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Fusion gene ID: 25391 |
FusionGeneSummary for OGG1_CBX2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: OGG1_CBX2 | Fusion gene ID: 25391 | Hgene | Tgene | Gene symbol | OGG1 | CBX2 | Gene ID | 4968 | 84733 |
| Gene name | 8-oxoguanine DNA glycosylase | chromobox 2 | |
| Synonyms | HMMH|HOGG1|MUTM|OGH1 | CDCA6|M33|SRXY5 | |
| Cytomap | 3p25.3 | 17q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | N-glycosylase/DNA lyase8-hydroxyguanine DNA glycosylaseAP lyaseDNA-apurinic or apyrimidinic site lyaseOGG1 type 1f | chromobox protein homolog 2Pc class homologcell division cycle associated 6chromobox homolog 2 (Pc class homolog, Drosophila)modifier 3 | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | O15527 | Q14781 | |
| Ensembl transtripts involved in fusion gene | ENST00000302003, ENST00000344629, ENST00000349503, ENST00000302036, ENST00000339511, ENST00000436092, ENST00000449570, ENST00000302008, ENST00000383826, | ENST00000310942, ENST00000269399, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: OGG1 [Title/Abstract] AND CBX2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | OGG1 | GO:0006979 | response to oxidative stress | 17148573 |
| Hgene | OGG1 | GO:0009314 | response to radiation | 17148573 |
| Hgene | OGG1 | GO:0033683 | nucleotide-excision repair, DNA incision | 19506022 |
| Hgene | OGG1 | GO:1901291 | negative regulation of double-strand break repair via single-strand annealing | 19506022 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI554178 | OGG1 | chr3 | 9799121 | + | CBX2 | chr17 | 77758760 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000302003 | ENST00000310942 | OGG1 | chr3 | 9799121 | + | CBX2 | chr17 | 77758760 | - |
| intron-intron | ENST00000302003 | ENST00000269399 | OGG1 | chr3 | 9799121 | + | CBX2 | chr17 | 77758760 | - |
| 3UTR-3CDS | ENST00000344629 | ENST00000310942 | OGG1 | chr3 | 9799121 | + | CBX2 | chr17 | 77758760 | - |
| 3UTR-intron | ENST00000344629 | ENST00000269399 | OGG1 | chr3 | 9799121 | + | CBX2 | chr17 | 77758760 | - |
| intron-3CDS | ENST00000349503 | ENST00000310942 | OGG1 | chr3 | 9799121 | + | CBX2 | chr17 | 77758760 | - |
| intron-intron | ENST00000349503 | ENST00000269399 | OGG1 | chr3 | 9799121 | + | CBX2 | chr17 | 77758760 | - |
| intron-3CDS | ENST00000302036 | ENST00000310942 | OGG1 | chr3 | 9799121 | + | CBX2 | chr17 | 77758760 | - |
| intron-intron | ENST00000302036 | ENST00000269399 | OGG1 | chr3 | 9799121 | + | CBX2 | chr17 | 77758760 | - |
| intron-3CDS | ENST00000339511 | ENST00000310942 | OGG1 | chr3 | 9799121 | + | CBX2 | chr17 | 77758760 | - |
| intron-intron | ENST00000339511 | ENST00000269399 | OGG1 | chr3 | 9799121 | + | CBX2 | chr17 | 77758760 | - |
| intron-3CDS | ENST00000436092 | ENST00000310942 | OGG1 | chr3 | 9799121 | + | CBX2 | chr17 | 77758760 | - |
| intron-intron | ENST00000436092 | ENST00000269399 | OGG1 | chr3 | 9799121 | + | CBX2 | chr17 | 77758760 | - |
| intron-3CDS | ENST00000449570 | ENST00000310942 | OGG1 | chr3 | 9799121 | + | CBX2 | chr17 | 77758760 | - |
| intron-intron | ENST00000449570 | ENST00000269399 | OGG1 | chr3 | 9799121 | + | CBX2 | chr17 | 77758760 | - |
| intron-3CDS | ENST00000302008 | ENST00000310942 | OGG1 | chr3 | 9799121 | + | CBX2 | chr17 | 77758760 | - |
| intron-intron | ENST00000302008 | ENST00000269399 | OGG1 | chr3 | 9799121 | + | CBX2 | chr17 | 77758760 | - |
| intron-3CDS | ENST00000383826 | ENST00000310942 | OGG1 | chr3 | 9799121 | + | CBX2 | chr17 | 77758760 | - |
| intron-intron | ENST00000383826 | ENST00000269399 | OGG1 | chr3 | 9799121 | + | CBX2 | chr17 | 77758760 | - |
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FusionProtFeatures for OGG1_CBX2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| OGG1 | CBX2 |
| Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain thetranscriptionally repressive state of many genes, including Hoxgenes, throughout development (PubMed:21282530). PcG PRC1 complexacts via chromatin remodeling and modification of histones; itmediates monoubiquitination of histone H2A 'Lys-119', renderingchromatin heritably changed in its expressibility(PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9'(H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a rolein the lineage differentiation of the germ layers in embryonicdevelopment (By similarity). Involved in sexual development,acting as activator of NR5A1 expression (PubMed:19361780).{ECO:0000250|UniProtKB:P30658, ECO:0000269|PubMed:19361780,ECO:0000269|PubMed:21282530}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for OGG1_CBX2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for OGG1_CBX2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for OGG1_CBX2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OGG1_CBX2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | OGG1 | C0024121 | Lung Neoplasms | 2 | CTD_human |
| Hgene | OGG1 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| Hgene | OGG1 | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Hgene | OGG1 | C0006111 | Brain Diseases | 1 | CTD_human |
| Hgene | OGG1 | C0008625 | Chromosome Aberrations | 1 | CTD_human |
| Hgene | OGG1 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
| Hgene | OGG1 | C0018781 | Noise-induced hearing loss | 1 | CTD_human |
| Hgene | OGG1 | C0018799 | Heart Diseases | 1 | CTD_human |
| Hgene | OGG1 | C0020179 | Huntington Disease | 1 | CTD_human |
| Hgene | OGG1 | C0020507 | Hyperplasia | 1 | CTD_human |
| Hgene | OGG1 | C0021364 | Male infertility | 1 | CTD_human |
| Hgene | OGG1 | C0024299 | Lymphoma | 1 | CTD_human |
| Hgene | OGG1 | C0026613 | Motor Skills Disorders | 1 | CTD_human |
| Hgene | OGG1 | C0027746 | Nerve Degeneration | 1 | CTD_human |
| Hgene | OGG1 | C0033054 | Prenatal Exposure Delayed Effects | 1 | CTD_human |
| Hgene | OGG1 | C0037274 | Dermatologic disorders | 1 | CTD_human |
| Hgene | OGG1 | C0042076 | Urologic Neoplasms | 1 | CTD_human |
| Hgene | OGG1 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| Tgene | CBX2 | C2751317 | 46, XY Sex Reversal 5 | 1 | CTD_human;UNIPROT |
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