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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25431

FusionGeneSummary for OOEP_EIF3A

check button Fusion gene summary
Fusion gene informationFusion gene name: OOEP_EIF3A
Fusion gene ID: 25431
HgeneTgene
Gene symbol

OOEP

EIF3A

Gene ID

441161

8661

Gene nameoocyte expressed proteineukaryotic translation initiation factor 3 subunit A
SynonymsC6orf156|FLOPED|HOEP19|KHDC2EIF3|EIF3S10|P167|TIF32|eIF3-p170|eIF3-theta|p180|p185
Cytomap

6q13

10q26.11

Type of geneprotein-codingprotein-coding
Descriptionoocyte-expressed protein homologKH homology domain containing 2KH homology domain-containing protein 2oocyte and embryo protein 19oocyte expressed protein homolog (dog)oocyte- and embryo-specific protein 19eukaryotic translation initiation factor 3 subunit AEIF3, p180 subunitcentrosomin homologcytoplasmic protein p167eIF-3-thetaeIF3 p167eIF3 p180eIF3 p185eukaryotic translation initiation factor 3 subunit 10eukaryotic translation initiation factor 3
Modification date2018032920180523
UniProtAcc

A6NGQ2

Q14152

Ensembl transtripts involved in fusion geneENST00000370363, ENST00000370359, 
ENST00000369144, ENST00000541549, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 6 X 2=72
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OOEP [Title/Abstract] AND EIF3A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEIF3A

GO:0001732

formation of cytoplasmic translation initiation complex

17581632

TgeneEIF3A

GO:0075522

IRES-dependent viral translational initiation

9573242|23766293|24357634

TgeneEIF3A

GO:0075525

viral translational termination-reinitiation

21347434


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE706163OOEPchr6

74083034

+EIF3Achr10

120816367

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000370363ENST00000369144OOEPchr6

74083034

+EIF3Achr10

120816367

-
intron-3CDSENST00000370363ENST00000541549OOEPchr6

74083034

+EIF3Achr10

120816367

-
intron-3CDSENST00000370359ENST00000369144OOEPchr6

74083034

+EIF3Achr10

120816367

-
intron-3CDSENST00000370359ENST00000541549OOEPchr6

74083034

+EIF3Achr10

120816367

-

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FusionProtFeatures for OOEP_EIF3A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OOEP

A6NGQ2

EIF3A

Q14152

As a member of the subcortical maternal complex (SCMC),plays an essential role for zygotes to progress beyond the firstembryonic cell divisions. {ECO:0000250}. RNA-binding component of the eukaryotic translationinitiation factor 3 (eIF-3) complex, which is required for severalsteps in the initiation of protein synthesis (PubMed:17581632,PubMed:25849773). The eIF-3 complex associates with the 40Sribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiationcomplex (43S PIC). The eIF-3 complex stimulates mRNA recruitmentto the 43S PIC and scanning of the mRNA for AUG recognition. TheeIF-3 complex is also required for disassembly and recycling ofpost-termination ribosomal complexes and subsequently preventspremature joining of the 40S and 60S ribosomal subunits prior toinitiation (PubMed:17581632, PubMed:11169732). The eIF-3 complexspecifically targets and initiates translation of a subset ofmRNAs involved in cell proliferation, including cell cycling,differentiation and apoptosis, and uses different modes of RNAstem-loop binding to exert either translational activation orrepression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732,ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773,ECO:0000269|PubMed:27462815}. (Microbial infection) Essential for the initiation oftranslation on type-1 viral ribosomal entry sites (IRESs), likefor HCV, PV, EV71 or BEV translation (PubMed:23766293,PubMed:24357634). {ECO:0000269|PubMed:23766293,ECO:0000269|PubMed:24357634}. (Microbial infection) In case of FCV infection, plays arole in the ribosomal termination-reinitiation event leading tothe translation of VP2 (PubMed:18056426).{ECO:0000269|PubMed:18056426}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OOEP_EIF3A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OOEP_EIF3A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OOEP_EIF3A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for OOEP_EIF3A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneEIF3AC0033578Prostatic Neoplasms1CTD_human