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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25547

FusionGeneSummary for OSBPL3_GABRG3

check button Fusion gene summary
Fusion gene informationFusion gene name: OSBPL3_GABRG3
Fusion gene ID: 25547
HgeneTgene
Gene symbol

OSBPL3

GABRG3

Gene ID

26031

2567

Gene nameoxysterol binding protein like 3gamma-aminobutyric acid type A receptor gamma3 subunit
SynonymsORP-3|ORP3|OSBP3-
Cytomap

7p15.3

15q12

Type of geneprotein-codingprotein-coding
Descriptionoxysterol-binding protein-related protein 3OSBP-related protein 3gamma-aminobutyric acid receptor subunit gamma-3GABA(A) receptor subunit gamma-3GABA(G) receptor, gamma 3gamma-aminobutyric acid (GABA) A receptor, gamma 3
Modification date2018052320180523
UniProtAcc

Q9H4L5

Q99928

Ensembl transtripts involved in fusion geneENST00000313367, ENST00000431825, 
ENST00000352860, ENST00000353930, 
ENST00000396431, ENST00000409069, 
ENST00000396429, ENST00000487020, 
ENST00000333743, ENST00000555083, 
ENST00000554786, 
Fusion gene scores* DoF score8 X 3 X 5=1202 X 2 X 2=8
# samples 72
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: OSBPL3 [Title/Abstract] AND GABRG3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-BH-A208-01AOSBPL3chr7

25019505

-GABRG3chr15

27725796

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000313367ENST00000333743OSBPL3chr7

25019505

-GABRG3chr15

27725796

+
5UTR-3CDSENST00000313367ENST00000555083OSBPL3chr7

25019505

-GABRG3chr15

27725796

+
5UTR-intronENST00000313367ENST00000554786OSBPL3chr7

25019505

-GABRG3chr15

27725796

+
5UTR-3CDSENST00000431825ENST00000333743OSBPL3chr7

25019505

-GABRG3chr15

27725796

+
5UTR-3CDSENST00000431825ENST00000555083OSBPL3chr7

25019505

-GABRG3chr15

27725796

+
5UTR-intronENST00000431825ENST00000554786OSBPL3chr7

25019505

-GABRG3chr15

27725796

+
5UTR-3CDSENST00000352860ENST00000333743OSBPL3chr7

25019505

-GABRG3chr15

27725796

+
5UTR-3CDSENST00000352860ENST00000555083OSBPL3chr7

25019505

-GABRG3chr15

27725796

+
5UTR-intronENST00000352860ENST00000554786OSBPL3chr7

25019505

-GABRG3chr15

27725796

+
5UTR-3CDSENST00000353930ENST00000333743OSBPL3chr7

25019505

-GABRG3chr15

27725796

+
5UTR-3CDSENST00000353930ENST00000555083OSBPL3chr7

25019505

-GABRG3chr15

27725796

+
5UTR-intronENST00000353930ENST00000554786OSBPL3chr7

25019505

-GABRG3chr15

27725796

+
intron-3CDSENST00000396431ENST00000333743OSBPL3chr7

25019505

-GABRG3chr15

27725796

+
intron-3CDSENST00000396431ENST00000555083OSBPL3chr7

25019505

-GABRG3chr15

27725796

+
intron-intronENST00000396431ENST00000554786OSBPL3chr7

25019505

-GABRG3chr15

27725796

+
intron-3CDSENST00000409069ENST00000333743OSBPL3chr7

25019505

-GABRG3chr15

27725796

+
intron-3CDSENST00000409069ENST00000555083OSBPL3chr7

25019505

-GABRG3chr15

27725796

+
intron-intronENST00000409069ENST00000554786OSBPL3chr7

25019505

-GABRG3chr15

27725796

+
intron-3CDSENST00000396429ENST00000333743OSBPL3chr7

25019505

-GABRG3chr15

27725796

+
intron-3CDSENST00000396429ENST00000555083OSBPL3chr7

25019505

-GABRG3chr15

27725796

+
intron-intronENST00000396429ENST00000554786OSBPL3chr7

25019505

-GABRG3chr15

27725796

+
intron-3CDSENST00000487020ENST00000333743OSBPL3chr7

25019505

-GABRG3chr15

27725796

+
intron-3CDSENST00000487020ENST00000555083OSBPL3chr7

25019505

-GABRG3chr15

27725796

+
intron-intronENST00000487020ENST00000554786OSBPL3chr7

25019505

-GABRG3chr15

27725796

+

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FusionProtFeatures for OSBPL3_GABRG3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OSBPL3

Q9H4L5

GABRG3

Q99928

GABA, the major inhibitory neurotransmitter in thevertebrate brain, mediates neuronal inhibition by binding to theGABA/benzodiazepine receptor and opening an integral chloridechannel.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OSBPL3_GABRG3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OSBPL3_GABRG3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
OSBPL3YWHAG, YWHAB, SFN, ELAVL1, YWHAE, VAPB, ENO1, NXF1, ARRDC1, TTI2, ADCYAP1, AURKA, SMC1A, VAPA, MMGT1, GLTSCR2, ZFPL1, CPNE2, TSPYL1, ACTR3B, HDAC11, ILVBL, JPH4, PRICKLE3, TRAF1, HIF1AN, KCTD3, CBY1GABRG3TP53


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OSBPL3_GABRG3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGABRG3Q99928DB00546AdinazolamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved
TgeneGABRG3Q99928DB00842OxazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved
TgeneGABRG3Q99928DB00898EthanolGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved
TgeneGABRG3Q99928DB01594CinolazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved
TgeneGABRG3Q99928DB01595NitrazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved
TgeneGABRG3Q99928DB00683MidazolamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit
TgeneGABRG3Q99928DB01215EstazolamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit
TgeneGABRG3Q99928DB01559ClotiazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit
TgeneGABRG3Q99928DB01567FludiazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit
TgeneGABRG3Q99928DB01588PrazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit
TgeneGABRG3Q99928DB01589QuazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit
TgeneGABRG3Q99928DB00690FlurazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit|investigational
TgeneGABRG3Q99928DB01558BromazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit|investigational
TgeneGABRG3Q99928DB00829DiazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit|investigational|vet_approved
TgeneGABRG3Q99928DB00801HalazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit|withdrawn
TgeneGABRG3Q99928DB00231TemazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|investigational
TgeneGABRG3Q99928DB00897TriazolamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|investigational

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RelatedDiseases for OSBPL3_GABRG3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGABRG3C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneGABRG3C3711376Isodicentric Chromosome 15 Syndrome1CTD_human