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Fusion gene ID: 25459 |
FusionGeneSummary for OR1N1_TMEM132A |
Fusion gene summary |
Fusion gene information | Fusion gene name: OR1N1_TMEM132A | Fusion gene ID: 25459 | Hgene | Tgene | Gene symbol | OR1N1 | TMEM132A | Gene ID | 138883 | 54972 |
Gene name | olfactory receptor family 1 subfamily N member 1 | transmembrane protein 132A | |
Synonyms | OR1-26|OR1N3|OR9-22 | GBP|HSPA5BP1 | |
Cytomap | 9q33.2 | 11q12.2 | |
Type of gene | protein-coding | protein-coding | |
Description | olfactory receptor 1N1olfactory receptor 1-26olfactory receptor 1N3olfactory receptor OR9-22olfactory receptor, family 1, subfamily N, member 3 | transmembrane protein 132AGRP78-binding proteinHSPA5-binding protein 1glucose-regulated protein, 78kDaheat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) binding protein 1heat shock 70kDa protein 5 binding protein 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8NGS0 | Q24JP5 | |
Ensembl transtripts involved in fusion gene | ENST00000304880, | ENST00000453848, ENST00000005286, ENST00000543732, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: OR1N1 [Title/Abstract] AND TMEM132A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF326121 | OR1N1 | chr9 | 125288822 | + | TMEM132A | chr11 | 60701345 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000304880 | ENST00000453848 | OR1N1 | chr9 | 125288822 | + | TMEM132A | chr11 | 60701345 | + |
intron-intron | ENST00000304880 | ENST00000005286 | OR1N1 | chr9 | 125288822 | + | TMEM132A | chr11 | 60701345 | + |
intron-intron | ENST00000304880 | ENST00000543732 | OR1N1 | chr9 | 125288822 | + | TMEM132A | chr11 | 60701345 | + |
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FusionProtFeatures for OR1N1_TMEM132A |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
OR1N1 | TMEM132A |
Odorant receptor. {ECO:0000305}. | May play a role in embryonic and postnatal developmentof the brain. Increased resistance to cell death induced by serumstarvation in cultured cells. Regulates cAMP-induced GFAP geneexpression via STAT3 phosphorylation (By similarity).{ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for OR1N1_TMEM132A |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for OR1N1_TMEM132A |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for OR1N1_TMEM132A |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OR1N1_TMEM132A |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |