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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25555

FusionGeneSummary for OSBPL5_RHOG

check button Fusion gene summary
Fusion gene informationFusion gene name: OSBPL5_RHOG
Fusion gene ID: 25555
HgeneTgene
Gene symbol

OSBPL5

RHOG

Gene ID

114879

391

Gene nameoxysterol binding protein like 5ras homolog family member G
SynonymsOBPH1|ORP5ARHG
Cytomap

11p15.4

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionoxysterol-binding protein-related protein 5ORP-5OSBP-related protein 5oxysterol-binding protein homolog 1oxysterol-binding protein homologue 1rho-related GTP-binding protein RhoGras homolog gene family, member G (rho G)
Modification date2018052320180523
UniProtAcc

Q9H0X9

P84095

Ensembl transtripts involved in fusion geneENST00000263650, ENST00000389989, 
ENST00000525498, ENST00000542243, 
ENST00000348039, ENST00000478260, 
ENST00000528124, 
ENST00000351018, 
ENST00000396979, ENST00000396978, 
ENST00000533217, 
Fusion gene scores* DoF score8 X 7 X 4=2244 X 3 X 3=36
# samples 94
** MAII scorelog2(9/224*10)=-1.31550182572793
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: OSBPL5 [Title/Abstract] AND RHOG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOSBPL5

GO:0015914

phospholipid transport

26206935

TgeneRHOG

GO:0007266

Rho protein signal transduction

12376551

TgeneRHOG

GO:0016601

Rac protein signal transduction

12376551

TgeneRHOG

GO:0030036

actin cytoskeleton organization

12545154

TgeneRHOG

GO:0045893

positive regulation of transcription, DNA-templated

12545154


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A2-A3XW-01AOSBPL5chr11

3147703

-RHOGchr11

3849436

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000263650ENST00000351018OSBPL5chr11

3147703

-RHOGchr11

3849436

-
5CDS-5UTRENST00000263650ENST00000396979OSBPL5chr11

3147703

-RHOGchr11

3849436

-
5CDS-5UTRENST00000263650ENST00000396978OSBPL5chr11

3147703

-RHOGchr11

3849436

-
5CDS-5UTRENST00000263650ENST00000533217OSBPL5chr11

3147703

-RHOGchr11

3849436

-
5CDS-5UTRENST00000389989ENST00000351018OSBPL5chr11

3147703

-RHOGchr11

3849436

-
5CDS-5UTRENST00000389989ENST00000396979OSBPL5chr11

3147703

-RHOGchr11

3849436

-
5CDS-5UTRENST00000389989ENST00000396978OSBPL5chr11

3147703

-RHOGchr11

3849436

-
5CDS-5UTRENST00000389989ENST00000533217OSBPL5chr11

3147703

-RHOGchr11

3849436

-
5CDS-5UTRENST00000525498ENST00000351018OSBPL5chr11

3147703

-RHOGchr11

3849436

-
5CDS-5UTRENST00000525498ENST00000396979OSBPL5chr11

3147703

-RHOGchr11

3849436

-
5CDS-5UTRENST00000525498ENST00000396978OSBPL5chr11

3147703

-RHOGchr11

3849436

-
5CDS-5UTRENST00000525498ENST00000533217OSBPL5chr11

3147703

-RHOGchr11

3849436

-
5UTR-5UTRENST00000542243ENST00000351018OSBPL5chr11

3147703

-RHOGchr11

3849436

-
5UTR-5UTRENST00000542243ENST00000396979OSBPL5chr11

3147703

-RHOGchr11

3849436

-
5UTR-5UTRENST00000542243ENST00000396978OSBPL5chr11

3147703

-RHOGchr11

3849436

-
5UTR-5UTRENST00000542243ENST00000533217OSBPL5chr11

3147703

-RHOGchr11

3849436

-
5CDS-5UTRENST00000348039ENST00000351018OSBPL5chr11

3147703

-RHOGchr11

3849436

-
5CDS-5UTRENST00000348039ENST00000396979OSBPL5chr11

3147703

-RHOGchr11

3849436

-
5CDS-5UTRENST00000348039ENST00000396978OSBPL5chr11

3147703

-RHOGchr11

3849436

-
5CDS-5UTRENST00000348039ENST00000533217OSBPL5chr11

3147703

-RHOGchr11

3849436

-
intron-5UTRENST00000478260ENST00000351018OSBPL5chr11

3147703

-RHOGchr11

3849436

-
intron-5UTRENST00000478260ENST00000396979OSBPL5chr11

3147703

-RHOGchr11

3849436

-
intron-5UTRENST00000478260ENST00000396978OSBPL5chr11

3147703

-RHOGchr11

3849436

-
intron-5UTRENST00000478260ENST00000533217OSBPL5chr11

3147703

-RHOGchr11

3849436

-
intron-5UTRENST00000528124ENST00000351018OSBPL5chr11

3147703

-RHOGchr11

3849436

-
intron-5UTRENST00000528124ENST00000396979OSBPL5chr11

3147703

-RHOGchr11

3849436

-
intron-5UTRENST00000528124ENST00000396978OSBPL5chr11

3147703

-RHOGchr11

3849436

-
intron-5UTRENST00000528124ENST00000533217OSBPL5chr11

3147703

-RHOGchr11

3849436

-

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FusionProtFeatures for OSBPL5_RHOG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OSBPL5

Q9H0X9

RHOG

P84095

Lipid transporter involved in lipid countertransportbetween the endoplasmic reticulum and the plasma membrane:specifically exchanges phosphatidylserine withphosphatidylinositol 4-phosphate (PI4P), deliveringphosphatidylserine to the plasma membrane in exchange for PI4P,which is degraded by the SAC1/SACM1L phosphatase in theendoplasmic reticulum. Binds phosphatidylserine and PI4P in amutually exclusive manner (PubMed:23934110, PubMed:26206935). Maycooperate with NPC1 to mediate the exit of cholesterol fromendosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesteroland cholesterol (PubMed:17428193). {ECO:0000269|PubMed:17428193,ECO:0000269|PubMed:21220512, ECO:0000269|PubMed:23934110,ECO:0000269|PubMed:26206935}. Required for the formation of membrane ruffles duringmacropinocytosis. Plays a role in cell migration and is requiredfor the formation of cup-like structures during trans-endothelialmigration of leukocytes. In case of Salmonella enterica infection,activated by SopB and ARHGEF26/SGEF, which induces cytoskeletonrearrangements and promotes bacterial entry.{ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883,ECO:0000269|PubMed:17875742, ECO:0000269|PubMed:20679435}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OSBPL5_RHOG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OSBPL5_RHOG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
OSBPL5HGS, NPC1, APP, KIFC3, LIMK1, MAGEA1, YWHAH, CDC23, RIOK3, IPO8, ZNF281, LRIF1, KLC4, PRR11, OSBPL8, NAGLU, PLD1, KLHL23RHOGARHGDIG, ELMOD2, DOCK1, KTN1, VAV3, MAP3K11, IQGAP2, ARHGDIA, FBXO6, TRIO, NT5E, RAB7A, ATP6AP2, ELMO1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OSBPL5_RHOG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for OSBPL5_RHOG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneOSBPL5C0001973Alcoholic Intoxication, Chronic1PSYGENET