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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25675

FusionGeneSummary for P4HA1_MSS51

check button Fusion gene summary
Fusion gene informationFusion gene name: P4HA1_MSS51
Fusion gene ID: 25675
HgeneTgene
Gene symbol

P4HA1

MSS51

Gene ID

5033

118490

Gene nameprolyl 4-hydroxylase subunit alpha 1MSS51 mitochondrial translational activator
SynonymsP4HAZMYND17
Cytomap

10q22.1

10q22.2

Type of geneprotein-codingprotein-coding
Descriptionprolyl 4-hydroxylase subunit alpha-1C-P4Halpha(I)collagen prolyl 4-hydroxylase alpha(I)procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide Iprocollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1prolyputative protein MSS51 homolog, mitochondrialMSS51 mitochondrial translational activator homologzinc finger MYND domain-containing protein 17zinc finger, MYND domain containing 17zinc finger, MYND-type containing 17
Modification date2018052320180522
UniProtAcc

P13674

Q4VC12

Ensembl transtripts involved in fusion geneENST00000307116, ENST00000373008, 
ENST00000263556, ENST00000412021, 
ENST00000440381, ENST00000394890, 
ENST00000299432, ENST00000372912, 
Fusion gene scores* DoF score7 X 4 X 5=1402 X 2 X 2=8
# samples 73
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/8*10)=1.90689059560852
Context

PubMed: P4HA1 [Title/Abstract] AND MSS51 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-85-A50M-01AP4HA1chr10

74831787

-MSS51chr10

75188059

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000307116ENST00000299432P4HA1chr10

74831787

-MSS51chr10

75188059

-
5CDS-intronENST00000307116ENST00000372912P4HA1chr10

74831787

-MSS51chr10

75188059

-
5CDS-5UTRENST00000373008ENST00000299432P4HA1chr10

74831787

-MSS51chr10

75188059

-
5CDS-intronENST00000373008ENST00000372912P4HA1chr10

74831787

-MSS51chr10

75188059

-
5CDS-5UTRENST00000263556ENST00000299432P4HA1chr10

74831787

-MSS51chr10

75188059

-
5CDS-intronENST00000263556ENST00000372912P4HA1chr10

74831787

-MSS51chr10

75188059

-
5CDS-5UTRENST00000412021ENST00000299432P4HA1chr10

74831787

-MSS51chr10

75188059

-
5CDS-intronENST00000412021ENST00000372912P4HA1chr10

74831787

-MSS51chr10

75188059

-
5CDS-5UTRENST00000440381ENST00000299432P4HA1chr10

74831787

-MSS51chr10

75188059

-
5CDS-intronENST00000440381ENST00000372912P4HA1chr10

74831787

-MSS51chr10

75188059

-
5CDS-5UTRENST00000394890ENST00000299432P4HA1chr10

74831787

-MSS51chr10

75188059

-
5CDS-intronENST00000394890ENST00000372912P4HA1chr10

74831787

-MSS51chr10

75188059

-

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FusionProtFeatures for P4HA1_MSS51


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
P4HA1

P13674

MSS51

Q4VC12

Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and otherproteins.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for P4HA1_MSS51


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for P4HA1_MSS51


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
P4HA1MYC, SMN1, IRF7, CDK9, ELAVL1, CUL3, UBL4A, CFTR, HDAC10, WWOX, IRS4, AATK, TSC22D4, EVPL, P4HB, PSMD5, TCTN3, TCTN1, RBM8A, RNF41, CPSF3, SLAIN2, UBA5, FIP1L1, PARD6B, ZNF526, GLI1, FOXA3, FOXG1, FOXL2, FOXP3, FOXS1, CTDSP2, COLQMSS51SEMG1, SEMG2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for P4HA1_MSS51


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneP4HA1P13674DB01275HydralazineProlyl 4-hydroxylase subunit alpha-1small moleculeapproved
HgeneP4HA1P13674DB00126Vitamin CProlyl 4-hydroxylase subunit alpha-1small moleculeapproved|nutraceutical

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RelatedDiseases for P4HA1_MSS51


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMSS51C0036341Schizophrenia1PSYGENET