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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2556

FusionGeneSummary for ARHGEF28_ARHGEF28

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGEF28_ARHGEF28
Fusion gene ID: 2556
HgeneTgene
Gene symbol

ARHGEF28

ARHGEF28

Gene ID

64283

64283

Gene nameRho guanine nucleotide exchange factor 28Rho guanine nucleotide exchange factor 28
SynonymsRGNEF|RIP2|p190RHOGEFRGNEF|RIP2|p190RHOGEF
Cytomap

5q13.2

5q13.2

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 28190 kDa guanine nucleotide exchange factorRho guanine nucleotide exchange factor (GEF) 28Rho interacting protein 2p190-RhoGEFrho-guanine nucleotide exchange factorrho guanine nucleotide exchange factor 28190 kDa guanine nucleotide exchange factorRho guanine nucleotide exchange factor (GEF) 28Rho interacting protein 2p190-RhoGEFrho-guanine nucleotide exchange factor
Modification date2018051920180519
UniProtAcc

Q8N1W1

Q8N1W1

Ensembl transtripts involved in fusion geneENST00000296794, ENST00000287898, 
ENST00000545377, ENST00000513042, 
ENST00000437974, ENST00000426542, 
ENST00000296799, ENST00000513841, 
ENST00000512883, 
ENST00000296794, 
ENST00000287898, ENST00000545377, 
ENST00000513042, ENST00000437974, 
ENST00000426542, ENST00000296799, 
ENST00000513841, ENST00000512883, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 2 X 1=4
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/4*10)=2.32192809488736
Context

PubMed: ARHGEF28 [Title/Abstract] AND ARHGEF28 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA481731ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000296794ENST00000296794ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000296794ENST00000287898ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000296794ENST00000545377ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000296794ENST00000513042ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000296794ENST00000437974ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000296794ENST00000426542ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000296794ENST00000296799ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000296794ENST00000513841ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000296794ENST00000512883ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000287898ENST00000296794ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000287898ENST00000287898ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000287898ENST00000545377ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000287898ENST00000513042ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000287898ENST00000437974ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000287898ENST00000426542ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000287898ENST00000296799ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000287898ENST00000513841ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000287898ENST00000512883ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000545377ENST00000296794ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000545377ENST00000287898ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000545377ENST00000545377ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000545377ENST00000513042ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000545377ENST00000437974ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000545377ENST00000426542ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000545377ENST00000296799ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000545377ENST00000513841ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000545377ENST00000512883ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000513042ENST00000296794ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000513042ENST00000287898ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000513042ENST00000545377ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000513042ENST00000513042ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000513042ENST00000437974ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000513042ENST00000426542ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000513042ENST00000296799ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000513042ENST00000513841ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000513042ENST00000512883ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000437974ENST00000296794ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000437974ENST00000287898ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000437974ENST00000545377ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000437974ENST00000513042ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000437974ENST00000437974ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000437974ENST00000426542ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000437974ENST00000296799ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000437974ENST00000513841ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000437974ENST00000512883ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000426542ENST00000296794ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000426542ENST00000287898ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000426542ENST00000545377ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000426542ENST00000513042ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000426542ENST00000437974ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000426542ENST00000426542ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000426542ENST00000296799ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000426542ENST00000513841ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000426542ENST00000512883ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000296799ENST00000296794ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000296799ENST00000287898ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000296799ENST00000545377ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000296799ENST00000513042ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000296799ENST00000437974ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000296799ENST00000426542ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000296799ENST00000296799ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000296799ENST00000513841ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000296799ENST00000512883ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000513841ENST00000296794ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000513841ENST00000287898ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000513841ENST00000545377ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000513841ENST00000513042ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000513841ENST00000437974ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000513841ENST00000426542ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000513841ENST00000296799ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000513841ENST00000513841ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000513841ENST00000512883ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000512883ENST00000296794ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000512883ENST00000287898ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000512883ENST00000545377ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000512883ENST00000513042ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000512883ENST00000437974ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000512883ENST00000426542ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000512883ENST00000296799ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000512883ENST00000513841ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+
intron-intronENST00000512883ENST00000512883ARHGEF28chr5

73024248

-ARHGEF28chr5

73024334

+

Top

FusionProtFeatures for ARHGEF28_ARHGEF28


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGEF28

Q8N1W1

ARHGEF28

Q8N1W1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARHGEF28_ARHGEF28


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARHGEF28_ARHGEF28


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ARHGEF28_ARHGEF28


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ARHGEF28_ARHGEF28


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource