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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25607

FusionGeneSummary for OSTF1_SYNE2

check button Fusion gene summary
Fusion gene informationFusion gene name: OSTF1_SYNE2
Fusion gene ID: 25607
HgeneTgene
Gene symbol

OSTF1

SYNE2

Gene ID

26578

23224

Gene nameosteoclast stimulating factor 1spectrin repeat containing nuclear envelope protein 2
SynonymsOSF|SH3P2|bA235O14.1EDMD5|KASH2|NUA|NUANCE|Nesp2|Nesprin-2|SYNE-2|TROPH
Cytomap

9q21.13

14q23.2

Type of geneprotein-codingprotein-coding
Descriptionosteoclast-stimulating factor 1nesprin-2KASH domain-containing protein 2nesprin 2nuclear envelope spectrin repeat protein 2nucleus and actin connecting element proteinpolytrophinspectrin repeat containing, nuclear envelope 2synaptic nuclear envelope protein 2synaptic nuclei exp
Modification date2018052220180523
UniProtAcc

Q92882

Q8WXH0

Ensembl transtripts involved in fusion geneENST00000346234, ENST00000357395, 
ENST00000358025, ENST00000344113, 
ENST00000341472, ENST00000356081, 
ENST00000554584, ENST00000555002, 
ENST00000394768, ENST00000556725, 
ENST00000553455, ENST00000555022, 
ENST00000554805, ENST00000458046, 
ENST00000441438, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 6 X 2=48
# samples 26
** MAII scorelog2(2/8*10)=1.32192809488736log2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: OSTF1 [Title/Abstract] AND SYNE2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSYNE2

GO:0090286

cytoskeletal anchoring at nuclear membrane

18396275


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW935999OSTF1chr9

77752773

-SYNE2chr14

64691734

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000346234ENST00000357395OSTF1chr9

77752773

-SYNE2chr14

64691734

-
intron-3CDSENST00000346234ENST00000358025OSTF1chr9

77752773

-SYNE2chr14

64691734

-
intron-3CDSENST00000346234ENST00000344113OSTF1chr9

77752773

-SYNE2chr14

64691734

-
intron-intronENST00000346234ENST00000341472OSTF1chr9

77752773

-SYNE2chr14

64691734

-
intron-intronENST00000346234ENST00000356081OSTF1chr9

77752773

-SYNE2chr14

64691734

-
intron-intronENST00000346234ENST00000554584OSTF1chr9

77752773

-SYNE2chr14

64691734

-
intron-intronENST00000346234ENST00000555002OSTF1chr9

77752773

-SYNE2chr14

64691734

-
intron-intronENST00000346234ENST00000394768OSTF1chr9

77752773

-SYNE2chr14

64691734

-
intron-intronENST00000346234ENST00000556725OSTF1chr9

77752773

-SYNE2chr14

64691734

-
intron-intronENST00000346234ENST00000553455OSTF1chr9

77752773

-SYNE2chr14

64691734

-
intron-intronENST00000346234ENST00000555022OSTF1chr9

77752773

-SYNE2chr14

64691734

-
intron-intronENST00000346234ENST00000554805OSTF1chr9

77752773

-SYNE2chr14

64691734

-
intron-intronENST00000346234ENST00000458046OSTF1chr9

77752773

-SYNE2chr14

64691734

-
intron-intronENST00000346234ENST00000441438OSTF1chr9

77752773

-SYNE2chr14

64691734

-

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FusionProtFeatures for OSTF1_SYNE2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OSTF1

Q92882

SYNE2

Q8WXH0

Induces bone resorption, acting probably through asignaling cascade which results in the secretion of factor(s)enhancing osteoclast formation and activity.{ECO:0000269|PubMed:10092216}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OSTF1_SYNE2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OSTF1_SYNE2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OSTF1_SYNE2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for OSTF1_SYNE2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSYNE2C0004238Atrial Fibrillation1CTD_human
TgeneSYNE2C0007134Renal Cell Carcinoma1CTD_human
TgeneSYNE2C2751805EMERY-DREIFUSS MUSCULAR DYSTROPHY 5, AUTOSOMAL DOMINANT1UNIPROT