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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25383

FusionGeneSummary for OGFOD1_CRNDE

check button Fusion gene summary
Fusion gene informationFusion gene name: OGFOD1_CRNDE
Fusion gene ID: 25383
HgeneTgene
Gene symbol

OGFOD1

CRNDE

Gene ID

55239

643911

Gene name2-oxoglutarate and iron dependent oxygenase domain containing 1colorectal neoplasia differentially expressed
SynonymsTPA1CRNDEP|LINC00180|NCRNA00180|PNAS-108|lincIRX5
Cytomap

16q13

16q12.2

Type of geneprotein-codingprotein-coding
Descriptionprolyl 3-hydroxylase OGFOD12-oxoglutarate and iron-dependent oxygenase domain-containing protein 1TPA1, termination and polyadenylation 1, homologtermination and polyadenylation 1 homologuS12 prolyl 3-hydroxylasecolorectal neoplasia differentially expressed peptidecolorectal neoplasia differentially expressed (non-protein coding)long intergenic non-protein coding RNA 180
Modification date2018052320180429
UniProtAcc

Q8N543

Ensembl transtripts involved in fusion geneENST00000566157, ENST00000568397, 
ENST00000565209, 
ENST00000560208, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 2 X 2=8
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: OGFOD1 [Title/Abstract] AND CRNDE [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOGFOD1

GO:0018126

protein hydroxylation

24550447|24550462

HgeneOGFOD1

GO:0019511

peptidyl-proline hydroxylation

24550447


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-78-7150-01AOGFOD1chr16

56510082

+CRNDEchr16

54957562

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000566157ENST00000560208OGFOD1chr16

56510082

+CRNDEchr16

54957562

-
5CDS-intronENST00000568397ENST00000560208OGFOD1chr16

56510082

+CRNDEchr16

54957562

-
intron-intronENST00000565209ENST00000560208OGFOD1chr16

56510082

+CRNDEchr16

54957562

-

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FusionProtFeatures for OGFOD1_CRNDE


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OGFOD1

Q8N543

CRNDE

Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of'Pro-62' of small ribosomal subunit uS12 (RPS23), therebyregulating protein translation termination efficiency. Involved instress granule formation. {ECO:0000269|PubMed:20154146,ECO:0000269|PubMed:24550447, ECO:0000269|PubMed:24550462}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OGFOD1_CRNDE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OGFOD1_CRNDE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
OGFOD1LIG4, AHCY, ALDH1B1, ASB6, ASNS, ATIC, CAPNS1, FH, ISOC1, MCTS1, STK26, MYO1E, EZR, GNPDA1, H2AFZ, MC1R, PYGL, RAD23A, TBCE, TRNT1, UBA6, UBR7, PDIA4, PRCP, PROSC, PTMA, PYGB, TBCB, TWF2, YWHAE, FGL1, SRRT, TRIM25CRNDE


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OGFOD1_CRNDE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneOGFOD1Q8N543DB00126Vitamin CProlyl 3-hydroxylase OGFOD1small moleculeapproved|nutraceutical

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RelatedDiseases for OGFOD1_CRNDE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource