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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25624

FusionGeneSummary for OTUD5_GRIPAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: OTUD5_GRIPAP1
Fusion gene ID: 25624
HgeneTgene
Gene symbol

OTUD5

GRIPAP1

Gene ID

55593

56850

Gene nameOTU deubiquitinase 5GRIP1 associated protein 1
SynonymsDUBAGRASP-1
Cytomap

Xp11.23

Xp11.23

Type of geneprotein-codingprotein-coding
DescriptionOTU domain-containing protein 5OTU domain containing 5deubiquinating enzyme Adeubiquitinating enzyme AGRIP1-associated protein 1
Modification date2018051920180519
UniProtAcc

Q96G74

Q4V328

Ensembl transtripts involved in fusion geneENST00000396743, ENST00000156084, 
ENST00000376488, ENST00000428668, 
ENST00000484499, 
ENST00000376425, 
ENST00000376444, ENST00000376441, 
ENST00000473581, ENST00000376423, 
Fusion gene scores* DoF score4 X 4 X 3=482 X 2 X 2=8
# samples 42
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: OTUD5 [Title/Abstract] AND GRIPAP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOTUD5

GO:0016579

protein deubiquitination

22245969

HgeneOTUD5

GO:0032496

response to lipopolysaccharide

22245969

HgeneOTUD5

GO:0070536

protein K63-linked deubiquitination

22245969|23827681

HgeneOTUD5

GO:0071108

protein K48-linked deubiquitination

22245969|23827681


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-2Y-A9GZ-01AOTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000396743ENST00000376425OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
In-frameENST00000396743ENST00000376444OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
In-frameENST00000396743ENST00000376441OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
5CDS-intronENST00000396743ENST00000473581OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
5CDS-intronENST00000396743ENST00000376423OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
In-frameENST00000156084ENST00000376425OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
In-frameENST00000156084ENST00000376444OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
In-frameENST00000156084ENST00000376441OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
5CDS-intronENST00000156084ENST00000473581OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
5CDS-intronENST00000156084ENST00000376423OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
In-frameENST00000376488ENST00000376425OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
In-frameENST00000376488ENST00000376444OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
In-frameENST00000376488ENST00000376441OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
5CDS-intronENST00000376488ENST00000473581OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
5CDS-intronENST00000376488ENST00000376423OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
intron-3CDSENST00000428668ENST00000376425OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
intron-3CDSENST00000428668ENST00000376444OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
intron-3CDSENST00000428668ENST00000376441OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
intron-intronENST00000428668ENST00000473581OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
intron-intronENST00000428668ENST00000376423OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
5UTR-3CDSENST00000484499ENST00000376425OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
5UTR-3CDSENST00000484499ENST00000376444OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
5UTR-3CDSENST00000484499ENST00000376441OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
5UTR-intronENST00000484499ENST00000473581OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-
5UTR-intronENST00000484499ENST00000376423OTUD5chrX

48814239

-GRIPAP1chrX

48855916

-

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FusionProtFeatures for OTUD5_GRIPAP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OTUD5

Q96G74

GRIPAP1

Q4V328

Deubiquitinating enzyme that functions as negativeregulator of the innate immune system. Acts via TRAF3deubiquitination and subsequent suppression of type I interferon(IFN) production. Has peptidase activity towards 'Lys-48'- and'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro). {ECO:0000269|PubMed:17991829,ECO:0000269|PubMed:22245969, ECO:0000269|PubMed:23827681}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOTUD5chrX:48814239chrX:48855916ENST00000156084-1933_174198572Compositional biasNote=Gly-rich
HgeneOTUD5chrX:48814239chrX:48855916ENST00000156084-195_113198572Compositional biasNote=Pro-rich
TgeneGRIPAP1chrX:48814239chrX:48855916ENST00000376423-020208_64114626Coiled coilOntology_term=ECO:0000255
TgeneGRIPAP1chrX:48814239chrX:48855916ENST00000376423-020701_73514626Coiled coilOntology_term=ECO:0000255
TgeneGRIPAP1chrX:48814239chrX:48855916ENST00000376423-020785_81414626Coiled coilOntology_term=ECO:0000255
TgeneGRIPAP1chrX:48814239chrX:48855916ENST00000376425-025208_64114811Coiled coilOntology_term=ECO:0000255
TgeneGRIPAP1chrX:48814239chrX:48855916ENST00000376425-025701_73514811Coiled coilOntology_term=ECO:0000255
TgeneGRIPAP1chrX:48814239chrX:48855916ENST00000376425-025785_81414811Coiled coilOntology_term=ECO:0000255
TgeneGRIPAP1chrX:48814239chrX:48855916ENST00000376441-026208_64114842Coiled coilOntology_term=ECO:0000255
TgeneGRIPAP1chrX:48814239chrX:48855916ENST00000376441-026701_73514842Coiled coilOntology_term=ECO:0000255
TgeneGRIPAP1chrX:48814239chrX:48855916ENST00000376441-026785_81414842Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOTUD5chrX:48814239chrX:48855916ENST00000428668-1933_174-71350Compositional biasNote=Gly-rich
HgeneOTUD5chrX:48814239chrX:48855916ENST00000428668-195_113-71350Compositional biasNote=Pro-rich
HgeneOTUD5chrX:48814239chrX:48855916ENST00000156084-19213_341198572DomainOTU
HgeneOTUD5chrX:48814239chrX:48855916ENST00000428668-19213_341-71350DomainOTU
HgeneOTUD5chrX:48814239chrX:48855916ENST00000156084-19218_224198572RegionCys-loop
HgeneOTUD5chrX:48814239chrX:48855916ENST00000156084-19273_283198572RegionVariable-loop
HgeneOTUD5chrX:48814239chrX:48855916ENST00000156084-19329_334198572RegionHis-loop
HgeneOTUD5chrX:48814239chrX:48855916ENST00000428668-19218_224-71350RegionCys-loop
HgeneOTUD5chrX:48814239chrX:48855916ENST00000428668-19273_283-71350RegionVariable-loop
HgeneOTUD5chrX:48814239chrX:48855916ENST00000428668-19329_334-71350RegionHis-loop
TgeneGRIPAP1chrX:48814239chrX:48855916ENST00000376423-0204_16114626Coiled coilOntology_term=ECO:0000255
TgeneGRIPAP1chrX:48814239chrX:48855916ENST00000376425-0254_16114811Coiled coilOntology_term=ECO:0000255
TgeneGRIPAP1chrX:48814239chrX:48855916ENST00000376441-0264_16114842Coiled coilOntology_term=ECO:0000255


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FusionGeneSequence for OTUD5_GRIPAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OTUD5_GRIPAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
OTUD5TRAF3, UBC, FLNA, GPX4, GRB2, GYS1, PKLR, SET, TP53, VARS, USP11, CACYBP, LANCL2, CTPS2, LONRF2, IGBP1, MOV10, GRN, PDCD5, DUSP13, TNFAIP3, TRIM35, RABGEF1, TRIM25GRIPAP1ARL15, CCNT1, GRIP1, CASP3, SPP1, RAB4A, HERC1, MYL6, MAP3K1, CCDC183, TCP10L2, HSPB1, TCP10L, NDEL1, EXOC1, CYB5D2, CGNL1, PKN3, NCKAP5L, TFPT, CCHCR1, YEATS4, TUFT1, RABGAP1L, GOLGA5, CLOCK, PSMD9, VPS53, DZIP3, RCOR1, HMG20A, CCDC132, CCDC93, OIP5, PHF21A, PTRF, PHLDB3, HAUS6, RPRD1A, ARNTL, MAX, GIT2, RABGEF1, NUF2, THAP11, VPS51, KDM1A, TSSC1, RABEP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OTUD5_GRIPAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for OTUD5_GRIPAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource