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Fusion gene ID: 2572 |
FusionGeneSummary for ARHGEF3_ACP6 |
Fusion gene summary |
Fusion gene information | Fusion gene name: ARHGEF3_ACP6 | Fusion gene ID: 2572 | Hgene | Tgene | Gene symbol | ARHGEF3 | ACP6 | Gene ID | 50650 | 51205 |
Gene name | Rho guanine nucleotide exchange factor 3 | acid phosphatase 6, lysophosphatidic | |
Synonyms | GEF3|STA3|XPLN | ACPL1|LPAP|PACPL1 | |
Cytomap | 3p14.3 | 1q21.2 | |
Type of gene | protein-coding | protein-coding | |
Description | rho guanine nucleotide exchange factor 359.8 kDA proteinRho guanine nucleotide exchange factor (GEF) 3RhoGEF proteinexchange factor found in platelets and leukemic and neuronal tissues, XPLN | lysophosphatidic acid phosphatase type 6acid phosphatase-like protein 1 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9NR81 | Q9NPH0 | |
Ensembl transtripts involved in fusion gene | ENST00000338458, ENST00000496106, ENST00000498517, ENST00000296315, ENST00000413728, ENST00000497267, ENST00000495373, | ENST00000369238, ENST00000460583, ENST00000392988, | |
Fusion gene scores | * DoF score | 14 X 11 X 7=1078 | 2 X 2 X 2=8 |
# samples | 15 | 2 | |
** MAII score | log2(15/1078*10)=-2.84532277225662 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: ARHGEF3 [Title/Abstract] AND ACP6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ACP6 | GO:2001311 | lysobisphosphatidic acid metabolic process | 23807634 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-AO-A0J6-01A | ARHGEF3 | chr3 | 56916320 | - | ACP6 | chr1 | 147131890 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000338458 | ENST00000369238 | ARHGEF3 | chr3 | 56916320 | - | ACP6 | chr1 | 147131890 | - |
5CDS-intron | ENST00000338458 | ENST00000460583 | ARHGEF3 | chr3 | 56916320 | - | ACP6 | chr1 | 147131890 | - |
5CDS-intron | ENST00000338458 | ENST00000392988 | ARHGEF3 | chr3 | 56916320 | - | ACP6 | chr1 | 147131890 | - |
In-frame | ENST00000496106 | ENST00000369238 | ARHGEF3 | chr3 | 56916320 | - | ACP6 | chr1 | 147131890 | - |
5CDS-intron | ENST00000496106 | ENST00000460583 | ARHGEF3 | chr3 | 56916320 | - | ACP6 | chr1 | 147131890 | - |
5CDS-intron | ENST00000496106 | ENST00000392988 | ARHGEF3 | chr3 | 56916320 | - | ACP6 | chr1 | 147131890 | - |
5UTR-3CDS | ENST00000498517 | ENST00000369238 | ARHGEF3 | chr3 | 56916320 | - | ACP6 | chr1 | 147131890 | - |
5UTR-intron | ENST00000498517 | ENST00000460583 | ARHGEF3 | chr3 | 56916320 | - | ACP6 | chr1 | 147131890 | - |
5UTR-intron | ENST00000498517 | ENST00000392988 | ARHGEF3 | chr3 | 56916320 | - | ACP6 | chr1 | 147131890 | - |
intron-3CDS | ENST00000296315 | ENST00000369238 | ARHGEF3 | chr3 | 56916320 | - | ACP6 | chr1 | 147131890 | - |
intron-intron | ENST00000296315 | ENST00000460583 | ARHGEF3 | chr3 | 56916320 | - | ACP6 | chr1 | 147131890 | - |
intron-intron | ENST00000296315 | ENST00000392988 | ARHGEF3 | chr3 | 56916320 | - | ACP6 | chr1 | 147131890 | - |
intron-3CDS | ENST00000413728 | ENST00000369238 | ARHGEF3 | chr3 | 56916320 | - | ACP6 | chr1 | 147131890 | - |
intron-intron | ENST00000413728 | ENST00000460583 | ARHGEF3 | chr3 | 56916320 | - | ACP6 | chr1 | 147131890 | - |
intron-intron | ENST00000413728 | ENST00000392988 | ARHGEF3 | chr3 | 56916320 | - | ACP6 | chr1 | 147131890 | - |
intron-3CDS | ENST00000497267 | ENST00000369238 | ARHGEF3 | chr3 | 56916320 | - | ACP6 | chr1 | 147131890 | - |
intron-intron | ENST00000497267 | ENST00000460583 | ARHGEF3 | chr3 | 56916320 | - | ACP6 | chr1 | 147131890 | - |
intron-intron | ENST00000497267 | ENST00000392988 | ARHGEF3 | chr3 | 56916320 | - | ACP6 | chr1 | 147131890 | - |
intron-3CDS | ENST00000495373 | ENST00000369238 | ARHGEF3 | chr3 | 56916320 | - | ACP6 | chr1 | 147131890 | - |
intron-intron | ENST00000495373 | ENST00000460583 | ARHGEF3 | chr3 | 56916320 | - | ACP6 | chr1 | 147131890 | - |
intron-intron | ENST00000495373 | ENST00000392988 | ARHGEF3 | chr3 | 56916320 | - | ACP6 | chr1 | 147131890 | - |
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FusionProtFeatures for ARHGEF3_ACP6 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ARHGEF3 | ACP6 |
Hydrolyzes lysophosphatidic acid (LPA) containing amedium length fatty acid chain to the correspondingmonoacylglycerol. Has highest activity with lysophosphatidic acidcontaining myristate (C14:0), monounsaturated oleate (C18:1) orpalmitate (C16:0), and lower activity with C18:0 and C6:0lysophosphatidic acid. {ECO:0000269|PubMed:10506173,ECO:0000269|PubMed:23807634}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >ARHGEF3 | chr3:56916320 | chr1:147131890 | ENST00000296315 | - | 1 | 10 | 122_304 | -57 | 527 | Domain | DH |
Hgene | >ARHGEF3 | chr3:56916320 | chr1:147131890 | ENST00000296315 | - | 1 | 10 | 291_449 | -57 | 527 | Domain | PH |
Hgene | >ARHGEF3 | chr3:56916320 | chr1:147131890 | ENST00000338458 | - | 4 | 13 | 122_304 | 64 | 559 | Domain | DH |
Hgene | >ARHGEF3 | chr3:56916320 | chr1:147131890 | ENST00000338458 | - | 4 | 13 | 291_449 | 64 | 559 | Domain | PH |
Hgene | >ARHGEF3 | chr3:56916320 | chr1:147131890 | ENST00000413728 | - | 1 | 10 | 122_304 | -182 | 533 | Domain | DH |
Hgene | >ARHGEF3 | chr3:56916320 | chr1:147131890 | ENST00000413728 | - | 1 | 10 | 291_449 | -182 | 533 | Domain | PH |
Tgene | ACP6 | chr3:56916320 | chr1:147131890 | ENST00000369238 | - | 0 | 10 | 58_168 | 73 | 429 | Region | Substrate binding |
Tgene | ACP6 | chr3:56916320 | chr1:147131890 | ENST00000392988 | - | 0 | 7 | 58_168 | 73 | 272 | Region | Substrate binding |
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FusionGeneSequence for ARHGEF3_ACP6 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_ARHGEF3_ENST00000338458_chr3_56916320_-_ACP6_ENST00000369238_chr1_147131890_-_420aa MDSSTAMNQCSCRGMEENKERPKRQRQNNFPMFPSPKAWNFRGRKRKQSTQDEDAVSLCSLDISVEWNPQLLEVPPQTQFDYTVTNLAGG PKPYSPYDSQYHETTLKGGMFAGQLTKVGMQQMFALGERLRKNYVEDIPFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEGPI IIHTDEADSEVLYPNYQSCWSLRQRTRGRRQTASLQPGISEDLKKVKDRMGIDSSDKVDFFILLDNVAAEQAHNLPSCPMLKRFARMIEQ RAVDTSLYILPKEDRESLQMAVGPFLHILESNLLKAVDSATAPDKIRKLYLYAAHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLES >In-frame_ARHGEF3_ENST00000496106_chr3_56916320_-_ACP6_ENST00000369238_chr1_147131890_-_394aa MRSERPMVWCCLFVRSQRKRKQSTQDEDAVSLCSLDISVEWNPQLLEVPPQTQFDYTVTNLAGGPKPYSPYDSQYHETTLKGGMFAGQLT KVGMQQMFALGERLRKNYVEDIPFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEGPIIIHTDEADSEVLYPNYQSCWSLRQRT RGRRQTASLQPGISEDLKKVKDRMGIDSSDKVDFFILLDNVAAEQAHNLPSCPMLKRFARMIEQRAVDTSLYILPKEDRESLQMAVGPFL HILESNLLKAVDSATAPDKIRKLYLYAAHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLESKEWFVQLYYHGKEQVPRGCPDGLCPL |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_ARHGEF3_ENST00000338458_chr3_56916320_-_ACP6_ENST00000369238_chr1_147131890_-_1260nt ATGGACAGTTCCACAGCAATGAATCAATGCAGCTGTAGAGGAATGGAAGAAAACAAGGAAAGGCCTAAACGGCAGCGGCAAAACAACTTT CCCATGTTTCCCTCTCCTAAAGCCTGGAATTTCAGAGGGCGAAAACGGAAACAGAGCACCCAAGATGAAGATGCTGTTAGCCTTTGCAGT CTCGACATAAGTGTAGAGTGGAACCCCCAGCTATTAGAGGTCCCACCCCAAACTCAGTTTGATTACACAGTCACCAATCTAGCTGGTGGT CCGAAACCATATTCTCCTTACGACTCTCAATACCATGAGACCACCCTGAAGGGGGGCATGTTTGCTGGGCAGCTGACCAAGGTGGGCATG CAGCAAATGTTTGCCTTGGGAGAGAGACTGAGGAAGAACTATGTGGAAGACATTCCCTTTCTTTCACCAACCTTCAACCCACAGGAGGTC TTTATTCGTTCCACTAACATTTTTCGGAATCTGGAGTCCACCCGTTGTTTGCTGGCTGGGCTTTTCCAGTGTCAGAAAGAAGGACCCATC ATCATCCACACTGATGAAGCAGATTCAGAAGTCTTGTATCCCAACTACCAAAGCTGCTGGAGCCTGAGGCAGAGAACCAGAGGCCGGAGG CAGACTGCCTCTTTACAGCCAGGAATCTCAGAGGATTTGAAAAAGGTGAAGGACAGGATGGGCATTGACAGTAGTGATAAAGTGGACTTC TTCATCCTCCTGGACAACGTGGCTGCCGAGCAGGCACACAACCTCCCAAGCTGCCCCATGCTGAAGAGATTTGCAAGGATGATCGAACAG AGAGCTGTGGACACATCCTTGTACATACTGCCCAAGGAAGACAGGGAAAGTCTTCAGATGGCAGTAGGCCCATTCCTCCACATCCTAGAG AGCAACCTGCTGAAAGCCGTGGACTCTGCCACTGCCCCCGACAAGATCAGAAAGCTGTATCTCTATGCGGCTCATGATGTGACCTTCATA CCGCTCTTAATGACCCTGGGGATTTTTGACCACAAATGGCCACCGTTTGCTGTTGACCTGACCATGGAACTTTACCAGCACCTGGAATCT AAGGAGTGGTTTGTGCAGCTCTATTACCACGGGAAGGAGCAGGTGCCGAGAGGTTGCCCTGATGGGCTCTGCCCGCTGGACATGTTCTTG AATGCCATGTCAGTTTATACCTTAAGCCCAGAAAAATACCACGCACTCTGCTCTCAAACTCAGGTGATGGAAGTTGGAAATGAAGAGTAA >In-frame_ARHGEF3_ENST00000496106_chr3_56916320_-_ACP6_ENST00000369238_chr1_147131890_-_1182nt ATGAGGTCAGAGCGCCCCATGGTGTGGTGCTGCCTCTTTGTCCGTTCGCAGCGAAAACGGAAACAGAGCACCCAAGATGAAGATGCTGTT AGCCTTTGCAGTCTCGACATAAGTGTAGAGTGGAACCCCCAGCTATTAGAGGTCCCACCCCAAACTCAGTTTGATTACACAGTCACCAAT CTAGCTGGTGGTCCGAAACCATATTCTCCTTACGACTCTCAATACCATGAGACCACCCTGAAGGGGGGCATGTTTGCTGGGCAGCTGACC AAGGTGGGCATGCAGCAAATGTTTGCCTTGGGAGAGAGACTGAGGAAGAACTATGTGGAAGACATTCCCTTTCTTTCACCAACCTTCAAC CCACAGGAGGTCTTTATTCGTTCCACTAACATTTTTCGGAATCTGGAGTCCACCCGTTGTTTGCTGGCTGGGCTTTTCCAGTGTCAGAAA GAAGGACCCATCATCATCCACACTGATGAAGCAGATTCAGAAGTCTTGTATCCCAACTACCAAAGCTGCTGGAGCCTGAGGCAGAGAACC