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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25414

FusionGeneSummary for OLFM2_TMEM205

check button Fusion gene summary
Fusion gene informationFusion gene name: OLFM2_TMEM205
Fusion gene ID: 25414
HgeneTgene
Gene symbol

OLFM2

TMEM205

Gene ID

93145

374882

Gene nameolfactomedin 2transmembrane protein 205
SynonymsNOE2|NOELIN2|NOELIN2_V1|OlfCUNQ501
Cytomap

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionnoelin-2neuronal olfactomedin related ER localized protein 2transmembrane protein 205MBC3205
Modification date2018051920180519
UniProtAcc

O95897

Q6UW68

Ensembl transtripts involved in fusion geneENST00000264833, ENST00000590841, 
ENST00000586218, ENST00000593256, 
ENST00000447337, ENST00000354882, 
ENST00000586590, ENST00000586956, 
ENST00000589555, ENST00000587948, 
ENST00000588560, 
Fusion gene scores* DoF score10 X 1 X 7=705 X 2 X 5=50
# samples 105
** MAII scorelog2(10/70*10)=0.514573172829758
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/50*10)=0
Context

PubMed: OLFM2 [Title/Abstract] AND TMEM205 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOLFM2

GO:0009306

protein secretion

21228389


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVOVTCGA-09-0366-01AOLFM2chr19

10046980

-TMEM205chr19

11456304

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264833ENST00000586218OLFM2chr19

10046980

-TMEM205chr19

11456304

-
5CDS-5UTRENST00000264833ENST00000593256OLFM2chr19

10046980

-TMEM205chr19

11456304

-
5CDS-5UTRENST00000264833ENST00000447337OLFM2chr19

10046980

-TMEM205chr19

11456304

-
5CDS-5UTRENST00000264833ENST00000354882OLFM2chr19

10046980

-TMEM205chr19

11456304

-
5CDS-5UTRENST00000264833ENST00000586590OLFM2chr19

10046980

-TMEM205chr19

11456304

-
5CDS-5UTRENST00000264833ENST00000586956OLFM2chr19

10046980

-TMEM205chr19

11456304

-
5CDS-5UTRENST00000264833ENST00000589555OLFM2chr19

10046980

-TMEM205chr19

11456304

-
5CDS-5UTRENST00000264833ENST00000587948OLFM2chr19

10046980

-TMEM205chr19

11456304

-
5CDS-5UTRENST00000264833ENST00000588560OLFM2chr19

10046980

-TMEM205chr19

11456304

-
intron-intronENST00000590841ENST00000586218OLFM2chr19

10046980

-TMEM205chr19

11456304

-
intron-5UTRENST00000590841ENST00000593256OLFM2chr19

10046980

-TMEM205chr19

11456304

-
intron-5UTRENST00000590841ENST00000447337OLFM2chr19

10046980

-TMEM205chr19

11456304

-
intron-5UTRENST00000590841ENST00000354882OLFM2chr19

10046980

-TMEM205chr19

11456304

-
intron-5UTRENST00000590841ENST00000586590OLFM2chr19

10046980

-TMEM205chr19

11456304

-
intron-5UTRENST00000590841ENST00000586956OLFM2chr19

10046980

-TMEM205chr19

11456304

-
intron-5UTRENST00000590841ENST00000589555OLFM2chr19

10046980

-TMEM205chr19

11456304

-
intron-5UTRENST00000590841ENST00000587948OLFM2chr19

10046980

-TMEM205chr19

11456304

-
intron-5UTRENST00000590841ENST00000588560OLFM2chr19

10046980

-TMEM205chr19

11456304

-

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FusionProtFeatures for OLFM2_TMEM205


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OLFM2

O95897

TMEM205

Q6UW68

Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expressionand translocation of OLFM2 to the nucleus where it binds to SRF,causing its dissociation from the transcriptional repressorHEY2/HERP1 and facilitating binding of SRF to target genes(PubMed:25298399). Plays a role in AMPAR complex organization (Bysimilarity). Is a regulator of vascular smooth-muscle cell (SMC)phenotypic switching, that acts by promoting RUNX2 and inhibitingMYOCD binding to SRF. SMC phenotypic switching is the processthrough which vascular SMCs undergo transition between a quiescentcontractile phenotype and a proliferative synthetic phenotype inresponse to pathological stimuli. SMC phenotypic plasticity isessential for vascular development and remodeling (By similarity).{ECO:0000250|UniProtKB:Q568Y7, ECO:0000250|UniProtKB:Q8BM13,ECO:0000269|PubMed:25298399}. In cancer cells, plays a role in resistance to thechemotherapeutic agent cisplatin. {ECO:0000269|PubMed:20589834}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OLFM2_TMEM205


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OLFM2_TMEM205


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
OLFM2SRSF5, ST13, BLOC1S6, KRTAP10-3, OLFM1, ZFHX4, RNF40, TUBB1, DVL2, FEM1B, OLFM3, KDM5C, MSTO1, LRIF1, ZSWIM8, CBY1, EGFL7, DTNB, SDF2L1, DPYSL4, METTL3, PEX6, GALNS, BMP7, ZNF507, C15orf39, FUT11, NCOR1, CTDNEP1, BANP, VCPIP1, USP54, GPATCH8, N4BP2L2, DNAJB9, HAUS8TMEM205CD1B, NRG1, HMOX2, IL9R, SLC18A1, B4GALT3, TMEM52B, COQ9, NDUFA4, TRDN, RBP4, TPM2, GDPD5, CORO1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OLFM2_TMEM205


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for OLFM2_TMEM205


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource