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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25382

FusionGeneSummary for OGDH_PAN3-AS1

check button Fusion gene summary
Fusion gene informationFusion gene name: OGDH_PAN3-AS1
Fusion gene ID: 25382
HgeneTgene
Gene symbol

OGDH

PAN3-AS1

Gene ID

4967

100288730

Gene nameoxoglutarate dehydrogenasePAN3 antisense RNA 1
SynonymsAKGDH|E1k|OGDC-
Cytomap

7p13

13q12.2

Type of geneprotein-codingncRNA
Description2-oxoglutarate dehydrogenase, mitochondrial2-oxoglutarate dehydrogenase complex component E1OGDC-E1oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)oxoglutarate decarboxylaseoxoglutarate dehydrogenase (succinyl-transferring)testicular tisPAN3 antisense RNA 1 (non-protein coding)
Modification date2018052520180329
UniProtAcc

Q02218

Ensembl transtripts involved in fusion geneENST00000439616, ENST00000443864, 
ENST00000447398, ENST00000449767, 
ENST00000444676, ENST00000222673, 
ENST00000543843, ENST00000459672, 
ENST00000563843, 
Fusion gene scores* DoF score2 X 2 X 1=41 X 1 X 1=1
# samples 32
** MAII scorelog2(3/4*10)=2.90689059560852log2(2/1*10)=4.32192809488736
Context

PubMed: OGDH [Title/Abstract] AND PAN3-AS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOGDH

GO:0006103

2-oxoglutarate metabolic process

24495017|29211711

HgeneOGDH

GO:0006104

succinyl-CoA metabolic process

24495017|29211711

HgeneOGDH

GO:0106077

histone succinylation

29211711


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF367739OGDHchr7

44676407

+PAN3-AS1chr13

28713182

+
ChiTaRS3.1BF367733OGDHchr7

44676407

+PAN3-AS1chr13

28713182

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000439616ENST00000563843OGDHchr7

44676407

+PAN3-AS1chr13

28713182

+
intron-intronENST00000443864ENST00000563843OGDHchr7

44676407

+PAN3-AS1chr13

28713182

+
intron-intronENST00000447398ENST00000563843OGDHchr7

44676407

+PAN3-AS1chr13

28713182

+
intron-intronENST00000449767ENST00000563843OGDHchr7

44676407

+PAN3-AS1chr13

28713182

+
intron-intronENST00000444676ENST00000563843OGDHchr7

44676407

+PAN3-AS1chr13

28713182

+
intron-intronENST00000222673ENST00000563843OGDHchr7

44676407

+PAN3-AS1chr13

28713182

+
intron-intronENST00000543843ENST00000563843OGDHchr7

44676407

+PAN3-AS1chr13

28713182

+
intron-intronENST00000459672ENST00000563843OGDHchr7

44676407

+PAN3-AS1chr13

28713182

+

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FusionProtFeatures for OGDH_PAN3-AS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OGDH

Q02218

PAN3-AS1

2-oxoglutarate dehydrogenase (E1) component of the 2-oxoglutarate dehydrogenase complex, which mediates thedecarboxylation of alpha-ketoglutarate (PubMed:24495017). The 2-oxoglutarate dehydrogenase complex catalyzes the overallconversion of 2-oxoglutarate to succinyl-CoA and CO(2)(PubMed:24495017). The 2-oxoglutarate dehydrogenase complex ismainly active in the mitochondrion (PubMed:29211711). A fractionof the 2-oxoglutarate dehydrogenase complex also localizes in thenucleus and is required for lysine succinylation of histones:associates with KAT2A on chromatin and provides succinyl-CoA tohistone succinyltransferase KAT2A (PubMed:29211711).{ECO:0000269|PubMed:24495017, ECO:0000269|PubMed:29211711}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OGDH_PAN3-AS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OGDH_PAN3-AS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OGDH_PAN3-AS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneOGDHQ02218DB00313Valproic Acid2-oxoglutarate dehydrogenase, mitochondrialsmall moleculeapproved|investigational
HgeneOGDHQ02218DB09092Xanthinol2-oxoglutarate dehydrogenase, mitochondrialsmall moleculeapproved|withdrawn

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RelatedDiseases for OGDH_PAN3-AS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource