr5:102345529chr5:102353088ENST00000438793+0251_494-157974RegionPeptidylglycine alpha-hydroxylating monooxygenase
TgenePAMchr5:102345529chr5:102353088ENST00000438793+025495_817-157974RegionPeptidyl-alpha-hydroxyglycine alpha-amidating lyase
TgenePAMchr5:102345529chr5:102353088ENST00000455264+0241_494-27906RegionPeptidylglycine alpha-hydroxylating monooxygenase
TgenePAMchr5:102345529chr5:102353088ENST00000455264+024495_817-27906RegionPeptidyl-alpha-hydroxyglycine alpha-amidating lyase
TgenePAMchr5:102345529chr5:102353088ENST00000304400+025498_541-62975RepeatNote=NHL 1
TgenePAMchr5:102345529chr5:102353088ENST00000304400+025567_608-62975RepeatNote=NHL 2
TgenePAMchr5:102345529chr5:102353088ENST00000304400+025617_662-62975RepeatNote=NHL 3
TgenePAMchr5:102345529chr5:102353088ENST00000304400+025670_714-62975RepeatNote=NHL 4
TgenePAMchr5:102345529chr5:102353088ENST00000304400+025766_809-62975RepeatNote=NHL 5
TgenePAMchr5:102345529chr5:102353088ENST00000346918+023498_541-153888RepeatNote=NHL 1
TgenePAMchr5:102345529chr5:102353088ENST00000346918+023567_608-153888RepeatNote=NHL 2
TgenePAMchr5:102345529chr5:102353088ENST00000346918+023617_662-153888RepeatNote=NHL 3
TgenePAMchr5:102345529chr5:102353088ENST00000346918+023670_714-153888RepeatNote=NHL 4
TgenePAMchr5:102345529chr5:102353088ENST00000346918+023766_809-153888RepeatNote=NHL 5
TgenePAMchr5:102345529chr5:102353088ENST00000348126+024498_541-125867RepeatNote=NHL 1
TgenePAMchr5:102345529chr5:102353088ENST00000348126+024567_608-125867RepeatNote=NHL 2
TgenePAMchr5:102345529chr5:102353088ENST00000348126+024617_662-125867RepeatNote=NHL 3
TgenePAMchr5:102345529chr5:102353088ENST00000348126+024670_714-125867RepeatNote=NHL 4
TgenePAMchr5:102345529chr5:102353088ENST00000348126+024766_809-125867RepeatNote=NHL 5
TgenePAMchr5:102345529chr5:102353088ENST00000438793+025498_541-157974RepeatNote=NHL 1
TgenePAMchr5:102345529chr5:102353088ENST00000438793+025567_608-157974RepeatNote=NHL 2
TgenePAMchr5:102345529chr5:102353088ENST00000438793+025617_662-157974RepeatNote=NHL 3
TgenePAMchr5:102345529chr5:102353088ENST00000438793+025670_714-157974RepeatNote=NHL 4
TgenePAMchr5:102345529chr5:102353088ENST00000438793+025766_809-157974RepeatNote=NHL 5
TgenePAMchr5:102345529chr5:102353088ENST00000455264+024498_541-27906RepeatNote=NHL 1
TgenePAMchr5:102345529chr5:102353088ENST00000455264+024567_608-27906RepeatNote=NHL 2
TgenePAMchr5:102345529chr5:102353088ENST00000455264+024617_662-27906RepeatNote=NHL 3
TgenePAMchr5:102345529chr5:102353088ENST00000455264+024670_714-27906RepeatNote=NHL 4
TgenePAMchr5:102345529chr5:102353088ENST00000455264+024766_809-27906RepeatNote=NHL 5
TgenePAMchr5:102345529chr5:102353088ENST00000304400+02531_863-62975Topological domainIntragranular
TgenePAMchr5:102345529chr5:102353088ENST00000304400+025888_973-62975Topological domainCytoplasmic
TgenePAMchr5:102345529chr5:102353088ENST00000346918+02331_863-153888Topological domainIntragranular
TgenePAMchr5:102345529chr5:102353088ENST00000346918+023888_973-153888Topological domainCytoplasmic
TgenePAMchr5:102345529chr5:102353088ENST00000348126+02431_863-125867Topological domainIntragranular
TgenePAMchr5:102345529chr5:102353088ENST00000348126+024888_973-125867Topological domainCytoplasmic
TgenePAMchr5:102345529chr5:102353088ENST00000438793+02531_863-157974Topological domainIntragranular
TgenePAMchr5:102345529chr5:102353088ENST00000438793+025888_973-157974Topological domainCytoplasmic
TgenePAMchr5:102345529chr5:102353088ENST00000455264+02431_863-27906Topological domainIntragranular
TgenePAMchr5:102345529chr5:102353088ENST00000455264+024888_973-27906Topological domainCytoplasmic
TgenePAMchr5:102345529chr5:102353088ENST00000304400+025864_887-62975TransmembraneHelical
TgenePAMchr5:102345529chr5:102353088ENST00000346918+023864_887-153888TransmembraneHelical
TgenePAMchr5:102345529chr5:102353088ENST00000348126+024864_887-125867TransmembraneHelical
TgenePAMchr5:102345529chr5:102353088ENST00000438793+025864_887-157974TransmembraneHelical
TgenePAMchr5:102345529chr5:102353088ENST00000455264+024864_887-27906TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PAM_PAM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PAM_PAM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgenePAMchr5:102345529chr5:102353088ENST00000304400+025925_942-62975RASSF9
TgenePAMchr5:102345529chr5:102353088ENST00000346918+023925_942-153888RASSF9
TgenePAMchr5:102345529chr5:102353088ENST00000348126+024925_942-125867RASSF9
TgenePAMchr5:102345529chr5:102353088ENST00000438793+025925_942-157974RASSF9
TgenePAMchr5:102345529chr5:102353088ENST00000455264+024925_942-27906RASSF9


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PAM_PAM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePAMP19021DB00126Vitamin CPeptidyl-glycine alpha-amidating monooxygenasesmall moleculeapproved|nutraceutical
TgenePAMP19021DB00126Vitamin CPeptidyl-glycine alpha-amidating monooxygenasesmall moleculeapproved|nutraceutical

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RelatedDiseases for PAM_PAM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePAMC0003469Anxiety Disorders1CTD_human
HgenePAMC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgenePAMC0036572Seizures1CTD_human
TgenePAMC0003469Anxiety Disorders1CTD_human
TgenePAMC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgenePAMC0036572Seizures1CTD_human