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Fusion gene ID: 25668 |
FusionGeneSummary for P2RX5_TRPV1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: P2RX5_TRPV1 | Fusion gene ID: 25668 | Hgene | Tgene | Gene symbol | P2RX5 | TRPV1 | Gene ID | 5026 | 7442 |
Gene name | purinergic receptor P2X 5 | transient receptor potential cation channel subfamily V member 1 | |
Synonyms | LRH-1|P2X5|P2X5R | VR1 | |
Cytomap | 17p13.2 | 17p13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | P2X purinoceptor 5ATP receptor subunitionotropic ATP receptor P2X5lymphoid-restricted histocompatibility antigen-1purinergic receptor P2X, ligand gated ion channel, 5 | transient receptor potential cation channel subfamily V member 1OTRPC1capsaicin receptorosm-9-like TRP channel 1transient receptor potential vanilloid 1atransient receptor potential vanilloid 1bvanilloid receptor subtype 1 | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | Q93086 | Q8NER1 | |
Ensembl transtripts involved in fusion gene | ENST00000552276, ENST00000435558, ENST00000551178, ENST00000547178, ENST00000225328, ENST00000345901, ENST00000552050, ENST00000550772, | ENST00000399759, ENST00000571088, ENST00000174621, ENST00000399756, ENST00000425167, ENST00000576351, ENST00000310522, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
# samples | 2 | 1 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: P2RX5 [Title/Abstract] AND TRPV1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TRPV1 | GO:0034605 | cellular response to heat | 11226139 |
Tgene | TRPV1 | GO:0050955 | thermoception | 10201375 |
Tgene | TRPV1 | GO:0071468 | cellular response to acidic pH | 11226139 |
Tgene | TRPV1 | GO:0098703 | calcium ion import across plasma membrane | 11226139 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-K1-A6RU-01A | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000552276 | ENST00000399759 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000552276 | ENST00000571088 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000552276 | ENST00000174621 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000552276 | ENST00000399756 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000552276 | ENST00000425167 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000552276 | ENST00000576351 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000552276 | ENST00000310522 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000435558 | ENST00000399759 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000435558 | ENST00000571088 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000435558 | ENST00000174621 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000435558 | ENST00000399756 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000435558 | ENST00000425167 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000435558 | ENST00000576351 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000435558 | ENST00000310522 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000551178 | ENST00000399759 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000551178 | ENST00000571088 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000551178 | ENST00000174621 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000551178 | ENST00000399756 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000551178 | ENST00000425167 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000551178 | ENST00000576351 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000551178 | ENST00000310522 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000547178 | ENST00000399759 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000547178 | ENST00000571088 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000547178 | ENST00000174621 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000547178 | ENST00000399756 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000547178 | ENST00000425167 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000547178 | ENST00000576351 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000547178 | ENST00000310522 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000225328 | ENST00000399759 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000225328 | ENST00000571088 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000225328 | ENST00000174621 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000225328 | ENST00000399756 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000225328 | ENST00000425167 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000225328 | ENST00000576351 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000225328 | ENST00000310522 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000345901 | ENST00000399759 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000345901 | ENST00000571088 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000345901 | ENST00000174621 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000345901 | ENST00000399756 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000345901 | ENST00000425167 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000345901 | ENST00000576351 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000345901 | ENST00000310522 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000552050 | ENST00000399759 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000552050 | ENST00000571088 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000552050 | ENST00000174621 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000552050 | ENST00000399756 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000552050 | ENST00000425167 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000552050 | ENST00000576351 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
Frame-shift | ENST00000552050 | ENST00000310522 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
intron-3CDS | ENST00000550772 | ENST00000399759 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
intron-3CDS | ENST00000550772 | ENST00000571088 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
intron-3CDS | ENST00000550772 | ENST00000174621 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
intron-3CDS | ENST00000550772 | ENST00000399756 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
intron-3CDS | ENST00000550772 | ENST00000425167 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
intron-3CDS | ENST00000550772 | ENST00000576351 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
intron-3CDS | ENST00000550772 | ENST00000310522 | P2RX5 | chr17 | 3582884 | - | TRPV1 | chr17 | 3475543 | - |
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FusionProtFeatures for P2RX5_TRPV1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
P2RX5 | TRPV1 |
Ligand-activated non-selective calcium permeant cationchannel involved in detection of noxious chemical and thermalstimuli. Seems to mediate proton influx and may be involved inintracellular acidosis in nociceptive neurons. Involved inmediation of inflammatory pain and hyperalgesia. Sensitized by aphosphatidylinositol second messenger system activated by receptortyrosine kinases, which involves PKC isozymes and PCL. Activationby vanilloids, like capsaicin, and temperatures higher than 42degrees Celsius, exhibits a time- and Ca(2+)-dependent outwardrectification, followed by a long-lasting refractory state. Mildextracellular acidic pH (6.5) potentiates channel activation bynoxious heat and vanilloids, whereas acidic conditions (pH <6)directly activate the channel. Can be activated by endogenouscompounds, including 12-hydroperoxytetraenoic acid and bradykinin.Acts as ionotropic endocannabinoid receptor with centralneuromodulatory effects. Triggers a form of long-term depression(TRPV1-LTD) mediated by the endocannabinoid anandamine in thehippocampus and nucleus accumbens by affecting AMPA receptorsendocytosis. {ECO:0000250|UniProtKB:O35433,ECO:0000269|PubMed:11050376, ECO:0000269|PubMed:11226139,ECO:0000269|PubMed:11243859, ECO:0000269|PubMed:12077606}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for P2RX5_TRPV1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for P2RX5_TRPV1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
P2RX5 | DNAJB9, FAM126A, STK17B, ITPA, ARV1, GALNS, TTC17, DPH1, CANX, USP30, BRAT1, PBXIP1, TNPO3, PDS5B, ADCK1, MSMO1, CLSTN1, TMEM131, MTFR1, WDR45B, NOP56, TIMM17A | TRPV1 | SYT9, SNAPIN, CALM1, TRPV1, OS9, EGFR, CBL, AKAP5 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for P2RX5_TRPV1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | TRPV1 | Q8NER1 | DB00316 | Acetaminophen | Transient receptor potential cation channel subfamily V member 1 | small molecule | approved |
Tgene | TRPV1 | Q8NER1 | DB06774 | Capsaicin | Transient receptor potential cation channel subfamily V member 1 | small molecule | approved |
Tgene | TRPV1 | Q8NER1 | DB09120 | Zucapsaicin | Transient receptor potential cation channel subfamily V member 1 | small molecule | approved|investigational |
Tgene | TRPV1 | Q8NER1 | DB09288 | Propacetamol | Transient receptor potential cation channel subfamily V member 1 | small molecule | approved|investigational |
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RelatedDiseases for P2RX5_TRPV1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TRPV1 | C0020429 | Hyperalgesia | 4 | CTD_human |
Tgene | TRPV1 | C0030193 | Pain | 4 | CTD_human |
Tgene | TRPV1 | C0021368 | Inflammation | 2 | CTD_human |
Tgene | TRPV1 | C0004153 | Atherosclerosis | 1 | CTD_human |
Tgene | TRPV1 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Tgene | TRPV1 | C0014556 | Epilepsy, Temporal Lobe | 1 | CTD_human |
Tgene | TRPV1 | C0014852 | Esophageal Diseases | 1 | CTD_human |
Tgene | TRPV1 | C0014868 | Esophagitis | 1 | CTD_human |
Tgene | TRPV1 | C0018834 | Heartburn | 1 | CTD_human |
Tgene | TRPV1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | TRPV1 | C0028754 | Obesity | 1 | CTD_human |
Tgene | TRPV1 | C0030305 | Pancreatitis | 1 | CTD_human |