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Fusion gene ID: 25850 |
FusionGeneSummary for PAK4_ZNF837 |
Fusion gene summary |
Fusion gene information | Fusion gene name: PAK4_ZNF837 | Fusion gene ID: 25850 | Hgene | Tgene | Gene symbol | PAK4 | ZNF837 | Gene ID | 10298 | 116412 |
Gene name | p21 (RAC1) activated kinase 4 | zinc finger protein 837 | |
Synonyms | - | - | |
Cytomap | 19q13.2 | 19q13.43 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein kinase PAK 4p21 protein (Cdc42/Rac)-activated kinase 4p21(CDKN1A)-activated kinase 4protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs | zinc finger protein 837 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | O96013 | Q96EG3 | |
Ensembl transtripts involved in fusion gene | ENST00000599470, ENST00000321944, ENST00000358301, ENST00000597766, ENST00000593690, ENST00000599386, ENST00000435673, ENST00000360442, | ENST00000427624, ENST00000597582, | |
Fusion gene scores | * DoF score | 13 X 4 X 6=312 | 3 X 1 X 3=9 |
# samples | 13 | 3 | |
** MAII score | log2(13/312*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PAK4 [Title/Abstract] AND ZNF837 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-24-1544-01A | PAK4 | chr19 | 39616559 | + | ZNF837 | chr19 | 58881295 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-5UTR | ENST00000599470 | ENST00000427624 | PAK4 | chr19 | 39616559 | + | ZNF837 | chr19 | 58881295 | - |
5UTR-5UTR | ENST00000599470 | ENST00000597582 | PAK4 | chr19 | 39616559 | + | ZNF837 | chr19 | 58881295 | - |
5UTR-5UTR | ENST00000321944 | ENST00000427624 | PAK4 | chr19 | 39616559 | + | ZNF837 | chr19 | 58881295 | - |
5UTR-5UTR | ENST00000321944 | ENST00000597582 | PAK4 | chr19 | 39616559 | + | ZNF837 | chr19 | 58881295 | - |
5UTR-5UTR | ENST00000358301 | ENST00000427624 | PAK4 | chr19 | 39616559 | + | ZNF837 | chr19 | 58881295 | - |
5UTR-5UTR | ENST00000358301 | ENST00000597582 | PAK4 | chr19 | 39616559 | + | ZNF837 | chr19 | 58881295 | - |
3UTR-5UTR | ENST00000597766 | ENST00000427624 | PAK4 | chr19 | 39616559 | + | ZNF837 | chr19 | 58881295 | - |
3UTR-5UTR | ENST00000597766 | ENST00000597582 | PAK4 | chr19 | 39616559 | + | ZNF837 | chr19 | 58881295 | - |
5UTR-5UTR | ENST00000593690 | ENST00000427624 | PAK4 | chr19 | 39616559 | + | ZNF837 | chr19 | 58881295 | - |
5UTR-5UTR | ENST00000593690 | ENST00000597582 | PAK4 | chr19 | 39616559 | + | ZNF837 | chr19 | 58881295 | - |
5UTR-5UTR | ENST00000599386 | ENST00000427624 | PAK4 | chr19 | 39616559 | + | ZNF837 | chr19 | 58881295 | - |
5UTR-5UTR | ENST00000599386 | ENST00000597582 | PAK4 | chr19 | 39616559 | + | ZNF837 | chr19 | 58881295 | - |
intron-5UTR | ENST00000435673 | ENST00000427624 | PAK4 | chr19 | 39616559 | + | ZNF837 | chr19 | 58881295 | - |
intron-5UTR | ENST00000435673 | ENST00000597582 | PAK4 | chr19 | 39616559 | + | ZNF837 | chr19 | 58881295 | - |
intron-5UTR | ENST00000360442 | ENST00000427624 | PAK4 | chr19 | 39616559 | + | ZNF837 | chr19 | 58881295 | - |
intron-5UTR | ENST00000360442 | ENST00000597582 | PAK4 | chr19 | 39616559 | + | ZNF837 | chr19 | 58881295 | - |
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FusionProtFeatures for PAK4_ZNF837 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
PAK4 | ZNF837 |
Serine/threonine protein kinase that plays a role in avariety of different signaling pathways including cytoskeletonregulation, cell migration, growth, proliferation or cellsurvival. Activation by various effectors including growth factorreceptors or active CDC42 and RAC1 results in a conformationalchange and a subsequent autophosphorylation on several serineand/or threonine residues. Phosphorylates and inactivates theprotein phosphatase SSH1, leading to increased inhibitoryphosphorylation of the actin binding/depolymerizing factorcofilin. Decreased cofilin activity may lead to stabilization ofactin filaments. Phosphorylates LIMK1, a kinase that also inhibitsthe activity of cofilin. Phosphorylates integrin beta5/ITGB5 andthus regulates cell motility. Phosphorylates ARHGEF2 and activatesthe downstream target RHOA that plays a role in the regulation ofassembly of focal adhesions and actin stress fibers. Stimulatescell survival by phosphorylating the BCL2 antagonist of cell deathBAD. Alternatively, inhibits apoptosis by preventing caspase-8binding to death domain receptors in a kinase independent manner.Plays a role in cell-cycle progression by controlling levels ofthe cell-cycle regulatory protein CDKN1A and by phosphorylatingRAN. {ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:11313478,ECO:0000269|PubMed:14560027, ECO:0000269|PubMed:15660133,ECO:0000269|PubMed:20507994, ECO:0000269|PubMed:20631255,ECO:0000269|PubMed:20805321, ECO:0000269|PubMed:26607847}. | May be involved in transcriptional regulation.{ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PAK4_ZNF837 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PAK4_ZNF837 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PAK4 | LRRK1, YWHAG, YWHAQ, CDC42, YWHAZ, SFN, DLST, LIMK1, RAC1, ITGB5, RAN, TERF1, POT1, APP, YWHAE, FBXO25, SRPK2, SRPK1, LATS2, YWHAB, SH3RF2, HECW2, PAK6, PAK7, LRRC16A, ARHGEF11, SUPT5H, GGNBP2, KLHL42, TMPRSS11A, DDX6, NAA20, NAA25, ABL1, PPM1B, NTRK1, TMEM17, XPO1, RCC2, RHOU, PAK4, PXN, VCL, RHOV, HIST1H1A, SNW1, CDC5L, MMP2, ITGB3, ITGAV, CDH1, EGFR, PPM1A, PTPN4, PTPN7, STYX, CDK6, MTUS2, KCTD3, KIF13B, CBY1, RAB3IP, G3BP1 | ZNF837 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PAK4_ZNF837 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PAK4_ZNF837 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |