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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25713

FusionGeneSummary for PABPC1L_PKIG

check button Fusion gene summary
Fusion gene informationFusion gene name: PABPC1L_PKIG
Fusion gene ID: 25713
HgeneTgene
Gene symbol

PABPC1L

PKIG

Gene ID

80336

11142

Gene namepoly(A) binding protein cytoplasmic 1 likecAMP-dependent protein kinase inhibitor gamma
SynonymsC20orf119|EPAB|PABPC1L1|dJ1069P2.3PKI-gamma
Cytomap

20q13.12

20q13.12

Type of geneprotein-codingprotein-coding
Descriptionpolyadenylate-binding protein 1-likeembryonic poly(A) binding proteincAMP-dependent protein kinase inhibitor gammaprotein kinase (cAMP-dependent, catalytic) inhibitor gamma
Modification date2018052320180523
UniProtAcc

Q4VXU2

Q9Y2B9

Ensembl transtripts involved in fusion geneENST00000217074, ENST00000255136, 
ENST00000537323, ENST00000217073, 
ENST00000490798, ENST00000372824, 
ENST00000372819, ENST00000217075, 
ENST00000372891, ENST00000372894, 
ENST00000372892, ENST00000372889, 
ENST00000372887, ENST00000372882, 
ENST00000477390, ENST00000372886, 
ENST00000349959, 
Fusion gene scores* DoF score3 X 3 X 2=184 X 4 X 4=64
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PABPC1L [Title/Abstract] AND PKIG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-AX-A2H4-01APABPC1Lchr20

43561826

+PKIGchr20

43227257

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000217074ENST00000372891PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
intron-intronENST00000217074ENST00000372894PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
intron-intronENST00000217074ENST00000372892PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
intron-5UTRENST00000217074ENST00000372889PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
intron-intronENST00000217074ENST00000372887PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
intron-intronENST00000217074ENST00000372882PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
intron-intronENST00000217074ENST00000477390PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
intron-intronENST00000217074ENST00000372886PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
intron-intronENST00000217074ENST00000349959PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000255136ENST00000372891PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000255136ENST00000372894PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000255136ENST00000372892PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-5UTRENST00000255136ENST00000372889PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000255136ENST00000372887PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000255136ENST00000372882PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000255136ENST00000477390PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000255136ENST00000372886PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000255136ENST00000349959PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
3UTR-intronENST00000537323ENST00000372891PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
3UTR-intronENST00000537323ENST00000372894PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
3UTR-intronENST00000537323ENST00000372892PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
3UTR-5UTRENST00000537323ENST00000372889PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
3UTR-intronENST00000537323ENST00000372887PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
3UTR-intronENST00000537323ENST00000372882PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
3UTR-intronENST00000537323ENST00000477390PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
3UTR-intronENST00000537323ENST00000372886PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
3UTR-intronENST00000537323ENST00000349959PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000217073ENST00000372891PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000217073ENST00000372894PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000217073ENST00000372892PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-5UTRENST00000217073ENST00000372889PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000217073ENST00000372887PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000217073ENST00000372882PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000217073ENST00000477390PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000217073ENST00000372886PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000217073ENST00000349959PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
intron-intronENST00000490798ENST00000372891PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
intron-intronENST00000490798ENST00000372894PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
intron-intronENST00000490798ENST00000372892PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
intron-5UTRENST00000490798ENST00000372889PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
intron-intronENST00000490798ENST00000372887PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
intron-intronENST00000490798ENST00000372882PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
intron-intronENST00000490798ENST00000477390PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
intron-intronENST00000490798ENST00000372886PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
intron-intronENST00000490798ENST00000349959PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000372824ENST00000372891PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000372824ENST00000372894PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000372824ENST00000372892PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-5UTRENST00000372824ENST00000372889PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000372824ENST00000372887PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000372824ENST00000372882PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000372824ENST00000477390PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000372824ENST00000372886PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000372824ENST00000349959PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000372819ENST00000372891PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000372819ENST00000372894PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000372819ENST00000372892PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-5UTRENST00000372819ENST00000372889PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000372819ENST00000372887PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000372819ENST00000372882PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000372819ENST00000477390PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000372819ENST00000372886PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000372819ENST00000349959PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000217075ENST00000372891PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000217075ENST00000372894PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000217075ENST00000372892PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-5UTRENST00000217075ENST00000372889PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000217075ENST00000372887PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000217075ENST00000372882PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000217075ENST00000477390PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000217075ENST00000372886PABPC1Lchr20

43561826

+PKIGchr20

43227257

+
5CDS-intronENST00000217075ENST00000349959PABPC1Lchr20

43561826

+PKIGchr20

43227257

+

Top

FusionProtFeatures for PABPC1L_PKIG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PABPC1L

Q4VXU2

PKIG

Q9Y2B9

Extremely potent competitive inhibitor of cAMP-dependentprotein kinase activity, this protein interacts with the catalyticsubunit of the enzyme after the cAMP-induced dissociation of itsregulatory chains. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PABPC1L_PKIG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PABPC1L_PKIG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PABPC1LPARK2, PAIP1, XPO1, CYLD, TRIM25PKIGRAB25, KPTN, RPA3, PRKACA, MEOX2, PRKACB, TYMS, TPM2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PABPC1L_PKIG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PABPC1L_PKIG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource