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Fusion gene ID: 25547 |
FusionGeneSummary for OSBPL3_GABRG3 |
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Fusion gene information | Fusion gene name: OSBPL3_GABRG3 | Fusion gene ID: 25547 | Hgene | Tgene | Gene symbol | OSBPL3 | GABRG3 | Gene ID | 26031 | 2567 |
Gene name | oxysterol binding protein like 3 | gamma-aminobutyric acid type A receptor gamma3 subunit | |
Synonyms | ORP-3|ORP3|OSBP3 | - | |
Cytomap | 7p15.3 | 15q12 | |
Type of gene | protein-coding | protein-coding | |
Description | oxysterol-binding protein-related protein 3OSBP-related protein 3 | gamma-aminobutyric acid receptor subunit gamma-3GABA(A) receptor subunit gamma-3GABA(G) receptor, gamma 3gamma-aminobutyric acid (GABA) A receptor, gamma 3 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9H4L5 | Q99928 | |
Ensembl transtripts involved in fusion gene | ENST00000313367, ENST00000431825, ENST00000352860, ENST00000353930, ENST00000396431, ENST00000409069, ENST00000396429, ENST00000487020, | ENST00000333743, ENST00000555083, ENST00000554786, | |
Fusion gene scores | * DoF score | 8 X 3 X 5=120 | 2 X 2 X 2=8 |
# samples | 7 | 2 | |
** MAII score | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: OSBPL3 [Title/Abstract] AND GABRG3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-BH-A208-01A | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000313367 | ENST00000333743 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
5UTR-3CDS | ENST00000313367 | ENST00000555083 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
5UTR-intron | ENST00000313367 | ENST00000554786 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
5UTR-3CDS | ENST00000431825 | ENST00000333743 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
5UTR-3CDS | ENST00000431825 | ENST00000555083 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
5UTR-intron | ENST00000431825 | ENST00000554786 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
5UTR-3CDS | ENST00000352860 | ENST00000333743 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
5UTR-3CDS | ENST00000352860 | ENST00000555083 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
5UTR-intron | ENST00000352860 | ENST00000554786 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
5UTR-3CDS | ENST00000353930 | ENST00000333743 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
5UTR-3CDS | ENST00000353930 | ENST00000555083 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
5UTR-intron | ENST00000353930 | ENST00000554786 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
intron-3CDS | ENST00000396431 | ENST00000333743 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
intron-3CDS | ENST00000396431 | ENST00000555083 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
intron-intron | ENST00000396431 | ENST00000554786 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
intron-3CDS | ENST00000409069 | ENST00000333743 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
intron-3CDS | ENST00000409069 | ENST00000555083 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
intron-intron | ENST00000409069 | ENST00000554786 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
intron-3CDS | ENST00000396429 | ENST00000333743 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
intron-3CDS | ENST00000396429 | ENST00000555083 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
intron-intron | ENST00000396429 | ENST00000554786 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
intron-3CDS | ENST00000487020 | ENST00000333743 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
intron-3CDS | ENST00000487020 | ENST00000555083 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
intron-intron | ENST00000487020 | ENST00000554786 | OSBPL3 | chr7 | 25019505 | - | GABRG3 | chr15 | 27725796 | + |
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FusionProtFeatures for OSBPL3_GABRG3 |
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Hgene | Tgene |
OSBPL3 | GABRG3 |
GABA, the major inhibitory neurotransmitter in thevertebrate brain, mediates neuronal inhibition by binding to theGABA/benzodiazepine receptor and opening an integral chloridechannel. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for OSBPL3_GABRG3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for OSBPL3_GABRG3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
OSBPL3 | YWHAG, YWHAB, SFN, ELAVL1, YWHAE, VAPB, ENO1, NXF1, ARRDC1, TTI2, ADCYAP1, AURKA, SMC1A, VAPA, MMGT1, GLTSCR2, ZFPL1, CPNE2, TSPYL1, ACTR3B, HDAC11, ILVBL, JPH4, PRICKLE3, TRAF1, HIF1AN, KCTD3, CBY1 | GABRG3 | TP53 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for OSBPL3_GABRG3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | GABRG3 | Q99928 | DB00546 | Adinazolam | Gamma-aminobutyric acid receptor subunit gamma-3 | small molecule | approved |
Tgene | GABRG3 | Q99928 | DB00842 | Oxazepam | Gamma-aminobutyric acid receptor subunit gamma-3 | small molecule | approved |
Tgene | GABRG3 | Q99928 | DB00898 | Ethanol | Gamma-aminobutyric acid receptor subunit gamma-3 | small molecule | approved |
Tgene | GABRG3 | Q99928 | DB01594 | Cinolazepam | Gamma-aminobutyric acid receptor subunit gamma-3 | small molecule | approved |
Tgene | GABRG3 | Q99928 | DB01595 | Nitrazepam | Gamma-aminobutyric acid receptor subunit gamma-3 | small molecule | approved |
Tgene | GABRG3 | Q99928 | DB00683 | Midazolam | Gamma-aminobutyric acid receptor subunit gamma-3 | small molecule | approved|illicit |
Tgene | GABRG3 | Q99928 | DB01215 | Estazolam | Gamma-aminobutyric acid receptor subunit gamma-3 | small molecule | approved|illicit |
Tgene | GABRG3 | Q99928 | DB01559 | Clotiazepam | Gamma-aminobutyric acid receptor subunit gamma-3 | small molecule | approved|illicit |
Tgene | GABRG3 | Q99928 | DB01567 | Fludiazepam | Gamma-aminobutyric acid receptor subunit gamma-3 | small molecule | approved|illicit |
Tgene | GABRG3 | Q99928 | DB01588 | Prazepam | Gamma-aminobutyric acid receptor subunit gamma-3 | small molecule | approved|illicit |
Tgene | GABRG3 | Q99928 | DB01589 | Quazepam | Gamma-aminobutyric acid receptor subunit gamma-3 | small molecule | approved|illicit |
Tgene | GABRG3 | Q99928 | DB00690 | Flurazepam | Gamma-aminobutyric acid receptor subunit gamma-3 | small molecule | approved|illicit|investigational |
Tgene | GABRG3 | Q99928 | DB01558 | Bromazepam | Gamma-aminobutyric acid receptor subunit gamma-3 | small molecule | approved|illicit|investigational |
Tgene | GABRG3 | Q99928 | DB00829 | Diazepam | Gamma-aminobutyric acid receptor subunit gamma-3 | small molecule | approved|illicit|investigational|vet_approved |
Tgene | GABRG3 | Q99928 | DB00801 | Halazepam | Gamma-aminobutyric acid receptor subunit gamma-3 | small molecule | approved|illicit|withdrawn |
Tgene | GABRG3 | Q99928 | DB00231 | Temazepam | Gamma-aminobutyric acid receptor subunit gamma-3 | small molecule | approved|investigational |
Tgene | GABRG3 | Q99928 | DB00897 | Triazolam | Gamma-aminobutyric acid receptor subunit gamma-3 | small molecule | approved|investigational |
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RelatedDiseases for OSBPL3_GABRG3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | GABRG3 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Tgene | GABRG3 | C3711376 | Isodicentric Chromosome 15 Syndrome | 1 | CTD_human |