FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 25595

FusionGeneSummary for OSER1_PDCD11

check button Fusion gene summary
Fusion gene informationFusion gene name: OSER1_PDCD11
Fusion gene ID: 25595
HgeneTgene
Gene symbol

OSER1

PDCD11

Gene ID

51526

22984

Gene nameoxidative stress responsive serine rich 1programmed cell death 11
SynonymsC20orf111|HSPC207|Osr1|Perit1|dJ1183I21.1ALG-4|ALG4|NFBP|RRP5
Cytomap

20q13.12

10q24.33

Type of geneprotein-codingprotein-coding
Descriptionoxidative stress-responsive serine-rich protein 1oxidative stress-responsive 1oxidative stress-responsive protein 1peroxide-inducible transcript 1 proteinprotein RRP5 homologNF-kappa-B-binding proteinapoptosis-linked gene 4programmed cell death protein 11
Modification date2018051920180523
UniProtAcc

Q9NX31

Q14690

Ensembl transtripts involved in fusion geneENST00000372970, ENST00000255174, 
ENST00000369797, ENST00000490787, 
Fusion gene scores* DoF score2 X 2 X 1=44 X 4 X 4=64
# samples 24
** MAII scorelog2(2/4*10)=2.32192809488736log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OSER1 [Title/Abstract] AND PDCD11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE084803OSER1chr20

42835675

-PDCD11chr10

105175774

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000372970ENST00000369797OSER1chr20

42835675

-PDCD11chr10

105175774

-
intron-intronENST00000372970ENST00000490787OSER1chr20

42835675

-PDCD11chr10

105175774

-
intron-intronENST00000255174ENST00000369797OSER1chr20

42835675

-PDCD11chr10

105175774

-
intron-intronENST00000255174ENST00000490787OSER1chr20

42835675

-PDCD11chr10

105175774

-

Top

FusionProtFeatures for OSER1_PDCD11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OSER1

Q9NX31

PDCD11

Q14690

Essential for the generation of mature 18S rRNA,specifically necessary for cleavages at sites A0, 1 and 2 of the47S precursor. Directly interacts with U3 snoRNA.{ECO:0000269|PubMed:17654514}. Involved in the biogenesis of rRNA. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for OSER1_PDCD11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for OSER1_PDCD11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for OSER1_PDCD11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for OSER1_PDCD11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource