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Fusion gene ID: 25661 |
FusionGeneSummary for OXSR1_MYD88 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: OXSR1_MYD88 | Fusion gene ID: 25661 | Hgene | Tgene | Gene symbol | OXSR1 | MYD88 | Gene ID | 9943 | 4615 |
| Gene name | oxidative stress responsive 1 | myeloid differentiation primary response 88 | |
| Synonyms | OSR1 | MYD88D | |
| Cytomap | 3p22.2 | 3p22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase OSR1oxidative stress-responsive 1 protein | myeloid differentiation primary response protein MyD88mutant myeloid differentiation primary response 88myeloid differentiation primary response gene (88) | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | O95747 | Q99836 | |
| Ensembl transtripts involved in fusion gene | ENST00000446845, ENST00000311806, ENST00000492714, | ENST00000417037, ENST00000396334, ENST00000424893, ENST00000495303, ENST00000443433, ENST00000481122, | |
| Fusion gene scores | * DoF score | 10 X 9 X 6=540 | 2 X 3 X 2=12 |
| # samples | 10 | 2 | |
| ** MAII score | log2(10/540*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/12*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: OXSR1 [Title/Abstract] AND MYD88 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | OXSR1 | GO:0006468 | protein phosphorylation | 14707132 |
| Hgene | OXSR1 | GO:0018107 | peptidyl-threonine phosphorylation | 24393035 |
| Hgene | OXSR1 | GO:0035556 | intracellular signal transduction | 14707132 |
| Tgene | MYD88 | GO:0070935 | 3'-UTR-mediated mRNA stabilization | 15294994 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-52-7809-01A | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38182248 | + |
| TCGA | LD | LUSC | TCGA-52-7809-01A | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38181355 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000446845 | ENST00000417037 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38182248 | + |
| Frame-shift | ENST00000446845 | ENST00000396334 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38182248 | + |
| Frame-shift | ENST00000446845 | ENST00000424893 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38182248 | + |
| In-frame | ENST00000446845 | ENST00000495303 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38182248 | + |
| In-frame | ENST00000446845 | ENST00000443433 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38182248 | + |
| 5CDS-3UTR | ENST00000446845 | ENST00000481122 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38182248 | + |
| Frame-shift | ENST00000311806 | ENST00000417037 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38182248 | + |
| Frame-shift | ENST00000311806 | ENST00000396334 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38182248 | + |
| Frame-shift | ENST00000311806 | ENST00000424893 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38182248 | + |
| In-frame | ENST00000311806 | ENST00000495303 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38182248 | + |
| In-frame | ENST00000311806 | ENST00000443433 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38182248 | + |
| 5CDS-3UTR | ENST00000311806 | ENST00000481122 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38182248 | + |
| intron-3CDS | ENST00000492714 | ENST00000417037 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38182248 | + |
| intron-3CDS | ENST00000492714 | ENST00000396334 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38182248 | + |
| intron-3CDS | ENST00000492714 | ENST00000424893 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38182248 | + |
| intron-3CDS | ENST00000492714 | ENST00000495303 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38182248 | + |
| intron-3CDS | ENST00000492714 | ENST00000443433 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38182248 | + |
| intron-3UTR | ENST00000492714 | ENST00000481122 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38182248 | + |
| In-frame | ENST00000446845 | ENST00000417037 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38181355 | + |
| In-frame | ENST00000446845 | ENST00000396334 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38181355 | + |
| 5CDS-intron | ENST00000446845 | ENST00000424893 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38181355 | + |
| 5CDS-intron | ENST00000446845 | ENST00000495303 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38181355 | + |
| 5CDS-intron | ENST00000446845 | ENST00000443433 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38181355 | + |
| 5CDS-3UTR | ENST00000446845 | ENST00000481122 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38181355 | + |
| In-frame | ENST00000311806 | ENST00000417037 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38181355 | + |
| In-frame | ENST00000311806 | ENST00000396334 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38181355 | + |
| 5CDS-intron | ENST00000311806 | ENST00000424893 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38181355 | + |
| 5CDS-intron | ENST00000311806 | ENST00000495303 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38181355 | + |
| 5CDS-intron | ENST00000311806 | ENST00000443433 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38181355 | + |
| 5CDS-3UTR | ENST00000311806 | ENST00000481122 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38181355 | + |
| intron-3CDS | ENST00000492714 | ENST00000417037 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38181355 | + |
| intron-3CDS | ENST00000492714 | ENST00000396334 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38181355 | + |
| intron-intron | ENST00000492714 | ENST00000424893 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38181355 | + |
| intron-intron | ENST00000492714 | ENST00000495303 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38181355 | + |
| intron-intron | ENST00000492714 | ENST00000443433 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38181355 | + |
| intron-3UTR | ENST00000492714 | ENST00000481122 | OXSR1 | chr3 | 38232330 | + | MYD88 | chr3 | 38181355 | + |
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FusionProtFeatures for OXSR1_MYD88 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| OXSR1 | MYD88 |
| Regulates downstream kinases in response toenvironmental stress. May also have a function in regulating theactin cytoskeleton. {ECO:0000269|PubMed:14707132,ECO:0000303|PubMed:14707132}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | OXSR1 | chr3:38232330 | chr3:38181355 | ENST00000311806 | + | 3 | 18 | 23_31 | 97 | 528 | Nucleotide binding | ATP |
| Tgene | >MYD88 | chr3:38232330 | chr3:38181355 | ENST00000443433 | + | 0 | 4 | 159_296 | 122 | 205 | Domain | TIR |
| Tgene | >MYD88 | chr3:38232330 | chr3:38181355 | ENST00000495303 | + | 0 | 3 | 159_296 | -2 | 160 | Domain | TIR |
| Tgene | >MYD88 | chr3:38232330 | chr3:38181355 | ENST00000495303 | + | 0 | 3 | 54_109 | -2 | 160 | Domain | Death |
| Tgene | >MYD88 | chr3:38232330 | chr3:38181355 | ENST00000495303 | + | 0 | 3 | 110_155 | -2 | 160 | Region | Intermediate domain |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >OXSR1 | chr3:38232330 | chr3:38181355 | ENST00000311806 | + | 3 | 18 | 17_291 | 97 | 528 | Domain | Protein kinase |
| Tgene | MYD88 | chr3:38232330 | chr3:38181355 | ENST00000443433 | + | 0 | 4 | 54_109 | 122 | 205 | Domain | Death |
| Tgene | MYD88 | chr3:38232330 | chr3:38181355 | ENST00000443433 | + | 0 | 4 | 110_155 | 122 | 205 | Region | Intermediate domain |
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FusionGeneSequence for OXSR1_MYD88 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for OXSR1_MYD88 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| OXSR1 | ELAVL1, TGFBR1, TGFBR2, APP, RNASEH2C, CDK9, SLFN5, ANP32A, ADSL, API5, BTF3L4, UBA6, RPL17, USP5, AIFM1, MAD2L1, EGFR, RELL2, RELT, ACAD10, MARS, OARD1, PFKP, THUMPD1, NTRK1, BAG6, SNW1, CDC5L, RELL1, FGB, SNRNP27, ICMT | MYD88 | SPOP, TLR2, TLR4, TLR5, TLR9, TLR3, IRAK1, RAC1, IRAK2, IRAK3, IL1R1, IRAK4, TIRAP, MYD88, TRAF6, MAP3K7, IL1RAP, IRF7, LRRFIP1, LRRFIP2, FLII, CISH, SARM1, SQSTM1, HDAC6, CBLB, TNIP1, TRAF3, STAP2, BTK, PELI1, IRF5, SMAD6, SMURF1, BST2, IL1RL1, TNFRSF13B, IKBKE, SASH1, SYK, SMAD3, SIAH1, USP7, TXN, FADD, MBIP, TLR7, POLR1C, MAL, MDM2, PRDX1, PFKL, SIAH2, CD93, IKBKG, IRF4, CYLD |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for OXSR1_MYD88 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OXSR1_MYD88 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | OXSR1 | C0020538 | Hypertensive disease | 1 | CTD_human |
| Hgene | OXSR1 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | MYD88 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| Tgene | MYD88 | C0014457 | Eosinophilia | 1 | CTD_human |
| Tgene | MYD88 | C0020538 | Hypertensive disease | 1 | CTD_human |
| Tgene | MYD88 | C0021368 | Inflammation | 1 | CTD_human |
| Tgene | MYD88 | C0024301 | Lymphoma, Follicular | 1 | CTD_human |
| Tgene | MYD88 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Tgene | MYD88 | C0032285 | Pneumonia | 1 | CTD_human |
| Tgene | MYD88 | C0035126 | Reperfusion Injury | 1 | CTD_human |
| Tgene | MYD88 | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human |
| Tgene | MYD88 | C0344315 | Depressed mood | 1 | PSYGENET |
| Tgene | MYD88 | C2677092 | MYD88 Deficiency | 1 | CTD_human;ORPHANET;UNIPROT |
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