FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 25374

FusionGeneSummary for ODF3B_ZNF609

check button Fusion gene summary
Fusion gene informationFusion gene name: ODF3B_ZNF609
Fusion gene ID: 25374
HgeneTgene
Gene symbol

ODF3B

ZNF609

Gene ID

440836

23060

Gene nameouter dense fiber of sperm tails 3Bzinc finger protein 609
SynonymsODF3L3-
Cytomap

22q13.33

15q22.31

Type of geneprotein-codingprotein-coding
Descriptionouter dense fiber protein 3Borf2 5' to PD-ECGF/TPouter dense fiber protein 3-like protein 3zinc finger protein 609
Modification date2018032920180519
UniProtAcc

A8MYP8

O15014

Ensembl transtripts involved in fusion geneENST00000401779, ENST00000329363, 
ENST00000403326, ENST00000405135, 
ENST00000428989, 
ENST00000326648, 
ENST00000416172, ENST00000559364, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 9 X 3=189
# samples 210
** MAII scorelog2(2/8*10)=1.32192809488736log2(10/189*10)=-0.918386234446348
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ODF3B [Title/Abstract] AND ZNF609 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZNF609

GO:2000291

regulation of myoblast proliferation

28344082


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW135599ODF3Bchr22

50968939

+ZNF609chr15

64967823

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000401779ENST00000326648ODF3Bchr22

50968939

+ZNF609chr15

64967823

-
intron-intronENST00000401779ENST00000416172ODF3Bchr22

50968939

+ZNF609chr15

64967823

-
intron-intronENST00000401779ENST00000559364ODF3Bchr22

50968939

+ZNF609chr15

64967823

-
intron-3CDSENST00000329363ENST00000326648ODF3Bchr22

50968939

+ZNF609chr15

64967823

-
intron-intronENST00000329363ENST00000416172ODF3Bchr22

50968939

+ZNF609chr15

64967823

-
intron-intronENST00000329363ENST00000559364ODF3Bchr22

50968939

+ZNF609chr15

64967823

-
intron-3CDSENST00000403326ENST00000326648ODF3Bchr22

50968939

+ZNF609chr15

64967823

-
intron-intronENST00000403326ENST00000416172ODF3Bchr22

50968939

+ZNF609chr15

64967823

-
intron-intronENST00000403326ENST00000559364ODF3Bchr22

50968939

+ZNF609chr15

64967823

-
intron-3CDSENST00000405135ENST00000326648ODF3Bchr22

50968939

+ZNF609chr15

64967823

-
intron-intronENST00000405135ENST00000416172ODF3Bchr22

50968939

+ZNF609chr15

64967823

-
intron-intronENST00000405135ENST00000559364ODF3Bchr22

50968939

+ZNF609chr15

64967823

-
intron-3CDSENST00000428989ENST00000326648ODF3Bchr22

50968939

+ZNF609chr15

64967823

-
intron-intronENST00000428989ENST00000416172ODF3Bchr22

50968939

+ZNF609chr15

64967823

-
intron-intronENST00000428989ENST00000559364ODF3Bchr22

50968939

+ZNF609chr15

64967823

-

Top

FusionProtFeatures for ODF3B_ZNF609


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ODF3B

A8MYP8

ZNF609

O15014

Transcription factor, which activates RAG1, and possiblyRAG2, transcription. Through the regulation of RAG1/2 expression,may regulate thymocyte maturation. Along with NIPBL and themultiprotein complex Integrator, promotes cortical neuronmigration during brain development by regulating the transcriptionof crucial genes in this process. Preferentially binds promoterscontaining paused RNA polymerase II. Up-regulates the expressionof SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others.{ECO:0000250|UniProtKB:Q8BZ47}. Isoform 2: Involved in the regulation of myoblastproliferation during myogenesis. {ECO:0000269|PubMed:28344082}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ODF3B_ZNF609


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ODF3B_ZNF609


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ODF3B_ZNF609


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ODF3B_ZNF609


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneODF3BC0032460Polycystic Ovary Syndrome1CTD_human