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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25585

FusionGeneSummary for OSBPL9_SERINC5

check button Fusion gene summary
Fusion gene informationFusion gene name: OSBPL9_SERINC5
Fusion gene ID: 25585
HgeneTgene
Gene symbol

OSBPL9

SERINC5

Gene ID

114883

256987

Gene nameoxysterol binding protein like 9serine incorporator 5
SynonymsORP-9|ORP9C5orf12|TPO1
Cytomap

1p32.3

5q14.1

Type of geneprotein-codingprotein-coding
Descriptionoxysterol-binding protein-related protein 9OSBP-related protein 9serine incorporator 5
Modification date2018052320180523
UniProtAcc

Q96SU4

Q86VE9

Ensembl transtripts involved in fusion geneENST00000371714, ENST00000371710, 
ENST00000337809, ENST00000435686, 
ENST00000447887, ENST00000453295, 
ENST00000428468, ENST00000530544, 
ENST00000531828, ENST00000361556, 
ENST00000473207, ENST00000462759, 
ENST00000486942, 		ENST00000507668, 
ENST00000512972, ENST00000509193, 
ENST00000512721, ENST00000513907, 
Fusion gene scores* DoF score10 X 8 X 6=4805 X 5 X 4=100
# samples 126
** MAII scorelog2(12/480*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OSBPL9 [Title/Abstract] AND SERINC5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSERINC5

GO:0009597

detection of virus

26416733|26416734

TgeneSERINC5

GO:0045087

innate immune response

26416733|26416734

TgeneSERINC5

GO:0051607

defense response to virus

26416733|26416734


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-CH-5771-01AOSBPL9chr1

52082893

+SERINC5chr5

79454785

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000371714ENST00000507668OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
Frame-shiftENST00000371714ENST00000512972OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
Frame-shiftENST00000371714ENST00000509193OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
Frame-shiftENST00000371714ENST00000512721OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
5CDS-intronENST00000371714ENST00000513907OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
Frame-shiftENST00000371710ENST00000507668OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
Frame-shiftENST00000371710ENST00000512972OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
Frame-shiftENST00000371710ENST00000509193OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
Frame-shiftENST00000371710ENST00000512721OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
5CDS-intronENST00000371710ENST00000513907OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
Frame-shiftENST00000337809ENST00000507668OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
Frame-shiftENST00000337809ENST00000512972OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
Frame-shiftENST00000337809ENST00000509193OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
Frame-shiftENST00000337809ENST00000512721OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
5CDS-intronENST00000337809ENST00000513907OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
5UTR-3CDSENST00000435686ENST00000507668OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
5UTR-3CDSENST00000435686ENST00000512972OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
5UTR-3CDSENST00000435686ENST00000509193OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
5UTR-3CDSENST00000435686ENST00000512721OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
5UTR-intronENST00000435686ENST00000513907OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
Frame-shiftENST00000447887ENST00000507668OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
Frame-shiftENST00000447887ENST00000512972OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
Frame-shiftENST00000447887ENST00000509193OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
Frame-shiftENST00000447887ENST00000512721OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
5CDS-intronENST00000447887ENST00000513907OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
Frame-shiftENST00000453295ENST00000507668OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
Frame-shiftENST00000453295ENST00000512972OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
Frame-shiftENST00000453295ENST00000509193OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
Frame-shiftENST00000453295ENST00000512721OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
5CDS-intronENST00000453295ENST00000513907OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
Frame-shiftENST00000428468ENST00000507668OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
Frame-shiftENST00000428468ENST00000512972OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
Frame-shiftENST00000428468ENST00000509193OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
Frame-shiftENST00000428468ENST00000512721OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
5CDS-intronENST00000428468ENST00000513907OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000530544ENST00000507668OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000530544ENST00000512972OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000530544ENST00000509193OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000530544ENST00000512721OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-intronENST00000530544ENST00000513907OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000531828ENST00000507668OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000531828ENST00000512972OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000531828ENST00000509193OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000531828ENST00000512721OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-intronENST00000531828ENST00000513907OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000361556ENST00000507668OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000361556ENST00000512972OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000361556ENST00000509193OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000361556ENST00000512721OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-intronENST00000361556ENST00000513907OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000473207ENST00000507668OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000473207ENST00000512972OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000473207ENST00000509193OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000473207ENST00000512721OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-intronENST00000473207ENST00000513907OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000462759ENST00000507668OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000462759ENST00000512972OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000462759ENST00000509193OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000462759ENST00000512721OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-intronENST00000462759ENST00000513907OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000486942ENST00000507668OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000486942ENST00000512972OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000486942ENST00000509193OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-3CDSENST00000486942ENST00000512721OSBPL9chr1

52082893

+SERINC5chr5

79454785

-
intron-intronENST00000486942ENST00000513907OSBPL9chr1

52082893

+SERINC5chr5

79454785

-

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FusionProtFeatures for OSBPL9_SERINC5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OSBPL9

Q96SU4

SERINC5

Q86VE9

Restriction factor required to restrict infectivity oflentiviruses, such as HIV-1: acts by inhibiting an early step ofviral infection. Impairs the penetration of the viral particleinto the cytoplasm (PubMed:26416733, PubMed:26416734). Enhancesthe incorporation of serine into phosphatidylserine andsphingolipids. May play a role in providing serine molecules forthe formation of myelin glycosphingolipids in oligodendrocytes (Bysimilarity). {ECO:0000250|UniProtKB:Q63175,ECO:0000269|PubMed:26416733, ECO:0000269|PubMed:26416734}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OSBPL9_SERINC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OSBPL9_SERINC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
OSBPL9GCH1, HIST1H2BL, VAPB, VAPA, WRAP73, DTNBP1, KBTBD6, USP11, OSBPL10, OSBPL11, HAUS1, BLOC1S2, TERF2, DNAJA1, CYP1A1, HSPB1, COPE, POLD2, NTRK1, KRAS, CHMP4B, FUZ, CFAP36SERINC5TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OSBPL9_SERINC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for OSBPL9_SERINC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource