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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25457

FusionGeneSummary for OPTN_HMGN5

check button Fusion gene summary
Fusion gene informationFusion gene name: OPTN_HMGN5
Fusion gene ID: 25457
HgeneTgene
Gene symbol

OPTN

HMGN5

Gene ID

10133

79366

Gene nameoptineurinhigh mobility group nucleosome binding domain 5
SynonymsALS12|FIP2|GLC1E|HIP7|HYPL|NRP|TFIIIA-INTPNBP-45|NSBP1
Cytomap

10p13

Xq21.1

Type of geneprotein-codingprotein-coding
DescriptionoptineurinE3-14.7K-interacting proteinFIP-2HIP-7Huntingtin interacting protein Lhuntingtin yeast partner Lhuntingtin-interacting protein 7huntingtin-interacting protein Lnemo-related proteinoptic neuropathy-inducing proteintranscription factor Ihigh mobility group nucleosome-binding domain-containing protein 5nucleosomal binding protein 1nucleosome-binding protein 1
Modification date2018052320180519
UniProtAcc

Q96CV9

P82970

Ensembl transtripts involved in fusion geneENST00000263036, ENST00000378764, 
ENST00000482140, ENST00000378757, 
ENST00000378752, ENST00000378748, 
ENST00000378747, 
ENST00000358130, 
ENST00000491275, 
Fusion gene scores* DoF score3 X 3 X 1=91 X 1 X 1=1
# samples 31
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: OPTN [Title/Abstract] AND HMGN5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOPTN

GO:0010508

positive regulation of autophagy

21617041

HgeneOPTN

GO:0090161

Golgi ribbon formation

15837803


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF812950OPTNchr10

13158300

-HMGN5chrX

80377092

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000263036ENST00000358130OPTNchr10

13158300

-HMGN5chrX

80377092

-
5CDS-5UTRENST00000263036ENST00000491275OPTNchr10

13158300

-HMGN5chrX

80377092

-
5CDS-5UTRENST00000378764ENST00000358130OPTNchr10

13158300

-HMGN5chrX

80377092

-
5CDS-5UTRENST00000378764ENST00000491275OPTNchr10

13158300

-HMGN5chrX

80377092

-
3UTR-5UTRENST00000482140ENST00000358130OPTNchr10

13158300

-HMGN5chrX

80377092

-
3UTR-5UTRENST00000482140ENST00000491275OPTNchr10

13158300

-HMGN5chrX

80377092

-
5CDS-5UTRENST00000378757ENST00000358130OPTNchr10

13158300

-HMGN5chrX

80377092

-
5CDS-5UTRENST00000378757ENST00000491275OPTNchr10

13158300

-HMGN5chrX

80377092

-
5CDS-5UTRENST00000378752ENST00000358130OPTNchr10

13158300

-HMGN5chrX

80377092

-
5CDS-5UTRENST00000378752ENST00000491275OPTNchr10

13158300

-HMGN5chrX

80377092

-
5CDS-5UTRENST00000378748ENST00000358130OPTNchr10

13158300

-HMGN5chrX

80377092

-
5CDS-5UTRENST00000378748ENST00000491275OPTNchr10

13158300

-HMGN5chrX

80377092

-
5CDS-5UTRENST00000378747ENST00000358130OPTNchr10

13158300

-HMGN5chrX

80377092

-
5CDS-5UTRENST00000378747ENST00000491275OPTNchr10

13158300

-HMGN5chrX

80377092

-

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FusionProtFeatures for OPTN_HMGN5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OPTN

Q96CV9

HMGN5

P82970

Preferentially binds to euchromatin and modulatescellular transcription by counteracting linker histone-mediatedchromatin compaction. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OPTN_HMGN5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OPTN_HMGN5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OPTN_HMGN5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for OPTN_HMGN5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneOPTNC0339573Glaucoma, Primary Open Angle11CTD_human;HPO;UNIPROT
HgeneOPTNC0029401Osteitis Deformans1CTD_human
HgeneOPTNC3150692AMYOTROPHIC LATERAL SCLEROSIS 121CTD_human;UNIPROT