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Fusion gene ID: 25754 |
FusionGeneSummary for PACSIN2_LGALS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PACSIN2_LGALS1 | Fusion gene ID: 25754 | Hgene | Tgene | Gene symbol | PACSIN2 | LGALS1 | Gene ID | 11252 | 3956 |
| Gene name | protein kinase C and casein kinase substrate in neurons 2 | galectin 1 | |
| Synonyms | SDPII | GAL1|GBP | |
| Cytomap | 22q13.2 | 22q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein kinase C and casein kinase substrate in neurons protein 2cytoplasmic phosphoprotein PACSIN2syndapin-2syndapin-IIsyndapin2 | galectin-114 kDa laminin-binding protein14 kDa lectinHBLHLBP14HPLS-Lac lectin 1beta-galactoside-binding lectin L-14-Ibeta-galactoside-binding protein 14kDagal-1galaptinlactose-binding lectin 1lectin, galactoside-binding, soluble, 1putative MA | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q9UNF0 | P09382 | |
| Ensembl transtripts involved in fusion gene | ENST00000337959, ENST00000263246, ENST00000407585, ENST00000403744, ENST00000402229, | ENST00000215909, ENST00000489315, | |
| Fusion gene scores | * DoF score | 16 X 9 X 8=1152 | 6 X 4 X 4=96 |
| # samples | 17 | 6 | |
| ** MAII score | log2(17/1152*10)=-2.76053406530461 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PACSIN2 [Title/Abstract] AND LGALS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PACSIN2 | GO:0097320 | plasma membrane tubulation | 23596323 |
| Tgene | LGALS1 | GO:0046598 | positive regulation of viral entry into host cell | 21670307 |
| Tgene | LGALS1 | GO:2001200 | positive regulation of dendritic cell differentiation | 16116184 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-BR-8295-01A | PACSIN2 | chr22 | 43272143 | - | LGALS1 | chr22 | 38072993 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000337959 | ENST00000215909 | PACSIN2 | chr22 | 43272143 | - | LGALS1 | chr22 | 38072993 | + |
| 5CDS-3UTR | ENST00000337959 | ENST00000489315 | PACSIN2 | chr22 | 43272143 | - | LGALS1 | chr22 | 38072993 | + |
| Frame-shift | ENST00000263246 | ENST00000215909 | PACSIN2 | chr22 | 43272143 | - | LGALS1 | chr22 | 38072993 | + |
| 5CDS-3UTR | ENST00000263246 | ENST00000489315 | PACSIN2 | chr22 | 43272143 | - | LGALS1 | chr22 | 38072993 | + |
| In-frame | ENST00000407585 | ENST00000215909 | PACSIN2 | chr22 | 43272143 | - | LGALS1 | chr22 | 38072993 | + |
| 5CDS-3UTR | ENST00000407585 | ENST00000489315 | PACSIN2 | chr22 | 43272143 | - | LGALS1 | chr22 | 38072993 | + |
| Frame-shift | ENST00000403744 | ENST00000215909 | PACSIN2 | chr22 | 43272143 | - | LGALS1 | chr22 | 38072993 | + |
| 5CDS-3UTR | ENST00000403744 | ENST00000489315 | PACSIN2 | chr22 | 43272143 | - | LGALS1 | chr22 | 38072993 | + |
| In-frame | ENST00000402229 | ENST00000215909 | PACSIN2 | chr22 | 43272143 | - | LGALS1 | chr22 | 38072993 | + |
