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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25663

FusionGeneSummary for OXSR1_SASH1

check button Fusion gene summary
Fusion gene informationFusion gene name: OXSR1_SASH1
Fusion gene ID: 25663
HgeneTgene
Gene symbol

OXSR1

SASH1

Gene ID

9943

23328

Gene nameoxidative stress responsive 1SAM and SH3 domain containing 1
SynonymsOSR1SH3D6A|dJ323M4.1
Cytomap

3p22.2

6q24.3-q25.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase OSR1oxidative stress-responsive 1 proteinSAM and SH3 domain-containing protein 1proline-glutamate repeat-containing protein
Modification date2018052320180523
UniProtAcc

O95747

O94885

Ensembl transtripts involved in fusion geneENST00000446845, ENST00000311806, 
ENST00000492714, 
ENST00000367469, 
ENST00000367467, ENST00000470750, 
Fusion gene scores* DoF score10 X 9 X 6=5407 X 6 X 4=168
# samples 107
** MAII scorelog2(10/540*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OXSR1 [Title/Abstract] AND SASH1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOXSR1

GO:0006468

protein phosphorylation

14707132

HgeneOXSR1

GO:0018107

peptidyl-threonine phosphorylation

24393035

HgeneOXSR1

GO:0035556

intracellular signal transduction

14707132

TgeneSASH1

GO:0000209

protein polyubiquitination

23776175

TgeneSASH1

GO:0010595

positive regulation of endothelial cell migration

23776175

TgeneSASH1

GO:1900044

regulation of protein K63-linked ubiquitination

23776175

TgeneSASH1

GO:1902498

regulation of protein autoubiquitination

23776175


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP368746OXSR1chr3

38295914

+SASH1chr6

148865017

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000446845ENST00000367469OXSR1chr3

38295914

+SASH1chr6

148865017

+
intron-intronENST00000446845ENST00000367467OXSR1chr3

38295914

+SASH1chr6

148865017

+
intron-intronENST00000446845ENST00000470750OXSR1chr3

38295914

+SASH1chr6

148865017

+
3UTR-intronENST00000311806ENST00000367469OXSR1chr3

38295914

+SASH1chr6

148865017

+
3UTR-intronENST00000311806ENST00000367467OXSR1chr3

38295914

+SASH1chr6

148865017

+
3UTR-intronENST00000311806ENST00000470750OXSR1chr3

38295914

+SASH1chr6

148865017

+
intron-intronENST00000492714ENST00000367469OXSR1chr3

38295914

+SASH1chr6

148865017

+
intron-intronENST00000492714ENST00000367467OXSR1chr3

38295914

+SASH1chr6

148865017

+
intron-intronENST00000492714ENST00000470750OXSR1chr3

38295914

+SASH1chr6

148865017

+

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FusionProtFeatures for OXSR1_SASH1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OXSR1

O95747

SASH1

O94885

Regulates downstream kinases in response toenvironmental stress. May also have a function in regulating theactin cytoskeleton. {ECO:0000269|PubMed:14707132,ECO:0000303|PubMed:14707132}. May have a role in a signaling pathway. Could act as atumor suppressor.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OXSR1_SASH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OXSR1_SASH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OXSR1_SASH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for OXSR1_SASH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneOXSR1C0020538Hypertensive disease1CTD_human
HgeneOXSR1C0036341Schizophrenia1PSYGENET