	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 25582

FusionGeneSummary for OSBPL9_FGGY

Fusion gene summary

Fusion gene information	Fusion gene name: OSBPL9_FGGY
	Fusion gene ID: 25582
		Hgene	Tgene
	Gene symbol	OSBPL9	FGGY
	Gene ID	114883	55277
	Gene name	oxysterol binding protein like 9	FGGY carbohydrate kinase domain containing
	Synonyms	ORP-9\|ORP9	-
	Cytomap	1p32.3	1p32.1
	Type of gene	protein-coding	protein-coding
	Description	oxysterol-binding protein-related protein 9OSBP-related protein 9	FGGY carbohydrate kinase domain-containing proteinD-ribulokinase
	Modification date	20180523	20180519
	UniProtAcc	Q96SU4	Q96C11
	Ensembl transtripts involved in fusion gene	ENST00000371714, ENST00000371710, ENST00000337809, ENST00000435686, ENST00000447887, ENST00000453295, ENST00000428468, ENST00000530544, ENST00000531828, ENST00000361556, ENST00000473207, ENST00000462759, ENST00000486942,	ENST00000474476, ENST00000371218, ENST00000303721, ENST00000371212, ENST00000371210,
Fusion gene scores	* DoF score	10 X 8 X 6=480	13 X 9 X 9=1053
	# samples	12	14
	** MAII score	log2(12/480*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/1053*10)=-2.91100670408075 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: OSBPL9 [Title/Abstract] AND FGGY [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	FGGY	GO:0019321	pentose metabolic process	27909055
Tgene	FGGY	GO:0046835	carbohydrate phosphorylation	27909055

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	LUAD	TCGA-67-3772-01A	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000371714	ENST00000474476	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000371714	ENST00000371218	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000371714	ENST00000303721	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000371714	ENST00000371212	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000371714	ENST00000371210	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000371710	ENST00000474476	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000371710	ENST00000371218	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000371710	ENST00000303721	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000371710	ENST00000371212	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000371710	ENST00000371210	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000337809	ENST00000474476	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000337809	ENST00000371218	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000337809	ENST00000303721	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000337809	ENST00000371212	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000337809	ENST00000371210	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000435686	ENST00000474476	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000435686	ENST00000371218	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000435686	ENST00000303721	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000435686	ENST00000371212	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000435686	ENST00000371210	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000447887	ENST00000474476	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000447887	ENST00000371218	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000447887	ENST00000303721	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000447887	ENST00000371212	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000447887	ENST00000371210	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000453295	ENST00000474476	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000453295	ENST00000371218	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000453295	ENST00000303721	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000453295	ENST00000371212	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000453295	ENST00000371210	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000428468	ENST00000474476	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000428468	ENST00000371218	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000428468	ENST00000303721	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000428468	ENST00000371212	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
5CDS-3UTR	ENST00000428468	ENST00000371210	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000530544	ENST00000474476	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000530544	ENST00000371218	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000530544	ENST00000303721	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000530544	ENST00000371212	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000530544	ENST00000371210	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000531828	ENST00000474476	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000531828	ENST00000371218	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000531828	ENST00000303721	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000531828	ENST00000371212	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000531828	ENST00000371210	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000361556	ENST00000474476	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000361556	ENST00000371218	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000361556	ENST00000303721	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000361556	ENST00000371212	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000361556	ENST00000371210	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000473207	ENST00000474476	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000473207	ENST00000371218	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000473207	ENST00000303721	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000473207	ENST00000371212	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000473207	ENST00000371210	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000462759	ENST00000474476	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000462759	ENST00000371218	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000462759	ENST00000303721	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000462759	ENST00000371212	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000462759	ENST00000371210	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000486942	ENST00000474476	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000486942	ENST00000371218	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000486942	ENST00000303721	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000486942	ENST00000371212	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+
intron-3UTR	ENST00000486942	ENST00000371210	OSBPL9	chr1	52135184	+	FGGY	chr1	60091660	+

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FusionProtFeatures for OSBPL9_FGGY

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
OSBPL9 Q96SU4	FGGY Q96C11

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for OSBPL9_FGGY

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OSBPL9_FGGY

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
OSBPL9	GCH1, HIST1H2BL, VAPB, VAPA, WRAP73, DTNBP1, KBTBD6, USP11, OSBPL10, OSBPL11, HAUS1, BLOC1S2, TERF2, DNAJA1, CYP1A1, HSPB1, COPE, POLD2, NTRK1, KRAS, CHMP4B, FUZ, CFAP36	FGGY	EAF1, NSFL1C

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for OSBPL9_FGGY

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for OSBPL9_FGGY

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 25582

FusionGeneSummary for OSBPL9_FGGY

FusionProtFeatures for OSBPL9_FGGY

FusionGeneSequence for OSBPL9_FGGY

FusionGenePPI for OSBPL9_FGGY

RelatedDrugs for OSBPL9_FGGY

RelatedDiseases for OSBPL9_FGGY