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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25483

FusionGeneSummary for ORC6_CST7

check button Fusion gene summary
Fusion gene informationFusion gene name: ORC6_CST7
Fusion gene ID: 25483
HgeneTgene
Gene symbol

ORC6

CST7

Gene ID

23594

8530

Gene nameorigin recognition complex subunit 6cystatin F
SynonymsORC6LCMAP
Cytomap

16q11.2

20p11.21

Type of geneprotein-codingprotein-coding
Descriptionorigin recognition complex subunit 6cystatin-Fcystatin-7cystatin-like metastasis-associated proteinleukocystatin
Modification date2018052320180519
UniProtAcc

Q9Y5N6

O76096

Ensembl transtripts involved in fusion geneENST00000219097, ENST00000568364, 
ENST00000566860, ENST00000575571, 
ENST00000376835, ENST00000480798, 
Fusion gene scores* DoF score3 X 3 X 3=272 X 2 X 1=4
# samples 32
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/4*10)=2.32192809488736
Context

PubMed: ORC6 [Title/Abstract] AND CST7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP431120ORC6chr16

46726341

+CST7chr20

24930146

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000219097ENST00000376835ORC6chr16

46726341

+CST7chr20

24930146

+
Frame-shitENST00000219097ENST00000480798ORC6chr16

46726341

+CST7chr20

24930146

+
Frame-shitENST00000568364ENST00000376835ORC6chr16

46726341

+CST7chr20

24930146

+
Frame-shitENST00000568364ENST00000480798ORC6chr16

46726341

+CST7chr20

24930146

+
Frame-shitENST00000566860ENST00000376835ORC6chr16

46726341

+CST7chr20

24930146

+
Frame-shitENST00000566860ENST00000480798ORC6chr16

46726341

+CST7chr20

24930146

+
intron-3CDSENST00000575571ENST00000376835ORC6chr16

46726341

+CST7chr20

24930146

+
intron-3CDSENST00000575571ENST00000480798ORC6chr16

46726341

+CST7chr20

24930146

+

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FusionProtFeatures for ORC6_CST7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ORC6

Q9Y5N6

CST7

O76096

Component of the origin recognition complex (ORC) thatbinds origins of replication. DNA-binding is ATP-dependent. Thespecific DNA sequences that define origins of replication have notbeen identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Doesnot bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3and H4K20me3. {ECO:0000269|PubMed:22427655}. Inhibits papain and cathepsin L but with affinitieslower than other cystatins. May play a role in immune regulationthrough inhibition of a unique target in the hematopoietic system.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ORC6_CST7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ORC6_CST7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ORC6_CST7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ORC6_CST7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneORC6C1868684EAR, PATELLA, SHORT STATURE SYNDROME1CTD_human;ORPHANET
HgeneORC6C3151113MEIER-GORLIN SYNDROME 31UNIPROT
TgeneCST7C0038356Stomach Neoplasms1CTD_human