| 5CDS-3UTR | ENST00000402229 | ENST00000489315 | PACSIN2 | chr22 | 43272143 | - | LGALS1 | chr22 | 38072993 | + |
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FusionProtFeatures for PACSIN2_LGALS1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PACSIN2 | LGALS1 |
| Lipid-binding protein that is able to promote thetubulation of the phosphatidic acid-containing membranes itpreferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surfacereceptors like the EGF receptor, contributing to itsinternalization in the absence of EGF stimulus. May also play arole in the formation of caveolae at the cell membrane. RecruitsDNM2 to caveolae, and thereby plays a role in caveola-mediatedendocytosis. {ECO:0000269|PubMed:21610094,ECO:0000269|PubMed:21693584, ECO:0000269|PubMed:23129763,ECO:0000269|PubMed:23236520, ECO:0000269|PubMed:23596323}. | Lectin that binds beta-galactoside and a wide array ofcomplex carbohydrates. Plays a role in regulating apoptosis, cellproliferation and cell differentiation. Inhibits CD45 proteinphosphatase activity and therefore the dephosphorylation of Lynkinase. Strong inducer of T-cell apoptosis.{ECO:0000269|PubMed:14617626, ECO:0000269|PubMed:18796645,ECO:0000269|PubMed:19497882, ECO:0000269|PubMed:24945728}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PACSIN2_LGALS1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PACSIN2_ENST00000407585_chr22_43272143_-_LGALS1_ENST00000215909_chr22_38072993_+_133aa GLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFD >In-frame_PACSIN2_ENST00000402229_chr22_43272143_-_LGALS1_ENST00000215909_chr22_38072993_+_133aa GLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PACSIN2_ENST00000407585_chr22_43272143_-_LGALS1_ENST00000215909_chr22_38072993_+_399nt GGTCTGGTCGCCAGCAACCTGAATCTCAAACCTGGAGAGTGCCTTCGAGTGCGAGGCGAGGTGGCTCCTGACGCTAAGAGCTTCGTGCTG AACCTGGGCAAAGACAGCAACAACCTGTGCCTGCACTTCAACCCTCGCTTCAACGCCCACGGCGACGCCAACACCATCGTGTGCAACAGC AAGGACGGCGGGGCCTGGGGGACCGAGCAGCGGGAGGCTGTCTTTCCCTTCCAGCCTGGAAGTGTTGCAGAGGTGTGCATCACCTTCGAC CAGGCCAACCTGACCGTCAAGCTGCCAGATGGATACGAATTCAAGTTCCCCAACCGCCTCAACCTGGAGGCCATCAACTACATGGCAGCT >In-frame_PACSIN2_ENST00000402229_chr22_43272143_-_LGALS1_ENST00000215909_chr22_38072993_+_399nt GGTCTGGTCGCCAGCAACCTGAATCTCAAACCTGGAGAGTGCCTTCGAGTGCGAGGCGAGGTGGCTCCTGACGCTAAGAGCTTCGTGCTG AACCTGGGCAAAGACAGCAACAACCTGTGCCTGCACTTCAACCCTCGCTTCAACGCCCACGGCGACGCCAACACCATCGTGTGCAACAGC AAGGACGGCGGGGCCTGGGGGACCGAGCAGCGGGAGGCTGTCTTTCCCTTCCAGCCTGGAAGTGTTGCAGAGGTGTGCATCACCTTCGAC CAGGCCAACCTGACCGTCAAGCTGCCAGATGGATACGAATTCAAGTTCCCCAACCGCCTCAACCTGGAGGCCATCAACTACATGGCAGCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PACSIN2_ENST00000407585_chr22_43272143_-_LGALS1_ENST00000215909_chr22_38072993_+_1841nt AGAGGTCAGACATGCCAGCAGGGTTGGAAAGAGGCAGGTACGGAAGCTGAGCTGCAGAGTTAGCCGGCATCTGACAGAAAAATGTTTGTC TACAGATTTTGAGCGTTCGAAGTTGACCCCTGACTAAGTATACTTTGCTGCTCCCTCAGCCTTTGAAAAAATGTCTGTCACATATGATGA TTCCGTTGGAGTAGAAGTGTCCAGCGACAGCTTCTGGGAGGTCGGGAACTACAAGCGGACTGTGAAGCGGATCGACGATGGCCACCGCCT GTGCAGCGACCTCATGAACTGCCTGCATGAGCGGGCGCGCATCGAGAAGGCGTATGCGCAGCAGCTCACTGAGTGGGCCCGGCGCTGGAG GCAGCTCGTGGAGAAAGGGCCCCAGTACGGGACCGTGGAGAAGGCCTGGATGGCCTTCATGTCCGAGGCAGAGAGGGTGAGCGAGCTGCA CCTCGAGGTGAAGGCCTCACTGATGAACGATGACTTCGAGAAGATCAAGAACTGGCAGAAGGAAGCCTTTCACAAGCAGATGATGGGCGG CTTCAAGGAGACCAAGGAAGCTGAGGACGGCTTTCGGAAGGCACAGAAGCCCTGGGCCAAGAAGCTGAAAGAGGTAGAAGCAGCAAAGAA AGCCCACCATGCAGCGTGCAAAGAGGAGAAGCTGGCTATCTCACGAGAAGCCAACAGCAAGGCAGACCCATCCCTCAACCCTGAACAGCT CAAGAAATTGCAAGACAAAATAGAAAAGTGCAAGCAAGATGTTCTTAAGACCAAAGAGAAGTATGAGAAGTCCCTGAAGGAACTCGACCA GGGCACACCCCAGTACATGGAGAACATGGAGCAGGTGTTTGAGCAGTGCCAGCAGTTCGAGGAGAAACGCCTTCGCTTCTTCCGGGAGGT TCTGCTGGAGGTTCAGAAGCACCTAGACCTGTCCAATGTGGCTGGCTACAAAGCCATTTACCATGACCTGGAGCAGAGCATCAGAGCAGC TGATGCAGTGGAGGACCTGAGGTGGTTCCGAGCCAATCACGGGCCGGGCATGGCCATGAACTGGCCGCAGTTTGAGGAGTGGTCCGCAGA CCTGAATCGAACCCTCAGCCGGAGAGAGAAGAAGAAGGCCACTGACGGCGTCACCCTGACGGGCATCAACCAGACAGGCGACCAGTCTCT GCCGAGTAAGCCCAGCAGTGTGAGCAGCTACGAGAAGACCCAGAGCTATCCCACCGACTGGTCAGACGATGAGTCTAACAACCCCTTCTC CTCCACGGATGCCAATGGGGACTCGAATCCATTCGACGACGACGCCACCTCGGGGACGGAAGTGCGAGTCCGGGCCCTGTATGACTATGA GGGGCAGGAGCATGATGAGCTGAGCTTCAAGGCTGGGTCTGGTCGCCAGCAACCTGAATCTCAAACCTGGAGAGTGCCTTCGAGTGCGAG GCGAGGTGGCTCCTGACGCTAAGAGCTTCGTGCTGAACCTGGGCAAAGACAGCAACAACCTGTGCCTGCACTTCAACCCTCGCTTCAACG CCCACGGCGACGCCAACACCATCGTGTGCAACAGCAAGGACGGCGGGGCCTGGGGGACCGAGCAGCGGGAGGCTGTCTTTCCCTTCCAGC CTGGAAGTGTTGCAGAGGTGTGCATCACCTTCGACCAGGCCAACCTGACCGTCAAGCTGCCAGATGGATACGAATTCAAGTTCCCCAACC GCCTCAACCTGGAGGCCATCAACTACATGGCAGCTGACGGTGACTTCAAGATCAAATGTGTGGCCTTTGACTGAAATCAGCCAGCCCATG >In-frame_PACSIN2_ENST00000402229_chr22_43272143_-_LGALS1_ENST00000215909_chr22_38072993_+_1997nt GGTCAGACATGCCAGCAGGGTTGGAAAGAGGCAGGTACGGAAGCTGAGCTGCAGAGTTAGCCGGCATCTGACAGAAAAATGTGAGTGTGC TGTGGAAGGCTTGCATTTCCTTTAAGGTTTGTCTACAGATTTTGAGCGTTCGAAGTTGACCCCTGACTAAGTATACTTTGCTGCTCCCTC AGCCTTTGAAAAAATGTCTGTCACATATGATGATTCCGTTGGAGTAGAAGTGTCCAGCGACAGCTTCTGGGAGGTCGGGAACTACAAGCG GACTGTGAAGCGGATCGACGATGGCCACCGCCTGTGCAGCGACCTCATGAACTGCCTGCATGAGCGGGCGCGCATCGAGAAGGCGTATGC GCAGCAGCTCACTGAGTGGGCCCGGCGCTGGAGGCAGCTCGTGGAGAAAGGGCCCCAGTACGGGACCGTGGAGAAGGCCTGGATGGCCTT CATGTCCGAGGCAGAGAGGGTGAGCGAGCTGCACCTCGAGGTGAAGGCCTCACTGATGAACGATGACTTCGAGAAGATCAAGAACTGGCA GAAGGAAGCCTTTCACAAGCAGATGATGGGCGGCTTCAAGGAGACCAAGGAAGCTGAGGACGGCTTTCGGAAGGCACAGAAGCCCTGGGC CAAGAAGCTGAAAGAGGTAGAAGCAGCAAAGAAAGCCCACCATGCAGCGTGCAAAGAGGAGAAGCTGGCTATCTCACGAGAAGCCAACAG CAAGGCAGACCCATCCCTCAACCCTGAACAGCTCAAGAAATTGCAAGACAAAATAGAAAAGTGCAAGCAAGATGTTCTTAAGACCAAAGA GAAGTATGAGAAGTCCCTGAAGGAACTCGACCAGGGCACACCCCAGTACATGGAGAACATGGAGCAGGTGTTTGAGCAGTGCCAGCAGTT CGAGGAGAAACGCCTTCGCTTCTTCCGGGAGGTTCTGCTGGAGGTTCAGAAGCACCTAGACCTGTCCAATGTGGCTGGCTACAAAGCCAT TTACCATGACCTGGAGCAGAGCATCAGAGCAGCTGATGCAGTGGAGGACCTGAGGTGGTTCCGAGCCAATCACGGGCCGGGCATGGCCAT GAACTGGCCGCAGTTTGAGGAGTGGTCCGCAGACCTGAATCGAACCCTCAGCCGGAGAGAGAAGAAGAAGGCCACTGACGGCGTCACCCT GACGGGCATCAACCAGACAGGCGACCAGTCTCTGCCGAGTAAGCCCAGCAGCACCCTTAATGTCCCGAGCAACCCCGCCCAGTCTGCGCA GTCACAGTCCAGCTACAACCCCTTCGAGGATGAGGACGACACGGGCAGCACCGTCAGTGAGAAGGACGACACTAAGGCCAAAAATGTGAG CAGCTACGAGAAGACCCAGAGCTATCCCACCGACTGGTCAGACGATGAGTCTAACAACCCCTTCTCCTCCACGGATGCCAATGGGGACTC GAATCCATTCGACGACGACGCCACCTCGGGGACGGAAGTGCGAGTCCGGGCCCTGTATGACTATGAGGGGCAGGAGCATGATGAGCTGAG CTTCAAGGCTGGGTCTGGTCGCCAGCAACCTGAATCTCAAACCTGGAGAGTGCCTTCGAGTGCGAGGCGAGGTGGCTCCTGACGCTAAGA GCTTCGTGCTGAACCTGGGCAAAGACAGCAACAACCTGTGCCTGCACTTCAACCCTCGCTTCAACGCCCACGGCGACGCCAACACCATCG TGTGCAACAGCAAGGACGGCGGGGCCTGGGGGACCGAGCAGCGGGAGGCTGTCTTTCCCTTCCAGCCTGGAAGTGTTGCAGAGGTGTGCA TCACCTTCGACCAGGCCAACCTGACCGTCAAGCTGCCAGATGGATACGAATTCAAGTTCCCCAACCGCCTCAACCTGGAGGCCATCAACT ACATGGCAGCTGACGGTGACTTCAAGATCAAATGTGTGGCCTTTGACTGAAATCAGCCAGCCCATGGCCCCCAATAAAGGCAGCTGCCTC |
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FusionGenePPI for PACSIN2_LGALS1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PACSIN2 | PACSIN3, PACSIN1, PACSIN2, FASLG, DNM1, SYNJ1, WASL, CARS, CYFIP2, ASAP1, DNM2, HSPA1A, HSPA8, KHDRBS1, MICALL1, APBB1IP, WAS, WIPF1, SBK1, TERF1, TERF2IP, POT1, SHBG, ANKS1A, COL4A3BP, FTL, PLOD2, PTPN12, UGP2, VASN, PPP2R5C, SWAP70, MEOX2, MOV10, NXF1, COBL, COBLL1, THG1L, WIPF2, MPRIP, HSPD1, PTGES3, ST13, EWSR1, TMEM17, ERP44, CDH1, RAI14, GTF2E2, TRIM25 | LGALS1 | SUSD2, MUC16, GEMIN4, LGALS3, SMN1, SNRPB, GEMIN2, CD2, HRAS, PTPRC, SPN, CD7, CD4, LGALS3BP, EGFR, CDC42, USP4, GTF2I, CLNS1A, FLNA, IGBP1, ALDOA, HSPA5, MYC, FN1, VCAM1, ITGA4, NPM1, ACO1, APEX1, FUBP1, HIST1H2BO, PSMG1, ICAM2, SLAMF7, CD68, DDX19B, SLAMF1, PSG1, PTGER3, HEPACAM2, EREG, ANXA11, ANXA2, CHORDC1, HNRNPL, ARF4, CRIP1, LASP1, LMAN1, PHB2, RAB10, RAE1, SOD1, UQCRFS1, PCBP1, PCBP2, PLIN3, RAB5C, RAC1, SERPINH1, TALDO1, UBE2N, HSPB2, PTEN, DBN1, MYH9, ATP6AP2, GOLT1B, LIMA1, MCM2, MCM5, U2AF2, NLGN3, ZNF131, LRFN4, ALCAM, LINGO2, PECAM1, CDHR5, S1PR2, NTRK3, VIPR2, LAMP1, TYW3, PTPRA, CHL1, ICOSLG, VASN, CD44, EFNB3, FZD10, SIGLEC7, CYLD |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PACSIN2_LGALS1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | LGALS1 | P09382 | DB11638 | Artenimol | Galectin-1 | small molecule | approved|investigational |
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RelatedDiseases for PACSIN2_LGALS1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PACSIN2 | C3495559 | Juvenile arthritis | 1 | CTD_human |
| Tgene | LGALS1 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Tgene | LGALS1 | C0022548 | Keloid | 1 | CTD_human |
| Tgene | LGALS1 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
| Tgene | LGALS1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | LGALS1 | C0027697 | Nephritis | 1 | CTD_human |
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