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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25465

FusionGeneSummary for ORAOV1_CCND1

check button Fusion gene summary
Fusion gene informationFusion gene name: ORAOV1_CCND1
Fusion gene ID: 25465
HgeneTgene
Gene symbol

ORAOV1

CCND1

Gene ID

595

Gene namecyclin D1
SynonymsBCL1|D11S287E|PRAD1|U21B31
Cytomap

11q13.3

Type of geneprotein-coding
DescriptionG1/S-specific cyclin-D1B-cell CLL/lymphoma 1B-cell lymphoma 1 proteinBCL-1 oncogenePRAD1 oncogene
Modification date20180527
UniProtAcc

Q8WV07

P24385

Ensembl transtripts involved in fusion geneENST00000542515, ENST00000279147, 
ENST00000536870, ENST00000535657, 
ENST00000539414, ENST00000542341, 
ENST00000227507, ENST00000536559, 
Fusion gene scores* DoF score7 X 6 X 5=21010 X 10 X 4=400
# samples 710
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/400*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ORAOV1 [Title/Abstract] AND CCND1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCCND1

GO:0000082

G1/S transition of mitotic cell cycle

19412162

TgeneCCND1

GO:0000122

negative regulation of transcription by RNA polymerase II

16569215|18417529

TgeneCCND1

GO:0001934

positive regulation of protein phosphorylation

8114739

TgeneCCND1

GO:0006974

cellular response to DNA damage stimulus

19412162

TgeneCCND1

GO:0010971

positive regulation of G2/M transition of mitotic cell cycle

19124461

TgeneCCND1

GO:0031571

mitotic G1 DNA damage checkpoint

19412162

TgeneCCND1

GO:0044321

response to leptin

17344214

TgeneCCND1

GO:0045737

positive regulation of cyclin-dependent protein serine/threonine kinase activity

8114739

TgeneCCND1

GO:0070141

response to UV-A

18483258

TgeneCCND1

GO:0071157

negative regulation of cell cycle arrest

19124461


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-DQ-7589-01AORAOV1chr11

69489958

-CCND1chr11

69457799

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000542515ENST00000227507ORAOV1chr11

69489958

-CCND1chr11

69457799

+
intron-intronENST00000542515ENST00000536559ORAOV1chr11

69489958

-CCND1chr11

69457799

+
In-frameENST00000279147ENST00000227507ORAOV1chr11

69489958

-CCND1chr11

69457799

+
5CDS-intronENST00000279147ENST00000536559ORAOV1chr11

69489958

-CCND1chr11

69457799

+
In-frameENST00000536870ENST00000227507ORAOV1chr11

69489958

-CCND1chr11

69457799

+
5CDS-intronENST00000536870ENST00000536559ORAOV1chr11

69489958

-CCND1chr11

69457799

+
In-frameENST00000535657ENST00000227507ORAOV1chr11

69489958

-CCND1chr11

69457799

+
5CDS-intronENST00000535657ENST00000536559ORAOV1chr11

69489958

-CCND1chr11

69457799

+
In-frameENST00000539414ENST00000227507ORAOV1chr11

69489958

-CCND1chr11

69457799

+
5CDS-intronENST00000539414ENST00000536559ORAOV1chr11

69489958

-CCND1chr11

69457799

+
In-frameENST00000542341ENST00000227507ORAOV1chr11

69489958

-CCND1chr11

69457799

+
5CDS-intronENST00000542341ENST00000536559ORAOV1chr11

69489958

-CCND1chr11

69457799

+

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FusionProtFeatures for ORAOV1_CCND1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ORAOV1

Q8WV07

CCND1

P24385

Regulatory component of the cyclin D1-CDK4 (DC) complexthat phosphorylates and inhibits members of the retinoblastoma(RB) protein family including RB1 and regulates the cell-cycleduring G(1)/S transition. Phosphorylation of RB1 allowsdissociation of the transcription factor E2F from the RB/E2Fcomplex and the subsequent transcription of E2F target genes whichare responsible for the progression through the G(1) phase.Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4complexes are major integrators of various mitogenenic andantimitogenic signals. Also substrate for SMAD3, phosphorylatingSMAD3 in a cell-cycle-dependent manner and repressing itstranscriptional activity. Component of the ternary complex, cyclinD1/CDK4/CDKN1B, required for nuclear translocation and activity ofthe cyclin D-CDK4 complex. Exhibits transcriptional corepressoractivity with INSM1 on the NEUROD1 and INS promoters in a cellcycle-independent manner. {ECO:0000269|PubMed:15241418,ECO:0000269|PubMed:16569215, ECO:0000269|PubMed:18417529,ECO:0000269|PubMed:9106657}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ORAOV1_CCND1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ORAOV1_CCND1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ORAOV1ELAVL1, CAND1, MSH3, YAE1D1, MMS19, ABCE1, TRIM25CCND1AR, HDAC3, AKAP8, THRB, THRA, KAT2B, NEUROD1, EP300, CDK4, CDK6, CDKN2A, TAF1, CCNDBP1, RB1, HERC5, CDKN1C, CDKN1B, ESR1, RBX1, STAT3, TSC2, NPDC1, NCOA3, NCOA1, RFC1, PCNA, BRCA1, XPO1, CDKN1A, INSM1, HSPA8, HDAC1, HDAC2, MAPK11, WDR77, PRMT5, MAPK1, SKP1, CUL1, CUL7, FBXW8, FBXO4, CRYAB, FBXO31, ARID4A, USP2, UHRF2, SP1, CDK1, MCM7, MCM2, MCM3, MCM6, ELAVL1, ITLN1, PSMA6, CDK2, PPP1CB, PPP1CC, CCND1, ATF2, BTRC, RBL2, UBTF, CARD11, ORC4, MCM10, TP73, CAMK1, BRINP1, LPL, RABEP1, POLR1B, RELA, NXF1, BCAS3, CDH13, KLK7, KLK9, RANBP9, SLC25A5, ATP2B1, BTD, REV3L, GSK3B, MDM2, TP53, PSMD7, CDC27, FZR1, DTNBP1, CDKN2C, TCHH, CDK5, TSR3, TRIM25, NR1H3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ORAOV1_CCND1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCCND1P24385DB01169Arsenic trioxideG1/S-specific cyclin-D1small moleculeapproved|investigational

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RelatedDiseases for ORAOV1_CCND1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCCND1C1458155Mammary Neoplasms6CTD_human
TgeneCCND1C2239176Liver carcinoma5CTD_human
TgeneCCND1C0009375Colonic Neoplasms4CTD_human
TgeneCCND1C0024667Animal Mammary Neoplasms4CTD_human
TgeneCCND1C0024668Mammary Neoplasms, Experimental3CTD_human
TgeneCCND1C0007621Neoplastic Cell Transformation2CTD_human
TgeneCCND1C0020507Hyperplasia2CTD_human
TgeneCCND1C0024121Lung Neoplasms2CTD_human
TgeneCCND1C0334634Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse2CTD_human;ORPHANET
TgeneCCND1C0001418Adenocarcinoma1CTD_human
TgeneCCND1C0006118Brain Neoplasms1CTD_human
TgeneCCND1C0007137Squamous cell carcinoma1CTD_human
TgeneCCND1C0007138Carcinoma, Transitional Cell1CTD_human
TgeneCCND1C0007528Cecal Neoplasms1CTD_human
TgeneCCND1C0007873Uterine Cervical Neoplasm1CTD_human
TgeneCCND1C0010606Adenoid Cystic Carcinoma1CTD_human
TgeneCCND1C0014859Esophageal Neoplasms1CTD_human
TgeneCCND1C0018923Hemangiosarcoma1CTD_human
TgeneCCND1C0020502Hyperparathyroidism1CTD_human
TgeneCCND1C0021846Intestinal Polyps1CTD_human
TgeneCCND1C0022665Kidney Neoplasm1CTD_human
TgeneCCND1C0023418leukemia1CTD_human
TgeneCCND1C0023903Liver neoplasms1CTD_human
TgeneCCND1C0026764Multiple Myeloma1CTD_human;ORPHANET
TgeneCCND1C0027659Neoplasms, Experimental1CTD_human
TgeneCCND1C0030354Papilloma1CTD_human
TgeneCCND1C0032927Precancerous Conditions1CTD_human
TgeneCCND1C0033578Prostatic Neoplasms1CTD_human
TgeneCCND1C0036095Salivary Gland Neoplasms1CTD_human
TgeneCCND1C0036341Schizophrenia1PSYGENET
TgeneCCND1C0038356Stomach Neoplasms1CTD_human
TgeneCCND1C0040136Thyroid Neoplasm1CTD_human
TgeneCCND1C0041696Unipolar Depression1PSYGENET
TgeneCCND1C0042076Urologic Neoplasms1CTD_human
TgeneCCND1C0151744Myocardial Ischemia1CTD_human
TgeneCCND1C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneCCND1C0919532Genomic Instability1CTD_human
TgeneCCND1C1269683Major Depressive Disorder1PSYGENET
TgeneCCND1C2931822Nasopharyngeal carcinoma1CTD_human