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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2572

FusionGeneSummary for ARHGEF3_ACP6

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGEF3_ACP6
Fusion gene ID: 2572
HgeneTgene
Gene symbol

ARHGEF3

ACP6

Gene ID

50650

51205

Gene nameRho guanine nucleotide exchange factor 3acid phosphatase 6, lysophosphatidic
SynonymsGEF3|STA3|XPLNACPL1|LPAP|PACPL1
Cytomap

3p14.3

1q21.2

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 359.8 kDA proteinRho guanine nucleotide exchange factor (GEF) 3RhoGEF proteinexchange factor found in platelets and leukemic and neuronal tissues, XPLNlysophosphatidic acid phosphatase type 6acid phosphatase-like protein 1
Modification date2018051920180519
UniProtAcc

Q9NR81

Q9NPH0

Ensembl transtripts involved in fusion geneENST00000338458, ENST00000496106, 
ENST00000498517, ENST00000296315, 
ENST00000413728, ENST00000497267, 
ENST00000495373, 
ENST00000369238, 
ENST00000460583, ENST00000392988, 
Fusion gene scores* DoF score14 X 11 X 7=10782 X 2 X 2=8
# samples 152
** MAII scorelog2(15/1078*10)=-2.84532277225662
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: ARHGEF3 [Title/Abstract] AND ACP6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneACP6

GO:2001311

lysobisphosphatidic acid metabolic process

23807634


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AO-A0J6-01AARHGEF3chr3

56916320

-ACP6chr1

147131890

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000338458ENST00000369238ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
5CDS-intronENST00000338458ENST00000460583ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
5CDS-intronENST00000338458ENST00000392988ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
In-frameENST00000496106ENST00000369238ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
5CDS-intronENST00000496106ENST00000460583ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
5CDS-intronENST00000496106ENST00000392988ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
5UTR-3CDSENST00000498517ENST00000369238ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
5UTR-intronENST00000498517ENST00000460583ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
5UTR-intronENST00000498517ENST00000392988ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-3CDSENST00000296315ENST00000369238ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-intronENST00000296315ENST00000460583ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-intronENST00000296315ENST00000392988ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-3CDSENST00000413728ENST00000369238ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-intronENST00000413728ENST00000460583ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-intronENST00000413728ENST00000392988ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-3CDSENST00000497267ENST00000369238ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-intronENST00000497267ENST00000460583ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-intronENST00000497267ENST00000392988ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-3CDSENST00000495373ENST00000369238ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-intronENST00000495373ENST00000460583ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-intronENST00000495373ENST00000392988ARHGEF3chr3

56916320

-ACP6chr1

147131890

-

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FusionProtFeatures for ARHGEF3_ACP6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGEF3

Q9NR81

ACP6

Q9NPH0

Hydrolyzes lysophosphatidic acid (LPA) containing amedium length fatty acid chain to the correspondingmonoacylglycerol. Has highest activity with lysophosphatidic acidcontaining myristate (C14:0), monounsaturated oleate (C18:1) orpalmitate (C16:0), and lower activity with C18:0 and C6:0lysophosphatidic acid. {ECO:0000269|PubMed:10506173,ECO:0000269|PubMed:23807634}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF3chr3:56916320chr1:147131890ENST00000296315-110122_304-57527DomainDH
HgeneARHGEF3chr3:56916320chr1:147131890ENST00000296315-110291_449-57527DomainPH
HgeneARHGEF3chr3:56916320chr1:147131890ENST00000338458-413122_30464559DomainDH
HgeneARHGEF3chr3:56916320chr1:147131890ENST00000338458-413291_44964559DomainPH
HgeneARHGEF3chr3:56916320chr1:147131890ENST00000413728-110122_304-182533DomainDH
HgeneARHGEF3chr3:56916320chr1:147131890ENST00000413728-110291_449-182533DomainPH
TgeneACP6chr3:56916320chr1:147131890ENST00000369238-01058_16873429RegionSubstrate binding
TgeneACP6chr3:56916320chr1:147131890ENST00000392988-0758_16873272RegionSubstrate binding


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FusionGeneSequence for ARHGEF3_ACP6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ARHGEF3_ENST00000338458_chr3_56916320_-_ACP6_ENST00000369238_chr1_147131890_-_420aa
MDSSTAMNQCSCRGMEENKERPKRQRQNNFPMFPSPKAWNFRGRKRKQSTQDEDAVSLCSLDISVEWNPQLLEVPPQTQFDYTVTNLAGG
PKPYSPYDSQYHETTLKGGMFAGQLTKVGMQQMFALGERLRKNYVEDIPFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEGPI
IIHTDEADSEVLYPNYQSCWSLRQRTRGRRQTASLQPGISEDLKKVKDRMGIDSSDKVDFFILLDNVAAEQAHNLPSCPMLKRFARMIEQ
RAVDTSLYILPKEDRESLQMAVGPFLHILESNLLKAVDSATAPDKIRKLYLYAAHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLES

>In-frame_ARHGEF3_ENST00000496106_chr3_56916320_-_ACP6_ENST00000369238_chr1_147131890_-_394aa
MRSERPMVWCCLFVRSQRKRKQSTQDEDAVSLCSLDISVEWNPQLLEVPPQTQFDYTVTNLAGGPKPYSPYDSQYHETTLKGGMFAGQLT
KVGMQQMFALGERLRKNYVEDIPFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEGPIIIHTDEADSEVLYPNYQSCWSLRQRT
RGRRQTASLQPGISEDLKKVKDRMGIDSSDKVDFFILLDNVAAEQAHNLPSCPMLKRFARMIEQRAVDTSLYILPKEDRESLQMAVGPFL
HILESNLLKAVDSATAPDKIRKLYLYAAHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLESKEWFVQLYYHGKEQVPRGCPDGLCPL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ARHGEF3_ENST00000338458_chr3_56916320_-_ACP6_ENST00000369238_chr1_147131890_-_1260nt
ATGGACAGTTCCACAGCAATGAATCAATGCAGCTGTAGAGGAATGGAAGAAAACAAGGAAAGGCCTAAACGGCAGCGGCAAAACAACTTT
CCCATGTTTCCCTCTCCTAAAGCCTGGAATTTCAGAGGGCGAAAACGGAAACAGAGCACCCAAGATGAAGATGCTGTTAGCCTTTGCAGT
CTCGACATAAGTGTAGAGTGGAACCCCCAGCTATTAGAGGTCCCACCCCAAACTCAGTTTGATTACACAGTCACCAATCTAGCTGGTGGT
CCGAAACCATATTCTCCTTACGACTCTCAATACCATGAGACCACCCTGAAGGGGGGCATGTTTGCTGGGCAGCTGACCAAGGTGGGCATG
CAGCAAATGTTTGCCTTGGGAGAGAGACTGAGGAAGAACTATGTGGAAGACATTCCCTTTCTTTCACCAACCTTCAACCCACAGGAGGTC
TTTATTCGTTCCACTAACATTTTTCGGAATCTGGAGTCCACCCGTTGTTTGCTGGCTGGGCTTTTCCAGTGTCAGAAAGAAGGACCCATC
ATCATCCACACTGATGAAGCAGATTCAGAAGTCTTGTATCCCAACTACCAAAGCTGCTGGAGCCTGAGGCAGAGAACCAGAGGCCGGAGG
CAGACTGCCTCTTTACAGCCAGGAATCTCAGAGGATTTGAAAAAGGTGAAGGACAGGATGGGCATTGACAGTAGTGATAAAGTGGACTTC
TTCATCCTCCTGGACAACGTGGCTGCCGAGCAGGCACACAACCTCCCAAGCTGCCCCATGCTGAAGAGATTTGCAAGGATGATCGAACAG
AGAGCTGTGGACACATCCTTGTACATACTGCCCAAGGAAGACAGGGAAAGTCTTCAGATGGCAGTAGGCCCATTCCTCCACATCCTAGAG
AGCAACCTGCTGAAAGCCGTGGACTCTGCCACTGCCCCCGACAAGATCAGAAAGCTGTATCTCTATGCGGCTCATGATGTGACCTTCATA
CCGCTCTTAATGACCCTGGGGATTTTTGACCACAAATGGCCACCGTTTGCTGTTGACCTGACCATGGAACTTTACCAGCACCTGGAATCT
AAGGAGTGGTTTGTGCAGCTCTATTACCACGGGAAGGAGCAGGTGCCGAGAGGTTGCCCTGATGGGCTCTGCCCGCTGGACATGTTCTTG
AATGCCATGTCAGTTTATACCTTAAGCCCAGAAAAATACCACGCACTCTGCTCTCAAACTCAGGTGATGGAAGTTGGAAATGAAGAGTAA

>In-frame_ARHGEF3_ENST00000496106_chr3_56916320_-_ACP6_ENST00000369238_chr1_147131890_-_1182nt
ATGAGGTCAGAGCGCCCCATGGTGTGGTGCTGCCTCTTTGTCCGTTCGCAGCGAAAACGGAAACAGAGCACCCAAGATGAAGATGCTGTT
AGCCTTTGCAGTCTCGACATAAGTGTAGAGTGGAACCCCCAGCTATTAGAGGTCCCACCCCAAACTCAGTTTGATTACACAGTCACCAAT
CTAGCTGGTGGTCCGAAACCATATTCTCCTTACGACTCTCAATACCATGAGACCACCCTGAAGGGGGGCATGTTTGCTGGGCAGCTGACC
AAGGTGGGCATGCAGCAAATGTTTGCCTTGGGAGAGAGACTGAGGAAGAACTATGTGGAAGACATTCCCTTTCTTTCACCAACCTTCAAC
CCACAGGAGGTCTTTATTCGTTCCACTAACATTTTTCGGAATCTGGAGTCCACCCGTTGTTTGCTGGCTGGGCTTTTCCAGTGTCAGAAA
GAAGGACCCATCATCATCCACACTGATGAAGCAGATTCAGAAGTCTTGTATCCCAACTACCAAAGCTGCTGGAGCCTGAGGCAGAGAACC
AGAGGCCGGAGGCAGACTGCCTCTTTACAGCCAGGAATCTCAGAGGATTTGAAAAAGGTGAAGGACAGGATGGGCATTGACAGTAGTGAT
AAAGTGGACTTCTTCATCCTCCTGGACAACGTGGCTGCCGAGCAGGCACACAACCTCCCAAGCTGCCCCATGCTGAAGAGATTTGCAAGG
ATGATCGAACAGAGAGCTGTGGACACATCCTTGTACATACTGCCCAAGGAAGACAGGGAAAGTCTTCAGATGGCAGTAGGCCCATTCCTC
CACATCCTAGAGAGCAACCTGCTGAAAGCCGTGGACTCTGCCACTGCCCCCGACAAGATCAGAAAGCTGTATCTCTATGCGGCTCATGAT
GTGACCTTCATACCGCTCTTAATGACCCTGGGGATTTTTGACCACAAATGGCCACCGTTTGCTGTTGACCTGACCATGGAACTTTACCAG
CACCTGGAATCTAAGGAGTGGTTTGTGCAGCTCTATTACCACGGGAAGGAGCAGGTGCCGAGAGGTTGCCCTGATGGGCTCTGCCCGCTG
GACATGTTCTTGAATGCCATGTCAGTTTATACCTTAAGCCCAGAAAAATACCACGCACTCTGCTCTCAAACTCAGGTGATGGAAGTTGGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_ARHGEF3_ENST00000338458_chr3_56916320_-_ACP6_ENST00000369238_chr1_147131890_-_6561nt
AGCCCAGGGGAGCCGCCGCCGCAGCCGCCGCCGCCGCGGTGAGTTTTCCAGCCTGGAGAGGCCGAACCAGCGCGGGGGTCGAGGAGACCT
GAGCCTGCCATACTGAGTCTATGGACAGTTCCACAGCAATGAATCAATGCAGCTGTAGAGGAATGGAAGAAAACAAGGAAAGGCCTAAAC
GGCAGCGGCAAAACAACTTTCCCATGTTTCCCTCTCCTAAAGCCTGGAATTTCAGAGGGCGAAAACGGAAACAGAGCACCCAAGATGAAG
ATGCTGTTAGCCTTTGCAGTCTCGACATAAGTGTAGAGTGGAACCCCCAGCTATTAGAGGTCCCACCCCAAACTCAGTTTGATTACACAG
TCACCAATCTAGCTGGTGGTCCGAAACCATATTCTCCTTACGACTCTCAATACCATGAGACCACCCTGAAGGGGGGCATGTTTGCTGGGC
AGCTGACCAAGGTGGGCATGCAGCAAATGTTTGCCTTGGGAGAGAGACTGAGGAAGAACTATGTGGAAGACATTCCCTTTCTTTCACCAA
CCTTCAACCCACAGGAGGTCTTTATTCGTTCCACTAACATTTTTCGGAATCTGGAGTCCACCCGTTGTTTGCTGGCTGGGCTTTTCCAGT
GTCAGAAAGAAGGACCCATCATCATCCACACTGATGAAGCAGATTCAGAAGTCTTGTATCCCAACTACCAAAGCTGCTGGAGCCTGAGGC
AGAGAACCAGAGGCCGGAGGCAGACTGCCTCTTTACAGCCAGGAATCTCAGAGGATTTGAAAAAGGTGAAGGACAGGATGGGCATTGACA
GTAGTGATAAAGTGGACTTCTTCATCCTCCTGGACAACGTGGCTGCCGAGCAGGCACACAACCTCCCAAGCTGCCCCATGCTGAAGAGAT
TTGCAAGGATGATCGAACAGAGAGCTGTGGACACATCCTTGTACATACTGCCCAAGGAAGACAGGGAAAGTCTTCAGATGGCAGTAGGCC
CATTCCTCCACATCCTAGAGAGCAACCTGCTGAAAGCCGTGGACTCTGCCACTGCCCCCGACAAGATCAGAAAGCTGTATCTCTATGCGG
CTCATGATGTGACCTTCATACCGCTCTTAATGACCCTGGGGATTTTTGACCACAAATGGCCACCGTTTGCTGTTGACCTGACCATGGAAC
TTTACCAGCACCTGGAATCTAAGGAGTGGTTTGTGCAGCTCTATTACCACGGGAAGGAGCAGGTGCCGAGAGGTTGCCCTGATGGGCTCT
GCCCGCTGGACATGTTCTTGAATGCCATGTCAGTTTATACCTTAAGCCCAGAAAAATACCACGCACTCTGCTCTCAAACTCAGGTGATGG
AAGTTGGAAATGAAGAGTAACTGATTTATAAAAGCAGGATGTGTTGATTTTAAAATAAAGTGCCTTTATACAATGCCTCCTGCTTTGTGT
GTTTGGGAAGAGGAGAGAGCAAGGGGTAATGTACTTTAATATAATGTAAGGATATTTCCTTTCTGTGGGTTTACTAAGATTTCTTCCTGA
ACGGAAAAGGGGTATAATATTGAGACCAAAAGGATATTTCTCTATTTTGTGAGTTGGTTTCTAAGGTTAGAAGCATCTTTGTGTGACACG
GGCTGGGGACATCATGACCCTGTAGAATTGTGTCGGTTTTGGACTTTAGTTCTTTTCTCCTATATTAATTTCACATGTATTGAGCTACCT
ACTAAGTAGTGATCATTATAAAGGTGAAAACACTCTGCCCTCAAGTTGTTGCAGTCCAGTGGGAGAGGCAGCCGAGTAAATCAGTGATAC
AGTGCTGTATGTTTTATGCTGTAATAGGTATTTGAGGGGCTATTTGGGTATAGAGAAGAAACTTCCTGCTCACATGGCAGGGGATGTGGG
GAACAGTCAAGGAAGGCTTCTGAAAAAGTCCTGGCCTGATCTGAGTAGAGAAAGGTGGGTAGGAGTTAACCAGGAAAGCAAGGATGAAAG
CGTGTTGCGTTTAGATAAAGGATAGGCTTCAAGGTCAGGGAACGTTGCTGGGTGGTGAGATGGAACCCTGATGTGGAGGCTCAGCAGGAA
GAAGCAGGAAGGACACTGGGCCCCTGGTGGTTTTAGTTCCAGAAACAAATGTGGGCCCCAGGGCTCTGCAATGGTAAGGCTGGAACTACT
CAACATAAGAGCTCCACCTTTAACTGTGCCCCCTAAGAGTACCTGATGATCCCCCTATCTCCTTGTCAATGTTGCTGTTCTTCTCCAGAA
TCTATTTCAACCCTTCTCTGATTTCAAACCACCAGTCCCTTTACCTCTCAGAGAAAACAGCAACCACAAAAGCCTCTCCACTTCCTACTA
TCTTAATATTGACAACTTCCAGATCAGGGAGCTGAGATATCTCAAGCTCAGGTTTCTCTTCTGAGCTTCAGACGCTTTTATCCACTTGGA
TTTCACTGGCACAAAACTTTCCATGTTAGAATCAAACCCCCCTCCTCCCAGACCTGCTTCTCCCACACACTTCCCTATCTGAATGAAAGA
CACCTCCACTCTCCACCCAGTTGCCAAATCAGAAATCTGTCTTTGTTTTCTTTGTCTCACATTTTCCTATGTCTAATCAGTTAAGTTTTA
TCAATACTACCTGTTTATTTCTTTAATCTATTCACATATCTTTATCCTCAATCTTCAGCATCCCCTTCCCATCCTCAGTCTGCTGGTTAC
TGTATTTCCTATTTTACTAAGAATCTAAAAGAGATCAGAAGAAAACTTCCACATCCCCCAACACCCAACCACCAAATCTGCTAACCCAGT
TGCATTGGTGCTTTTATAGCCTTCCTTCCTCCCTCTTACTAAGAATGAACCAACACTATTCCTATCAAAGCCCAACCCTCTAGCTTTACA
TTGACTCCTAGTGTCTTTTTTCTGGATTGTCAATTTTTTTCCTGACCAATTATTCTATTAGCAATACAAATATGCTGTAAAATCTCTTAA
ACTTTTTTCTCTGCATCTTTGAACTGCTGTTCTCTTTTCCTTCTCCCCTTCATAGCAGAACTCCTCAAAAGAGTTGCTACCTCTAATTCT
TCCCTTCCAGTTCTCTCATGAACCAGCTACAATTAAGTATTCACCCCCACCACTCCATGGAAACTGCTCTTGTCAAAATCATCAATAGCC
TTTGTGTGGTGAATCCAATAGCCAGTTTTCATTCTTCTTACTAAGCTTCTCATCAGTATTCCTAGACTATTTCCTTCACTGGCTTCGACA
AATGCTTTCTTGGTTTTCCTCCAATTTCTCGACTTTGTTCCTGCTGAATCTACCTTTTTCTAATCCGTAAGTGTTGGGGTGTCCCAGGGC
TTACTCCTTGGACCTTTTTTCCACCTTTTCCCCTACACTCACCCACTAGGTGATCTCAAGAATTTCCAGTTTGAGGCCGGGCGCGGTGGC
TCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACCTGAGGCCAGGAGTTCGAGACCAGCCTGGCCAACATGGCAAA
ACCCTGTCTCCACTAAACCTGCCTCTACTAAAAATACAAAAATTATTATATTTTTATAAAATTATTATAATTTTATAAAATTATTATATT
TATGGAGTACAATGTGATGTAATCCCAGCTACTCGGAAGGCTGTATGTGTCTATTTATGGAGTACAATGTGCCTGTAATCCCAGCTACTT
GGGAGGCTGAGGCAGGAGAATCACTTCAACCTAGGAGGCAGAGGTTGTGCTGAGCCAAGATCGTGCCATTGCACTCCAGCCTGGGCAACA
AGAGAGAAATAACATCTCAAAAAAAAAAAAAAAGAATTTCCAGTTTTAAATATTTACACAATGTCTCCTAAATTTATACCTTCAACCTAG
ACCTTTCCCTGTGAATCCCAGTCTCATTTCCAACAGTCTAATCAATGTCTCTATTTGGATGTTTAAGATATACAATAGGTATCAAACTTC
CCATTGTCCACAATAAACTCTCAATTTCCGTGCCTTTTCAAACTTACTCCTTCCACAGGCTTTCCCATCTAGGTAAATGACACCACCATT
CACCCTGTTGCTTTGGCCAAGAACTTTAGAACTGCCCTTGACTCCCCTCTTTTTCTCATATCCTACCTCTACTACATCAGTAACTCCTGT
TGTATCTCTCTTCAAACTATATCCAGAATTGACCATGTCCCAATACTTCCATTGCTACTGTCTTAGTCCCAGTGTCATCTTTTACCTGGA
TTATTGTAAAGGCCTCGTAACTAGTCTTCCTGTTTCTGCCCTTCCCTTCTCTGCCCATCTATTCTCAACACAGTGTTGCTTTTAAAACAA
AGTAAGATCGTGCCACTCTTCTGCTCTAAATTCCCCATTGGTTTCTCATCTCAAACTAAGGGCCAGTCATAATGCCCTCACGGTCCTATG
ACATCTCACTGCACCCCAGCCATACTCGCCATCTTACCATTCTTCTTCTTTTTTGTAATAAAAACTTTTTACTTTCTTTTTAGTTGACAG
ATAATAATTGCGTATATTTATGGAGTACAATGTGATGTTTTGATATATGTATGCATGAGGGAATGATTAAATCAAGCTAATTAACATATT
CATCACTTCATCTACTCATCACTTTCTTGTGGTGAAAATGTTTCAGATATACTCTTTAGTAGTTTTCAGGTGTACAGTCGCTGTGGTTTG
AGTGCTTTTGTCTTCTCTAAATTTGATGTTGACACTTAGTGCCCAGTACAATGTTACTGGGAGGTGGAGCCTAATGGGGATGTTTAATGG
ATTAATGCCATTATAAAAAGGGCTTGCAGGAATGGGTTCCTTCTCTTTTGCTTTTCTGCCATATGATGACAAAGTGTTCCTCCTCTCTGG
AGGATGCAGCAACAGGCACCATCTTTGAAGCAGAGAGACCAGGCCCTAACCTTCTGGTGCCTTGATCTTGGACTTCTCAGCTTCCAGAAC
TGTGAGATAATAAATTTCTGTTCATTACAAATTACCCCATCTGTGGTATTCTGTTATAGCAACACAAAATGGACTAAGACAACAGTATAC
TGTTATGAACTATGGTCACCATGCTGTGCACTAGATCACAAAAACTTATTTCTACTGTTTAACTGAAACTTTGTACATTTTGACTAACAT
CTCCCTTTTTCCCATCATCCCATCCCATTCTTACTATCGTTGAAGATGGAGTATGCCAAGTAGTCCTGAGCCATGTCCTCACCTCGGGGT
GAGCACCTGTTGTTCCTGTGCCTGGAATGCTCTCCTAGACATTTGCGTGGCTAGCTCCCTCTTTTCATTCAGATCTCAGCTCATTGTCAT
CTCAGAGAGGCCCTCCTTGCCCTCCTTCTACCTCCTGCCTTAGGTATACTCTGCCACCTTCTGTCATGGGCTGAATTGTGTCCCCCCTAA
ATCCATATGTTGACATCTTAACCCCTAGTACAGTAAGTCCTCACTTGATGCTATCAATAGGCTCTTGGAAATGTCGGCTTTCAGTGAAAG
GACATATAGCAGGTCCTTGAATAACATTGTGTTTTGTTCAACATCGTTGCCTTGTAACACTGATGAGCAAAACAGTTGGTTCTCTAATAT
GTTGTTTTACTTAAAGCTACAGTTTCCAAGAACCTATCAATGATGTTGAGGACTGAATGTACCTCAGGTGTAATGTATTTGGAGATAGGG
CCTTTTAAGAGGTAAAGTAAATGAGGTCATATGGGTAGGCTGTAATCCAATATGACTGGAATCCTTATAAGAAGAGGAAATGAGGACACA
GACACAGAGGGAAGATGACTATCTGCAAGTCAAGGAGAGAGGCCTCAGAAGAAACCAATGCTGCTGACACCACGATCTTGGACTTCTAGC
CTCTAGCACTGTGAGGAAATAAATTTCTGTTGTTTAAGCCACCTAGTCTGTGATACTTTGCTACGGCAGGCCCTAGCAAATGAATACACT
TGTCTTGTCTTTCCCCCGCCCTGTGATATTTATCAGTGCCGGATATTACATATTTGTGTATCTATATGCTTATTTCCCTGACTAAAATGG
AAGCTCCATGAAGGCAGATTTCCTCTTGTTCACTGATGTGTCCCCAGCACCTGGAATAGTGCCTAGTGCATGCCAGTGCTCAGACACTTG
GACATTTGAATGACATATCCCCTCTGTCACTTCTCTCCGGGGCCCAAGGCCACCCTCCTAGGTTACCACAGTGGCTTCCTAATGGGCCAT
ACCCTCACTTGCTTTCCATCACCCCCTGAGACCTGGCCCCTGCATACCTCTCCAGCTTCACCCCTCACATATCTCCCTAGCCAGACCTAT
AGTATGTTTTAAAAAAAAAGGAAATCGCACTCCTCTGGCCTCTTTACCTTGGCACACATTTTTCCATCACCTGACCCCTGACCCACACTC
CCTTTTCCTGTGTAATCCAATTATCTCTAGGCCTCCCGTGTTTCTGTTTGTCCTTCAATAGAAGGTTGTTTGTCTTGTCTTTTATTGTAT

>In-frame_ARHGEF3_ENST00000496106_chr3_56916320_-_ACP6_ENST00000369238_chr1_147131890_-_6485nt
ATGCAGCCCAAGTGGCGGGGAGGAGTTCCTTCAGGGAAACTATGCTCAGCCCTGTTCAGAGAATCCTGTGCACAGGGCTCCACTGCAGTT
AGGAGCCGGTGAGTCCGGGTGGATGAGGTCAGAGCGCCCCATGGTGTGGTGCTGCCTCTTTGTCCGTTCGCAGCGAAAACGGAAACAGAG
CACCCAAGATGAAGATGCTGTTAGCCTTTGCAGTCTCGACATAAGTGTAGAGTGGAACCCCCAGCTATTAGAGGTCCCACCCCAAACTCA
GTTTGATTACACAGTCACCAATCTAGCTGGTGGTCCGAAACCATATTCTCCTTACGACTCTCAATACCATGAGACCACCCTGAAGGGGGG
CATGTTTGCTGGGCAGCTGACCAAGGTGGGCATGCAGCAAATGTTTGCCTTGGGAGAGAGACTGAGGAAGAACTATGTGGAAGACATTCC
CTTTCTTTCACCAACCTTCAACCCACAGGAGGTCTTTATTCGTTCCACTAACATTTTTCGGAATCTGGAGTCCACCCGTTGTTTGCTGGC
TGGGCTTTTCCAGTGTCAGAAAGAAGGACCCATCATCATCCACACTGATGAAGCAGATTCAGAAGTCTTGTATCCCAACTACCAAAGCTG
CTGGAGCCTGAGGCAGAGAACCAGAGGCCGGAGGCAGACTGCCTCTTTACAGCCAGGAATCTCAGAGGATTTGAAAAAGGTGAAGGACAG
GATGGGCATTGACAGTAGTGATAAAGTGGACTTCTTCATCCTCCTGGACAACGTGGCTGCCGAGCAGGCACACAACCTCCCAAGCTGCCC
CATGCTGAAGAGATTTGCAAGGATGATCGAACAGAGAGCTGTGGACACATCCTTGTACATACTGCCCAAGGAAGACAGGGAAAGTCTTCA
GATGGCAGTAGGCCCATTCCTCCACATCCTAGAGAGCAACCTGCTGAAAGCCGTGGACTCTGCCACTGCCCCCGACAAGATCAGAAAGCT
GTATCTCTATGCGGCTCATGATGTGACCTTCATACCGCTCTTAATGACCCTGGGGATTTTTGACCACAAATGGCCACCGTTTGCTGTTGA
CCTGACCATGGAACTTTACCAGCACCTGGAATCTAAGGAGTGGTTTGTGCAGCTCTATTACCACGGGAAGGAGCAGGTGCCGAGAGGTTG
CCCTGATGGGCTCTGCCCGCTGGACATGTTCTTGAATGCCATGTCAGTTTATACCTTAAGCCCAGAAAAATACCACGCACTCTGCTCTCA
AACTCAGGTGATGGAAGTTGGAAATGAAGAGTAACTGATTTATAAAAGCAGGATGTGTTGATTTTAAAATAAAGTGCCTTTATACAATGC
CTCCTGCTTTGTGTGTTTGGGAAGAGGAGAGAGCAAGGGGTAATGTACTTTAATATAATGTAAGGATATTTCCTTTCTGTGGGTTTACTA
AGATTTCTTCCTGAACGGAAAAGGGGTATAATATTGAGACCAAAAGGATATTTCTCTATTTTGTGAGTTGGTTTCTAAGGTTAGAAGCAT
CTTTGTGTGACACGGGCTGGGGACATCATGACCCTGTAGAATTGTGTCGGTTTTGGACTTTAGTTCTTTTCTCCTATATTAATTTCACAT
GTATTGAGCTACCTACTAAGTAGTGATCATTATAAAGGTGAAAACACTCTGCCCTCAAGTTGTTGCAGTCCAGTGGGAGAGGCAGCCGAG
TAAATCAGTGATACAGTGCTGTATGTTTTATGCTGTAATAGGTATTTGAGGGGCTATTTGGGTATAGAGAAGAAACTTCCTGCTCACATG
GCAGGGGATGTGGGGAACAGTCAAGGAAGGCTTCTGAAAAAGTCCTGGCCTGATCTGAGTAGAGAAAGGTGGGTAGGAGTTAACCAGGAA
AGCAAGGATGAAAGCGTGTTGCGTTTAGATAAAGGATAGGCTTCAAGGTCAGGGAACGTTGCTGGGTGGTGAGATGGAACCCTGATGTGG
AGGCTCAGCAGGAAGAAGCAGGAAGGACACTGGGCCCCTGGTGGTTTTAGTTCCAGAAACAAATGTGGGCCCCAGGGCTCTGCAATGGTA
AGGCTGGAACTACTCAACATAAGAGCTCCACCTTTAACTGTGCCCCCTAAGAGTACCTGATGATCCCCCTATCTCCTTGTCAATGTTGCT
GTTCTTCTCCAGAATCTATTTCAACCCTTCTCTGATTTCAAACCACCAGTCCCTTTACCTCTCAGAGAAAACAGCAACCACAAAAGCCTC
TCCACTTCCTACTATCTTAATATTGACAACTTCCAGATCAGGGAGCTGAGATATCTCAAGCTCAGGTTTCTCTTCTGAGCTTCAGACGCT
TTTATCCACTTGGATTTCACTGGCACAAAACTTTCCATGTTAGAATCAAACCCCCCTCCTCCCAGACCTGCTTCTCCCACACACTTCCCT
ATCTGAATGAAAGACACCTCCACTCTCCACCCAGTTGCCAAATCAGAAATCTGTCTTTGTTTTCTTTGTCTCACATTTTCCTATGTCTAA
TCAGTTAAGTTTTATCAATACTACCTGTTTATTTCTTTAATCTATTCACATATCTTTATCCTCAATCTTCAGCATCCCCTTCCCATCCTC
AGTCTGCTGGTTACTGTATTTCCTATTTTACTAAGAATCTAAAAGAGATCAGAAGAAAACTTCCACATCCCCCAACACCCAACCACCAAA
TCTGCTAACCCAGTTGCATTGGTGCTTTTATAGCCTTCCTTCCTCCCTCTTACTAAGAATGAACCAACACTATTCCTATCAAAGCCCAAC
CCTCTAGCTTTACATTGACTCCTAGTGTCTTTTTTCTGGATTGTCAATTTTTTTCCTGACCAATTATTCTATTAGCAATACAAATATGCT
GTAAAATCTCTTAAACTTTTTTCTCTGCATCTTTGAACTGCTGTTCTCTTTTCCTTCTCCCCTTCATAGCAGAACTCCTCAAAAGAGTTG
CTACCTCTAATTCTTCCCTTCCAGTTCTCTCATGAACCAGCTACAATTAAGTATTCACCCCCACCACTCCATGGAAACTGCTCTTGTCAA
AATCATCAATAGCCTTTGTGTGGTGAATCCAATAGCCAGTTTTCATTCTTCTTACTAAGCTTCTCATCAGTATTCCTAGACTATTTCCTT
CACTGGCTTCGACAAATGCTTTCTTGGTTTTCCTCCAATTTCTCGACTTTGTTCCTGCTGAATCTACCTTTTTCTAATCCGTAAGTGTTG
GGGTGTCCCAGGGCTTACTCCTTGGACCTTTTTTCCACCTTTTCCCCTACACTCACCCACTAGGTGATCTCAAGAATTTCCAGTTTGAGG
CCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACCTGAGGCCAGGAGTTCGAGACCAGCCTG
GCCAACATGGCAAAACCCTGTCTCCACTAAACCTGCCTCTACTAAAAATACAAAAATTATTATATTTTTATAAAATTATTATAATTTTAT
AAAATTATTATATTTATGGAGTACAATGTGATGTAATCCCAGCTACTCGGAAGGCTGTATGTGTCTATTTATGGAGTACAATGTGCCTGT
AATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTCAACCTAGGAGGCAGAGGTTGTGCTGAGCCAAGATCGTGCCATTGCACTC
CAGCCTGGGCAACAAGAGAGAAATAACATCTCAAAAAAAAAAAAAAAGAATTTCCAGTTTTAAATATTTACACAATGTCTCCTAAATTTA
TACCTTCAACCTAGACCTTTCCCTGTGAATCCCAGTCTCATTTCCAACAGTCTAATCAATGTCTCTATTTGGATGTTTAAGATATACAAT
AGGTATCAAACTTCCCATTGTCCACAATAAACTCTCAATTTCCGTGCCTTTTCAAACTTACTCCTTCCACAGGCTTTCCCATCTAGGTAA
ATGACACCACCATTCACCCTGTTGCTTTGGCCAAGAACTTTAGAACTGCCCTTGACTCCCCTCTTTTTCTCATATCCTACCTCTACTACA
TCAGTAACTCCTGTTGTATCTCTCTTCAAACTATATCCAGAATTGACCATGTCCCAATACTTCCATTGCTACTGTCTTAGTCCCAGTGTC
ATCTTTTACCTGGATTATTGTAAAGGCCTCGTAACTAGTCTTCCTGTTTCTGCCCTTCCCTTCTCTGCCCATCTATTCTCAACACAGTGT
TGCTTTTAAAACAAAGTAAGATCGTGCCACTCTTCTGCTCTAAATTCCCCATTGGTTTCTCATCTCAAACTAAGGGCCAGTCATAATGCC
CTCACGGTCCTATGACATCTCACTGCACCCCAGCCATACTCGCCATCTTACCATTCTTCTTCTTTTTTGTAATAAAAACTTTTTACTTTC
TTTTTAGTTGACAGATAATAATTGCGTATATTTATGGAGTACAATGTGATGTTTTGATATATGTATGCATGAGGGAATGATTAAATCAAG
CTAATTAACATATTCATCACTTCATCTACTCATCACTTTCTTGTGGTGAAAATGTTTCAGATATACTCTTTAGTAGTTTTCAGGTGTACA
GTCGCTGTGGTTTGAGTGCTTTTGTCTTCTCTAAATTTGATGTTGACACTTAGTGCCCAGTACAATGTTACTGGGAGGTGGAGCCTAATG
GGGATGTTTAATGGATTAATGCCATTATAAAAAGGGCTTGCAGGAATGGGTTCCTTCTCTTTTGCTTTTCTGCCATATGATGACAAAGTG
TTCCTCCTCTCTGGAGGATGCAGCAACAGGCACCATCTTTGAAGCAGAGAGACCAGGCCCTAACCTTCTGGTGCCTTGATCTTGGACTTC
TCAGCTTCCAGAACTGTGAGATAATAAATTTCTGTTCATTACAAATTACCCCATCTGTGGTATTCTGTTATAGCAACACAAAATGGACTA
AGACAACAGTATACTGTTATGAACTATGGTCACCATGCTGTGCACTAGATCACAAAAACTTATTTCTACTGTTTAACTGAAACTTTGTAC
ATTTTGACTAACATCTCCCTTTTTCCCATCATCCCATCCCATTCTTACTATCGTTGAAGATGGAGTATGCCAAGTAGTCCTGAGCCATGT
CCTCACCTCGGGGTGAGCACCTGTTGTTCCTGTGCCTGGAATGCTCTCCTAGACATTTGCGTGGCTAGCTCCCTCTTTTCATTCAGATCT
CAGCTCATTGTCATCTCAGAGAGGCCCTCCTTGCCCTCCTTCTACCTCCTGCCTTAGGTATACTCTGCCACCTTCTGTCATGGGCTGAAT
TGTGTCCCCCCTAAATCCATATGTTGACATCTTAACCCCTAGTACAGTAAGTCCTCACTTGATGCTATCAATAGGCTCTTGGAAATGTCG
GCTTTCAGTGAAAGGACATATAGCAGGTCCTTGAATAACATTGTGTTTTGTTCAACATCGTTGCCTTGTAACACTGATGAGCAAAACAGT
TGGTTCTCTAATATGTTGTTTTACTTAAAGCTACAGTTTCCAAGAACCTATCAATGATGTTGAGGACTGAATGTACCTCAGGTGTAATGT
ATTTGGAGATAGGGCCTTTTAAGAGGTAAAGTAAATGAGGTCATATGGGTAGGCTGTAATCCAATATGACTGGAATCCTTATAAGAAGAG
GAAATGAGGACACAGACACAGAGGGAAGATGACTATCTGCAAGTCAAGGAGAGAGGCCTCAGAAGAAACCAATGCTGCTGACACCACGAT
CTTGGACTTCTAGCCTCTAGCACTGTGAGGAAATAAATTTCTGTTGTTTAAGCCACCTAGTCTGTGATACTTTGCTACGGCAGGCCCTAG
CAAATGAATACACTTGTCTTGTCTTTCCCCCGCCCTGTGATATTTATCAGTGCCGGATATTACATATTTGTGTATCTATATGCTTATTTC
CCTGACTAAAATGGAAGCTCCATGAAGGCAGATTTCCTCTTGTTCACTGATGTGTCCCCAGCACCTGGAATAGTGCCTAGTGCATGCCAG
TGCTCAGACACTTGGACATTTGAATGACATATCCCCTCTGTCACTTCTCTCCGGGGCCCAAGGCCACCCTCCTAGGTTACCACAGTGGCT
TCCTAATGGGCCATACCCTCACTTGCTTTCCATCACCCCCTGAGACCTGGCCCCTGCATACCTCTCCAGCTTCACCCCTCACATATCTCC
CTAGCCAGACCTATAGTATGTTTTAAAAAAAAAGGAAATCGCACTCCTCTGGCCTCTTTACCTTGGCACACATTTTTCCATCACCTGACC
CCTGACCCACACTCCCTTTTCCTGTGTAATCCAATTATCTCTAGGCCTCCCGTGTTTCTGTTTGTCCTTCAATAGAAGGTTGTTTGTCTT
GTCTTTTATTGTATTTCTAGAACCAAGTGCAGAGACTGTACAAAGTGGACCTCAGCAAAGATTTACCGAATGAATAAATGAGTTCAGAAC


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FusionGenePPI for ARHGEF3_ACP6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARHGEF3RHOA, RHOB, TRIM23, TRIM27, CEP70, SHMT2, NXF1, XPO1ACP6ILK, RGS10, RSU1, DHX36, DHCR7, LIMS1, ERH, SLC35F6, GNG7, FAM9B, ACP6, NME4, STOML2, ECH1, CYCS, NRD1, PMPCB, PMPCA, ACN9, BOLA3, C1QBP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARHGEF3_ACP6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARHGEF3_ACP6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource