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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25364

FusionGeneSummary for OCLN_NUDT3

check button Fusion gene summary
Fusion gene informationFusion gene name: OCLN_NUDT3
Fusion gene ID: 25364
HgeneTgene
Gene symbol

OCLN

NUDT3

Gene ID

100506658

11165

Gene nameoccludinnudix hydrolase 3
SynonymsBLCPMG|PPP1R115|PTORCH1DIPP|DIPP-1|DIPP1
Cytomap

5q13.2

6p21.31

Type of geneprotein-codingprotein-coding
Descriptionoccludinphosphatase 1, regulatory subunit 115tight junction protein occludindiphosphoinositol polyphosphate phosphohydrolase 1diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1nucleoside diphosphate-linked moiety X motif 3nudix (nucleoside diphosphate linked moiety X)-type motif 3nudix motif 3
Modification date2018051920180523
UniProtAcc

Q16625

O95989

Ensembl transtripts involved in fusion geneENST00000355237, ENST00000396442, 
ENST00000380766, ENST00000538151, 
ENST00000542132, ENST00000514370, 
ENST00000607016, 
Fusion gene scores* DoF score6 X 4 X 5=1205 X 3 X 5=75
# samples 67
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/75*10)=-0.0995356735509144
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OCLN [Title/Abstract] AND NUDT3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNUDT3

GO:0071544

diphosphoinositol polyphosphate catabolic process

10585413


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCSTCGA-N5-A4RS-01AOCLNchr5

68800121

+NUDT3chr6

34263462

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000355237ENST00000607016OCLNchr5

68800121

+NUDT3chr6

34263462

-
Frame-shiftENST00000396442ENST00000607016OCLNchr5

68800121

+NUDT3chr6

34263462

-
Frame-shiftENST00000380766ENST00000607016OCLNchr5

68800121

+NUDT3chr6

34263462

-
5UTR-3CDSENST00000538151ENST00000607016OCLNchr5

68800121

+NUDT3chr6

34263462

-
5UTR-3CDSENST00000542132ENST00000607016OCLNchr5

68800121

+NUDT3chr6

34263462

-
intron-3CDSENST00000514370ENST00000607016OCLNchr5

68800121

+NUDT3chr6

34263462

-

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FusionProtFeatures for OCLN_NUDT3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OCLN

Q16625

NUDT3

O95989

Cleaves a beta-phosphate from the diphosphate groups inPP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4(bisdiphosphoinositol tetrakisphosphate), suggesting that it mayplay a role in signal transduction. InsP6 (inositolhexakisphophate) is not a substrate. Acts as a negative regulatorof the ERK1/2 pathway. Also able to catalyze the hydrolysis ofdinucleoside oligophosphates, with Ap6A and Ap5A being thepreferred substrates. The major reaction products are ADP and p4afrom Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. {ECO:0000269|PubMed:9822604}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OCLN_NUDT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OCLN_NUDT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
OCLNTJP2, RAB8B, YES1, TJP1, GJB1, ITCH, EPN1, EPS15, HGS, NEDD4L, TGFBR1, TGFBR2, LYN, TNFAIP3, CLEC7A, SYNE4, SNW1, CSNK1E, ULK1, CSNK1A1, MPZL2, CD1B, TMEM171, IGSF8, SLAMF1, DLK1, SLC18A1, TMEM17, TMEM216, FATE1, CDH1, PTPN2, FBLN1, MFAP4, CTAGE5, TMEM30B, C4A, SDC1, SIGLECL1, NEDD4, NDUFAF1, TNFSF8, ANTXR1, ACAD9, EFEMP1, SYT12, DNAJC13, PREB, MAN1A1, TNFSF9, CSNK2A1, OCLNNUDT3SOX30, ASB13, RAB17, RPL8, RPLP1, TNNT3, TUBGCP4, WDR74, ITFG1, FXYD3, RNF126, OAT, DDR1, EEF1G, PDCD5, REEP5, VPS51, PRKD3, RPL17, UBR1, MCM5, ARL6IP1, NUDT5, NR2C1, DBN1, HES1, APEX1, TUBA1A, MEX3B, DNAJA1, CHCHD3, PEX5, ALAS1, XPNPEP1, MAF1, CCL11, ELAVL1, IQCB1, MOV10, NXF1, AP1S2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OCLN_NUDT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for OCLN_NUDT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneOCLNC1458155Mammary Neoplasms2CTD_human
HgeneOCLNC0007621Neoplastic Cell Transformation1CTD_human
HgeneOCLNC0019156Hepatic Veno-Occlusive Disease1CTD_human
HgeneOCLNC0035309Retinal Diseases1CTD_human
HgeneOCLNC0038002Splenomegaly1CTD_human
HgeneOCLNC2609414Acute kidney injury1CTD_human
HgeneOCLNC3489725Pseudo-TORCH syndrome1CTD_human;ORPHANET;UNIPROT