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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25666

FusionGeneSummary for P2RX4_ZNF664

check button Fusion gene summary
Fusion gene informationFusion gene name: P2RX4_ZNF664
Fusion gene ID: 25666
HgeneTgene
Gene symbol

P2RX4

ZNF664

Gene ID

5025

144348

Gene namepurinergic receptor P2X 4zinc finger protein 664
SynonymsP2X4|P2X4RZFOC1|ZNF176
Cytomap

12q24.31

12q24.31

Type of geneprotein-codingprotein-coding
DescriptionP2X purinoceptor 4ATP receptorATP-gated cation channel proteinP2X receptor, subunit 4purinergic receptor P2X, ligand gated ion channel, 4purinergic receptor P2X4purinoceptor P2X4zinc finger protein 664zinc finger Organ of Corti 1zinc finger protein 176zinc finger protein from organ of Corti
Modification date2018052320180519
UniProtAcc

Q99571

Q8N3J9

Ensembl transtripts involved in fusion geneENST00000337233, ENST00000359949, 
ENST00000540930, ENST00000541532, 
ENST00000543171, 
ENST00000537532, 
ENST00000539644, ENST00000392404, 
ENST00000538932, ENST00000337815, 
Fusion gene scores* DoF score1 X 1 X 1=18 X 7 X 3=168
# samples 18
** MAII scorelog2(1/1*10)=3.32192809488736log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: P2RX4 [Title/Abstract] AND ZNF664 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneP2RX4

GO:0007165

signal transduction

9016352

HgeneP2RX4

GO:0010524

positive regulation of calcium ion transport into cytosol

10969036

HgeneP2RX4

GO:0033198

response to ATP

9016352

HgeneP2RX4

GO:0034220

ion transmembrane transport

10515189

HgeneP2RX4

GO:0034405

response to fluid shear stress

10969036

HgeneP2RX4

GO:0050850

positive regulation of calcium-mediated signaling

10969036

HgeneP2RX4

GO:0051899

membrane depolarization

9016352

HgeneP2RX4

GO:0070588

calcium ion transmembrane transport

9016352

HgeneP2RX4

GO:0071318

cellular response to ATP

10515189

HgeneP2RX4

GO:0097190

apoptotic signaling pathway

17264311


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-73-4668-01AP2RX4chr12

121648101

+ZNF664chr12

124495928

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000337233ENST00000537532P2RX4chr12

121648101

+ZNF664chr12

124495928

+
5CDS-5UTRENST00000337233ENST00000539644P2RX4chr12

121648101

+ZNF664chr12

124495928

+
5CDS-5UTRENST00000337233ENST00000392404P2RX4chr12

121648101

+ZNF664chr12

124495928

+
5CDS-5UTRENST00000337233ENST00000538932P2RX4chr12

121648101

+ZNF664chr12

124495928

+
5CDS-5UTRENST00000337233ENST00000337815P2RX4chr12

121648101

+ZNF664chr12

124495928

+
5CDS-3UTRENST00000359949ENST00000537532P2RX4chr12

121648101

+ZNF664chr12

124495928

+
5CDS-5UTRENST00000359949ENST00000539644P2RX4chr12

121648101

+ZNF664chr12

124495928

+
5CDS-5UTRENST00000359949ENST00000392404P2RX4chr12

121648101

+ZNF664chr12

124495928

+
5CDS-5UTRENST00000359949ENST00000538932P2RX4chr12

121648101

+ZNF664chr12

124495928

+
5CDS-5UTRENST00000359949ENST00000337815P2RX4chr12

121648101

+ZNF664chr12

124495928

+
3UTR-3UTRENST00000540930ENST00000537532P2RX4chr12

121648101

+ZNF664chr12

124495928

+
3UTR-5UTRENST00000540930ENST00000539644P2RX4chr12

121648101

+ZNF664chr12

124495928

+
3UTR-5UTRENST00000540930ENST00000392404P2RX4chr12

121648101

+ZNF664chr12

124495928

+
3UTR-5UTRENST00000540930ENST00000538932P2RX4chr12

121648101

+ZNF664chr12

124495928

+
3UTR-5UTRENST00000540930ENST00000337815P2RX4chr12

121648101

+ZNF664chr12

124495928

+
5CDS-3UTRENST00000541532ENST00000537532P2RX4chr12

121648101

+ZNF664chr12

124495928

+
5CDS-5UTRENST00000541532ENST00000539644P2RX4chr12

121648101

+ZNF664chr12

124495928

+
5CDS-5UTRENST00000541532ENST00000392404P2RX4chr12

121648101

+ZNF664chr12

124495928

+
5CDS-5UTRENST00000541532ENST00000538932P2RX4chr12

121648101

+ZNF664chr12

124495928

+
5CDS-5UTRENST00000541532ENST00000337815P2RX4chr12

121648101

+ZNF664chr12

124495928

+
5UTR-3UTRENST00000543171ENST00000537532P2RX4chr12

121648101

+ZNF664chr12

124495928

+
5UTR-5UTRENST00000543171ENST00000539644P2RX4chr12

121648101

+ZNF664chr12

124495928

+
5UTR-5UTRENST00000543171ENST00000392404P2RX4chr12

121648101

+ZNF664chr12

124495928

+
5UTR-5UTRENST00000543171ENST00000538932P2RX4chr12

121648101

+ZNF664chr12

124495928

+
5UTR-5UTRENST00000543171ENST00000337815P2RX4chr12

121648101

+ZNF664chr12

124495928

+

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FusionProtFeatures for P2RX4_ZNF664


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
P2RX4

Q99571

ZNF664

Q8N3J9

May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for P2RX4_ZNF664


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for P2RX4_ZNF664


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
P2RX4CDH5, WNT4, MCM2, KRTAP5-9, PIH1D3, NOTCH2NL, C17orf62, EIF2B5, EMC1, FDFT1, ARMCX3, FAM20B, EIF2B1, GALNT1, SPTLC2, TMEM246, HS2ST1, PIGH, TNPO3, ADCK4, EIF2B3, EIF2B4, SAAL1, EIF2B2, DNAJC19, KCNJ8, EMC7, PLD6, SPPL2B, CSGALNACT2, GLT8D1, ORC4ZNF664ELAVL1, VWCE, RGS20, RETN, ZNF227, IGFBP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for P2RX4_ZNF664


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneP2RX4Q99571DB09119Eslicarbazepine acetateP2X purinoceptor 4small moleculeapproved

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RelatedDiseases for P2RX4_ZNF664


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneP2RX4C0014544Epilepsy1CTD_human
HgeneP2RX4C0014556Epilepsy, Temporal Lobe1CTD_human