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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25392

FusionGeneSummary for OGG1_MTCH1

check button Fusion gene summary
Fusion gene informationFusion gene name: OGG1_MTCH1
Fusion gene ID: 25392
HgeneTgene
Gene symbol

OGG1

MTCH1

Gene ID

4968

23787

Gene name8-oxoguanine DNA glycosylasemitochondrial carrier 1
SynonymsHMMH|HOGG1|MUTM|OGH1CGI-64|PIG60|PSAP|SLC25A49
Cytomap

3p25.3

6p21.2

Type of geneprotein-codingprotein-coding
DescriptionN-glycosylase/DNA lyase8-hydroxyguanine DNA glycosylaseAP lyaseDNA-apurinic or apyrimidinic site lyaseOGG1 type 1fmitochondrial carrier homolog 1cell proliferation-inducing protein 60presenilin-associated proteinsolute carrier family 25, member 49
Modification date2018052720180523
UniProtAcc

O15527

Q9NZJ7

Ensembl transtripts involved in fusion geneENST00000302003, ENST00000344629, 
ENST00000349503, ENST00000302036, 
ENST00000339511, ENST00000436092, 
ENST00000449570, ENST00000302008, 
ENST00000383826, 		ENST00000373627, 
ENST00000373616, ENST00000471737, 
ENST00000538808, 
Fusion gene scores* DoF score2 X 2 X 1=47 X 8 X 1=56
# samples 28
** MAII scorelog2(2/4*10)=2.32192809488736log2(8/56*10)=0.514573172829758
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: OGG1 [Title/Abstract] AND MTCH1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOGG1

GO:0006979

response to oxidative stress

17148573

HgeneOGG1

GO:0009314

response to radiation

17148573

HgeneOGG1

GO:0033683

nucleotide-excision repair, DNA incision

19506022

HgeneOGG1

GO:1901291

negative regulation of double-strand break repair via single-strand annealing

19506022


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ184316OGG1chr3

9804597

+MTCH1chr6

36940526

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000302003ENST00000373627OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-3CDSENST00000302003ENST00000373616OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-intronENST00000302003ENST00000471737OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-intronENST00000302003ENST00000538808OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-3CDSENST00000344629ENST00000373627OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-3CDSENST00000344629ENST00000373616OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-intronENST00000344629ENST00000471737OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-intronENST00000344629ENST00000538808OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-3CDSENST00000349503ENST00000373627OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-3CDSENST00000349503ENST00000373616OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-intronENST00000349503ENST00000471737OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-intronENST00000349503ENST00000538808OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-3CDSENST00000302036ENST00000373627OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-3CDSENST00000302036ENST00000373616OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-intronENST00000302036ENST00000471737OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-intronENST00000302036ENST00000538808OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-3CDSENST00000339511ENST00000373627OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-3CDSENST00000339511ENST00000373616OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-intronENST00000339511ENST00000471737OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-intronENST00000339511ENST00000538808OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-3CDSENST00000436092ENST00000373627OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-3CDSENST00000436092ENST00000373616OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-intronENST00000436092ENST00000471737OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-intronENST00000436092ENST00000538808OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-3CDSENST00000449570ENST00000373627OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-3CDSENST00000449570ENST00000373616OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-intronENST00000449570ENST00000471737OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-intronENST00000449570ENST00000538808OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-3CDSENST00000302008ENST00000373627OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-3CDSENST00000302008ENST00000373616OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-intronENST00000302008ENST00000471737OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-intronENST00000302008ENST00000538808OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-3CDSENST00000383826ENST00000373627OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-3CDSENST00000383826ENST00000373616OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-intronENST00000383826ENST00000471737OGG1chr3

9804597

+MTCH1chr6

36940526

+
intron-intronENST00000383826ENST00000538808OGG1chr3

9804597

+MTCH1chr6

36940526

+

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FusionProtFeatures for OGG1_MTCH1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OGG1

O15527

MTCH1

Q9NZJ7


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OGG1_MTCH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OGG1_MTCH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OGG1_MTCH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for OGG1_MTCH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneOGG1C0024121Lung Neoplasms2CTD_human
HgeneOGG1C0033578Prostatic Neoplasms2CTD_human
HgeneOGG1C0001418Adenocarcinoma1CTD_human
HgeneOGG1C0006111Brain Diseases1CTD_human
HgeneOGG1C0008625Chromosome Aberrations1CTD_human
HgeneOGG1C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneOGG1C0018781Noise-induced hearing loss1CTD_human
HgeneOGG1C0018799Heart Diseases1CTD_human
HgeneOGG1C0020179Huntington Disease1CTD_human
HgeneOGG1C0020507Hyperplasia1CTD_human
HgeneOGG1C0021364Male infertility1CTD_human
HgeneOGG1C0024299Lymphoma1CTD_human
HgeneOGG1C0026613Motor Skills Disorders1CTD_human
HgeneOGG1C0027746Nerve Degeneration1CTD_human
HgeneOGG1C0033054Prenatal Exposure Delayed Effects1CTD_human
HgeneOGG1C0037274Dermatologic disorders1CTD_human
HgeneOGG1C0042076Urologic Neoplasms1CTD_human
HgeneOGG1C0152013Adenocarcinoma of lung (disorder)1CTD_human