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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25415

FusionGeneSummary for OLFM3_RIMS1

check button Fusion gene summary
Fusion gene informationFusion gene name: OLFM3_RIMS1
Fusion gene ID: 25415
HgeneTgene
Gene symbol

OLFM3

RIMS1

Gene ID

118427

22999

Gene nameolfactomedin 3regulating synaptic membrane exocytosis 1
SynonymsNOE3|NOELIN3|OPTIMEDINCORD7|RAB3IP2|RIM|RIM1
Cytomap

1p21.1

6q13

Type of geneprotein-codingprotein-coding
Descriptionnoelin-3olfactomedin related ER localized protein 3regulating synaptic membrane exocytosis protein 1RAB3-interacting protein 2rab-3-interacting protein 2rab3-interacting molecule 1
Modification date2018051920180523
UniProtAcc

Q96PB7

Q86UR5

Ensembl transtripts involved in fusion geneENST00000370103, ENST00000462354, 
ENST00000536598, ENST00000338858, 
ENST00000359814, 
ENST00000491071, 
ENST00000348717, ENST00000518273, 
ENST00000522291, ENST00000517960, 
ENST00000521978, ENST00000520567, 
ENST00000264839, ENST00000401910, 
ENST00000523963, ENST00000425662, 
ENST00000517827, ENST00000538414, 
ENST00000431478, ENST00000414192, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 2=32
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: OLFM3 [Title/Abstract] AND RIMS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRIMS1

GO:0065003

protein-containing complex assembly

11438518

TgeneRIMS1

GO:1903861

positive regulation of dendrite extension

23999003


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA062426OLFM3chr1

102462304

-RIMS1chr6

73100298

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000370103ENST00000491071OLFM3chr1

102462304

-RIMS1chr6

73100298

+
Frame-shitENST00000370103ENST00000348717OLFM3chr1

102462304

-RIMS1chr6

73100298

+
Frame-shitENST00000370103ENST00000518273OLFM3chr1

102462304

-RIMS1chr6

73100298

+
Frame-shitENST00000370103ENST00000522291OLFM3chr1

102462304

-RIMS1chr6

73100298

+
Frame-shitENST00000370103ENST00000517960OLFM3chr1

102462304

-RIMS1chr6

73100298

+
Frame-shitENST00000370103ENST00000521978OLFM3chr1

102462304

-RIMS1chr6

73100298

+
Frame-shitENST00000370103ENST00000520567OLFM3chr1

102462304

-RIMS1chr6

73100298

+
Frame-shitENST00000370103ENST00000264839OLFM3chr1

102462304

-RIMS1chr6

73100298

+
Frame-shitENST00000370103ENST00000401910OLFM3chr1

102462304

-RIMS1chr6

73100298

+
Frame-shitENST00000370103ENST00000523963OLFM3chr1

102462304

-RIMS1chr6

73100298

+
Frame-shitENST00000370103ENST00000425662OLFM3chr1

102462304

-RIMS1chr6

73100298

+
Frame-shitENST00000370103ENST00000517827OLFM3chr1

102462304

-RIMS1chr6

73100298

+
Frame-shitENST00000370103ENST00000538414OLFM3chr1

102462304

-RIMS1chr6

73100298

+
5CDS-3UTRENST00000370103ENST00000431478OLFM3chr1

102462304

-RIMS1chr6

73100298

+
5CDS-5UTRENST00000370103ENST00000414192OLFM3chr1

102462304

-RIMS1chr6

73100298

+
5UTR-3CDSENST00000462354ENST00000491071OLFM3chr1

102462304

-RIMS1chr6

73100298

+
5UTR-3CDSENST00000462354ENST00000348717OLFM3chr1

102462304

-RIMS1chr6

73100298

+
5UTR-3CDSENST00000462354ENST00000518273OLFM3chr1

102462304

-RIMS1chr6

73100298

+
5UTR-3CDSENST00000462354ENST00000522291OLFM3chr1

102462304

-RIMS1chr6

73100298

+
5UTR-3CDSENST00000462354ENST00000517960OLFM3chr1

102462304

-RIMS1chr6

73100298

+
5UTR-3CDSENST00000462354ENST00000521978OLFM3chr1

102462304

-RIMS1chr6

73100298

+
5UTR-3CDSENST00000462354ENST00000520567OLFM3chr1

102462304

-RIMS1chr6

73100298

+
5UTR-3CDSENST00000462354ENST00000264839OLFM3chr1

102462304

-RIMS1chr6

73100298

+
5UTR-3CDSENST00000462354ENST00000401910OLFM3chr1

102462304

-RIMS1chr6

73100298

+
5UTR-3CDSENST00000462354ENST00000523963OLFM3chr1

102462304

-RIMS1chr6

73100298

+
5UTR-3CDSENST00000462354ENST00000425662OLFM3chr1

102462304

-RIMS1chr6

73100298

+
5UTR-3CDSENST00000462354ENST00000517827OLFM3chr1

102462304

-RIMS1chr6

73100298

+
5UTR-3CDSENST00000462354ENST00000538414OLFM3chr1

102462304

-RIMS1chr6

73100298

+
5UTR-3UTRENST00000462354ENST00000431478OLFM3chr1

102462304

-RIMS1chr6

73100298

+
5UTR-5UTRENST00000462354ENST00000414192OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000536598ENST00000491071OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000536598ENST00000348717OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000536598ENST00000518273OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000536598ENST00000522291OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000536598ENST00000517960OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000536598ENST00000521978OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000536598ENST00000520567OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000536598ENST00000264839OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000536598ENST00000401910OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000536598ENST00000523963OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000536598ENST00000425662OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000536598ENST00000517827OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000536598ENST00000538414OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3UTRENST00000536598ENST00000431478OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-5UTRENST00000536598ENST00000414192OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000338858ENST00000491071OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000338858ENST00000348717OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000338858ENST00000518273OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000338858ENST00000522291OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000338858ENST00000517960OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000338858ENST00000521978OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000338858ENST00000520567OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000338858ENST00000264839OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000338858ENST00000401910OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000338858ENST00000523963OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000338858ENST00000425662OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000338858ENST00000517827OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000338858ENST00000538414OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3UTRENST00000338858ENST00000431478OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-5UTRENST00000338858ENST00000414192OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000359814ENST00000491071OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000359814ENST00000348717OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000359814ENST00000518273OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000359814ENST00000522291OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000359814ENST00000517960OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000359814ENST00000521978OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000359814ENST00000520567OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000359814ENST00000264839OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000359814ENST00000401910OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000359814ENST00000523963OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000359814ENST00000425662OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000359814ENST00000517827OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3CDSENST00000359814ENST00000538414OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-3UTRENST00000359814ENST00000431478OLFM3chr1

102462304

-RIMS1chr6

73100298

+
intron-5UTRENST00000359814ENST00000414192OLFM3chr1

102462304

-RIMS1chr6

73100298

+

Top

FusionProtFeatures for OLFM3_RIMS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OLFM3

Q96PB7

RIMS1

Q86UR5


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OLFM3_RIMS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OLFM3_RIMS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
OLFM3MYOC, APP, STUB1, GLRX3, ADAMTSL4, OLFM2, RNF20, LRP1B, EHD4, AGRNRIMS1LRRK1, ERC2, BSN, YWHAH, CAMK2A, UNC13B, RAB3A, MYH1, KRAS, PDK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for OLFM3_RIMS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for OLFM3_RIMS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRIMS1C0004352Autistic Disorder1CTD_human
TgeneRIMS1C1863634Cone-Rod Dystrophy 71CTD_human;UNIPROT