AGAGGCCGGAGGCAGACTGCCTCTTTACAGCCAGGAATCTCAGAGGATTTGAAAAAGGTGAAGGACAGGATGGGCATTGACAGTAGTGAT AAAGTGGACTTCTTCATCCTCCTGGACAACGTGGCTGCCGAGCAGGCACACAACCTCCCAAGCTGCCCCATGCTGAAGAGATTTGCAAGG ATGATCGAACAGAGAGCTGTGGACACATCCTTGTACATACTGCCCAAGGAAGACAGGGAAAGTCTTCAGATGGCAGTAGGCCCATTCCTC CACATCCTAGAGAGCAACCTGCTGAAAGCCGTGGACTCTGCCACTGCCCCCGACAAGATCAGAAAGCTGTATCTCTATGCGGCTCATGAT GTGACCTTCATACCGCTCTTAATGACCCTGGGGATTTTTGACCACAAATGGCCACCGTTTGCTGTTGACCTGACCATGGAACTTTACCAG CACCTGGAATCTAAGGAGTGGTTTGTGCAGCTCTATTACCACGGGAAGGAGCAGGTGCCGAGAGGTTGCCCTGATGGGCTCTGCCCGCTG GACATGTTCTTGAATGCCATGTCAGTTTATACCTTAAGCCCAGAAAAATACCACGCACTCTGCTCTCAAACTCAGGTGATGGAAGTTGGA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_ARHGEF3_ENST00000338458_chr3_56916320_-_ACP6_ENST00000369238_chr1_147131890_-_6561nt AGCCCAGGGGAGCCGCCGCCGCAGCCGCCGCCGCCGCGGTGAGTTTTCCAGCCTGGAGAGGCCGAACCAGCGCGGGGGTCGAGGAGACCT GAGCCTGCCATACTGAGTCTATGGACAGTTCCACAGCAATGAATCAATGCAGCTGTAGAGGAATGGAAGAAAACAAGGAAAGGCCTAAAC GGCAGCGGCAAAACAACTTTCCCATGTTTCCCTCTCCTAAAGCCTGGAATTTCAGAGGGCGAAAACGGAAACAGAGCACCCAAGATGAAG ATGCTGTTAGCCTTTGCAGTCTCGACATAAGTGTAGAGTGGAACCCCCAGCTATTAGAGGTCCCACCCCAAACTCAGTTTGATTACACAG TCACCAATCTAGCTGGTGGTCCGAAACCATATTCTCCTTACGACTCTCAATACCATGAGACCACCCTGAAGGGGGGCATGTTTGCTGGGC AGCTGACCAAGGTGGGCATGCAGCAAATGTTTGCCTTGGGAGAGAGACTGAGGAAGAACTATGTGGAAGACATTCCCTTTCTTTCACCAA CCTTCAACCCACAGGAGGTCTTTATTCGTTCCACTAACATTTTTCGGAATCTGGAGTCCACCCGTTGTTTGCTGGCTGGGCTTTTCCAGT GTCAGAAAGAAGGACCCATCATCATCCACACTGATGAAGCAGATTCAGAAGTCTTGTATCCCAACTACCAAAGCTGCTGGAGCCTGAGGC AGAGAACCAGAGGCCGGAGGCAGACTGCCTCTTTACAGCCAGGAATCTCAGAGGATTTGAAAAAGGTGAAGGACAGGATGGGCATTGACA GTAGTGATAAAGTGGACTTCTTCATCCTCCTGGACAACGTGGCTGCCGAGCAGGCACACAACCTCCCAAGCTGCCCCATGCTGAAGAGAT TTGCAAGGATGATCGAACAGAGAGCTGTGGACACATCCTTGTACATACTGCCCAAGGAAGACAGGGAAAGTCTTCAGATGGCAGTAGGCC CATTCCTCCACATCCTAGAGAGCAACCTGCTGAAAGCCGTGGACTCTGCCACTGCCCCCGACAAGATCAGAAAGCTGTATCTCTATGCGG CTCATGATGTGACCTTCATACCGCTCTTAATGACCCTGGGGATTTTTGACCACAAATGGCCACCGTTTGCTGTTGACCTGACCATGGAAC TTTACCAGCACCTGGAATCTAAGGAGTGGTTTGTGCAGCTCTATTACCACGGGAAGGAGCAGGTGCCGAGAGGTTGCCCTGATGGGCTCT GCCCGCTGGACATGTTCTTGAATGCCATGTCAGTTTATACCTTAAGCCCAGAAAAATACCACGCACTCTGCTCTCAAACTCAGGTGATGG AAGTTGGAAATGAAGAGTAACTGATTTATAAAAGCAGGATGTGTTGATTTTAAAATAAAGTGCCTTTATACAATGCCTCCTGCTTTGTGT GTTTGGGAAGAGGAGAGAGCAAGGGGTAATGTACTTTAATATAATGTAAGGATATTTCCTTTCTGTGGGTTTACTAAGATTTCTTCCTGA ACGGAAAAGGGGTATAATATTGAGACCAAAAGGATATTTCTCTATTTTGTGAGTTGGTTTCTAAGGTTAGAAGCATCTTTGTGTGACACG GGCTGGGGACATCATGACCCTGTAGAATTGTGTCGGTTTTGGACTTTAGTTCTTTTCTCCTATATTAATTTCACATGTATTGAGCTACCT ACTAAGTAGTGATCATTATAAAGGTGAAAACACTCTGCCCTCAAGTTGTTGCAGTCCAGTGGGAGAGGCAGCCGAGTAAATCAGTGATAC AGTGCTGTATGTTTTATGCTGTAATAGGTATTTGAGGGGCTATTTGGGTATAGAGAAGAAACTTCCTGCTCACATGGCAGGGGATGTGGG GAACAGTCAAGGAAGGCTTCTGAAAAAGTCCTGGCCTGATCTGAGTAGAGAAAGGTGGGTAGGAGTTAACCAGGAAAGCAAGGATGAAAG CGTGTTGCGTTTAGATAAAGGATAGGCTTCAAGGTCAGGGAACGTTGCTGGGTGGTGAGATGGAACCCTGATGTGGAGGCTCAGCAGGAA GAAGCAGGAAGGACACTGGGCCCCTGGTGGTTTTAGTTCCAGAAACAAATGTGGGCCCCAGGGCTCTGCAATGGTAAGGCTGGAACTACT CAACATAAGAGCTCCACCTTTAACTGTGCCCCCTAAGAGTACCTGATGATCCCCCTATCTCCTTGTCAATGTTGCTGTTCTTCTCCAGAA TCTATTTCAACCCTTCTCTGATTTCAAACCACCAGTCCCTTTACCTCTCAGAGAAAACAGCAACCACAAAAGCCTCTCCACTTCCTACTA TCTTAATATTGACAACTTCCAGATCAGGGAGCTGAGATATCTCAAGCTCAGGTTTCTCTTCTGAGCTTCAGACGCTTTTATCCACTTGGA TTTCACTGGCACAAAACTTTCCATGTTAGAATCAAACCCCCCTCCTCCCAGACCTGCTTCTCCCACACACTTCCCTATCTGAATGAAAGA CACCTCCACTCTCCACCCAGTTGCCAAATCAGAAATCTGTCTTTGTTTTCTTTGTCTCACATTTTCCTATGTCTAATCAGTTAAGTTTTA TCAATACTACCTGTTTATTTCTTTAATCTATTCACATATCTTTATCCTCAATCTTCAGCATCCCCTTCCCATCCTCAGTCTGCTGGTTAC TGTATTTCCTATTTTACTAAGAATCTAAAAGAGATCAGAAGAAAACTTCCACATCCCCCAACACCCAACCACCAAATCTGCTAACCCAGT TGCATTGGTGCTTTTATAGCCTTCCTTCCTCCCTCTTACTAAGAATGAACCAACACTATTCCTATCAAAGCCCAACCCTCTAGCTTTACA TTGACTCCTAGTGTCTTTTTTCTGGATTGTCAATTTTTTTCCTGACCAATTATTCTATTAGCAATACAAATATGCTGTAAAATCTCTTAA ACTTTTTTCTCTGCATCTTTGAACTGCTGTTCTCTTTTCCTTCTCCCCTTCATAGCAGAACTCCTCAAAAGAGTTGCTACCTCTAATTCT TCCCTTCCAGTTCTCTCATGAACCAGCTACAATTAAGTATTCACCCCCACCACTCCATGGAAACTGCTCTTGTCAAAATCATCAATAGCC TTTGTGTGGTGAATCCAATAGCCAGTTTTCATTCTTCTTACTAAGCTTCTCATCAGTATTCCTAGACTATTTCCTTCACTGGCTTCGACA AATGCTTTCTTGGTTTTCCTCCAATTTCTCGACTTTGTTCCTGCTGAATCTACCTTTTTCTAATCCGTAAGTGTTGGGGTGTCCCAGGGC TTACTCCTTGGACCTTTTTTCCACCTTTTCCCCTACACTCACCCACTAGGTGATCTCAAGAATTTCCAGTTTGAGGCCGGGCGCGGTGGC TCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACCTGAGGCCAGGAGTTCGAGACCAGCCTGGCCAACATGGCAAA ACCCTGTCTCCACTAAACCTGCCTCTACTAAAAATACAAAAATTATTATATTTTTATAAAATTATTATAATTTTATAAAATTATTATATT TATGGAGTACAATGTGATGTAATCCCAGCTACTCGGAAGGCTGTATGTGTCTATTTATGGAGTACAATGTGCCTGTAATCCCAGCTACTT GGGAGGCTGAGGCAGGAGAATCACTTCAACCTAGGAGGCAGAGGTTGTGCTGAGCCAAGATCGTGCCATTGCACTCCAGCCTGGGCAACA AGAGAGAAATAACATCTCAAAAAAAAAAAAAAAGAATTTCCAGTTTTAAATATTTACACAATGTCTCCTAAATTTATACCTTCAACCTAG ACCTTTCCCTGTGAATCCCAGTCTCATTTCCAACAGTCTAATCAATGTCTCTATTTGGATGTTTAAGATATACAATAGGTATCAAACTTC CCATTGTCCACAATAAACTCTCAATTTCCGTGCCTTTTCAAACTTACTCCTTCCACAGGCTTTCCCATCTAGGTAAATGACACCACCATT CACCCTGTTGCTTTGGCCAAGAACTTTAGAACTGCCCTTGACTCCCCTCTTTTTCTCATATCCTACCTCTACTACATCAGTAACTCCTGT TGTATCTCTCTTCAAACTATATCCAGAATTGACCATGTCCCAATACTTCCATTGCTACTGTCTTAGTCCCAGTGTCATCTTTTACCTGGA TTATTGTAAAGGCCTCGTAACTAGTCTTCCTGTTTCTGCCCTTCCCTTCTCTGCCCATCTATTCTCAACACAGTGTTGCTTTTAAAACAA AGTAAGATCGTGCCACTCTTCTGCTCTAAATTCCCCATTGGTTTCTCATCTCAAACTAAGGGCCAGTCATAATGCCCTCACGGTCCTATG ACATCTCACTGCACCCCAGCCATACTCGCCATCTTACCATTCTTCTTCTTTTTTGTAATAAAAACTTTTTACTTTCTTTTTAGTTGACAG ATAATAATTGCGTATATTTATGGAGTACAATGTGATGTTTTGATATATGTATGCATGAGGGAATGATTAAATCAAGCTAATTAACATATT CATCACTTCATCTACTCATCACTTTCTTGTGGTGAAAATGTTTCAGATATACTCTTTAGTAGTTTTCAGGTGTACAGTCGCTGTGGTTTG AGTGCTTTTGTCTTCTCTAAATTTGATGTTGACACTTAGTGCCCAGTACAATGTTACTGGGAGGTGGAGCCTAATGGGGATGTTTAATGG ATTAATGCCATTATAAAAAGGGCTTGCAGGAATGGGTTCCTTCTCTTTTGCTTTTCTGCCATATGATGACAAAGTGTTCCTCCTCTCTGG AGGATGCAGCAACAGGCACCATCTTTGAAGCAGAGAGACCAGGCCCTAACCTTCTGGTGCCTTGATCTTGGACTTCTCAGCTTCCAGAAC TGTGAGATAATAAATTTCTGTTCATTACAAATTACCCCATCTGTGGTATTCTGTTATAGCAACACAAAATGGACTAAGACAACAGTATAC TGTTATGAACTATGGTCACCATGCTGTGCACTAGATCACAAAAACTTATTTCTACTGTTTAACTGAAACTTTGTACATTTTGACTAACAT CTCCCTTTTTCCCATCATCCCATCCCATTCTTACTATCGTTGAAGATGGAGTATGCCAAGTAGTCCTGAGCCATGTCCTCACCTCGGGGT GAGCACCTGTTGTTCCTGTGCCTGGAATGCTCTCCTAGACATTTGCGTGGCTAGCTCCCTCTTTTCATTCAGATCTCAGCTCATTGTCAT CTCAGAGAGGCCCTCCTTGCCCTCCTTCTACCTCCTGCCTTAGGTATACTCTGCCACCTTCTGTCATGGGCTGAATTGTGTCCCCCCTAA ATCCATATGTTGACATCTTAACCCCTAGTACAGTAAGTCCTCACTTGATGCTATCAATAGGCTCTTGGAAATGTCGGCTTTCAGTGAAAG GACATATAGCAGGTCCTTGAATAACATTGTGTTTTGTTCAACATCGTTGCCTTGTAACACTGATGAGCAAAACAGTTGGTTCTCTAATAT GTTGTTTTACTTAAAGCTACAGTTTCCAAGAACCTATCAATGATGTTGAGGACTGAATGTACCTCAGGTGTAATGTATTTGGAGATAGGG CCTTTTAAGAGGTAAAGTAAATGAGGTCATATGGGTAGGCTGTAATCCAATATGACTGGAATCCTTATAAGAAGAGGAAATGAGGACACA GACACAGAGGGAAGATGACTATCTGCAAGTCAAGGAGAGAGGCCTCAGAAGAAACCAATGCTGCTGACACCACGATCTTGGACTTCTAGC CTCTAGCACTGTGAGGAAATAAATTTCTGTTGTTTAAGCCACCTAGTCTGTGATACTTTGCTACGGCAGGCCCTAGCAAATGAATACACT TGTCTTGTCTTTCCCCCGCCCTGTGATATTTATCAGTGCCGGATATTACATATTTGTGTATCTATATGCTTATTTCCCTGACTAAAATGG AAGCTCCATGAAGGCAGATTTCCTCTTGTTCACTGATGTGTCCCCAGCACCTGGAATAGTGCCTAGTGCATGCCAGTGCTCAGACACTTG GACATTTGAATGACATATCCCCTCTGTCACTTCTCTCCGGGGCCCAAGGCCACCCTCCTAGGTTACCACAGTGGCTTCCTAATGGGCCAT ACCCTCACTTGCTTTCCATCACCCCCTGAGACCTGGCCCCTGCATACCTCTCCAGCTTCACCCCTCACATATCTCCCTAGCCAGACCTAT AGTATGTTTTAAAAAAAAAGGAAATCGCACTCCTCTGGCCTCTTTACCTTGGCACACATTTTTCCATCACCTGACCCCTGACCCACACTC CCTTTTCCTGTGTAATCCAATTATCTCTAGGCCTCCCGTGTTTCTGTTTGTCCTTCAATAGAAGGTTGTTTGTCTTGTCTTTTATTGTAT >In-frame_ARHGEF3_ENST00000496106_chr3_56916320_-_ACP6_ENST00000369238_chr1_147131890_-_6485nt ATGCAGCCCAAGTGGCGGGGAGGAGTTCCTTCAGGGAAACTATGCTCAGCCCTGTTCAGAGAATCCTGTGCACAGGGCTCCACTGCAGTT AGGAGCCGGTGAGTCCGGGTGGATGAGGTCAGAGCGCCCCATGGTGTGGTGCTGCCTCTTTGTCCGTTCGCAGCGAAAACGGAAACAGAG CACCCAAGATGAAGATGCTGTTAGCCTTTGCAGTCTCGACATAAGTGTAGAGTGGAACCCCCAGCTATTAGAGGTCCCACCCCAAACTCA GTTTGATTACACAGTCACCAATCTAGCTGGTGGTCCGAAACCATATTCTCCTTACGACTCTCAATACCATGAGACCACCCTGAAGGGGGG CATGTTTGCTGGGCAGCTGACCAAGGTGGGCATGCAGCAAATGTTTGCCTTGGGAGAGAGACTGAGGAAGAACTATGTGGAAGACATTCC CTTTCTTTCACCAACCTTCAACCCACAGGAGGTCTTTATTCGTTCCACTAACATTTTTCGGAATCTGGAGTCCACCCGTTGTTTGCTGGC TGGGCTTTTCCAGTGTCAGAAAGAAGGACCCATCATCATCCACACTGATGAAGCAGATTCAGAAGTCTTGTATCCCAACTACCAAAGCTG CTGGAGCCTGAGGCAGAGAACCAGAGGCCGGAGGCAGACTGCCTCTTTACAGCCAGGAATCTCAGAGGATTTGAAAAAGGTGAAGGACAG GATGGGCATTGACAGTAGTGATAAAGTGGACTTCTTCATCCTCCTGGACAACGTGGCTGCCGAGCAGGCACACAACCTCCCAAGCTGCCC CATGCTGAAGAGATTTGCAAGGATGATCGAACAGAGAGCTGTGGACACATCCTTGTACATACTGCCCAAGGAAGACAGGGAAAGTCTTCA GATGGCAGTAGGCCCATTCCTCCACATCCTAGAGAGCAACCTGCTGAAAGCCGTGGACTCTGCCACTGCCCCCGACAAGATCAGAAAGCT GTATCTCTATGCGGCTCATGATGTGACCTTCATACCGCTCTTAATGACCCTGGGGATTTTTGACCACAAATGGCCACCGTTTGCTGTTGA CCTGACCATGGAACTTTACCAGCACCTGGAATCTAAGGAGTGGTTTGTGCAGCTCTATTACCACGGGAAGGAGCAGGTGCCGAGAGGTTG CCCTGATGGGCTCTGCCCGCTGGACATGTTCTTGAATGCCATGTCAGTTTATACCTTAAGCCCAGAAAAATACCACGCACTCTGCTCTCA AACTCAGGTGATGGAAGTTGGAAATGAAGAGTAACTGATTTATAAAAGCAGGATGTGTTGATTTTAAAATAAAGTGCCTTTATACAATGC CTCCTGCTTTGTGTGTTTGGGAAGAGGAGAGAGCAAGGGGTAATGTACTTTAATATAATGTAAGGATATTTCCTTTCTGTGGGTTTACTA AGATTTCTTCCTGAACGGAAAAGGGGTATAATATTGAGACCAAAAGGATATTTCTCTATTTTGTGAGTTGGTTTCTAAGGTTAGAAGCAT CTTTGTGTGACACGGGCTGGGGACATCATGACCCTGTAGAATTGTGTCGGTTTTGGACTTTAGTTCTTTTCTCCTATATTAATTTCACAT GTATTGAGCTACCTACTAAGTAGTGATCATTATAAAGGTGAAAACACTCTGCCCTCAAGTTGTTGCAGTCCAGTGGGAGAGGCAGCCGAG TAAATCAGTGATACAGTGCTGTATGTTTTATGCTGTAATAGGTATTTGAGGGGCTATTTGGGTATAGAGAAGAAACTTCCTGCTCACATG GCAGGGGATGTGGGGAACAGTCAAGGAAGGCTTCTGAAAAAGTCCTGGCCTGATCTGAGTAGAGAAAGGTGGGTAGGAGTTAACCAGGAA AGCAAGGATGAAAGCGTGTTGCGTTTAGATAAAGGATAGGCTTCAAGGTCAGGGAACGTTGCTGGGTGGTGAGATGGAACCCTGATGTGG AGGCTCAGCAGGAAGAAGCAGGAAGGACACTGGGCCCCTGGTGGTTTTAGTTCCAGAAACAAATGTGGGCCCCAGGGCTCTGCAATGGTA AGGCTGGAACTACTCAACATAAGAGCTCCACCTTTAACTGTGCCCCCTAAGAGTACCTGATGATCCCCCTATCTCCTTGTCAATGTTGCT GTTCTTCTCCAGAATCTATTTCAACCCTTCTCTGATTTCAAACCACCAGTCCCTTTACCTCTCAGAGAAAACAGCAACCACAAAAGCCTC TCCACTTCCTACTATCTTAATATTGACAACTTCCAGATCAGGGAGCTGAGATATCTCAAGCTCAGGTTTCTCTTCTGAGCTTCAGACGCT TTTATCCACTTGGATTTCACTGGCACAAAACTTTCCATGTTAGAATCAAACCCCCCTCCTCCCAGACCTGCTTCTCCCACACACTTCCCT ATCTGAATGAAAGACACCTCCACTCTCCACCCAGTTGCCAAATCAGAAATCTGTCTTTGTTTTCTTTGTCTCACATTTTCCTATGTCTAA TCAGTTAAGTTTTATCAATACTACCTGTTTATTTCTTTAATCTATTCACATATCTTTATCCTCAATCTTCAGCATCCCCTTCCCATCCTC AGTCTGCTGGTTACTGTATTTCCTATTTTACTAAGAATCTAAAAGAGATCAGAAGAAAACTTCCACATCCCCCAACACCCAACCACCAAA TCTGCTAACCCAGTTGCATTGGTGCTTTTATAGCCTTCCTTCCTCCCTCTTACTAAGAATGAACCAACACTATTCCTATCAAAGCCCAAC CCTCTAGCTTTACATTGACTCCTAGTGTCTTTTTTCTGGATTGTCAATTTTTTTCCTGACCAATTATTCTATTAGCAATACAAATATGCT GTAAAATCTCTTAAACTTTTTTCTCTGCATCTTTGAACTGCTGTTCTCTTTTCCTTCTCCCCTTCATAGCAGAACTCCTCAAAAGAGTTG CTACCTCTAATTCTTCCCTTCCAGTTCTCTCATGAACCAGCTACAATTAAGTATTCACCCCCACCACTCCATGGAAACTGCTCTTGTCAA AATCATCAATAGCCTTTGTGTGGTGAATCCAATAGCCAGTTTTCATTCTTCTTACTAAGCTTCTCATCAGTATTCCTAGACTATTTCCTT CACTGGCTTCGACAAATGCTTTCTTGGTTTTCCTCCAATTTCTCGACTTTGTTCCTGCTGAATCTACCTTTTTCTAATCCGTAAGTGTTG GGGTGTCCCAGGGCTTACTCCTTGGACCTTTTTTCCACCTTTTCCCCTACACTCACCCACTAGGTGATCTCAAGAATTTCCAGTTTGAGG CCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACCTGAGGCCAGGAGTTCGAGACCAGCCTG GCCAACATGGCAAAACCCTGTCTCCACTAAACCTGCCTCTACTAAAAATACAAAAATTATTATATTTTTATAAAATTATTATAATTTTAT AAAATTATTATATTTATGGAGTACAATGTGATGTAATCCCAGCTACTCGGAAGGCTGTATGTGTCTATTTATGGAGTACAATGTGCCTGT AATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTCAACCTAGGAGGCAGAGGTTGTGCTGAGCCAAGATCGTGCCATTGCACTC CAGCCTGGGCAACAAGAGAGAAATAACATCTCAAAAAAAAAAAAAAAGAATTTCCAGTTTTAAATATTTACACAATGTCTCCTAAATTTA TACCTTCAACCTAGACCTTTCCCTGTGAATCCCAGTCTCATTTCCAACAGTCTAATCAATGTCTCTATTTGGATGTTTAAGATATACAAT AGGTATCAAACTTCCCATTGTCCACAATAAACTCTCAATTTCCGTGCCTTTTCAAACTTACTCCTTCCACAGGCTTTCCCATCTAGGTAA ATGACACCACCATTCACCCTGTTGCTTTGGCCAAGAACTTTAGAACTGCCCTTGACTCCCCTCTTTTTCTCATATCCTACCTCTACTACA TCAGTAACTCCTGTTGTATCTCTCTTCAAACTATATCCAGAATTGACCATGTCCCAATACTTCCATTGCTACTGTCTTAGTCCCAGTGTC ATCTTTTACCTGGATTATTGTAAAGGCCTCGTAACTAGTCTTCCTGTTTCTGCCCTTCCCTTCTCTGCCCATCTATTCTCAACACAGTGT TGCTTTTAAAACAAAGTAAGATCGTGCCACTCTTCTGCTCTAAATTCCCCATTGGTTTCTCATCTCAAACTAAGGGCCAGTCATAATGCC CTCACGGTCCTATGACATCTCACTGCACCCCAGCCATACTCGCCATCTTACCATTCTTCTTCTTTTTTGTAATAAAAACTTTTTACTTTC TTTTTAGTTGACAGATAATAATTGCGTATATTTATGGAGTACAATGTGATGTTTTGATATATGTATGCATGAGGGAATGATTAAATCAAG CTAATTAACATATTCATCACTTCATCTACTCATCACTTTCTTGTGGTGAAAATGTTTCAGATATACTCTTTAGTAGTTTTCAGGTGTACA GTCGCTGTGGTTTGAGTGCTTTTGTCTTCTCTAAATTTGATGTTGACACTTAGTGCCCAGTACAATGTTACTGGGAGGTGGAGCCTAATG GGGATGTTTAATGGATTAATGCCATTATAAAAAGGGCTTGCAGGAATGGGTTCCTTCTCTTTTGCTTTTCTGCCATATGATGACAAAGTG TTCCTCCTCTCTGGAGGATGCAGCAACAGGCACCATCTTTGAAGCAGAGAGACCAGGCCCTAACCTTCTGGTGCCTTGATCTTGGACTTC TCAGCTTCCAGAACTGTGAGATAATAAATTTCTGTTCATTACAAATTACCCCATCTGTGGTATTCTGTTATAGCAACACAAAATGGACTA AGACAACAGTATACTGTTATGAACTATGGTCACCATGCTGTGCACTAGATCACAAAAACTTATTTCTACTGTTTAACTGAAACTTTGTAC ATTTTGACTAACATCTCCCTTTTTCCCATCATCCCATCCCATTCTTACTATCGTTGAAGATGGAGTATGCCAAGTAGTCCTGAGCCATGT CCTCACCTCGGGGTGAGCACCTGTTGTTCCTGTGCCTGGAATGCTCTCCTAGACATTTGCGTGGCTAGCTCCCTCTTTTCATTCAGATCT CAGCTCATTGTCATCTCAGAGAGGCCCTCCTTGCCCTCCTTCTACCTCCTGCCTTAGGTATACTCTGCCACCTTCTGTCATGGGCTGAAT TGTGTCCCCCCTAAATCCATATGTTGACATCTTAACCCCTAGTACAGTAAGTCCTCACTTGATGCTATCAATAGGCTCTTGGAAATGTCG GCTTTCAGTGAAAGGACATATAGCAGGTCCTTGAATAACATTGTGTTTTGTTCAACATCGTTGCCTTGTAACACTGATGAGCAAAACAGT TGGTTCTCTAATATGTTGTTTTACTTAAAGCTACAGTTTCCAAGAACCTATCAATGATGTTGAGGACTGAATGTACCTCAGGTGTAATGT ATTTGGAGATAGGGCCTTTTAAGAGGTAAAGTAAATGAGGTCATATGGGTAGGCTGTAATCCAATATGACTGGAATCCTTATAAGAAGAG GAAATGAGGACACAGACACAGAGGGAAGATGACTATCTGCAAGTCAAGGAGAGAGGCCTCAGAAGAAACCAATGCTGCTGACACCACGAT CTTGGACTTCTAGCCTCTAGCACTGTGAGGAAATAAATTTCTGTTGTTTAAGCCACCTAGTCTGTGATACTTTGCTACGGCAGGCCCTAG CAAATGAATACACTTGTCTTGTCTTTCCCCCGCCCTGTGATATTTATCAGTGCCGGATATTACATATTTGTGTATCTATATGCTTATTTC CCTGACTAAAATGGAAGCTCCATGAAGGCAGATTTCCTCTTGTTCACTGATGTGTCCCCAGCACCTGGAATAGTGCCTAGTGCATGCCAG TGCTCAGACACTTGGACATTTGAATGACATATCCCCTCTGTCACTTCTCTCCGGGGCCCAAGGCCACCCTCCTAGGTTACCACAGTGGCT TCCTAATGGGCCATACCCTCACTTGCTTTCCATCACCCCCTGAGACCTGGCCCCTGCATACCTCTCCAGCTTCACCCCTCACATATCTCC CTAGCCAGACCTATAGTATGTTTTAAAAAAAAAGGAAATCGCACTCCTCTGGCCTCTTTACCTTGGCACACATTTTTCCATCACCTGACC CCTGACCCACACTCCCTTTTCCTGTGTAATCCAATTATCTCTAGGCCTCCCGTGTTTCTGTTTGTCCTTCAATAGAAGGTTGTTTGTCTT GTCTTTTATTGTATTTCTAGAACCAAGTGCAGAGACTGTACAAAGTGGACCTCAGCAAAGATTTACCGAATGAATAAATGAGTTCAGAAC |
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FusionGenePPI for ARHGEF3_ACP6 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ARHGEF3 | RHOA, RHOB, TRIM23, TRIM27, CEP70, SHMT2, NXF1, XPO1 | ACP6 | ILK, RGS10, RSU1, DHX36, DHCR7, LIMS1, ERH, SLC35F6, GNG7, FAM9B, ACP6, NME4, STOML2, ECH1, CYCS, NRD1, PMPCB, PMPCA, ACN9, BOLA3, C1QBP |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARHGEF3_ACP6 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARHGEF3_ACP6 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |