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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25583

FusionGeneSummary for OSBPL9_FKBP5

check button Fusion gene summary
Fusion gene informationFusion gene name: OSBPL9_FKBP5
Fusion gene ID: 25583
HgeneTgene
Gene symbol

OSBPL9

FKBP5

Gene ID

114883

2289

Gene nameoxysterol binding protein like 9FK506 binding protein 5
SynonymsORP-9|ORP9AIG6|FKBP51|FKBP54|P54|PPIase|Ptg-10
Cytomap

1p32.3

6p21.31

Type of geneprotein-codingprotein-coding
Descriptionoxysterol-binding protein-related protein 9OSBP-related protein 9peptidyl-prolyl cis-trans isomerase FKBP551 kDa FK506-binding protein51 kDa FKBP54 kDa progesterone receptor-associated immunophilinFF1 antigenFKBP-51HSP90-binding immunophilinPPIase FKBP5T-cell FK506-binding proteinandrogen-regulated protein 6p
Modification date2018052320180527
UniProtAcc

Q96SU4

Q13451

Ensembl transtripts involved in fusion geneENST00000371714, ENST00000371710, 
ENST00000337809, ENST00000435686, 
ENST00000447887, ENST00000453295, 
ENST00000428468, ENST00000530544, 
ENST00000531828, ENST00000361556, 
ENST00000473207, ENST00000462759, 
ENST00000486942, 		ENST00000539068, 
ENST00000536438, ENST00000357266, 
ENST00000540787, ENST00000542713, 
Fusion gene scores* DoF score10 X 8 X 6=48011 X 11 X 7=847
# samples 1217
** MAII scorelog2(12/480*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/847*10)=-2.3168272231945
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OSBPL9 [Title/Abstract] AND FKBP5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFKBP5

GO:0061077

chaperone-mediated protein folding

11350175


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-AB3A-01AOSBPL9chr1

52082893

+FKBP5chr6

35610620

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000371714ENST00000539068OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-5UTRENST00000371714ENST00000536438OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-5UTRENST00000371714ENST00000357266OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-intronENST00000371714ENST00000540787OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-5UTRENST00000371714ENST00000542713OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-5UTRENST00000371710ENST00000539068OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-5UTRENST00000371710ENST00000536438OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-5UTRENST00000371710ENST00000357266OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-intronENST00000371710ENST00000540787OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-5UTRENST00000371710ENST00000542713OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-5UTRENST00000337809ENST00000539068OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-5UTRENST00000337809ENST00000536438OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-5UTRENST00000337809ENST00000357266OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-intronENST00000337809ENST00000540787OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-5UTRENST00000337809ENST00000542713OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5UTR-5UTRENST00000435686ENST00000539068OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5UTR-5UTRENST00000435686ENST00000536438OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5UTR-5UTRENST00000435686ENST00000357266OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5UTR-intronENST00000435686ENST00000540787OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5UTR-5UTRENST00000435686ENST00000542713OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-5UTRENST00000447887ENST00000539068OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-5UTRENST00000447887ENST00000536438OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-5UTRENST00000447887ENST00000357266OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-intronENST00000447887ENST00000540787OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-5UTRENST00000447887ENST00000542713OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-5UTRENST00000453295ENST00000539068OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-5UTRENST00000453295ENST00000536438OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-5UTRENST00000453295ENST00000357266OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-intronENST00000453295ENST00000540787OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-5UTRENST00000453295ENST00000542713OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-5UTRENST00000428468ENST00000539068OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-5UTRENST00000428468ENST00000536438OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-5UTRENST00000428468ENST00000357266OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-intronENST00000428468ENST00000540787OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
5CDS-5UTRENST00000428468ENST00000542713OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000530544ENST00000539068OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000530544ENST00000536438OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000530544ENST00000357266OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-intronENST00000530544ENST00000540787OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000530544ENST00000542713OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000531828ENST00000539068OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000531828ENST00000536438OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000531828ENST00000357266OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-intronENST00000531828ENST00000540787OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000531828ENST00000542713OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000361556ENST00000539068OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000361556ENST00000536438OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000361556ENST00000357266OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-intronENST00000361556ENST00000540787OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000361556ENST00000542713OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000473207ENST00000539068OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000473207ENST00000536438OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000473207ENST00000357266OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-intronENST00000473207ENST00000540787OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000473207ENST00000542713OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000462759ENST00000539068OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000462759ENST00000536438OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000462759ENST00000357266OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-intronENST00000462759ENST00000540787OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000462759ENST00000542713OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000486942ENST00000539068OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000486942ENST00000536438OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000486942ENST00000357266OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-intronENST00000486942ENST00000540787OSBPL9chr1

52082893

+FKBP5chr6

35610620

-
intron-5UTRENST00000486942ENST00000542713OSBPL9chr1

52082893

+FKBP5chr6

35610620

-

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FusionProtFeatures for OSBPL9_FKBP5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OSBPL9

Q96SU4

FKBP5

Q13451

Immunophilin protein with PPIase and co-chaperoneactivities. Component of unligated steroid receptorsheterocomplexes through interaction with heat-shock protein 90(HSP90). Plays a role in the intracellular trafficking ofheterooligomeric forms of steroid hormone receptors maintainingthe complex into the cytoplasm when unliganded.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OSBPL9_FKBP5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OSBPL9_FKBP5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
OSBPL9GCH1, HIST1H2BL, VAPB, VAPA, WRAP73, DTNBP1, KBTBD6, USP11, OSBPL10, OSBPL11, HAUS1, BLOC1S2, TERF2, DNAJA1, CYP1A1, HSPB1, COPE, POLD2, NTRK1, KRAS, CHMP4B, FUZ, CFAP36FKBP5MAP3K1, IKBKE, ESR1, FES, HSF1, PGR, HSP90AA1, USP49, PHLPP1, CDK9, STK11, STIP1, IKBKB, RIPK3, AKT1, NR3C1, NR3C2, AR, HSPA4, PTGES3, LRRK1, MAGEA11, APP, CLK3, CDK15, MAGED2, MCM3, MCM5, MGEA5, OGFR, TPM3, TRAP1, USP7, PRKAA1, AGO1, AHSA1, CDC37, CDC37L1, SUGT1, NUDCD3, HSP90AB1, ILK, NUDC, AGO2, CACYBP, CHUK, AURKB, ARAF, GLMN, TTC4, CHORDC1, LRRC40, IKBKG, KIAA1279, ANKMY2, EGLN1, HGH1, MCMBP, PDCD2, CDK4, CDK11A, TUBA1A, PNPLA2, DNAJB6, C14orf80, CXorf57, PYGL, MCM4, HSF4, IRS4, LIMK2, SGK2, TSSK6, ULK3, AGO3, MOS, PSKH2, PIPOX, SGK1, CDKL1, CDKL4, AURKC, CDK18, CDK7, CDK13, CDK3, RPS6KB2, DUT, TLE3, NTRK1, XRCC3, TINF2, FBXW7, DUSP2, DUSP8, AMACR, MAP3K6, PRKACB, AKT3, PDIK1L, STK35, NEK11, ABHD15, WDR90, CDK6, ATG7, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OSBPL9_FKBP5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for OSBPL9_FKBP5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFKBP5C0005586Bipolar Disorder5PSYGENET
TgeneFKBP5C0011570Mental Depression5PSYGENET
TgeneFKBP5C0011581Depressive disorder5PSYGENET
TgeneFKBP5C0041696Unipolar Depression5PSYGENET
TgeneFKBP5C0525045Mood Disorders5PSYGENET
TgeneFKBP5C1269683Major Depressive Disorder5CTD_human;PSYGENET
TgeneFKBP5C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneFKBP5C0003873Rheumatoid Arthritis1CTD_human
TgeneFKBP5C0014175Endometriosis1CTD_human
TgeneFKBP5C0021290Neonatal disorder1CTD_human
TgeneFKBP5C0033975Psychotic Disorders1PSYGENET
TgeneFKBP5C0349204Nonorganic psychosis1PSYGENET
TgeneFKBP5C0525041Neurobehavioral Manifestations1CTD_human
TgeneFKBP5C2362914clinical depression1PSYGENET