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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25464

FusionGeneSummary for ORAI2_WHSC1

check button Fusion gene summary
Fusion gene informationFusion gene name: ORAI2_WHSC1
Fusion gene ID: 25464
HgeneTgene
Gene symbol

ORAI2

WHSC1

Gene ID

80228

7468

Gene nameORAI calcium release-activated calcium modulator 2nuclear receptor binding SET domain protein 2
SynonymsC7orf19|CBCIP2|MEM142B|TMEM142BKMT3F|KMT3G|MMSET|REIIBP|TRX5|WHS|WHSC1
Cytomap

7q22.1

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionprotein orai-2CAP-binding protein complex interacting protein 2H_NH0514P08.8putative protein ORAI2-2transmembrane protein 142Bhistone-lysine N-methyltransferase NSD2IL5 promoter REII region-binding proteinWolf-Hirschhorn syndrome candidate 1multiple myeloma SET domain containing protein type IIInuclear SET domain-containing protein 2probable histone-lysine N-methyltransfera
Modification date2018052320180519
UniProtAcc

Q96SN7

Ensembl transtripts involved in fusion geneENST00000488996, ENST00000356387, 
ENST00000478730, ENST00000403646, 
ENST00000473939, 		ENST00000508803, 
ENST00000382892, ENST00000382891, 
ENST00000382895, ENST00000482415, 
ENST00000382888, ENST00000514045, 
ENST00000436793, ENST00000420906, 
ENST00000503128, ENST00000398261, 
Fusion gene scores* DoF score3 X 3 X 3=275 X 5 X 1=25
# samples 36
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/25*10)=1.26303440583379
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ORAI2 [Title/Abstract] AND WHSC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DQ090923ORAI2chr7

102091939

+WHSC1chr4

1913300

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000488996ENST00000508803ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000488996ENST00000382892ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000488996ENST00000382891ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000488996ENST00000382895ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000488996ENST00000482415ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000488996ENST00000382888ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000488996ENST00000514045ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000488996ENST00000436793ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000488996ENST00000420906ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000488996ENST00000503128ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000488996ENST00000398261ORAI2chr7

102091939

+WHSC1chr4

1913300

+
3UTR-intronENST00000356387ENST00000508803ORAI2chr7

102091939

+WHSC1chr4

1913300

+
3UTR-intronENST00000356387ENST00000382892ORAI2chr7

102091939

+WHSC1chr4

1913300

+
3UTR-intronENST00000356387ENST00000382891ORAI2chr7

102091939

+WHSC1chr4

1913300

+
3UTR-intronENST00000356387ENST00000382895ORAI2chr7

102091939

+WHSC1chr4

1913300

+
3UTR-intronENST00000356387ENST00000482415ORAI2chr7

102091939

+WHSC1chr4

1913300

+
3UTR-intronENST00000356387ENST00000382888ORAI2chr7

102091939

+WHSC1chr4

1913300

+
3UTR-intronENST00000356387ENST00000514045ORAI2chr7

102091939

+WHSC1chr4

1913300

+
3UTR-intronENST00000356387ENST00000436793ORAI2chr7

102091939

+WHSC1chr4

1913300

+
3UTR-intronENST00000356387ENST00000420906ORAI2chr7

102091939

+WHSC1chr4

1913300

+
3UTR-intronENST00000356387ENST00000503128ORAI2chr7

102091939

+WHSC1chr4

1913300

+
3UTR-intronENST00000356387ENST00000398261ORAI2chr7

102091939

+WHSC1chr4

1913300

+
3UTR-intronENST00000478730ENST00000508803ORAI2chr7

102091939

+WHSC1chr4

1913300

+
3UTR-intronENST00000478730ENST00000382892ORAI2chr7

102091939

+WHSC1chr4

1913300

+
3UTR-intronENST00000478730ENST00000382891ORAI2chr7

102091939

+WHSC1chr4

1913300

+
3UTR-intronENST00000478730ENST00000382895ORAI2chr7

102091939

+WHSC1chr4

1913300

+
3UTR-intronENST00000478730ENST00000482415ORAI2chr7

102091939

+WHSC1chr4

1913300

+
3UTR-intronENST00000478730ENST00000382888ORAI2chr7

102091939

+WHSC1chr4

1913300

+
3UTR-intronENST00000478730ENST00000514045ORAI2chr7

102091939

+WHSC1chr4

1913300

+
3UTR-intronENST00000478730ENST00000436793ORAI2chr7

102091939

+WHSC1chr4

1913300

+
3UTR-intronENST00000478730ENST00000420906ORAI2chr7

102091939

+WHSC1chr4

1913300

+
3UTR-intronENST00000478730ENST00000503128ORAI2chr7

102091939

+WHSC1chr4

1913300

+
3UTR-intronENST00000478730ENST00000398261ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000403646ENST00000508803ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000403646ENST00000382892ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000403646ENST00000382891ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000403646ENST00000382895ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000403646ENST00000482415ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000403646ENST00000382888ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000403646ENST00000514045ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000403646ENST00000436793ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000403646ENST00000420906ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000403646ENST00000503128ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000403646ENST00000398261ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000473939ENST00000508803ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000473939ENST00000382892ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000473939ENST00000382891ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000473939ENST00000382895ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000473939ENST00000482415ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000473939ENST00000382888ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000473939ENST00000514045ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000473939ENST00000436793ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000473939ENST00000420906ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000473939ENST00000503128ORAI2chr7

102091939

+WHSC1chr4

1913300

+
intron-intronENST00000473939ENST00000398261ORAI2chr7

102091939

+WHSC1chr4

1913300

+

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FusionProtFeatures for ORAI2_WHSC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ORAI2

Q96SN7

WHSC1

Ca(2+) release-activated Ca(2+)-like (CRAC-like) channelsubunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.{ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:17452328}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ORAI2_WHSC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ORAI2_WHSC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ORAI2_WHSC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ORAI2_WHSC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource