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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25793

FusionGeneSummary for PAG1_STYX

check button Fusion gene summary
Fusion gene informationFusion gene name: PAG1_STYX
Fusion gene ID: 25793
HgeneTgene
Gene symbol

PAG1

STYX

Gene ID

55824

6815

Gene namephosphoprotein membrane anchor with glycosphingolipid microdomains 1serine/threonine/tyrosine interacting protein
SynonymsCBP|PAG-
Cytomap

8q21.13

14q22.1

Type of geneprotein-codingprotein-coding
Descriptionphosphoprotein associated with glycosphingolipid-enriched microdomains 1Csk-binding proteinphosphoprotein associated with glycosphingolipid microdomains 1transmembrane adapter protein PAGtransmembrane adaptor protein PAGtransmembrane phosphoprotein Cserine/threonine/tyrosine-interacting proteinprotein tyrosine phosphatase-like protein
Modification date2018052320180523
UniProtAcc

Q9NWQ8

Q8WUJ0

Ensembl transtripts involved in fusion geneENST00000220597, ENST00000523463, 
ENST00000442123, ENST00000354586, 
ENST00000556861, 
Fusion gene scores* DoF score6 X 5 X 4=1205 X 5 X 2=50
# samples 65
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/50*10)=0
Context

PubMed: PAG1 [Title/Abstract] AND STYX [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePAG1

GO:0035556

intracellular signal transduction

10790433

HgenePAG1

GO:0050863

regulation of T cell activation

10790433

TgeneSTYX

GO:0032091

negative regulation of protein binding

28007894


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF691397PAG1chr8

81882643

-STYXchr14

53240340

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000220597ENST00000442123PAG1chr8

81882643

-STYXchr14

53240340

+
intron-3UTRENST00000220597ENST00000354586PAG1chr8

81882643

-STYXchr14

53240340

+
intron-3UTRENST00000220597ENST00000556861PAG1chr8

81882643

-STYXchr14

53240340

+
intron-3UTRENST00000523463ENST00000442123PAG1chr8

81882643

-STYXchr14

53240340

+
intron-3UTRENST00000523463ENST00000354586PAG1chr8

81882643

-STYXchr14

53240340

+
intron-3UTRENST00000523463ENST00000556861PAG1chr8

81882643

-STYXchr14

53240340

+

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FusionProtFeatures for PAG1_STYX


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PAG1

Q9NWQ8

STYX

Q8WUJ0

Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinityimmunoglobulin epsilon receptor)-mediated signaling in mast cells.Promotes CSK activation and recruitment to lipid rafts, whichresults in LCK inhibition. Inhibits immunological synapseformation by preventing dynamic arrangement of lipid raftproteins. May be involved in cell adhesion signaling.{ECO:0000269|PubMed:10790433}. Catalytically inactive phosphatase (PubMed:23847209).Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2)(PubMed:23847209). Modulates cell-fate decisions and cellmigration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2)(PubMed:23847209). By binding to the F-box of FBXW7, prevents theassembly of FBXW7 into the SCF E3 ubiquitin-protein ligasecomplex, and thereby inhibits degradation of its substrates(PubMed:28007894). Plays a role in spermatogenesis (Bysimilarity). {ECO:0000250|UniProtKB:Q60969,ECO:0000269|PubMed:23847209, ECO:0000269|PubMed:28007894}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PAG1_STYX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PAG1_STYX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PAG1_STYX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PAG1_STYX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePAG1C0036341Schizophrenia1CTD_human
HgenePAG1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human