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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25805

FusionGeneSummary for PAIP2_SIL1

check button Fusion gene summary
Fusion gene informationFusion gene name: PAIP2_SIL1
Fusion gene ID: 25805
HgeneTgene
Gene symbol

PAIP2

SIL1

Gene ID

51247

64374

Gene namepoly(A) binding protein interacting protein 2SIL1 nucleotide exchange factor
SynonymsPAIP-2|PAIP2ABAP|MSS|ULG5
Cytomap

5q31.2

5q31.2

Type of geneprotein-codingprotein-coding
Descriptionpolyadenylate-binding protein-interacting protein 2PABC1-interacting protein 2PABP-interacting protein 2polyA-binding protein-interacting protein 2nucleotide exchange factor SIL1BiP-associated proteinSIL1 homolog, endoplasmic reticulum chaperoneSIL1-like protein endoplasmic reticulum chaperone
Modification date2018051920180523
UniProtAcc

Q9BPZ3

Q9H173

Ensembl transtripts involved in fusion geneENST00000265192, ENST00000511381, 
ENST00000511706, ENST00000394795, 
ENST00000510080, 
ENST00000394817, 
ENST00000265195, ENST00000509534, 
ENST00000515008, 
Fusion gene scores* DoF score6 X 4 X 4=964 X 3 X 3=36
# samples 64
** MAII scorelog2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PAIP2 [Title/Abstract] AND SIL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePAIP2

GO:0045947

negative regulation of translational initiation

11172725


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A48P-01APAIP2chr5

138677669

+SIL1chr5

138386735

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000265192ENST00000394817PAIP2chr5

138677669

+SIL1chr5

138386735

-
5UTR-3CDSENST00000265192ENST00000265195PAIP2chr5

138677669

+SIL1chr5

138386735

-
5UTR-3CDSENST00000265192ENST00000509534PAIP2chr5

138677669

+SIL1chr5

138386735

-
5UTR-intronENST00000265192ENST00000515008PAIP2chr5

138677669

+SIL1chr5

138386735

-
3UTR-3CDSENST00000511381ENST00000394817PAIP2chr5

138677669

+SIL1chr5

138386735

-
3UTR-3CDSENST00000511381ENST00000265195PAIP2chr5

138677669

+SIL1chr5

138386735

-
3UTR-3CDSENST00000511381ENST00000509534PAIP2chr5

138677669

+SIL1chr5

138386735

-
3UTR-intronENST00000511381ENST00000515008PAIP2chr5

138677669

+SIL1chr5

138386735

-
5UTR-3CDSENST00000511706ENST00000394817PAIP2chr5

138677669

+SIL1chr5

138386735

-
5UTR-3CDSENST00000511706ENST00000265195PAIP2chr5

138677669

+SIL1chr5

138386735

-
5UTR-3CDSENST00000511706ENST00000509534PAIP2chr5

138677669

+SIL1chr5

138386735

-
5UTR-intronENST00000511706ENST00000515008PAIP2chr5

138677669

+SIL1chr5

138386735

-
intron-3CDSENST00000394795ENST00000394817PAIP2chr5

138677669

+SIL1chr5

138386735

-
intron-3CDSENST00000394795ENST00000265195PAIP2chr5

138677669

+SIL1chr5

138386735

-
intron-3CDSENST00000394795ENST00000509534PAIP2chr5

138677669

+SIL1chr5

138386735

-
intron-intronENST00000394795ENST00000515008PAIP2chr5

138677669

+SIL1chr5

138386735

-
intron-3CDSENST00000510080ENST00000394817PAIP2chr5

138677669

+SIL1chr5

138386735

-
intron-3CDSENST00000510080ENST00000265195PAIP2chr5

138677669

+SIL1chr5

138386735

-
intron-3CDSENST00000510080ENST00000509534PAIP2chr5

138677669

+SIL1chr5

138386735

-
intron-intronENST00000510080ENST00000515008PAIP2chr5

138677669

+SIL1chr5

138386735

-

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FusionProtFeatures for PAIP2_SIL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PAIP2

Q9BPZ3

SIL1

Q9H173

Acts as a repressor in the regulation of translationinitiation of poly(A)-containing mRNAs. Its inhibitory activity ontranslation is mediated via its action on PABPC1. Displaces theinteraction of PABPC1 with poly(A) RNA and competes with PAIP1 forbinding to PABPC1. Its association with PABPC1 results indisruption of the cytoplasmic poly(A) RNP structure organization.{ECO:0000269|PubMed:11172725}. Required for protein translocation and folding in theendoplasmic reticulum (ER). Functions as a nucleotide exchangefactor for the ER lumenal chaperone HSPA5.{ECO:0000269|PubMed:12356756}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PAIP2_SIL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PAIP2_SIL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PAIP2PABPC1, UBR5, APP, IGBP1, BAG3, RPL11, NXF1, HNRNPA1, PAIP1, SCCPDH, XPO1, TRIM25SIL1HSPA5, SMAD9, CCND3, FBXO6, UBQLN1, GLB1L3, PON2, PFDN4, PSMD8, TCTN1, CEP192, POC1A, POC1B, EDRF1, CNTNAP1, ERGIC2, UBR1, TDGF1, UBR2, COL14A1, OMA1, SERPINB11, PTPRO


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PAIP2_SIL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PAIP2_SIL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSIL1C0033578Prostatic Neoplasms1CTD_human