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Fusion gene ID: 25802 |
FusionGeneSummary for PAIP2_CXXC5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PAIP2_CXXC5 | Fusion gene ID: 25802 | Hgene | Tgene | Gene symbol | PAIP2 | CXXC5 | Gene ID | 51247 | 51523 |
| Gene name | poly(A) binding protein interacting protein 2 | CXXC finger protein 5 | |
| Synonyms | PAIP-2|PAIP2A | CF5|HSPC195|RINF|WID | |
| Cytomap | 5q31.2 | 5q31.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | polyadenylate-binding protein-interacting protein 2PABC1-interacting protein 2PABP-interacting protein 2polyA-binding protein-interacting protein 2 | CXXC-type zinc finger protein 5CXXC finger 5 proteinWT1-induced Inhibitor of Dishevelledputative MAPK-activating protein PM08putative NF-kappa-B-activating protein 102retinoid-inducible nuclear factor | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q9BPZ3 | Q7LFL8 | |
| Ensembl transtripts involved in fusion gene | ENST00000265192, ENST00000511381, ENST00000511706, ENST00000394795, ENST00000510080, | ENST00000302517, ENST00000511048, ENST00000515038, | |
| Fusion gene scores | * DoF score | 6 X 4 X 4=96 | 2 X 2 X 2=8 |
| # samples | 6 | 2 | |
| ** MAII score | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: PAIP2 [Title/Abstract] AND CXXC5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PAIP2 | GO:0045947 | negative regulation of translational initiation | 11172725 |
| Tgene | CXXC5 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 23303788 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCS | TCGA-N5-A59E-01A | PAIP2 | chr5 | 138677669 | + | CXXC5 | chr5 | 139059949 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-5UTR | ENST00000265192 | ENST00000302517 | PAIP2 | chr5 | 138677669 | + | CXXC5 | chr5 | 139059949 | + |
| 5UTR-5UTR | ENST00000265192 | ENST00000511048 | PAIP2 | chr5 | 138677669 | + | CXXC5 | chr5 | 139059949 | + |
| 5UTR-intron | ENST00000265192 | ENST00000515038 | PAIP2 | chr5 | 138677669 | + | CXXC5 | chr5 | 139059949 | + |
| 3UTR-5UTR | ENST00000511381 | ENST00000302517 | PAIP2 | chr5 | 138677669 | + | CXXC5 | chr5 | 139059949 | + |
| 3UTR-5UTR | ENST00000511381 | ENST00000511048 | PAIP2 | chr5 | 138677669 | + | CXXC5 | chr5 | 139059949 | + |
| 3UTR-intron | ENST00000511381 | ENST00000515038 | PAIP2 | chr5 | 138677669 | + | CXXC5 | chr5 | 139059949 | + |
| 5UTR-5UTR | ENST00000511706 | ENST00000302517 | PAIP2 | chr5 | 138677669 | + | CXXC5 | chr5 | 139059949 | + |
| 5UTR-5UTR | ENST00000511706 | ENST00000511048 | PAIP2 | chr5 | 138677669 | + | CXXC5 | chr5 | 139059949 | + |
| 5UTR-intron | ENST00000511706 | ENST00000515038 | PAIP2 | chr5 | 138677669 | + | CXXC5 | chr5 | 139059949 | + |
| intron-5UTR | ENST00000394795 | ENST00000302517 | PAIP2 | chr5 | 138677669 | + | CXXC5 | chr5 | 139059949 | + |
| intron-5UTR | ENST00000394795 | ENST00000511048 | PAIP2 | chr5 | 138677669 | + | CXXC5 | chr5 | 139059949 | + |
| intron-intron | ENST00000394795 | ENST00000515038 | PAIP2 | chr5 | 138677669 | + | CXXC5 | chr5 | 139059949 | + |
| intron-5UTR | ENST00000510080 | ENST00000302517 | PAIP2 | chr5 | 138677669 | + | CXXC5 | chr5 | 139059949 | + |
| intron-5UTR | ENST00000510080 | ENST00000511048 | PAIP2 | chr5 | 138677669 | + | CXXC5 | chr5 | 139059949 | + |
| intron-intron | ENST00000510080 | ENST00000515038 | PAIP2 | chr5 | 138677669 | + | CXXC5 | chr5 | 139059949 | + |
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FusionProtFeatures for PAIP2_CXXC5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PAIP2 | CXXC5 |
| Acts as a repressor in the regulation of translationinitiation of poly(A)-containing mRNAs. Its inhibitory activity ontranslation is mediated via its action on PABPC1. Displaces theinteraction of PABPC1 with poly(A) RNA and competes with PAIP1 forbinding to PABPC1. Its association with PABPC1 results indisruption of the cytoplasmic poly(A) RNP structure organization.{ECO:0000269|PubMed:11172725}. | May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediatedmodulation of canonical Wnt signaling activity in neural stemcells (By similarity). Required for DNA damage-induced ATMphosphorylation, p53 activation and cell cycle arrest. Involved inmyelopoiesis. Transcription factor. Binds to the oxygen responsiveelement of COX4I2 and represses its transcription under hypoxiaconditions (4% oxygen), as well as normoxia conditions (20%oxygen) (PubMed:23303788). May repress COX4I2 transactivationinduced by CHCHD2 and RBPJ (PubMed:23303788). {ECO:0000250,ECO:0000269|PubMed:19182210, ECO:0000269|PubMed:19557330,ECO:0000269|PubMed:23303788}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PAIP2_CXXC5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PAIP2_CXXC5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PAIP2 | PABPC1, UBR5, APP, IGBP1, BAG3, RPL11, NXF1, HNRNPA1, PAIP1, SCCPDH, XPO1, TRIM25 | CXXC5 | ATM, SMAD7, SMAD9, SKIL, SMAD3, SMAD5, VDR, FOXL2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PAIP2_CXXC5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PAIP2_CXXC5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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