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Fusion gene ID: 25421 |
FusionGeneSummary for OLFM4_TOP2B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: OLFM4_TOP2B | Fusion gene ID: 25421 | Hgene | Tgene | Gene symbol | OLFM4 | TOP2B | Gene ID | 10562 | 7155 |
| Gene name | olfactomedin 4 | DNA topoisomerase II beta | |
| Synonyms | GC1|GW112|OLM4|OlfD|UNQ362|bA209J19.1|hGC-1|hOLfD | TOPIIB|top2beta | |
| Cytomap | 13q14.3 | 3p24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | olfactomedin-4G-CSF-stimulated clone 1 proteinantiapoptotic protein GW112 | DNA topoisomerase 2-betaDNA topoisomerase II, 180 kDDNA topoisomerase II, beta isozymeU937 associated antigenantigen MLAA-44topo II betatopoisomerase (DNA) II beta 180kDatopoisomerase II betatopoisomerase IIb | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q6UX06 | Q02880 | |
| Ensembl transtripts involved in fusion gene | ENST00000219022, | ENST00000435706, ENST00000264331, ENST00000542520, ENST00000540199, ENST00000475717, | |
| Fusion gene scores | * DoF score | 6 X 3 X 3=54 | 7 X 8 X 3=168 |
| # samples | 7 | 8 | |
| ** MAII score | log2(7/54*10)=0.374395514781498 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: OLFM4 [Title/Abstract] AND TOP2B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | OLFM4 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading | 16566923 |
| Tgene | TOP2B | GO:0006265 | DNA topological change | 10684600 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-J4-A6G1-01A | OLFM4 | chr13 | 53626192 | + | TOP2B | chr3 | 25674074 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000219022 | ENST00000435706 | OLFM4 | chr13 | 53626192 | + | TOP2B | chr3 | 25674074 | - |
| Frame-shift | ENST00000219022 | ENST00000264331 | OLFM4 | chr13 | 53626192 | + | TOP2B | chr3 | 25674074 | - |
| 5CDS-intron | ENST00000219022 | ENST00000542520 | OLFM4 | chr13 | 53626192 | + | TOP2B | chr3 | 25674074 | - |
| 5CDS-intron | ENST00000219022 | ENST00000540199 | OLFM4 | chr13 | 53626192 | + | TOP2B | chr3 | 25674074 | - |
| 5CDS-intron | ENST00000219022 | ENST00000475717 | OLFM4 | chr13 | 53626192 | + | TOP2B | chr3 | 25674074 | - |
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FusionProtFeatures for OLFM4_TOP2B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| OLFM4 | TOP2B |
| May promote proliferation of pancreatic cancer cells byfavoring the transition from the S to G2/M phase. In myeloidleukemic cell lines, inhibits cell growth and induces celldifferentiation and apoptosis. May play a role in the inhibitionof EIF4EBP1 phosphorylation/deactivation. Facilitates celladhesion, most probably through interaction with cell surfacelectins and cadherin. {ECO:0000269|PubMed:16566923,ECO:0000269|PubMed:17270022, ECO:0000269|PubMed:20724538}. | Control of topological states of DNA by transientbreakage and subsequent rejoining of DNA strands. Topoisomerase IImakes double-strand breaks. {ECO:0000269|PubMed:10684600}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for OLFM4_TOP2B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for OLFM4_TOP2B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| OLFM4 | APP, CCDC155, SYNE4, LDLRAD1, RBPMS, TOR3A, NID2, TRUB2, RDH13, ZNF281, GNL3L, WDR59, P3H4, DNAJB9, MTFR1L, DDX11L8, FUT8, C17orf70, BMP7, RPUSD3, INTS6, LEPREL2, EXOC8, EMILIN3, COL18A1, DHFRL1, ETV3, TFB2M, FUT11, ERF, GNPTG, ALDH16A1, PDF, USP54, SDF2L1 | TOP2B | TOPBP1, HDAC1, HDAC2, MTA2, TOP2A, TP53, SUMO1, CD3E, CSNK2B, ESR1, PARP1, SRRM1, PML, RARA, USF1, RANBP2, CUL5, BAZ1B, SMARCA2, SMARCB1, SMARCC1, SMARCA4, SMARCC2, SMARCE1, SMARCD2, SEPT7, SFPQ, HNRNPR, NCSTN, SNRPE, RBM14, HDAC3, IK, MSH2, S100A9, SNRNP200, XPC, NOTCH1, RPA1, RPA2, RPA3, ERG, EIF6, CUL7, OBSL1, UBE2I, SUMO2, CTCF, LAMTOR5, UNK, GLYR1, POLE3, SUPT16H, TOP1, NTRK1, SCARNA22, IFI16, SPICE1, CEP164, DAXX, RPL10, FOXD3, ASB3, HSD3B2, PLAUR, GPATCH4, COX15, DLST |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for OLFM4_TOP2B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | TOP2B | Q02880 | DB00694 | Daunorubicin | DNA topoisomerase 2-beta | small molecule | approved |
| Tgene | TOP2B | Q02880 | DB00773 | Etoposide | DNA topoisomerase 2-beta | small molecule | approved |
| Tgene | TOP2B | Q02880 | DB00380 | Dexrazoxane | DNA topoisomerase 2-beta | small molecule | approved|withdrawn |
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RelatedDiseases for OLFM4_TOP2B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | OLFM4 | C0014175 | Endometriosis | 1 | CTD_human |
| Tgene | TOP2B | C0023470 | Myeloid Leukemia | 1 | CTD_human |
| Tgene | TOP2B | C0282612 | Prostatic Intraepithelial Neoplasias | 1 | CTD_human |
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